Room-temperature X-band electron spin resonance spectra of copper(II)-doped nickel diethyldithiocarbamate powders have been studied as a function of copper(II) doping. At low dopant concentrations (less than 5 mole %) the concentration variation of linewidths predicted by a simple dipolar broade...

A strong influence of the Ni content in on the barrier properties of the surface films, spontaneously formed on Cu–Ni alloys (containing 10–40 at.% of Ni) in a slightly alkaline NaCl solution or previously produced by forming bis(diethyldithiocarbamato)Cu(II) and Ni(II) surface complexes, were...

Solid solutions of bis(N,N-diethyldithiocarbamato)copper(II) in a zinc matrix were studied by means of EPR. The spectra may be interpreted with a S=1 Hamiltonian giving proof of spin-spin interactions between pairs of copper ions within isolated dimers. The magnetic parameters obtained were used...

The structure of bis[N,N-di(trifluoroethyl)dithiocarbamato]nickel(II) has been determined by single- crystal X-ray diffraction methods. The compound forms strongly pleochroic monoclinic crystals in the space group P21/n (no. 14, C52b) with a=8.519(2), b=8.912(1), c=11.098(2) Å, β=103.18(2)° an...

Halogen exchange was observed when bis(NN-diethyldithiocarbamato) nickel(II), Ni(dtc)2, was refluxed with excess α,α′-dibromo-o-xylene in 1,2-dichloroethane forming α,α′-dichloro-o-xylene and α, α′-bromochloro-o-xylene. This exchange is absent without Ni(dtc)2 or when bis(o-ethylaxantha...

The standard formation enthalpy (298 K) of tris(diethyldithiocarbamato)cobalt(III) has been derived by solution calorimetry as ΔfH⊖m(Co[S2CN(C2H5)2]3) = −233.8 ± 20 kJ mol−1. The thermochemical measurements are based on a ligand-exchange reaction involving the complete displacement of pentane-...

The IR spectra (300–4000 cm−1) of bis-(N,N-diethyldithiocarbamato)-nickel(II) as N2 matrix and oriented polycrystalline layer are reported. All the observed bands are assigned and classified on the grounds of their polarisation in the symmetry classes of D2h, the highest possible molecular symm...

A new nickel(II) dithiocarbamate complex, bis(2,2,2-trifluoroethylhydrogendithiocarbamato)nickel(II), has been synthesised. A detailed analysis of the IR and electronic spectra of bis(di-2,2,2-trifluoroethyldithiocarbamato)nickel(II) and bis(2,2,2-trifluoroethylhydrogendithiocarbamato)nickel(II)...

Publisher SummaryThis chapter discusses the use of 10-formyl-5,8-dideazafolate as substrate for rat 10-formyltetrahydrofolate dehydrogenase. 10-formyltetrahydrofolate (10-HCO-H4PteGlu) is susceptible to oxidative degradation and must be protected by reducing agents during synthesis and use in en...

STAT3 has been extensively studied as a potential antitumor target. Though studies on regulating STAT3 mainly focus on the inhibition of STAT3 phosphorylation at Tyr705 residue, the phosphorylation at Ser727 residue of STAT3 protein is also closely associated with the mitochondrial import of STA...

BackgroundPulmonary arterial hypertension (PAH) is a chronic fatal disease. The treatment of PAH is less than ideal and the control is far from satisfactory worldwide. Vaccination provides a promising approach for treatment of PAH.

Multiple intracellular transforming signals regulate eukaryotic translation initiation factor 4E (eIF4E)-binding protein (4E-BP1). The signals result in hierarchical phosphorylation of 4E-BP1, resulting in release of eIF4E, relieving translational repression and enhancing oncogenic protein synth...

A series of 9-(2-(1-arylethylidene)hydrazinyl)acridine and its analogs were designed, synthesized and evaluated for biological activities. Various biochemical assays were performed to determine the free radical scavenging capacity of synthesized compounds (4a–4j). Anticancer activity of these c...

ObjectiveThough metastasis-associated protein 1 (MTA1) is widely overexpressed in human cancers and is associated with advanced clinicopathological characteristics and survival in related diseases, the association between MTA1 and endometrial cancer (EC) is little known and needs to be studied.

A simple and convenient method for the synthesis of cyclopropanes substituted with carbohydrate analogues is described. The addition of trifluoromethyl diazo compounds to 5-(R)-hydroxypyridazin-3-one derivative of d-(+)-galactose proceeded in almost quantitative yields and high syn-selectivity. ...

Eight Schiff bases (N-(R-salicylidene)–cycloalkilamines, R=H, 5-NO2 and 5-Br) obtained from cyclopropyl, cyclobutyl- and cyclopentylamine were investigated in terms of intramolecular hydrogen bond formation in chloroform solution and in the solid state. The relationship between cycloalkyl ring ...

Trans-(1R*,2R*,3R*)-Ethyl 2-(3,4-dimethoxyphenyl)-3-methylcyclopropane-1-carboxylate (6) and its cis isomer 7 were obtained from the reaction of the methyl isoeugenol (5) with ethyl diazoacetate. The reduction and bromination reactions of the ester 6 and 7 together with the hydrolysis of all est...

To evaluate the influence of stereochemistry on biological activities of cis-cyclopropyl combretastatin A4 (CA4) analogues, we have prepared several cyclopropyl compounds in their pure enantiomeric forms. The key reactions in our synthesis are the cyclopropanation of a (Z)-alkenylboron compound ...

The novel semiconductor heterojunction of MIL-53(Fe)/BiOCl composite was first prepared through the solvothermal reaction. The prepared materials were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission elect...

(−)-6-(7-Methoxy-2-trifluoromethylpyrazolo[1,5-a]pyridin-4-yl)-5-methyl-4,5-dihydro-3-(2H)-pyridazinone (KCA-1490) is a dual PDE3/4 inhibitor that exhibits potent combined bronchodilatory and anti-inflammatory activity. A survey of potential bicyclic heteroaromatic replacement subunits for the p...