The oral drug FTY720 affects sphingosine-1-phosphate (S1P) signaling on targeted cells that bear the S1P receptors S1P1, S1P3, S1P4, and S1P5. We examined the effect of FTY720 treatment on the biology of mouse neural progenitor cells (NPCs) after transplantation in a viral model of demyelination...

The sphingosine-1-phosphate type 1 (S1P1) receptor is a new target in the treatment of auto-immune diseases as evidenced by the recent approval of FTY720 (Fingolimod). The ligand-binding pocket of the S1P1 receptor has been generally characterised but detailed insight into ligand-specific differ...

The segregation capacity of cholinium dihydrogen phosphate (N1112OHDHP) in aqueous solutions of two non-ionic surfactants belonging to Triton X family (Triton X-100 and Triton X-102) was explored at different temperatures from T = (298.15 to 333.15) K. The experimental data for each binodal curv...

Two Schiff base ligands bearing organic acid moiety, vis., N-(2-thienylmethylidene)-2-amino-4-chlorobenzoic acid (HL1) and N-(2-hydroxybenzylidene)-2-amino-4-chlorobenzoic acid (H2L2) have been synthesized by the interaction of 2-thiophenecarboxaldehyde and 2-hydroxybenzaldehyde with 2-amino-4-c...

A high-performance liquid chromatographic method has been developed for the simultaneous determination of chloroprocaine hydrochloride and its hydrolytic degradation product, 4-amino-2-chlorobenzoic acid. Separation is achieved using a μ-Bondapak C18 column and the eluant, water-acetonitrile-me...

2-(p-amylcinnamoyl)amino-4-chlorobenzoic acid (PACA), pharmacological inhibitor of phospholipase A2 (PLA2), inhibits epinephrine-stimulated thromboxane production in human platelets. In this study, we investigated the effect of PACA on meiotic maturation individually in stages V and VI oocytes. ...

The solubility of 2-amino-4-chlorobenzoic acid in eleven organic solvents including N-methyl-2-pyrrolidone, ethanol, n-propanol, isopropanol, ethyl benzene, toluene, n-butanol, acetonitrile, ethyl acetate, 1,4-dioxane and acetone were determined experimentally using the isothermal saturation met...

A novel complex [Tb(L)2(H2O)3·H2O] (where L=2-amino-4-chlorobenzoic acid) was synthesized and characterized by a series of analysis. The molecular formula of complex was confirmed by Fourier transform infrared (FT-IR) spectroscopy and thermogravimetric/differential thermogravimetric (TG-DTG) me...

6-O-(2-Nitrobenzyl)guanosine and 4-O-(2-nitrobenzyl)uridine triphosphates (NBGTP, NBUTP) were synthesized, and their biochemical and photophysical properties were evaluated. We synthesized NBUTP using the canonical triphosphate synthesis method and NBGTP from 2′,3′-O-TBDMS guanosine via a trip...

The Cl exchange reactions of hexachlorocyclotriphosphazene, N3P3Cl6, with two equimolar amounts of N-alkyl-N′-mono(4-fluorobenzyl)diamines (1–3), FC6H4CH2NH(CH2)nNHR1 (n = 2 and 3, R1 = CH3 or C2H5), and N-alkyl-N′-mono(4-nitrobenzyl)diamines (4 and 5), NO2C6H4CH2NH(CH2)nNHR1 (n = 2, R1 = CH3...

A series of 2,6-dinitro-4-(trifluoromethyl)phenoxysalicylaldoxime derivatives (1h–20h) have been designed and synthesized, and their biological activities were also evaluated as potential antiproliferation and tubulin polymerization inhibitors. Among all the compounds, 2h showed the most potent...

A single, inexpensive diagnostic test capable of rapidly identifying a wide range of genetic biomarkers would prove invaluable in precision medicine. Previous work has demonstrated the potential for high-throughput, label-free detection of A-G-C-T content in DNA k-mers, providing an alternative ...

The capability of transient analysis has been implemented in the SARAX code system recently. Alternatively, two calculation schemes using the point-kinetics model and 3-D transport-based spatially-dependent model have been developed. Based on these, two transient benchmarks of sodium fast reacto...

The catechol-O-methyltransferase (COMT) gene is a candidate gene for schizophrenia because of its role in the breakdown of dopamine in the prefrontal cortex. The COMT gene contains a functional polymorphism changing enzyme activity that has been associated with some neuropsychiatric (endo)phenot...

Photoexcited o-nitro chromophore in o-nitrobenzylic systems has led to the design and development of many useful photochromic systems such as photolabile protecting groups, photoresists, for controlled release of bioactive compounds, as well as efficient photosynthons giving direct access to man...

A practical synthetic method for the direct synthesis of unsymmetrically substituted ureas from N-Alloc-, N-Cbz-, and N-Boc-protected amines is described. In this study, efficient direct conversion of the Alloc-, Cbz-, and Boc-carbamate compounds to ureas was achieved in the presence of DABAL-Me...

In order to determine the structural requirements for cytotoxicity against various tumor cell lines, a new series of 16E-arylidene androstene amides with varying degrees of unsaturation in ring A has been synthesized. Characterization and in vitro cytotoxic studies of the newly synthesized compo...

Six organotin(IV) carboxylates of the type R2SnL2 [R = CH3 (1), n-C4H9 (2), n-C8H17 (3)] and R3SnL [R = CH3 (4), n-C4H9 (5), C6H5 (6), where L = 2-(4-ethoxybenzylidene) butanoic acid, have been synthesized and characterized by elemental analysis, FT-IR and NMR (1H, 13C). The complex (1) was also...

In vitro biochemical and electrophysiological methods were used to assess the potential antagonist properties of the novel compounds (+)-WAY 100 135 [N-tert-butyl-3,4-(2-methoxyphenyl)piperazin-1-yl-2-phenylpropanamide dihydrochloride] and SDZ 216–525 [methyl 4-(4-(4-(1,1,3-trioxo-2H-1,2-benzio...

The present study evaluated in the rat the ability of various 5-HT1A receptor agonists to exert an “anxiolytic-like” release of the suppression of lever pressing for food induced by the withdrawal of a conditioned signal for safety withdrawal presentation of a conditioned signal for punishment...