A series of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines were synthesized and evaluated as potential positron emission tomography (PET) tracers for the corticotropin-releasing factor type-1 (CRF1) receptor. Compounds 27, 28, 29, and 30 all displayed ...

O-hexyl O-2,5-dichlorophenyl phosphoramidate (HDCP) is a chiral analogous compound of the methamidophos insecticide that induces delayed neuropathy, and the R-(+)-HDCP enantiomer is an inhibitor of neuropathy target esterase (NTE). This enantiomer is not hydrolized by Ca2+-dependent phosphotries...

O-Hexyl O-2,5-dichlorophenyl phosphoramidate (HDCP) induces delayed neuropathy in hens. It has been used as a tool to identify new A-esterase activities in animal tissues. This study shows the EDTA-resistant, Cu2+- and Zn2+-dependent hydrolysis of racemic HDCP in domestic and sea bird serum usin...

The key function of microtubules and mitotic spindle in cell division make them attractive targets in anticancer therapy. In the present study, functionalized in 3 position 2-phenyl- and 2-alkylbenzo[b]furans were synthesized and evaluated as antitumor agents. Among the synthesized derivatives 1...

Tris(2-(2-formylphenoxy)ethyl)amine was designed and synthesized by reaction of salicylaldehyde with tris(2-chloroethyl)amine hydrochloride and evaluated as a new multi-functional cross-linker for preparation of new pH- and thermo-responsive chitosan hydrogels through formation of covalent Schif...

A highly electrophilic pyrone, 2-cyano-6-(trifluoromethyl)-4H-pyran-4-one, was synthesized. The reactions of this cyanopyrone with N-nucleophiles can proceed with or without substitution of the cyano group to give a wide range of novel trifluoromethylated compounds. An oxindole derivative was sy...

Glutaric acid is an attractive C5 dicarboxylic acid with wide applications in the biochemical industry. Glutaric acid can be produced by fermentation and bioconversion, and several of its biosynthesis pathways have been well characterized, especially the simple pathway involving glutaric acid fr...

Chlorogenic acids (CGA; including 5-caffeoylquinic acid and its regio-isomers) in Taraxacum antungense Kitag. have antioxidant and anti-inflammatory properties and exert other pharmacological effects. T. antungense hydroxycinnamoyl-CoA quinate hydroxycinnamoyl transferase (TaHQT)1 and TaHQT2, wh...

Lithocholic acid is a cytotoxic bile acid oxidized at the C-3 position by human cytochrome P450 3A (CYP3A) to form 3-ketocholanoic acid, but it is not known whether this metabolite is cytotoxic. Tocotrienols, in their various isomeric forms, are vitamin E analogues. In the present study, the hyp...

Occurrence of per- and poly-fluoroalkyl substances (PFASs) in the environment and biota has raised a great concern to public health because these compounds are persistent, bioaccumulative, and toxic. Biodegradation of polyfluoroalkyl substances, particularly long-chain fluorotelomer-based produc...

Differential heats of adsorption were measured for ethane and ethene on a siliceous ZSM-5, H-[Al]ZSM-5, H-[Fe]ZSM-5, Li-[Al]ZSM-5, H(Zn)-[Al]ZSM-5, and H(Zn)-[Fe]ZSM-5 at 195 K in order to characterize the nature of interactions between the olefin functional group and both Brønsted sites and exc...

Dicarboxylic acids, such as the phthalic acids and their derivatives, are monomeric components in several important polyesters and polyamides. In most cases, these compounds are derived from fossil fuels and are not easily biodegradable. Dipicolinic acid (DPA) is a biologically derived aromatic ...

Ni-ZSM-5 bi-functional catalysts were prepared by ion-exchanged (Li+, Na+, K+) in alkaline solution with different alkali concentrations. Highly selective alkanes and aromatics were abtained separately in the conversion of oleic acid by adjusting the relative strength between metal centres and a...

Tungstophosphoric (TPA) supported on mesoporouus niobiumoxophosphate (NbP) catalysts were prepared with different loadings. The synthesized materials employed as heterogeneous solid acid catalysts for selective etherification of 5-hydroxymethylfurfural to 5-ethoxymethylfurfural. Physico-chemical...

In this work, the date palm petiole was transformed into activated carbon implying sodium hydroxide as the activating agent. The carbon obtained was exerted for the adsorption of indigo carmine in batch and continuous mode. The properties of activated carbon were established. The effects of pH, ...

Hybrid materials based on montmorillonite, a cationic polymer and carminic acid were prepared. The surface charge of montmorillonite was inversed thanks to the cationic polymer, polydiallyldimethylammonium chloride. Samples were characterized by a set of different techniques including Infrared (...

The kinetic and equilibrium parameters of the quantitative adsorption for Indigo Carmine (IC) removed by commercial activated carbon (AC) were studied by UV–visible absorption spectroscopy. AC with a high specific surface area (1250.320 m2/g) was characterized by the Brunauer–Emmett–Teller (B...

Herein we report the modulating effect of sodium dodecyl sulphate (SDS), hexadecyl-pyridinium chloride (HDPC) and octylphenol ethoxylate (Triton X100) on the degradation of indigo carmine (IC) and crystal violet (CV) in bicarbonate-activated peroxide (BAP) system. Upon the addition of surfactant...

Indigo carmine in aqueous solution was effectively degraded using ZnO-Bi2O3/Graphitic Carbon Nitride heterojunction structure by visible light/H2O2 system. The mechanism of photocatalytic degradation of Indigo carmine shows the responsible species for the degradation of Indigo carmine in the ZnO...

The chemical composition of the scale insect Dactylopius coccus was analyzed with the aim to discover new possible intermediates in the biosynthesis of carminic acid. UPLC-DAD/HRMS analyses of fresh and dried insects resulted in the identification of three novel carminic acid analogues and the v...