A series of 5-(1,3-benzothiazol-6-yl)-4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazole derivatives was synthesized as transforming growth factor-β (TGF-β) type I receptor (also known as activin-like kinase 5 or ALK5) inhibitors. These compounds were evaluated for their ALK5 inhibitory activity in an...

Sulfonated semi-crystalline poly(arylene ether)s copolymers containing 1,4-bis(4-fluorobenzoyl)benzene (1,4-FBB), with different degrees of sulfonation (DS), were successfully synthesized via direct polycondensation of 3,3’-disulfonate-4,4’-difluorodiphenylsulfone, bisphenol A, and 1,4-bis(4-f...

CF3CFBr2 was employed in catalytic olefination reactions of aromatic aldehydes. In situ prepared hydrazones of aldehydes were transformed to β-fluoro-β-(trifluoromethyl)styrenes by reaction with CF3CFBr2 under CuCl catalysis. Based on this reaction, a novel stereoselective approach towards β-...

AimsMicroRNAs (miRNAs) are small noncoding RNAs that negatively control gene expression at the translational level. There are compelling evidences indicating that the expression of let-7e is downregulated in various cancers, however, the role of let-7e in colorectal cancer (CRC) and its mechanis...

A synthetic gene specifying a putative 3,4-dihydroxy-2-butanone 4-phosphate synthase of Candida albicans directed the synthesis of a 22.5 kDa peptide in a recombinant Escherichia coli strain. The recombinant protein was purified to apparent homogeneity by two chromatographic steps and was shown ...

A model compound 4-phenyl-2-butanone was used for studying the effect of glycerol in yeast Saccharomyces cerevisiae catalyzed reaction culture on the enantioselectivity for producing R- and S-4-phenyl-2-butanol under various reaction conditions. As the volume percentage of glycerol in the cell c...

As a new kind of power storage, supercapacitors have attracted much attention due to their short charge and discharge time, good cycle performance, large power density, and environmental friendliness. However, the main drawback of supercapacitors is lower energy density than batteries, as well a...

PurposeTo our knowledge no medication has been shown to be effective for preventing recurrent calcium phosphate urinary stones. Potassium citrate may protect against calcium phosphate stones by enhancing urine citrate excretion and lowering urine calcium but it raises urine pH, which increases c...

PurposeTo our knowledge it is unknown whether the benefits of medical management of urolithiasis outweigh the potential side effects of the medications used, including potassium citrate and thiazide diuretics. Therefore, we evaluated the relationship between potassium citrate or thiazides and ov...

The potential utility of butenolides as substrates in the electroreductive cyclization reaction has been investigated. A variety of butenolides bearing either an α,β,-unsaturated ester, an α,β,δ,-unsaturated ester, allylic bromide, bromide, mesylate or aldehyde functionality on the appendin...

Silver nanoparticle (SNP)-containing ceramic filter (SNP-CF) has been widely investigated for water disinfection but the filters usually lose their antibacterial efficacy after short time because of silver leaching. In this study, the SNP-CF has been successfully prepared by an in-situ reduction...

The electrodeposition-redox replacement (EDRR) process was studied to control the creation of copper and silver containing particles on the surface of a carbon nanotube film. Synthetic solutions simulating typical hydrometallurgical copper electrolysis process solutions (40 g/L Cu, 120 g/L H2SO4...

ObjectiveThe current use of nanoparticles in personal care and cosmetics, food safety, agriculture, medicine and pharmacy has led to a growing concern on the toxicity of these emerging materials to humans and also to the environment. Nanoparticles assessment (determination and size distribution)...

The aim of this study was to examine efficacy of different fractions of TEMPO-oxidized cellulose nanocrystals (TOCNs) as a reducing and capping agent of silver nanoparticles (AgNPs). Silver nanoparticles were prepared by thermal treatment of AgNO3 in aqueous suspensions of TOCN fractions. Three ...

Silver nanoparticles (Ag-NPs) have potential applications in life science, food chemistry, biomedicine, photocatalysis and cosmetics fields due to its unique optical, electrical and catalytic properties besides the strong antibacterial property. Apple pomace, a by-product of apple juice producti...

A convenient and facile synthesis of 4-(3-chlorophenyl)-1-(3-chloropropyl)piperazin-1-ium chloride is accomplished by stirring 1-(3-Chlorophenyl)piperazine hydrochloride with 3-chloropropanal by reductive amination in ethanol. The resulting compound was characterized using spectral data analysis...

A series of novel 1-substituted-4-(2-methylphenyl)-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones were synthesized by the cyclization of 2-hydrazino-3-(2-methylphenyl)-3H-quinazolin-4-one with various one carbon donors. The starting material 2-hydrazino-3-(2-methylphenyl)-3H-quinazolin-4-one was syn...

FT-IR and FT-Raman spectra of 2-Benzylsulfanyl-4-[(4-methylphenyl)-sulfanyl]-6-pentylpyrimidine-5-carbonitrile were recorded and analyzed. The structure of the molecule has been optimized and the structural characteristics have been determined by density functional theory. The geometrical parame...

A heterocyclic azo dye derived from 3H-pyrazol-3-one and m-cresol was synthesized and structurally confirmed by single crystal X-ray diffraction (SXRD) analysis along with UV–Vis, FT-IR and NMR spectroscopic techniques. This dye exists in azo tautomeric form which crystallizes in the orthorhomb...

N-(2-Methylphenyl)-2,2-dichloroacetamide (2MPA) and N-(4-methylphenyl)-2,2-dichloroacetamide (4MPA) of the configuration XyC6H5−y–NHCO–CHCl2 (where, X = CH3 and y = 1) were synthesised and an extensive spectroscopic investigations have been carried out by recording the Fourier transform infrar...