Polystyrene has been alkylated by reaction with 2,4-dichlorobenzyl chloride in dichloromethane at −5 °C in presence of anhydrous aluminium chloride. The alkylated polystyrene has been characterized by IR and NMR spectroscopy. The chlorine content (26.7 wt%) shows that 97% of the styrene units h...

Earlier studies have shown that 1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide (AF-2364) is a potential male contraceptive when administered orally to adult Sprague–Dawley rats. This compound induces reversible germ cell loss from the seminiferous epithelium by disrupting cell adhesion fun...

Vibronically excited but jet-cooled 2,4-dichlorobenzyl radical was generated from the precursor 2,4-dichlorotoluene using a pinhole-type glass nozzle designed for the dual purposes of corona discharge and supersonic jet expansion. From the analysis of the visible vibronic emission spectra of the...

In order to see the effects of non-bonding electrons in oxygen atoms on the cleavage of a bond between N-1 of the benzotriazole moiety and the α-carbon atom bonded to N-1 by lithium (6a) and sodium naphthalenides (6b), 2-[2-aryl-2-(benzotriazol-1-yl)ethyl]tetrahydro-2H-pyrans (4), and 2-[2-aryl...

The performance of the microaeration hydrolytic acidification (MAHA) process and microbial community were investigated under different organic loading rates (OLRs) for the pretreatment of 2-butenal manufacture wastewater (2-BMW). Results indicated that OLRs had different impact on the performanc...

A series of N-thiazole substituted arylacetamides were designed on the basis of metabolic mechanism of the aminothiazole fragment as glucokinase (GK) activators for the treatment of type 2 diabetes. Instead of introducing a substituent to block the metabolic sensitive C-5 position on the thiazol...

The synthesis of bis-[2-[(tetrahydro-2H-pyran-2-yl)thio]phenyl] diazine is reported and its potential as a spectrophotometric reagent for Hg2+ is explored. The dye reacts in 1:1 stoichiometry with Hg2+ and the product of this reaction, which is extracted into chloroform, has a molar absorptivity...

Studies directed at the amine exchange reaction of vinamidinium salts followed by sodium borohydride reduction to secondary and tertiary allylic amines are described. The tertiary allylic amines were alkylated and subjected to base mediated rearrangement to yield a variety of highly functionaliz...

Structure activity correlation revealed that the quinoxaline ring is a satisfactory backbone for anticancer activity and a specific functional group at position 1 and 2 can improve the activity. In this basis, besides quinoxaline, imidazoles as potential anticancer agents were used as a suppleme...

Charge-transfer salts formed by the electron donor tetrathiafulvalene and electron acceptor halogen have been the focus of significant interest in constructing high conductivity supramolecular nano-materials. However, the stable supramolecular gel systems of TTF-X2 combinations with controlled s...

The new method of the synthesis of 6,7-dihydro-4H-thiazolo[4,5-b]pyridin-5-ones, based on decarboxylation of corresponding 2,4-diamino-5-thiazolecarboxylic acids has been elaborated; unstable derivatives of 2,4-diaminothiazole, generated in situ as a result of decarboxylation, react with aldehyd...

Levetiracetam, a novel antiepileptic drug, is administered as the S-enantiomer of etiracetam according to the predominant pharmacodynamic advantage compared to its R-enantiomer. Thus, the content of enantiomer is restricted explicitly, which creates a hotspot focused on the stereochemistry of le...

BackgroundWAG/Rij rats represent a validated genetic animal model of epileptogenesis, absence epilepsy and depressive-like comorbidity. Some treatments (e.g. ethosuximide), using specific protocols, prevent the development of spontaneous absence seizures. Accordingly, ethosuximide increases remi...

Despite being one of the most commonly prescribed antiepileptic drugs, levetiracetam is marketed in oral and intravenous dosage forms, which are associated to drug-drug interactions and drug-resistant epilepsy (DRE). The purpose of the present study was to assess the potential of the intranasal ...

Background and aimsThe relationship between anti-epileptic usage and oxidative damage has not yet been clearly understood. In our study, we investigated oxidative stress parameters, carnitine levels, liver function tests (LFT) and their relationship in epileptic children treated with valproic ac...

SERS provides essential data regarding the interaction of molecules in drugs with DNA. In the present study silver nanoparticles were synthesized using a solution combustion method with urea as fuel. The prepared silver nanoparticles are rod like structure. Surface-enhanced Raman scattering (SER...

Formyl peptide receptor2 (FPR2) is a G-protein coupled receptor that plays critical roles in inflammatory reactions. FPR2-specific interaction can be possibly used to facilitate the resolution of pathological inflammatory responses by enhancing endogenous anti-inflammation systems. Starting from...

Single crystal X‐ray diffraction (SCXRD), powder X-ray diffraction (PXRD), and solid‐state NMR (SSNMR) techniques are used to analyze the structures of two nonsolvated polymorphs of {4‐(4‐chloro‐3‐fluorophenyl)‐2‐[4‐(methyloxy)phenyl]‐1,3‐thiazol‐5‐yl} acetic acid. These polymorphs ...

A new chalcone derivative, (2E)-3-(2-chloro-4-fluorophenyl)-1-(3,4-dimethoxyphenyl)prop-2-en-1-one (a) was synthesized and single crystals were grown by slow evaporation technique. The FT-Raman and FT-IR spectra of the sample were recorded in the region 3500–100 cm−1 and 4000–400 cm−1 respecti...

In this study, a novel ligand, 7-(2,3-dicyanophenoxy)-3-(2-chloro-4-fluorophenyl)coumarin was synthesized by the reaction of 3-(2-chloro-4-fluorophenyl)-7-hydroxycoumarin with 1,2-dicyano-3-nitrobenzen in dry DMF as the solvent in the presence of K2CO3 as the base. The preparation of the corresp...