We have carried out a structural and vibrational study for 3-amino-2-(4-chlorophenyl) quinazolin-4(3H)-one by using the available experimental infrared spectrum and theoretical calculations based the density functional theory (DFT). The structural properties for the compound, such as the bonds o...

The hybrid derivative of heteropolytungstate bearing two aniline groups, namely (nBu4N)3[NaHPW9O34{As(O)C6H4NH2}2], was post-functionalized in the presence of 1,4-phenylene diisothiocyanate (PDITC). The resulting molecular moiety was characterized by IR, 1H and 31P NMR spectroscopy. In a second ...

A film of 1-octadecyl-1H-1,2,4-triazole (OTA) was formed on a fresh copper surface by self-assembly technique. The optimum concentration of OTA and immersion time for the formation of a protective OTA film have been established using electrochemical impedance spectroscopy (EIS). These are (i) 15...

The formation of a protective layer by dipping copper specimens in a hydroalcoholic solution of a silanic agent with a long aliphatic chain (n-octadecyl-trimethoxy-silane, OctadecS) was studied using electrochemical techniques (impedance spectroscopy and potentiodynamic polarization curve) and F...

In this present study, magnetic Fe3O4@SiO2 nanoparticles (MNPs) functionalized with octadecyl groups (Fe3O4@SiO2-C18 NPs) were synthesized, characterized and employed, for the first time, as powerful nanosorbent to extract endogenous volatile organic metabolites (EVOMs) namely, hexanal, heptanal...

The gas sorption and transport properties of poly(octadecyl acrylate) are described for the semi-crystalline and molten states. The change in permeability upon traversing the melting point, or permeation switch, was observed to be as high as two orders of magnitude depending on the penetrant. An...

In this article, a novel method for preparation of octadecyl-bonded silica (ODS), which is highly inert to basic compounds, is described. This method is based on end-capping reaction of hexamethyldisilazane with residual silanol groups on ODS packing using atomic layer deposition (ALD) technique...

In present work, for improving the electrochemical performance of conductive polymer, POAP/1-octadecyl-3-methylimidazolium Bromide ([OMD]Br) composite films have been fabricated by POAP electropolymerization in the presence of [OMD]Br as active electrodes for electrochemical supercapacitors. Dif...

Monolithic silica in MonoSpin for solid-phase extraction of drugs from whole blood samples was developed to facilitate high-throughput analysis. Monolithic silica of various pore sizes and octadecyl contents were synthesized, and their effects on recovery rates were evaluated. The silica monolit...

Acyclovir (ACV), an analog of 2′-deoxyguanosine, exhibits poor bioavailability due to limited permeability. In this study, the aim was to improve the bioavailability and permeability of ACV. N,N,N-trimethyl-O-octadecyl chitosan (TMSC) was synthesized by covalently bonding a long alkyl chain and...

Octadecyl-modified silicas bearing different amounts of octadecyl groups were synthesized by non-hydrolytic condensation of a C18-hybrid silica sol on spheroidal silica. The modified materials were characterized by a set of complementary techniques, including diffuse reflectance infrared spectro...

Octadecyl ferulate was prepared using solid acid catalyst, monitored using Supercritical Fluid Chromatography and purified to a 42% yield. Differential scanning calorimetry measurements determined octadecyl ferulate to have melting/solidification phase transitions at 67 and 39 °C, respectively....

The products from the replacement of two chlorofunctions of PCl3 by a pair of phosphoniumylidyl substituents or by both a phosphoniumylidyl and an amino substituent are ionic phosphenium chlorides and not covalent chlorophosphines.

The addition of lithiated bis(diethylamino)phosphine borane complex to enantiopure p-toluenesulfinimines is highly diastereoselective, affording the corresponding addition products with high efficiency (yields from 72 to 100%). The addition products were readily converted into α-amino-α-arylme...

The reaction of bis(diethylamino)chlorophosphine borane complex with lithium naphthalenide affords the lithiated derivative 3 which undergoes nucleophilic substitution with primary and secondary alkyl halides, allylic and benzylic bromides and aryl iodides or bromides in good yields. The substit...

Based on the definition of a 5-HT4 receptor antagonist pharmacophore, a series of pyrrolo[1,2-a]thieno[3,2-e] and pyrrolo[1,2-a]thieno[2,3-e] pyrazine derivatives were designed, prepared, and evaluated to determine the properties necessary for high-affinity binding to 5-HT4 receptors. The compou...

The mechanisms for isomerisation and dissociation of the title ions have been probed by a combination of mass spectrometric techniques. In contrast to the other 10 ionised methyl pentenyl ethers, each of which has a unique and characteristic reactivity, these three isomers show many common featu...

A series of fluoren-9-yl ethyl amides (2) were synthesized and evaluated for human melatonin MT1 and MT2 receptor binding. N-[2-(2,7-dimethoxyfluoren-9-yl)ethyl]propanamide (2b) was selected and evaluated in functional assays measuring intrinsic activity at the human MT1 and MT2 receptors and de...

The sphingosine 1-phosphate (S1P) receptor modulators have emerged as a new therapeutic opportunity paradigm for the treatment of immune-mediated demyelinating diseases such as multiple sclerosis (MS). The S1P analog fingolimod (FTY720) has been shown to alleviate disease burden in immune-mediat...

In the search for bioactive sphingosine 1-phosphate (S1P) receptor ligands, a series of 2-amino-2-heterocyclic-propanols were synthesized. These molecules were discovered to be substrates of human-sphingosine kinases 1 and 2 (SPHK1 and SPHK2). When phosphorylated, the resultant phosphates showed...