Vibrational spectral analysis of 2-[(4-chlorobenzyl)sulfanyl]-4-(2-methylpropyl)-6-(phenylsulfanyl)-pyrimidine-5-carbonitrile was carried out using FT-IR and FT-Raman spectroscopic techniques. The equilibrium geometry and vibrational wave numbers have been computed using density functional B3LYP...

The liquid phase chlorination of benzyl chloride (BC) has been investigated in the presence of a series of zeolite catalysts at 353 K under atmospheric pressure. A comparative study of these catalysts reveals that zeolite K-L exhibits the higher rate of BC conversion (76.4 mmol g−1 h−1), except ...

4-Chlorophenylmethanesulfonamide and (4-chlorobenzyl)sulfamide derivatives of histamine homologues were prepared and found to be potent and selective histamine H3 receptor antagonists. High receptor affinity and low differences in the data from the bioassays were achieved with the imidazol-4-ylb...

The in vitro hepatic microsomal metabolism of N-(4-chlorobenzyl)-N′-benzoylhydrazine (CBBAH), a model compound representing N-alkyl substituted hydrazides, was studied using hepatic washed rat microsomal preparations fortified with NADPH to identify the possible N-oxidative, N-dealkylated and h...

Three new molecular solids, [nClBzPyN(CH3)2][Ni(mnt)2]([BzPyN(CH3)2]+ = benzyl-4-dimethylaminopyridinium; mnt2− = maleonitriledithiolate; n = 2(1), 3(2), 4(3)), have been prepared and characterized. The [Ni(mnt)2]− anions of 1 and 2 form a 1D column in which the former is non-uniform one with th...

In this study, 4,4'-(butane-1,4-diyl)bis(1-((1-(4-chlorobenzyl)-1H-1,2,3-triazol-5-yl)methyl)-3-methyl-1H-1,2,4-triazol-5(4H)-one) was synthesized and characterized by FT-IR, 1H NMR and 13C NMR. In addition, quantum chemical calculations of the structure, vibrational frequencies, gauge incl...

Thiazole derivatives are potential candidates for drug development. They can be efficiently synthesized and are extremely active against several diseases, including diabetes. In our present study, we investigated the anti-diabetic, anti-oxidant and anti-inflammatory properties of 2-[(4-Chloroben...

Fourier transform infrared (FT-IR) spectroscopy in the region 400–4000 cm−1, proton and carbon-13 NMR chemical shifts and UV–Vis. absorption wavelengths of 3-p-chlorobenzyl-4-(4-carboxybenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-one molecule have been experimentally investigated. For monom...

The cytotoxic activity of a new series of 2-(4′-chlorobenzyl)-5,6-disubstituted imidazo[2,1-b][1,3,4]thiadiazoles against different human and murine cancer cell lines is reported. Among the tested compounds, two derivatives namely 2-(4-chlorobenzyl)-6-(2-oxo-2H-chromen-3-yl)imidazo[2,1-b][1,3,4...

In the present study, the partly and fully-substituted monospiro (4–6, 4a-6d), cis-dispiro (7–9), trans-dispiro (10–15) cyclotriphosphazenes were synthesized for the investigations of their chemical, stereogenic and biological properties. The cis/trans phosphazenes (7–12) have two stereogeni...

In the present work, the intensification of phase transfer catalyzed reaction has been investigated based on the use of ultrasound. The synthesis of 1-benzyloy-4-nitrobenzene from 1-chloronitrobenzene and benzyl alcohol catalyzed using potassium hydroxide flakes and also tetrabutylammonium bromi...

Lysine specific demethylase 1 (LSD1) plays a vital role in epigenetic regulation of gene activation and repression in several human cancers and is recognized as a promising antitumor therapeutic target. In this paper, a series of 4-(4-benzyloxy)phenoxypiperidines were synthesized and evaluated. ...

Epidemiological data showed that the number of obese people increases swiftly in all countries. Obesity can evoke metabolic syndrome or second type diabetes (T2D). So, the aim of our study was to investigate the influence of 2-[4-(benzyloxy) phenoxy] acetic acid on metabolic parameters of monoso...

IntroductionAnti-TPO receptor (anti-c-Mpl) antibodies exist and could affect rhTPO treatment in ITP.

The steric hindered Aib-Aib-Aib tripeptide was synthesized in mild conditions, using PyBroP for the coupling of two Aib and Fmoc-Aib-NCA for the generation of the tripeptide, which was obtained with an excellent yield in THF. The coupling of Gln was carried out in the presence of BOP.

The first studies on a series of the small synthetic thiol proteinase inhibitors, conservative common sequences in several thiol proteinase inhibitors, are described. Among the many interesting findings with synthetic thiol proteinase inhibitors was the observation that the most effective analog...

The synthesis of 1,8-bis(dimethylaminomethylethynyl)-3,6-di(tert-butyl)fluorene-9-yl-acetic acid, a potentially dinucleating ligand containing two N-donor and bridging carboxylate groups, is described. The electronically disfavored 1,8-disubstitution of the fluorene ring system was achieved by u...

The photoisomerization of α-(9″-anthryl)ethyl spiro[cyclopropane-1,9′-fluorene]-2-carboxylates (1c⇄2c) proceeds diastereoselectively through the selective intramolecular energy transfer from the second triplet state of anthryl group to the fluorenyl moiety. Asymmetric induction using opticall...

A series of novel 2-aryl-6-bromo-4-chloro-8-iodoquinazolines were prepared and subjected to sequential two-step (Sonogashira and subsequent one-pot bis-Suzuki) and one-pot three-step Sonogashira cross-coupling reactions to afford unsymmetrical polycarbo-substituted quinazolines. Selectivity in t...

In order to explore the anticancer effect associated with the thiazolidinone framework, several 2-(5-((5-(4-chlorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid derivatives 5(a–l) were synthesized. Variation in the functional group at C-terminal of the thiazolidinone le...