A new concise and facile method was explored to synthesize a collection of new 3-arylidene azetidin-2-ones, which could be regarded as the derivatives of the hybrid scaffold of bioactive natural cinnamamide and heterocycle azetidi-2-one. The structures of the synthesized compounds were character...

In the present study, we used crystal structure of mycobacterial pantothenate synthetase (PS) bound with 2-(2-(benzofuran-2-ylsulfonylcarbamoyl)-5-methoxy-1H-indol-1-yl) acetic acid inhibitor for virtual screening of antitubercular compound database to identify new scaffolds. One of the identifi...

Numerical evaluation of exact high-order modes of uniform Timoshenko beams is a classic problem in the field of acoustics and vibration. In the classic method, however, the determinant of the frequency matrix dominated by hyperbolic functions can increase exponentially and quickly reach the prec...

Exact D-optimal Bayesian designs for time series experiments are discussed in this article. This work is motivated by an RNA sequencing experiment and two disease surveillance studies, where the response is count type and has a correlated structure over time points. The conditional distribution ...

The heterogeneous green pickup and delivery problem (GPDP) aims to minimize carbon emissions of pickups and deliveries by a fleet of heterogeneous vehicles. We propose the first exact algorithm for solving the heterogeneous GPDP. This exact algorithm is based on a set partitioning model and the ...

McDougall (1989) proved that neutral surfaces possess an exact geostrophic streamfunction, but its form has remained unknown. The exact geostrophic streamfunction for neutral surfaces is derived here. It involves a path integral of the specific volume along a neutral trajectory. On a neutral sur...

This paper deals with two main aspects of Photovoltaic systems. One is the analysis of Photovoltaic panel using the datasheet values provided on the PV panel and the other is to find the exact values of parameters of PV panel. Characterization of PV panels refers to the ability to predict the pa...

Every (left) linear function on a subspace of a finite-dimensional vector space over a (skew) field can be extended to a (left) linear function on the whole space. This paper explores the extent to what this basic fact of linear algebra is applicable to more general structures. Semifields with a...

In this paper we study the asymptotic behaviour of an exact controllability problem for a second order linear evolution equation defined in a two-component composite with ε-periodic disconnected inclusions of size ε. On the interface we prescribe a jump of the solution that varies according to...

We study the invariants (in particular, the central invariants) of suitable Poisson pencils from the point of view of the theory of bi-Hamiltonian reduction, paying a particular attention to the case where the Poisson pencil is exact. We show that the exactness is preserved by the reduction. In ...

Using generalized enriched categories, in this paper we show that Rosický's proof of cartesian closedness of the exact completion of the category of topological spaces can be extended to a wide range of topological categories over Set, like metric spaces, approach spaces, ultrametric spaces...

Hirota equation has been studied in the past years, which can be used to describe the nonlinear waves in the fluids and nonlinear optical fibers. In this paper, nonlocal Hirota equations with the space (S)-, time (T)- and space–time (ST)-symmetry have been discussed. By virtue of the Hirota bil...

Malaria remains one of the most serious global infectious diseases. An important target for antimalarial chemotherapy is the enzyme dihydroorotate dehydrogenase from Plasmodium falciparum (PfDHODH), which is responsible for the conversion of dihydroorotate to orotate in the de novo pyrimidine bi...

ContextMatrix metalloproteinases (MMPs) are a family of proteolytic enzymes, the zinc-dependent endopeptidases involved in the degradation of extracellular matrix (ECM) and releasing growth factors and cytokines residing in ECM. Amongst 23 types of MMPs, an isomer called MMP-9 has been found to ...

Indoleamine 2,3-dioxygenase (IDO) is a heme dioxygenase which has been shown to be involved in the pathological immune escape of diseases such as cancer. The synthesis and structure–activity relationships (SAR) of a novel series of IDO inhibitors based on the indol-2-yl ethanone scaffold is des...

The cross-coupling reaction of bis-triisopropylsilyl disulfide 1 on alkynes yielded 1,2-bis-triisopropylsilanylsulfanyl-alkenes 2, a new chemical class. A series of tri and tetrasubstituted olefins 2 were prepared and their behavior toward electrophiles was studied. The triisopropylsilyl groups ...

In this report, we describe the parallel as well as conventional synthesis of 1,2-diaryl-1-ethanones via environmentally benign acylation of arenes with in situ generated arylacetyl trifluoroacetates. A wide variety of arylacetic acids I participated in trifluoroacetic anhydride/ phosphoric acid...

In the presence of catalytic amounts of RhH(PPh3)4, 1,2-bis(diphenylphosphino)ethane (dppe), and dimethyl disulfide, ketones without α-activating groups were α-methylthiolated with 1,2-diphenyl-2-methylthio-1-ethanone giving α-methylthio ketones. The reaction of unsymmetrical ketones proceede...

We present an important opinion about the electron effect of the intermolecular cyclcotrimerization of unsymmetrical diaryalkynes in the presence of Co2(CO)8 on the production of corresponding 1,2,4-regioisomer or 1,3,5-regioisomer derivatives with excellent yields and high regioselectivity.

The three organic dye molecules (JY31, JY32 and JY33) were applied to the photoactive layer in solar cells. Photophysical and photochemical characteristic have been investigated with natural bond orbital (NBO), frontier molecular orbital, ionization potentials, electron affinities, absorption pr...