A series of novel 5[β-(phenothiazinyl-10-yl)ethyl]-1-(acyl)-1,2,3,4-tetrazoles (3–14) have been synthesized via condensation of 5-[β-(phenothiazinyl-10-yl)ethyl]-1-2,3,4-tetrazole (2) with various acylating/sulphonating reagents. 5-[β-(phenothiazinyl-10-yl)ethyl]-1-2,3,4-tetrazole was synthe...

Carbonyl selenide easily reacted with elemental sulfur at low temperature to form carbonyl sulfide in a good yield, and reaction of ammonium salts of selenocarbamates with elemental sulfur brought about ready transformation to those of thiocarbamates. On the basis of the high catalytic activity ...

Purified thiocarbamate-inducible ThcF of Rhodococcus erythropolis NI86/21, overexpressed in Escherichia coli, displayed several characteristics of the HASH family of enzymes that groups prokaryotic proteins of the α/β hydrolase superfamily possessing serine-dependent hydrolase and/or haloperox...

Synthesis of new acylthiocarbamates has been carried out. To establish the preferential conformation and to explain the behaviour chemically, the structure of isopropyl N-(2-furoyl)thiocarbamate 3m has been determined by single-crystal X-ray analysis. The most stable conformation E,Z′ establish...

A simple and efficient method for the conversion of alcohols and phenols to primary O-thiocarbamates and S-thiocarbamates in the absence of solvent (solvent-free condition) using silica sulfuric acid (SiO2OSO3H) as a solid acid is described. The products are easily distinguished by IR, NMR and X...

New S-thiocarbamates possessing a 10,11-dihydro-5H-dibenzo[a,d]cycloheptene moiety were obtained unexpectedly in the process of preparing new O-thiocarbamates starting from 5-dibenzosuberol (10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ol) and aroyl-isothiocyanates. These compounds were obtained v...

A series of new O-perfluoroalkyl thiocarbamates were synthesized by the reaction of isothiocyanates with perfluoroalkyl alcohols. Substituent effects on the barrier to rotation around the NCS bond in these thiocarbamates were investigated using variable temperature 1H NMR spectroscopy. The free ...

A simple and clean protocol for the synthesis of various alkyl and (hetero)aryl S-thiocarbamates was established. The usage of in situ generated hydroxide as both an oxygen source and hydrogen source as well as biomass-derived 2-methyltetrahydrofuran as a green reaction medium, the avoidance of ...

Dielectric and viscoelastic relaxation measurements have been performed on poly(2-chloroethyl methacrylate) and poly(3-chloropropyl methacrylate) between −140°C and the glass transition temperatures. The splitting of the dipolar relaxations from those of conductive origin in the dielectric spec...

Compounds of general formula M(bdhe)ClO4 (M = Mn, Fe, Co, Ni, Cu, Zn) are formed by reaction between the tripod-like ligand NN-bis(2-diethylaminoethyl)-2-hydroxyethylamine (bdhe) and metal diperchlorate in acetone. Conductometric, spectroscopic and X-ray diffraction data indicate that all these ...

Chronic inflammation has been associated to cancer development by the alteration of several inflammatory pathways, such as Nuclear Factor-κB pathway. In particular, IκB kinase α (IKKα), one of two catalytic subunit of IKK complex, has been described to be associated to cancer progression and...

Mammary serine protease inhibitor or Maspin has been characterized as a class II tumor suppressor gene in several cancer types, among them prostate cancer (CaP). Androgen ablation is an effective therapy for CaP, but with short-term effectiveness, thus new therapeutic strategies are actively sou...

Aceanthrylene (ACE), a cyclopenta-fused polycyclic aromatic hydrocarbon (CP-PAH) related to anthracene, has been studied for its ability to be metabolized, to form DNA adducts, and to morphologically transform C3H10T1/2CL8 mouse embryo fibroblasts in culture. Although ACE has been previously sho...

Optically transparent semiorganic nonlinear optical bulk single crystal of l-ornithine monohydrochloride (LOMHCL) of dimension 11×3×2 mm3 has been grown from its aqueous solution by slow solvent evaporation technique. The grown crystal was characterized by powder X-ray diffraction to confirm t...

l- Ornithine Mono Hydrochloride (LOMHCl) single crystals were grown successfully by slow evaporation solution technique (SEST). Optically transparent and desirable quality single crystals of LOMHCl having dimensions 30 × 11 × 5 mm3 were obtained in a span of 16 days. The grown crystals were su...

Amino acid family crystals exhibit excellent nonlinear optical and electro optical properties. l-Ornithine monohydrochloride single crystal, belongs to the amino acid group, was grown by the slow evaporation solution growth technique at room temperature. The grown crystals were characterized by ...

l-Ornithine monohydrochloride was evaluated in two in vitro genotoxicity assays and a rat 90-day oral toxicity study.No evidence of genotoxicity was observed in the reverse bacterial mutation assay or the chromosome aberration test at doses of up to 5000 μg/plate or 1686 μg/mL, respectively, b...

STM2360 is a gene located in a small operon of undetermined function in Salmonella enterica serovar Typhimurium LT2. The amino acid sequence of STM2360 shows significant similarity (∼30% identity) to diaminopimelate decarboxylase (DapDC), a Fold III pyridoxal-5′-phosphate (PLP) dependent enzym...

The photogeneration mechanism of a series of 21 bis-nitrile imines with different types of linkage, and their subsequent thermal reactions, especially cycloadditions, are investigated by means of stationary and time-resolved methods. The short-living nitrile imines are efficiently photo-generate...

The one-pot regioselective preparation of 5-aryl/alkyl-2-vinyl-2H-tetrazoles from 5-substituted tetrazoles via a very simple procedure using 1,2-dibromoethane and triethylamine without the need of any catalyst is described. The mechanism of this reaction is also discussed.