By utilizing flexible bis(tetrazole)-functionalized thioether ligand to assemble with copper acetate and Anderson-type polyoxometalate Na3[CrMo6(OH)6O18]·8H2O, a novel octamolybdate-based metal-organic complex [CuI2(bmte)2CuII(γ-Mo8O26)(H2O)2]·2H2O (1), [bmte = 1,2-bis(1-methyl-5-mercapto-1,2...
2′-(Tetrazole-5-yl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carbox-anilide 1,1-dioxide which was designed by the structural hybridization of tranilast and piroxicam, markedly exhibited the inhibitory effects on the antigen-induced histamine release from rat PEC, 48 h homologous PCA in rats an...
The different complexes of the most stable tautomer of tetrazole (2H-tetrazole) with guanidine were optimized in the gas phase to find the most stable structure of guanidinium tetrazolate (GT). The calculations were performed using density functional theory (DFT) employing wB97XD functional and ...
Two new coordination polymers directed by different inorganic anions, namely [Zn2(mtz)(SO4)(OH)(H2O)]n (1) and [Zn6(mtz)9(NO3)2]n (2) (Hmtz = 5-methyl-1H-tetrazole) were synthesized under solvothermal conditions and characterized by single crystal X-ray diffraction analyses. Compound 1 features ...
A simple, fast and sensitive method for the quantitative determination of 1-methyl-1H-tetrazole-5-thiol using HPLC is reported. Samples are deproteinated by plasma water filtration and injected into a HPLC system capable of column switching and backflushing the analytical column. The limit of qu...
Inhibition of mild steel corrosion in 1N hydrochloric acid with 4-amino-6-methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one (AMTDT) and (4-amino-4H-1,2,4-triazole-3,5-diyl) dimethanol (ATD) was investigated by polarization (Tafel), electrochemical impedance (EIS), adsorption and computational ...
Three Schiff’s bases namely (3-phenylallylidene) amino-5-(pyridine-4-yl)-4H-1,2,4-triazole-3-thiol (SB-1), 3-mercapto-5 (pyridine-4-yl)-4H-1,2,4-triazole-4-yl) imino) methyl) phenol (SB-2) and (4-nitrobenzylidene) amino)-5-(pyridine-4-yl)-4H-1,2,4-triazole-3-thiol (SB-3) were synthesized and in...
Key compound 2-(4-amino-5-oxo-3-(thiophene-2-ylmethyl)-4,5-dihydro-1,2,4-tiazole-1-yl) acetohydrazide (3) was synthesized by reacting hydrazine hydrate with ethyl-2-(4-amino-5-oxo-3-(thiophene-2-ylmethyl)-4,5-dihydro-1,2,4-tiazole-1yl)acetate (2), obtained in basic media from 4-amino-5-(thiophen...
In this work, a rapid, selective naked eyes colorimetric chemical probe for the detection of Cr3 + was developed based on functionalization of gold nanoparticles. For this purpose, surface of Au NPs was functionalized using 4-amino-5-methyl-4H-1,2,4-triazole-3-thiol (AMTT). Through colorimetric ...
In the present work, 4-amino-5-methyl-4H-1,2,4-triazole-3-thiol (AMTT) was synthesized and characterized using FTIR and 1H NMR. The triazole was for the first time investigated as a novel corrosion inhibitor for copper in 3.5% NaCl solution employing the electrochemical impedance spectroscopy (E...
Alzheimer's disease (AD) is a well known neurodegenerative disorder alarming millions of people worldwide and the subsequent epidemiological statistics highlights the implication of the disease. AD is a multi-factorial disease, a variety of single-target directed drugs that have reached cli...
PARP-1, a nuclear protein, is one of the key member of the DNA repair assembly and thereby emerged as an attractive target in anti-cancer drug discovery. PARP-1 plays a key role in terms of base excision repair, which is an important pathway for cell survival in breast cancer with BRCA1/BRCA2-mu...
ObjectivesTo design a five step procedure for the synthesis of seven novel sulphur containing 1,2,4-triazole derivatives namely 4-[(3-(4-Chloro-phenoxymethyl)-5-(4-substituted-benzylsulfonyl)-1,2,4-triazol-4-yl)methyl]-morpholine from 4-Chloro-phenol and Ethylbromoacetate as starting compounds a...
Monoalkylations of different nucleophilic azoles were investigated with the electron-deficient trans-3,3,3-trifluoro-1-nitropropene (1) as alkylating reagent without addition of any catalyst. In each case, the bonding of the alkene at the azole occurs regioselectively at the trifluoromethyl-subs...
Started from salicylic acid (SA) and related commercialized plant activators, based on molecular three-dimensional shape and pharmacophore similarity comparison (SHAFTS), a new lead compound benzotriazole was predicted and a series of benzotriazole derivatives were designed and synthesized. The ...
Glycyrrhetinic acid (GA) is a major constituent of the herb Glycyrrhiza glabra, and many of its derivatives demonstrate a broad spectrum of antiviral activities. In the current study, 18 water-soluble β-cyclodextrin (CD)-GA conjugates, in which GA was covalently coupled to the primary face of β...
In this work, we report the synthesis of a novel carbohydrate-lithocholic acid conjugate linked through of 1,2,3-triazole rings and its derivatives in good to excellent yields. The conjugate was synthesized via copper-catalyzed azide−alkyne cycloaddition (CuAAC) from methyl 4,6-O-benzylidene-2,3...
Two substituted 1,2,3-triazoles 4 and 6 have been synthesized by the 1,3-dipolar cycloaddition reaction of 4-azido-8-(trifluoromethyl)quinoline 2 with ethyl acetoacetate and acetylacetone, respectively. The reaction of 2 with ethyl acetoacetate afforded 1-[8-(trifluoromethyl)quinolin-4-yl]-5-met...
The design, synthesis and biological evaluation of a library of 1,2,3-triazole carboxylates incorporating carboxylic acid, hydroxymethyl, carboxylic acid hydrazide, carboxamide and benzenesulfonamide moieties is disclosed. All the novel compounds were investigated for their inhibition potential ...
Three series of novel compounds derived from 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid bearing piperazine carboxamides, (5-(substituted phenyl)-1,3,4-oxadiazol-2-yl) and (5-(alkylthio)-1,3,4-oxadiazol-2-yl) substitutions at the 4-position were synthesized. Synthesized compounds ...
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