A new procedure based on generation and subsequent reduction of orange-colored fluphenazine hydrochloride radical (FPH + ) is presented for the screening of total antioxidant capacity (TAC) of various fruit matrices. The FPH + was obtained by mixing fluphenazine hydrochloride wit...
The construction and electrochemical response characteristics of poly(vinyl chloride) (PVC), membrane sensors for determination of fluphenazine hydrochloride and nortriptyline hydrochloride are described. The method is based on the formation of the ion-pair complexes between the two drugs cation...
A rapid, simple, and highly sensitive second-derivative synchronous fluorimetric (SDSF) method has been developed for the simultaneous analysis of binary mixtures of fluphenazine hydrochloride (FLZ) and nortriptyline hydrochloride (NTP) in their co-formulated tablets. The method is based upon me...
Micellization behavior of sodium dodecylsulfate (SDS) has been studied in the presence of phenothiazine drug triflupromazine hydrochloride (TFP) in the concentration range (0.01–0.50mM) in water as well as in aqueous solutions of ethanol (1–10%, v/v) using conductivity and surface tension meas...
The 1 9 F nuclear magnetic resonance (NMR) spin-lattice relaxation time (T 1 ) of the trifluoromethyl signal of triflupromazine (TFZ) was measured in aqueous suspensions of phosphatidylcholine (lecithin) small unilamellar vesicles (SUV). The observed T 1 value depende...
The second-derivative spectra of chlorpromazine (CPZ) or triflupromazine (TFZ) in buffer solutions (pH 7.4) containing various amounts of BSA (the reference solutions contained the same amount of BSA) showed derivative isosbestic points. The residual background signals derived from incomplete su...
The formation of mixed micelles built of 7,12-dioxolithocholic and the following hydrophobic bile acids was examined by conductometric method: cholic (C), deoxycholic (D), chenodeoxycholic (CD), 12-oxolithocholic (12-oxoL), 7-oxolithocholic (7-oxoL), ursodeoxycholic (UD) and hiodeoxycholic (HD)....
ObjectiveTo evaluate the teratogenic effect of very large doses of nitrazepam in children born to pregnant women who attempted suicide and to check the feasibility of self‐poisoning pregnant women model.Design and settingComparative analysis of exposed children and their unexposed sibs born to ...
This chapter contains sections titled: Introduction Chemistry Mechanism of action Pharmacokinetics Drug interactions Serum level monitoring Efficacy Tolerance Adverse effects Place in current therapy References
] oxidation states, the pre- and post-IET states. The comparison of the dynamics and conformations of the iNOS construct at the two oxidation states has allowed us to identify key factors related to facilitating the FMN–heme IET process. The computational results demonstrated, for the first tim...
The structural and dynamical properties of five FMN binding protein (FBP) dimers, WT (wild type), E13K (Glu13 replaced by Lys), E13R (Glu13 replaced by Arg), E13T (Glu13 replaced by Thr) and E13Q (Glu13 replaced by Gln), were investigated using a method of molecular dynamics simulation (MDS). In...
D-Ribitol-5-phosphate (Rbt-5-P) is an important metabolite in the pentose phosphate pathway and an integral part of bacterial cell wall polysaccharides, specifically as polyribosyl ribitol phosphate (PRP) in Haemophilus influenzae type b (Hib). The major objective of this study was to investigat...
The design of biofuel cell anodes with substantially decreased potential is a prerequisite for the development of biofuel cells with large open-circuit voltage and power density. Redox polymers with covalently attached phenothiazine derivatives such of thionine acetate, toluidine blue, azure B s...
Electro-enzymatic biotransformation requires an efficient and robust electronic communication between the biomolecules and electrodes, often performed by the relevant electron transfer (ET) mediating systems. Of those, redox-labeled dendrimeric structures, biocompatible and bearing spatially ord...
Cofactor flavin adenine dinucleotide (FAD) plays a vital role in many FAD‐dependent enzymatic reactions; therefore, how to efficiently accelerate FAD synthesis and regeneration is an important topic in biocatalysis and metabolic engineering. In this study, a system involving the synthesis pathw...
The biosynthesis of the antibiotic metabolities oosponol and oospoglycol by the fungus Gloeophyllum abietinum has been analysed using 1 3 C-labelled acetate, malonate, serine and formate as precursors and 1 3 C NMR as the analytical method. The polyketide pathway could b...
Desiccants are used in potato production to remove haulms prior to harvest to facilitate harvest. New formulations of the desiccant endothal were compared to diquat for potential as a top desiccant on four potato cultivars. Tubers were stored at 3 o C and 95% RH for determination of daug...
This study investigated the effect of percutaneous catheter drainage (PCD) on pancreatic injury in severe acute pancreatitis (SAP) rats.Sixty Wistar rats were equally randomized into three groups: a sham operated control group, an SAP control group, and a PCD group. The levels of inflammatory cy...
The regulator of cytokine signaling known as protein inhibitor of activated STAT-1 (PIAS1) is increasingly understood to have diverse regulatory functions for inflammation, but its effect in inflammatory conditions such as severe acute pancreatitis (SAP) has not previously been reported. The aim...
A cyclodextrin-modified micellar electrokinetic chromatographic method was established to determine five anthraquinone derivatives and a distyrene derivative in Rhubarb. The six components were successfully separated by using the mixed micellar system consisting of 20mmol/l SC and 20mmol/l STC w...
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