ABSTRACTThe crystal structures of the analgesic compounds anhydrous naloxone and naltrexone hydrochloride were determined ab initio from high resolution laboratory X‐ray powder diffraction data. Both compounds crystallize in the orthorhombic space group P212121 with lattice parameters of a = 14...
Naltrexone hydrochloride (NTX) is a promising treatment for corneal disorders linked to diabetes mellitus (diabetic keratopathy). However, NTX has a major stability problem due to autoxidation, which is likely to hinder its formulation as eye drops for treatment of diabetic keratopathy. In this ...
Naltrexone hydrochloride (NTX) is an innovative drug used in ophthalmology for treatment of ocular surface diseases such as impaired corneal wound healing and severe dry eye. Poor chemical stability has been a major limitation for development of NTX in solution form. The aim of this study was to...
Naltrexone (NTX) is a potent opioid growth factor receptor (OGFR) antagonist proved to be useful for treatment of ocular surface complications. The aim of this work was to explore the feasibility of designing NTX-imprinted 2-hydroxyethyl methacrylate-based hydrogels for sustained drug release on...
ABSTRACT:This study aimed at preparing and evaluating Span 60-based niosomes for ocular delivery of naltrexone hydrochloride (NTX). Selected charged lipids [dicetyl phosphate (DCP) and stearyl amine (STA)] and surfactants [poly-24-oxyethylene cholesteryl ether (C24) and sodium cholate (CH)] were...
A thermosensitive hydrogel of PLGA-PEG-PLGA triblock synthesized via ring opening polymerization using microwave irradiation method was used to control the release of naltrexone HCl drug. In the present work, the injectable prepared hydrogel was dissolved in phosphate buffer with different amoun...
The FT-IR and FT-Raman spectra of the synthesized compound, 2-isopropyl-5-methylcyclohexyl quinoline-2-carboxylate is recorded and analyzed. Optimized molecular structure, wave numbers, corresponding assignments regarding 2-isopropyl-5-methylcyclohexyl quinoline-2-carboxylate has become screened...
A series of 1-adamantanecarboxamides was synthesized and examined for their potency as a selective 5-HT2 receptor antagonist. We found (S)-N-{1-[2-(4-fluorophenyl)ethyl]pyrrolidin-3-yl}-1-adamantanecarboxamide hydrochloride hydrate (10-(S), Y-39241) to have a high affinity and selectivity for 5-...
We were the first to detect 3-benzyl-5-[1-(2-pyrrolidin-1-ylethyl)-1H-indol-3-yl]-1,2,4-oxadiazole (given name BzODZ-EPyr) as a new synthetic cannabinoid, in illegal market of new psychoactive compounds (NPS). The compound was known only from pharmaceutical literature so far. BzODZ-EPyr was iden...
The inflammatory caspases (caspase-1, -4 and -5) are potential therapeutic targets for autoimmune and inflammatory diseases due to their involvement in the immune response upon inflammasome formation. A series of small molecules based on the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine s...
Reactions of N-alkyl-2,3-dihydro-4-pyridones and 4-(pyrrolidin-1-yl)furan-2(5H)-one with aldehydes and triethylsilane in a one-flask procedure provided C5 and C3 alkylated derivatives, respectively. Mannich-type reactions with formaldehyde and carbamates in the presence of lithium perchlorate fu...
The hydrothermal synthesis of nano sized magnesium oxide materials in various shapes using different precursors have been explored in this work. Herein the organic base of hexamethylenetetramine (HMTA) was first time used as a hydrolysis base instead of usually used urea and the optimized condit...
The dehydration of magnesium acetate tetrahydrate was studied by simultaneous TG—DTG—DTA under various sealed atmospheres (open, quasi-sealed, and completely sealed). It had been reported for this salt that dehydration was a single-stage loss of water. In the case of quasi-sealed systems (29.8...
In this study, ultraviolet (UV) irradiation, ozonation (O3) and their combination (UV/O3) were used to decompose clofibric acid (CA). The results show that UV system exhibited a very high CA removal rate (0.20 min−1) but the lowest mineralization (14.8%) accompanied by the formation of more toxi...
The effects of ethephon and abscisic acid (ABA) application on ripening-related genes of pre-harvest ‘Kohi’ kiwifruit (Actinidia chinensis) were studied to clarify the possibility of the fruit ripening on the vine. The fruits were treated on the vine at mature stage with 250 µL⋅L−1 ethephon o...
The effects of ethephon, abscisic acid (ABA), and nordihydroguaiaretic acid (NDGA) application on the ripening of pre-harvest ‘Kohi’ kiwifruit (Actinidia chinensis) were studied. The fruits were treated on-vine at 155 days after full bloom (DAFB) (mature stage) with 250 μL/L ethephon, 100 μm...
The study aimed to investigate the effect of two plant growth regulators, namely ethephon (Eth) and methyl jasmonate (Ja-Me) at different concentrations and combinations (1% Eth; 1% Ja-Me; 5% Ja-Me; 1% Eth+1% Ja-Me; and 1% Eth+5% Ja-Me) on physicochemical properties of Acacia seyal var. seyal gu...
Cotton is one of the most important economic crops and its production is influenced by various adverse factors. Boll shedding at an inappropriate period causes the severe loss of cotton yield. Ethephon can promote the formation of abscission layer cells, resulting in boll shedding. To genome-wid...
To improve peel color of ethephon-degreened citrus fruit, in this study, the effects of blue light emiting diode (LED) light (450 nm) irradiation on chlorophyll and carotenoid metabolism of ethephon-degreened mandarin fruit were evaluated. Deeper and faster coloration were observed in blue LED l...
Cuticular wax is the outermost thin hydrophobic layer covering the surface of aerial plant parts, which provides a primary waterproof barrier and protection against different environmental stresses. The aim of the present study was to investigate the role of ethephon, as an ethylene-releasing co...
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