The diuretic activity of 6-chloro-2,3-dihydro-1-propionyl-4(1H)-quinolinone 4-oxime 1 (M12285) was previously shown to derive from a 6-chloro-2,3-dihydro-1-propionyl-4(1H)-quinolinone 4-oxime-O-sulfonic acid salt as a rat metabolite. Thus, in the present study, the potassium salt 2 (M17000) was ...

It was found that rhenium complex was an efficient catalyst for the acylative cleavage of C–O bond of ethers with acyl chlorides. When acyclic ethers were allowed to react with acyl chlorides in the presence of a catalytic amount of ReBr(CO)5, acylative cleavage of C–O bond of acyclic ethers s...

Efficient TBHP/R4N+X– promoted hydroaroylations of dialkyl azo-1,2-dicarboxylates with methyl arenes, aldehydes, aryl methanols and arylmethyl chlorides are described. These oxidation/oxygenation and hydroaroylation processes were carried out by tert-butyl hydroperoxide as terminal oxidant/oxyg...

It is known that an oil-in-water emulsion increases in consistency and stability on addition of cetostearyl alcohol. When either cetyl alcohol or stearyl alcohol was added individually, the emulsion stability decreased. On storage at room temperature, unstable emulsions decreased in consistency ...

We describe here the synthesis and the binding interaction with σ1 and σ2 receptors of a series of new benzo[d]oxazol-2(3H)-one derivatives variously substituted on the N-benzyl moiety. The results of binding studies confirm the notion that the benzoxazolone moiety confers preference towards σ...

Sphingosine kinase (SphK)-catalyzed production of sphingosine-1-phosphate (S1P) regulates cell growth, survival and proliferation as well as inflammatory status in animals. In recent study we reported the N′-(3-(benzyloxy)benzylidene)-3,4,5-trihydroxybenzohydrazide scaffold as a potent SphK inh...

New triazine derivatives 2,4-diamino-3,6-dihydro-6-(2-chlorophenyl)-1,3,5-triazine (1) and 1-(2-chlorobenzyl)-5-(2-chlorophenyl)-N-[(1E)-(2-chlorophenyl)methylene]-1,2,4-triazolidin-3-amine (2) were synthesized by a one-pot synthesis using 2-chlorobenzaldehyde, guanidine and aminoguanidine, resp...

Pyridone 1 was identified from a high-throughput cell-based phenotypic screen against Mycobacterium tuberculosis (Mtb) including multi-drug resistant tuberculosis (MDR-TB) as a novel anti-TB agent and subsequently optimized series using cell-based Mtb assay. Preliminary structure activity relati...

Reaction of 3-amino-6-methyl-4-phenylpyridin-2(1H)-one with aromatic aldehydes afforded the corresponding Schiff bases, the reduction of which with sodium borohydride led to the formation of 3-(arylmethyl)-6-methyl-4-phenylpyridin-2(1H)-ones. Acylation of 3-amino-6-methyl-4-phenylpyridin-2(1H)-o...

4-Benzyloxy-3,3-difluoro-4-phenyl-2-phenylsulfonylbut-1-ene (3) underwent the allylic defluorination reaction with aryl- and alkylthiolate, and alkoxides without any additive reagents to give the monofluoroalkenes 4–5 in good yields. Reactions of 3 with various Grignard reagents such as alkyl-,...

The theory developed in the preceding paper for calculating the vibrational frequencies of molecules in terms of mixtures of vibrations within groups, and skeletal vibrations due to group rotations and translations, is applied to C2H6 and C2D6. It is shown that the matrix elements in the secular...

The infrared spectra of CH3CH3, CD3CD3 and CH3CD3 have been measured under medium resolution (∼0.4 cm−1). The rotation-vibration bands have been analysed, and the rotational constants B″ have been obtained from the parallel bands. By using the A″ values determined by Welsh et al., the Corioli...

A tandem-ICR mass spectrometer was used to study internal-energy effects in proton (deuteron) transfer to ethane. Product distributions for reactions of ArD+, D3+, N2H+, CO2H+, CO2D+, CD5+, N2OD+, and COD+ with ethane (or ethane-d6) and rate constants for reaction of ArD+, D3+, CO2D+, and CD5+ a...

Spectra are reported for crystalline ethane, ethane-d2 and their mutual solid solutions. The evidence indicates definitely at least two molecules per unit cell and that there cannot be a three-fold symmetry axis through the molecules. A structure for the solid is tentatively proposed; it is base...

Nanosize cobalt boride particles were synthesized from the vapor phase using a 30 kW–4 MHz radio frequency (RF) thermal plasma. Cobalt and boron powder mixtures used as precursors in different composition and feed rate were evaporated immediately in the high temperature plasma and cobalt boride...

New fracture toughness (KC) data for cobalt boride (CoB and Co2B) coatings were obtained using the Vickers depth-sensing microindentation technique. The coatings were developed on the surface of a CoCrMo alloy using the powder-pack boriding process at temperatures between 1223 and 1273 K using v...

The production of clean hydrogen fuel by the electrolysis of water requires highly active, low-cost and facilely prepared electrocatalyst that minimizes energy consumption. Here we report an active cobalt boride (CoB)-derived electrocatalyst for both oxygen evolution reaction (OER) and hydrogen ...

This work presents an experimental-numerical study on the resistance of cobalt borides (CoB/Co2B) to contact fatigue. The boride layers were formed at the surface of a CoCrMo alloy using the powder-pack boriding process at temperatures of 1123 K for 3 h and 1223 K for 1 and 5 h of exposure times...

New results about the indentation properties of cobalt boride layer exposed to a diffusion annealing process (DAP) are presented in this study. Initially, the cobalt boride layer (CoB-Co2B) was developed at the surface of the ASTM F1537 alloy using the powder-pack boriding process (PPBP) at 1273...

Four stereoisomers of 7-isopropenyl-4a-methyl-3-methyleneoctahydrochromenon-2-one have been obtained for the first time. The key step of the synthesis involves asymmetric Michael addition of chiral enamines derived from dihydrocarvone to acrylate 1. Absolute configurations were established by X-...