In aggressive tumors, alkylglyceronephosphate synthase (AGPS) controls cellular ether phospholipid utilization and metabolism to promote cancer cell proliferation and motility. SAR studies on the first-in-class AGPS inhibitor 1, discovered by our group, led to the 2,6-difluoro analog 2i which sh...
With graphene oxide, zinc sulfate, sodium thiosulfate and thioglycerol (TG) as starting materials, reduced graphene oxide/zinc sulfide nanocomposite (rGO/ZnS) was successively synthesized with a facile one step method under ambient conditions. Thiosulfate was not only the sulfur source for the s...
Premixed calcium phosphate cements (CPC's) are becoming the material of choice for injectable cements as a result of their effective delivery to the target implantation site. For orthopaedic use, it is of vital importance that the attributes of these CPC's are not compromised by irradi...
In this study, commercial cellulose membranes were surface coated with alpha‑zirconium phosphate nanoparticles (α-ZrP-n) to study their impact on the overall removal efficiency of heavy metals from synthetic metal mixture wastewater solution. A total of four homogeneous solutions (0.25, 0.50, 0...
The effect of hexadecyl dithiocarbamate on phosphate coatings on mild steel was studied using an optimized phosphating bath. The coating characteristics were evaluated and compared with chromic acid sealing. The inclusion of hexadecyl dithiocarbamate in the phosphating bath resulted in film form...
Catalytic amount of vanadium reagent with tert-butylhydroperoxide as the oxidant was found to be an excellent oxidizing agent in aqueous medium. Vanadium pentoxide with aq tert-butylhydroperoxide readily oxidizes primary benzylic azides to the corresponding acids and secondary benzylic azides to...
Amine-free silylation of various alcohols catalyzed by 4-methylpyridine N-oxide in the presence of MS4A at room temperature was developed. This simple method gave various silyl ethers in a high yield.
A rapid and sensitive method has been devised in order to detect and estimate the synthesis of the enzyme alcohol oxidase (AOX) by fungi, by way of the use of two chemical complexes, namely, acetylacetone (3,5-diacetyl-1,4-dihydrolutidine) and acetylacetanilide (3,5-di-N-phenylacetyl-1,4-dihydro...
Sodium alginate, a naturally occurring macromolecule, in its granular form and without any post-modification was found to be an efficient and recoverable bifunctional heterogeneous organocatalyst for the domino synthesis of various 2-amino-3-cyano-4H-pyran annulated derivatives through three-com...
In this study, we investigated the effect of disodium cromoglycate (DSCG) against viral infection in vitro and in vivo, particularly against the human influenza virus infection. The in vivo effect of DSCG on viral infection was assessed by using a murine model of respiratory tract infection. Adm...
Representative samples of several types of naturally occurring amides from south and southeast Asian Glycosmis species were synthesized for proof of structures and for bioactivity testing. With one exception (senecioic acid) all these amides were characterized by sulfur containing acid component...
Formamidines and formimidates (L = (p-MeC6H4 NH)(p-MeC6H4N=)CH; L′ = (p-MeC6H4N=) (EtO)CH are shown to yield metal complexes, not obtained directly before. The following complexes were characterized through spectral and magnetic data: L2Ag+, L2AgNO3, L2ZnBr2, L2CdBr2, L3Cd2Br4, LHgCl2, L2CoCl2,...
Phase diagrams of the Langmuir monolayer of dicyclopropyl alpha mycolic acid (α-MA), cyclopropyl methoxy mycolic acid (MeO-MA), and cyclopropyl ketomycolic acids (Keto-MA) from Mycobacterium tuberculosis were obtained by thermodynamic analysis of the surface pressure (π) vs. average molecular ...
Upon high-energy collisional activation, oxofatty-acid ions undergo fragmentations to produce a unique pattern of product ions by which the position of the ketone is revealed. The reactions occurring in the vicinity of the ketone, which are the subject of this article, produce a spectral pattern...
The oxidation of 12-oxo-(Z)-9-octadecenoic acid with potassium permanganate in an alkaline medium is described, erythro-9,10-Dihydroxy-12-oxooctadecanoic acid and 9,12-epoxyoctadeca-9,11-dienoic acid are obtained as minor and major products, respectively. The furanoid structure of the latter aci...
High molecular weight products of the ozonolysis reaction of particle-phase 9-octadecenoic acid (oleic acid) have been studied by photoelectron resonance capture ionization (PERCI) mass spectrometry (MS). Oleic acid particles (dg=202nm, σg=1.97) were reacted with ozone (1.8×10−4 atm) in a flow...
The CF2 containing 6,6- and 10,10-difluorooctadecanoic acids 7 and 8, respectively have been synthesised and their Langmuir isotherms evaluated. In marked contrast to the behaviour of octadecanoic acid (stearic acid) 1 it is demonstrated that spreading on an aqueous subphase generates an unstabl...
This paper, describing electron ionization mass spectral fragmentation of some hydroxycarboxylic and oxocarboxylic acid trimethylsilyl derivatives, focuses on the formation of fragment ions resulting from the interactions between the two functionalities of these compounds. These interactions res...
The development of “molecular rulers” would allow one to quantitatively locate the penetration depth of intercalants within lipid bilayers. To this end, an attempt was made to correlate the 13C NMR chemical shift of polarizable “reporter” carbons (e.g., carbonyls) of intercalants within DMPC...
SummaryWe revealed the complex metabolic pathway of the PUFA saturation metabolism in lactic acid bacteria in detail. The enzyme system was found to consist of four enzymes. The concerned action of these enzymes accomplishes the saturation of a C=C double bond and generated unique fatty acid mol...
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