A systematic study of the reactivity of (E)-4,4,4-trifluorobut-2-en-1-yl 4-methylbenzenesulfonate towards different classes of nucleophiles (alcohols, amines, thiols and malonates) was performed. A single set of reaction conditions (with small variations) allowed the isolation of the substitutio...

The title compound 4-[(dimethylamino)methylene]-2-ferrocenyl-5-oxo-4,5-dihydrofuran-3-carboxaldehyde was synthesized by reacting 3-ferrocenoylpropionic acid with Vilsmeier reagent. This result is rather unexpected, since 3-aroylpropanoic acids under these conditions usually give the correspondin...

Cardiovascular disease (CVD) is largely related to complications from atherosclerotic disease such as myocardial infarction (MI) and ischemic stroke and accounts for more than 30% of overall global mortality. Understanding the biochemical changes that occur in cardiac tissue following myocardial...

A novel series of pyrazolo[1,5-a]pyrimidines were synthesized and proved by their spectral and elemental analysis, some elected of the newly synthesized compounds were examined for their cytotoxic activity employing MTT assay on two cancer cell lines (Breast and Hela cancers). Compounds 5, 7e an...

Gangjee et al. recently reported a novel series of 2-amino-4-methyl-5-phenylethyl substituted-7-benzyl-pyrrolo[2,3-d]pyrimidines, some of which exhibited two digit nanomolar antitumor and antimitotic activity and were not subject to P-glycoprotein (Pgp) or multidrug resistance protein 1 (MRP1) m...

The metalation of chloro- and methoxy-substituted acetophenone ketals with butyllithium (BuLi) and with N,N,N′,N″,N″-pentamethyldiethylenetriamine-complexed butyllithium (BuLi/PMDTA) has been investigated. The lithio species thus generated were carboxylated to benzoic acids. Lithiations with ...

Arylated 1-methyl-1H-indoles were prepared by Suzuki–Miyaura cross-coupling reactions of 2,3-dibromo-1-methyl-1H-indole and 2,3,6-tribromo-1-methyl-1H-indole. The reactions proceed with very good regioselectivity in favour of position 2.

In this work, the vibrational spectral analysis was carried out using FT-IR and FT-Raman spectroscopy of (2E)-1-(4-Chlorophenyl)-3-[4-(propan-2-yl)phenyl]prop-2-en-1-one. The computations were performed at DFT level of theory to get the optimizedgeometry and vibrational wave numbers of the norma...

Herein, the design and synthesis of 10 novel N′-arylidene pyrazole-3-carbohydrazides are described. Compounds were pretended to act as dual agents against diabetes and oxidative stress, two correlated pathologies involved in metabolic syndrome development and progression. The antioxidant capaci...

A series of 2-(2,3-dimethoxyphenyl)-4-(aminomethyl)imidazole derivatives was prepared and their affinity for dopamine D2 and D3 receptors was measured using in vitro binding assays. Several oxadiazole analogues were also prepared and tested for their affinity for dopamine D2 and D3 receptors. Th...

Enthalpies of transfer of sodium salts of monomethyl esters of oxalic, malonic, succinic, adipic, fumaric, maleic, o-phthalic, isophthalic, and terephthalic acids from water to water-methanol and water-tert-butyl alcohol mixtures have been determined by calorimetry. Using literature data for the...

When 4,4′-dinitrostilbene-2,2′-disulfonate (DSD) is submitted to UV or visible light in aqueous solution, the main photochemical process is a reversible trans–cis isomerisation, the cis form absorbs at shorter wavelength than the trans isomer. The UV spectrum of cis form may be obtained not o...

Solid–liquid equilibrium (SLE) measurements for disodium 4,4′-dinitrostilbene-2,2′-disulfonate (DNSNa) and sodium 4-nitrotoluene-2-sulfonate (NTSNa) in aqueous ethylene glycol monoethyl ether solution and aqueous ethylene glycol monobutyl ether solution were conducted using a dynamic method o...

Gold nanoparticles supported on three metal oxides, TiO2, Al2O3 and Fe2O3, were prepared by a modified precipitation-deposition method using urea as an additive. These catalysts were tested in chemoselective reduction of 4,4′-dinitrostilbene-2,2′-disulfonic acid to 4,4′-diaminostilbene-2,2′-...

The FT-IR and FT-Raman spectra of 4-methyl-3-nitro benzyl chloride (MNBC) molecule have been recorded in the range of 4000–400 cm−1 and 3500–50 cm−1 respectively. The molecular geometry and vibrational frequencies in the ground state are calculated using the DFT/B3LYP method with 6-311+G (d, p...

To acquire remarkable cathode materials for lithium-sulfur batteries with ultrahigh utilization of active materials and superior cycling stability, we firstly employ carboxylated carbon nanotubes to prepare the NiCo2S4@CNTs/S for lithium-sulfur batteries via a simple hydrothermal method, followi...

In this paper, by employing first principles calculations, a two dimensional global minimum structure of Lithium Sulfide (Li2S) was predicted with a wide direct band gap and an inversed sandwich structure 1T-MoS2. The electronic properties investigations reveal that the predicted Li2S monolayer ...

Entrapping polysulfide from dissolution into electrolyte by strong chemisorption of polar materials has been widely reported in lithium-sulfur (Li-S) battery. Here, for the first time, zinc sulfide (ZnS) was demonstrated as an activation catalyst in Li-S battery to suppress the soluble polysulfi...

Identification and synthesis of novel 3-alkoxy-5-phenoxy-N-thiazolyl benzamides as glucokinase activators are described. Removal of an aniline structure of the prototype lead (2a) and incorporation of an alkoxy or phenoxy substituent led to the identification of 3-Isopropoxy-5-[4-(methylsulfonyl...

The crystal structure of 2-amino-N′-[(1Z)-1-(4-chlorophenyl)ethylidene]benzohydrazide (I) is determined by X-ray diffraction at room temperature. The structure of I also was characterized by elemental analysis, mass, FT-IR and NMR spectroscopic techniques. The compound crystallizes in triclinic...