The impact of ethanolic coconut husk extract (ECHE) at different concentrations (0–0.25 g extract/100 g surimi) and pre-emulsification on the properties and stability of sardine (Sardinella albella) surimi gel fortified with seabass oil during refrigerated storage of 10 days were investigated. ...

A series of novel tripeptidyl epoxyketone derivatives constructed from β-amino acid were designed, synthesized and evaluated as proteasome inhibitors. All target compounds were tested for their proteasome inhibitory activities and selected compounds were tested for their anti-proliferation acti...

Reaction of fullerene, sarcosine and gossypol through the Prato reaction resulted in some unexpected N-methylfulleropyrrolidines. These fulleropyrrolidines were fully characterized via rigorous structure determination through multiple spectral experiments, which included 1D, 2D NMR, FT-IR, MS an...

Four new crystalline solids, namely [Co2(µ2-5-Clnic)2(µ3-5-Clnic)2(µ2-H2O)]n (1), [Co(5-Clnic)2(H2O)4]·2(5-ClnicH) (2), [Pb(µ2-5-Clnic)2(phen)]n (3), and [Cd(5-Clnic)2(phen)2]·3H2O (4) were generated by hydrothermal self-assembly methods from the corresponding metal(II) chlorides, 5-chloro...

The theoretical molecular geometry and the IR, UV, 1H and 13C NMR spectroscopic properties of 2-[2-(dimethylamino)ethyl]-6-methoxy-4-(pyridin-2-yl)-1(2H)-phthalazinone with the previously demonstrated in vivo analgesic activity were characterized. The conformational analysis, performed using the...

Reaction of copper(II) nitrate with N-2-(R-pyridyl)salicylaldimine affords the mononuclear bis[salicylaldehydato-κO,O′]copper(II) (1) via acidic hydrolysis of the aldimine ligand back to the salicylaldehyde. Similarly, reaction with (R)-N-1-(p-BrC6H4)ethyl-salicylaldimine or (R)-1-(p-BrC6H4)-N...

A new series of low melting and hydrophobic ionic liquids (ILs) containing the bis[bis(pentafluoroethyl)phosphinyl]imide anion, [(C2F5)2P(O)]2N− (FPI), and ammonium, phosphonium, imidazolium, pyridinium or pyrrolidinium cations were prepared and characterized. Their density, viscosity, melting p...

The synthesis of new ionic liquids with tris(perfluoroalkyl)trifluorophosphate (FAP) anions is described. The physico-chemical properties (conductivity, viscosity, electrochemical and thermal stability) of this new generation of ionic liquids (molten salts) are discussed. FAP-ionic liquids show ...

A series of diaryl(fluoroalkyl)sulfonium salts were synthesized from electron-rich diaryl sulfides and fluoroalkyl trifluoromethanesulfonates under solvent-free conditions. Unlike diaryl sulfides, dialkyl and alkyl(aryl) sulfides reacted with fluoroalkyl trifluoromethanesulfonates (e.g. CF3SO3CH...

In this work, we introduce the use of an electrochemical sensor based on ion-channel mechanism in order to investigate the interaction between different-functionalized calixarene mercaptoalkyl derivatives and dopamine at the aqueous/organic interface. Three different calix[4]arene derivatives, f...

We previously reported 4-(3-((6-bromonaphthalen-2-yl)oxy)-2-hydroxypropyl)-N,N-dimethylpiperazine-1-sulfonamide (1) as a novel heat shock protein 90 inhibitor with moderate activity. In our ongoing efforts for the discovery of Hsp90 modulators we undertake structural investigations on 1. Series ...

Six novel 2-arylimidazo[2,1-b]benzothiazole (IBT) derivatives were synthesized as potential tridentate radiotracers for AD imaging purposes. Two of these ligands (6a,b) were successfully labeled with 99mTc radionuclide at high radiochemical purity using fac-[99mTc(CO)3(H2O)3]+ synthon. [99mTc]7a...

We successfully synthesize a series of bis-thiol-substituted calix[4]arene derivatives bearing diverse groups on the upper-rim/lower-rim ([email protected], [email protected], [email protected], [email protected], [email protected]). For the first time, we apply these derivatives as interface mo...

Some ferrocene compounds, such as tamoxifen derivatives hydroxyferrocifen 1 and ferrociphenol 2, show strong antiproliferative activity on hormone-dependent and hormone-independent breast cancer cells. In order to evaluate their antimicrobial activity, they were tested, together with their purel...

In this work we describe the synthesis, docking studies and biological evaluation of a focused library of novel arylpiperazinyl derivatives of 8-acetyl-7-hydroxy-4-methylcoumarin. The new compounds were screened for their 5-HT1A and 5-HT2A receptor affinity. Among the evaluated compounds, six di...

In the present study, we are reporting the synthesis of a triazoles incorporated fluorescent hexahydroquinoline appended calix[4]arene 7 and its highly selective optical recognition ability towards Hg2+. The optical sensor 7 was synthesized via two different synthetic pathways and unambiguously ...

A series of berberine-phenyl-benzoheterocyclic (26–29) and tacrine-phenyl-benzoheterocyclic hybrids (44–46) were synthesised and evaluated as multifunctional anti-Alzheimer’s disease agents. Compound 44b, tacrine linked with phenyl-benzothiazole by 3-carbon spacers, was the most potent AChE i...

The interaction of a cationic water-soluble porphyrin, 5,10,15,20-tetrakis[4-(3-pyridiniumpropoxy)phenyl]prophyrin tetrakisbromide (TPPOC3Py), with β-CD and HP-β-CD in aqueous solution has been studied by UV–vis, 1H NMR, 2D-NOESY and MALDI-TOF MS, and it reveals that a stable 1:1 inclusion co...

In the present work, we synthesised a functionalised calix[4]arene with 5,11-di(N-methyl-E-(4-pyridylethylene) moiety (CX[4]), and investigated interactions of it with HemiMeQ[6], HemiMeQ[7], and Q[8]) in both water and DMSO using fluorescence spectrophotometry and 1H NMR spectroscopy. Titration...

Anti-HIV-1 drug design has been notably challenging due to the virus’ ability to mutate and develop immunity against commercially available drugs. The aims of this project were to develop a series of fleximer base analogues that not only possess inherent flexibility that can remain active when ...