Kinetic study on the complexation of caffeic acid with ferric chloride was performed in aqueous solution at pH 9.0. The complex was characterized by IR, UV–Vis spectroscopy and FE-SEM techniques. Kinetic data were obtained and used to model the reaction kinetics for the disappearance of the caf...

Iron(III) hydrolysis and chloride complexation in hydrothermal solutions was studied experimentally using UV–Vis spectrophotometry and based on density functional theory (DFT) and time-dependent density functional theory (TD-DFT) techniques. The strong ligand-to-metal charge transitions (LMCT) ...

Iron is essential in fundamental bioactivities, so it makes sense to improve the efficiency of iron on epithelial transport. In this work, a novel polysaccharide‑iron(III) complex (FVP-Fe(III)) was prepared from Flammulina velutipes with a specific structure. The FVP-Fe(III) had a molecular weig...

A new azomethine iron (III) complexes based on esters of biphenyl-4-carboxylic acid and NO3−, Cl−, PF6− counter-ions were synthesized. The complexation of iron salts with Schiff base proceeds in binary solvent and leads to production of biligand systems with two functional centers which determin...

The objective of this research is to elucidate the coordination chemistry and the structure of complexes formed with siderochelates organic ligands and the physico-chemical studies of iron(III) complexation. Three dihydroxamic acids synthesized ((LCyEt)2−, (LCyPr)2− and (LO)2−) mimicking a funga...

As iron supplement, the antioxidant activities of APS-iron (III) complex were comprehensively evaluated by 5-axe cobweb charts, which indicated the APS-iron (III) complex had a certain antioxidant activity and been weaker than that of APS. The results of immunological activity experiments indica...

A water-soluble polysaccharide was isolated from marine green algae Ulva pertusa and then chelated with iron to prepare the polysaccharide‑iron (III) complex. The immunomodulatory activities of sulfated polysaccharide and polysaccharide‑iron (III) complex were investigated through a mice immune-...

The gaseous mediator hydrogen sulfide (H2S) is synthesized mainly by cystathionine γ-lyase in the heart and plays a role in the regulation of cardiovascular homeostasis. Here we first overview the state of the art in the literature on the cardioprotective effects of H2S in various models of car...

Fucosylated chondroitin sulfate (fCS) and its depolymerized derivative (DfCS), prepared from sea cucumbers, are well-known for their anticoagulant activity. However, their other functional activities are poorly understood. Recently, we obtained fCS oligosaccharides from Isostichopus Badionotus b...

Chiral [(1R)-10-(N,N-diethylsulfamoyl)isobornyl] 2H-azirine 1 [Timén, A. S.; Somfai, P. J. Org. Chem. 2003, 9958–9963; Timén, A. S.; Fisher, A.; Somfai, P. Chem. Commun. 2003, 1150–1151]. was combined to a number of 1,4-disubstituted-2-aza-1,3-dienes 2a–g [Alves, M. J.; Durães, M. M.; Gil F...

Several nitrogen precursors without nitrogen hydrogen bonds were tested to dope ZnSe in a MOVPE process. Bisditrimethylsilylamidozinc (ZnBTM), trimethylsilylazide (TMSiN) and triallylamine (TAN) were used to grow ZnSe:N with ditertiarybutylselenide (DTBSe), diisopropylselenide (DIPSe) and dimeth...

Photoluminescence (PL), C-V and I-V characteristics of MOVPE-grown ZnSe:N doped using triallylamine (TAN) have been investigated. In our experiments, the use of TAN as dopant source does and lead to the incorporation of nitrogen into the lattice at the VIII ratio optimized for the growth of undo...

Anilines react with triallylamine in dioxane at 180 °C in the presence of a catalytic amount of ruthenium chloride and triphenylphosphine together with tin(II) chloride dihydrate to afford the corresponding 2-ethyl-3-methylquinolines in good yields.

Current therapy of depression is less than ideal with remission rates of only 25–35% and response rates of 45–60%. It has been hypothesized that a dysfunctional dopaminergic system in the mesocorticolimbic pathway in depressive disorder may lead to development of anhedonia associated with loss...

The first synthesis of 1,4-diazepine 2,5-dione peptides containing a β-amino acid in which the β carbon is also the anomeric carbon of a furanoid sugar is described. These new anomeric spirosugars obtained with a stereoselective control in the d-gulo, d-manno, d-allo and d-ribo series can be r...

3-(tert-Butyl)-4-hydroxyphenyl 2,4-dichlorobenzoate (1) was discovered in our in-house high throughput screening as a moderate FXR antagonist. To improve the potency and the stability of the hit 1, forty derivatives were synthesized and SAR was systematically explored. The results turn out that ...

We have previously reported the discovery and initial SAR of the [1,7]naphthyridine-3-carbonitriles and quinoline-3-carbonitriles as Tumor Progression Loci-2 (Tpl2) kinase inhibitors. In this paper, we report new SAR efforts which have led to the identification of 4-alkylamino-[1,7]naphthyridine...

Enhanced expression of NADPH oxidase (NOX) and the subsequent production of reactive oxygen species (ROS) are associated with lung cancer. In the present study, fifty 6-amino-2,4,5-trimethylpyridin-3-ol derivatives were screened for anticancer activity by targeting NOX2-derived ROS. The compound...

Sofalcone, isolated from the root of the Chinese medicinal plant Sophora subprostrata, is well known to be a mucosal protective agent for gastritis and peptic ulcer treatment. Although the LC–MS/MS and HPLC-DAD methods for assay of plasma concentration of sofalcone were reported before for the ...

Minimal and split-valence shell basis set calculations, both with and without d orbitais, predict the radical centre to be pyramidal, with the planar radical only 0.3 kcal mol−1 higher. The barrier to internal rotation is 2 kcal mol−1. There is no evidence of bridging from chlorine.