In this present investigation, 2-imino-(3,4-dimethoxybenzyl)ethane sulphonic acid was anchored on a silver nanoparticle mediated by sugarcane sap. The Schiff base was synthesized from 2-aminoethanesulphonic acid and 3,4-dimethoxybenzaldehyde under lemon juice catalyzed conditions while the nanop...

AimsThe aim of the study was to evaluate the potential of naturally occurring isothiocyanates and doxorubicin in combined treatment of doxorubicin-resistant colon cancer. Doxorubicin is a cytostatic commonly used to treat many different types of cancer but its usage is often abrogated by severe ...

N-(3,4-dimethoxybenzyl)-hexadecanamide (DMH) was characterized by using Fourier Transform infrared (FT-IR) and Raman (FT-Raman), Ultraviolet- Visible (UV-Visible) and Hydrogen and Carbon Nuclear Magnetic Resonance (1H and 13C NMR) spectroscopies. The structural, electronic, topological and vibra...

A procedure was developed for measuring small amounts of phenylmercuric nitrate in aqueous solutions. The method depends on the formation of insoluble phenylmercuric iodide upon titration of phenylmercuric nitrate with potassium iodide. The end-point can be detected using an iodide-sensitive ele...

In the present study, the antifungal effects of phenylmercuric nitrate and benzalkonium chloride versus those of natamycin and ketoconazole were assessed against 216 filamentous fungi isolates from cases of fungal keratitis. They included 112 Fusarium isolates, 94 Aspergillus isolates, and 10 Al...

The as-prepared SWNTs are always a mixture of metallic (m-) and semiconducting (s-) tubes with quite different electrochemical properties which is a major barrier for their application in many fields. Based on the noncovalent interactions between planar aromatic molecules and SWNTs, the pyrene d...

Monofunctional Pt(II) complexes bind to G residues in DNA and, if the carrier ligands are bulky, cause DNA structural distortions that lead to anticancer activity. We assessed the steric effects of the tridentate carrier ligand, N(H)6-Medpa (N-(6-methyl-2-picolyl)-N-(2-picolyl)amine), bearing a ...

We efficiently synthesized 2′-O,4′-C-aminomethylene-bridged nucleic acid (2′,4′-BNANC) monomers bearing the four nucleobases, guanine, adenine, thymine, and 5-methylcytosine and incorporated these monomers into oligonucleotides. Initially, we carried out the transglycosylation reaction on se...

Rap GTPases mediate fundamental cellular processes, including cell adhesion, migration and intracellular signal transduction. The subcellular activity of these GTPases is regulated by dedicated activators (guanine nucleotide exchange factors, GEFs) and deactivators (GTPase-activating proteins, G...

In this study; the synthesis, structural characterization and electrochemical sensor properties of SWCNTs covalently functionalized with different BODIPY derivatives toward guanine and adenine were investigated. The target SWCNTs-BODIPY hybrids (CB, CB1 and CB2) were synthesized by the reaction ...

The agglomeration of metal catalysts can limit the performance of fuel cells. Herein, an easy, scalable, one-pot microwave-assisted method is proposed to introduce guanine, which is a nucleobase found in deoxyribonucleic acid and ribonucleic acid, to the reduced graphene oxide-supported palladiu...

A sensor for the determination of guanine (G) and hydrogen peroxide (H2O2) is developed based on Ni–Fe Prussian blue analogues hollow nanocubes (Ni–Fe PBA HNCs) for the first time. As a remarkable redox probe towards G and H2O2 oxidation, Ni–Fe PBA HNCs exhibit a series of predominant sensing...

(2S,3S)-1,2:3,4-diepoxybutane (DEB) cross-links DNA guanines by forming the intermediate epoxy-adduct ((2′S,3′S)-N-7-(3′,4′-epoxy-2′-hydroxybut-1′-yl)guanine [EHBG]). This process is presently considered a primary mechanism for the action of treosulfan (TREO), the prodrug that transforms t...

Prodrug treosulfan undergoes a pH and temperature-dependent activation to the monoepoxide intermediate (EBDM) and (2S,3S)-1,2:3,4-diepoxybutane (DEB). The latter DNA cross-linker is presently believed to mainly account for the pharmacological action of treosulfan. However, neither respective mon...

Vascular adhesion protein-1 (VAP-1) is a promising therapeutic target for the treatment of diabetic nephropathy. Here, we conducted optimization studies of our lead compound 1, which we previously reported as a novel VAP-1 inhibitor, to enhance the inhibition of human VAP-1 and to reduce CYP3A4 ...

Acyl CoA:monoacylglycerol acyltransferase-2 (MGAT2) has emerged as a potential peripheral target for the treatment of obesity and metabolic disorders. We previously identified a novel series of N-phenylindoline-5-sulfonamide derivatives exemplified by 2 as potent and orally bioavailable MGAT2 in...

A series of silver monoimidazol-2-ylidene chlorides and silver bisimidazol-2-ylidene tetraphenylborates, bearing pendant N-β-chloroethyl (-CHEt-CH2Cl; -CHMe-CHPhCl) and N-vinyl (-CEt = CH2; -CMe = CHPh) substituents were synthesized and their structure analysed by IR, mass spectra and NMR. Ster...

Organophosphate esters (OPs) are substitutes for polybrominated diphenyl ether (PBDE) flame retardants. China is the largest producer of OPs globally, with the production rate increasing at 15% annually. Since some OPs are neurodevelopmental and/or carcinogenic toxicants, human exposure is a con...

Carbon and chlorine compound specific isotope analysis (CSIA) of bis(2-chloroethyl) ether (BCEE) was performed to distinguish the primary processes contributing to observed concentration reductions in an anaerobic groundwater plume. Laboratory microcosms were constructed to demonstrate and obtai...

Enantiomerically pure and racemic mixtures of β-chloroethylamines hydrochlorides with one and two stereogenic centres were used to synthesise 1,4-dialkyl-1,3-diimines, which in turn gave place to a series of imidazolium chlorides and tetraphenylborates bearing pendant N-β-chloroethyl substitue...