Culturing of mouse spleen cells with aloctin A (Alo A), a lectin having anti-tumor activity, resulted in the induction of cells cytotoxic to syngeneic and allogenic tumor cells in vitro. Alo A-induced killer cells could be generated from spleen cells of natural killer cell-deficient beige mice b...

Culturing of mouse spleen cells with IL2-containing MLA144 conditioned medium (MLA144 CM) resulted in the induction of cells cytotoxic to syngeneic and allogeneic tumor cells in vitro. The cytotoxicity was markedly augmented by the presence of aloctin A (Alo A), a lectin having anti-tumor activi...

Water-soluble CuInS2 ternary quantum dots (QDs) capped by mercaptopropionic acid were directly synthesized in aqueous solution. Consequently, the CuInS2 QDs were covalently linked to 3-aminophenyl boronic acid molecules to form the 3-aminophenyl boronic acid-functionalized CuInS2 QDs (F-CuInS2 Q...

Renal cell carcinoma (RCC) often expresses a high density of sialic acid-rich glycoproteins which helps these late-stage cancer cells to enter the blood stream or urine. Blood diagnosis is a complex and time-consuming process. In this study, we developed a facile and non-invasive electrochemical...

Sialic acid (SA) is a notable tumor marker in human. Its increased level beyond the normal concentration in human biological samples is related to different kinds of cancers development. In this contribution, a novel colorimetric assay is reported for SA detection in form of N-acetylneuraminic a...

A series of 2-(3,5-substituted 4-aminophenyl)acetamide and propanamide derivatives were investigated as human TRPV1 antagonists. The analysis of the structure-activity relationship indicated that 2-(3,5-dihalo 4-aminophenyl)acetamide analogues displayed excellent antagonism of hTRPV1 activation ...

Syntheses of novel 5-aryl-2,3,5,6-tetrahydro-3H-imidazo[2,1-b] [1,3,5]benzotriazepine derivatives 3a–g were performed by reacting 2-(2-aminoarylimino)imidazolidines 1a–b with corresponding aryl aldehydes. The compounds 3 incorporating aminal group upon treatment with 2,3-dichloro-5,6-dicyano-1...

The synthesis and pharmacological characterisation of (1-methyl-1H-imidazol-2-yl)-methanamine and its derivatives in PtII complexes are described. Six out of eleven new PtII complexes showed a significant cytotoxic effect on NCI-H460 lung cancer cell line with EC50 values between 1.1 and 0.115 m...

SummaryNovel 1,3,4-Oxadiazoles bearing benzimidazole nucleus were designed, synthesized using 2-(2-(substituted phenoxymethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide and carbon disulfide. These newly synthesized benzimidazolyl oxadiazoles along with benzimidazolyl acetates and benzimidazolyl ac...

A transition-metal-free insertion of benzyl group between aldehyde and imidazole of 2-(1H-benzo[d]imidazol-1-yl)benzaldehyde was achieved for the first time. Two diverse sets of quinolin-4-one derivatives: benzo[4,5]imidazo[1,2-a]quinolin-5(7H)-ones (2) and 3-arylquinolin-4-ones (3) were synthes...

IR and Raman spectra of 1-[3-(1H-imidazol-1-yl)propyl]-3-phenylthiourea (HIPPT) have been recorded in the solid phase and the vibrational wave numbers are calculated theoretically by B3LYP/6-31G(d,p) (6D, 7F) method. All the fundamental vibrational modes have been assigned using potential energy...

The reaction of 2,4-di-O-benzoyl-myo-inositol-1,3,5-orthoformate and its 6-O-substituted derivatives with alkyl halides in the presence of silver (I) oxide has been studied systematically. The nature of the product obtained depends on the amount of silver (I) oxide and alkyl halides used as well...

Synthetic sequences starting from commercially available myo-inositol necessarily involve protection–deprotection strategies of its six hydroxyl groups. Several strategies have been developed/attempted over the last several decades leading to the synthesis of naturally occurring phosphoinositol...

scyllo-Inositol derived 1,2-trans-diequatorial halohydrins can be efficiently converted to the corresponding epoxides in the presence of lithium hydride. The structure of one of the epoxides was determined by single crystal X-ray diffraction analysis. This provides a potential route for the prep...

Fenofibric acid is a hypolipidemic drug that is used as an active ingredient per se or is administered in the form of fenofibrate that releases fenofibric acid after absorption. The metabolism of fenofibric acid is mediated primarily by glucuronidation. However, the other part of fenofibric acid...

Boll weevils, Anthonomus grandis Boheman, were either dipped in or injected with a solution of [14C]diflubenzuron (N-[[(4-chlorophenyl)amino]carbonyl]-2,6-difluorobenzamide) or fed on cotton squares that had been treated with the chemical to determine its turnover time and metabolic fate. No sig...

The molecular structures of two isomeric 2-(chlorophenyl)-3-[(chlorobenzylidene)-amino] substituted 2,3-dihydroquinazolin-4(1H)-ones have been determined via single crystal XRD. Both isomers contain chloro substitutions on each of the phenyl rings and as a result a broad spectrum of halogen medi...

A fascinating selectivity in the direction of the formation of the formamidine was observed upon the reaction of isobutyl 6-amino-4-(2-chlorophenyl)-5-cyano-2-methyl-4H-pyran-3-carboxylate with N,N-dimethyl formamide. A development in selectivity is explored and a probable mechanism for the reac...

A new series of N-dichloroacetyl-bis(2-chlorophenyl)piperidin-4-ones 4-6 has been synthesized and characterized using IR, 1H, 13C, DEPT and 2D (COSY and HSQC) NMR spectral techniques. The NMR spectral data indicate that the N-acylpiperidin-4-ones 4-6 prefer to exist in an equilibrium between the...

Different concentrations of copolymer of (N-(4-chlorophenyl) acrylamide) (CA) with methyl methacrylate (MMA) were prepared and the reactivity ratio values of copolymerization were calculated using 1H NMR technique. Thermal analysis of the copolymers showed that the thermal stability is intermedi...