SummaryDuring cerebellar development, Sonic hedgehog (Shh) signaling drives the proliferation of granule cell precursors (GCPs). Aberrant activation of Shh signaling causes overproliferation of GCPs, leading to medulloblastoma. Although the Shh-binding protein Boc associates with the Shh recepto...
The photochemical reaction of (η5-C5H5)Fe(CO)2I with (l)- and (d)-tryptophan methyl ester in the presence of diisopropylamine in benzene leads to complexation of the (η5-C5H5)Fe(CO)2 moiety to the deprotonated indole nitrogen. This reaction takes place without detectable (
(N-[9-fluorenylmethoxycarbonyl]-)-l-leucine (FMOC-l-leucine) and rosiglitazone, two ligands of peroxisome proliferator-activated receptor γ (PPARγ), were evaluated in mature (adult mice) and immature (pups) brain injury models. In adult magnesium-deficient mice, a model responsive to both neur...
The first total synthesis of NPTX-5 and NPTX-6, Joro spider (Nephila clavata) toxins having a 4-hydroxyindole nucleus and a unique putreanine trimer and tetramer acylpolyamine chain, respectively, has been achieved by the iterative use of a key azide compound.
The first and highly efficient synthesis of NPTX-10 and NPTX-12, new neurotoxins of Joro spider (Nephila clavata), utilizing key azide intermediates is described
The first and highly efficient total synthesis of Nephilatoxin-7 (NPTX-7), a new neurotoxin of Joro spider (Nephila clavata), has been achieved by employing the azide strategy wherein the three characteristic polyamine components of the toxin, cadaverine and bis-putreanine, were efficiently cons...
The first total synthesis of Nephilatoxin-1 (NPTX-1), a Joro spider (Nephila clavata) toxin having a 4-hydroxyindole nucleus, has been achieved by using two key azide intermediates.
A facile synthesis of 6-hydroxyindole-3-acetic acid 1a, which is the proposed aromatic subunit of NPTX-1∼6, is described. Radical cyclization of isonitrile 2 successfully afforded 9 in high yield. The aromatic subunit of NPTX-1∼6 was confirmed as 4-hydroxyindole-3-acetic acid 12 by comparison ...
The first and efficient synthesis of Nephilatoxins (NPTX-9 and NPTX-11), new neurotoxins of Joro spider (Nephila clavata), has been achieved by employing a key azide intermediate as the polyamine unit.
Publisher SummaryThis chapter outlines polymers containing esters groups in the backbone. Poly(esters) are common polymers used as both thermoplastic materials and as fibers. The polymeric chain contains an acid fragment and an alcohol fragment. Similarly, to polyamides, two series of polyesters...
A new organic nonlinear optical crystal 2-amino-5-chloropyridinium-L-tartarate [2A5CPLTA] has been synthesized and the crystals were grown by slow evaporation solution technique at room temperature using methanol as solvent. The crystal structure of the title compound has been determined by the ...
A new and accurate chiral liquid chromatographic method was developed for the enantiomeric resolution of Rivastigmine hydrogen tartarate, (−)S-N-ethyl-3-[(1-dimethyl-amino)ethyl]-N-methylphenyl-carbamate hydrogen tartarate, a cholinesterase inhibitor in bulk drugs. The enantiomers of Rivastigmin...
The electrochemical behaviour of carbon steel in a wide range of concentrations (0.1–1 M) of gluconate and tartarate was studied by potentiodynamic and open circuit measurements. The results showed that the rate of height of corrosion increases with increasing of the concentration of organic ac...
An isocratic chiral HPLC method was developed for the separation of tolterodine tartarate enantiomers. The mobile phase consists of n-hexane and isopropyl alcohol in the ratio of 980:20 (v/v) with 1 ml diethylamine and 0.6 ml trifluoroacetic acid. Chiralcel OD-H (250 mm × 4.6 mm) column was use...
The inhibitive effect of tartarate was studied as a coinhibitor with tungstate in preventing carbon steel corrosion in aqueous solutions. Open circuit potential measurements, weight-loss measurements and polarization studies were conducted to understand the domains of corrosion and passivation. ...
ABSTRACTA simple, accurate and precise high-performance thin-layer chromatographic method has been developed for the estimation of Atorvastatin Calcium and Metoprolol Tartarate simultaneously from a capsule dosage form. The method employed Silica gel 60F254s precoated plates as stationary phase ...
Cu2In2O5 with orthorhombic structure and CdIn2O4 spinel oxide have been synthesized by the precursor method via the tartarate route. The complex precursors, (NH4)12[Cu2In2(C4O6H4)2(C4O6H3)6]·6H2O(I) and (NH4)4[CdIn2(C4O6H4)4(OH)4(H2O)2] (II), have been characterized by infrared spectroscopy (IR...
Zolpidem tartarate is a non-benzodiazepine, sedative-hypnotic, which finds its major use in various types of insomnia. The present work relates to development of multiparticulate floating drug delivery system based on gas generation technique to prolong the gastric residence time and to increase...
Citrate and tartarate based food preservatives can be used to enhance the emulsifying properties of sodium dodecylsulfate (SDS) based micellar system and thus making it appropriate for food applications. Exploration of interactions between the two species is the key constraint for execution of s...
Un-doped and doped strontium aluminates (Sr3Al2O6, Sr3Al2O6:Tb3+, Sr3Al2O6:Tb3+,Eu3+ and Sr3Al2O6:Tb3+,Eu3+/Eu2+) were synthesized through a soft chemical method – the tartarate precursor route. The tartarate precursors were characterized by infrared spectroscopy (IR) and thermal analysis. The ...
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