Selective mono-fluorination of 1,2- and 1,3-diols was achieved using N,N-diethyl-4-methoxybenzamide diethyl acetal and Et3N-3HF. The reaction proceeds through a cyclic acetal of the benzamide, and only one hydroxy group was fluorinated and another one was acylated.

A novel pathway for the synthesis of pyridine and 3-picoline was developed in this work. The method involved the condensation of gas-phase acrolein diethyl acetal and ammonia over the ZnO/HZSM-5 catalyst in a fixed-bed reactor. The problem of polymerization in existing process was effectively so...

The solubilities of N,N-dimethylformamide diethyl acetal were measured at temperatures ranging from 313 to 353 K and pressures from 7.8 to 13.3 MPa in supercritical carbon dioxide. The measured solubility data were correlated using the Chrastil, Sung and Shim (SS), and Jouyban–Chan–Foster (JCF...

The research was designed to synthesize novel single-atom silver-manganese nanocatalysts with a simple method for producing highly demanded ethyl glycolate (EGly) and acetaldehyde diethyl acetal (ADA) by hydrogenating bioresources-derivable diethyl oxalate (DEO) under different temperatures. DEO...

There are insufficient toxicity data on the target material propanal diethyl acetal (CAS # 4744-08-5). Hence, in silico evaluation was conducted to determine read-across analogs for this material. Based on structural similarity, reactivity, metabolism data, physical–chemical properties, and exp...

Chitosan oligosaccharide hydrochloride (COS-HCl) has an unpleasant taste. To improve this taste, we used an enzymatic hydrolysis with chitosan to manufacture hydrochloride-free chitosan oligosaccharide (HFCOS). We found that HFCOS powder with weight-average molecular weight (Mw) of approximately...

RésuméN-(tétrazo1-5-y1 ) azetldin-2-ones can be conveniently prepared by reacting N-unsubstituted beta-lactams with 1-benzyl 5-fluoro 1H-tetrazole

A new glycosyl donor possessing an anomeric O-(1-phenyltetrazol-5-yl) group is prepared from 2,3,4,6-tetra- O-benzyl-d-glucose (2) and commercially available 5-chloro-1-phenyl-1H-tetrazole (1). The synthesis of glycosides derived from the donor and a few primary and secondary alcohols is reported.

Compound 1-benzyl-5-amino-1H-tetrazole (BAT) was synthesized and characterized by 1H NMR, FT–IR, and UV–Vis spectroscopies and elemental (CHNS) analysis. The crystal structure was further elucidated by single-crystal X-ray diffraction. Density functional theory (DFT) calculations with B3LYP an...

A series of 1-aryl-5-benzyl-1H-tetrazoles has been obtained during the reaction of 1-aryl-5-methyl-1H-tetrazoles with 1,2-dehydrobenzene. The mechanism of product formation was investigated.

During the cyclization reaction of benzyl alcohol containing amides, using NaN3 and SiCl4, additional unique chlorination development was observed to yield the novel azoles 1-[4-chloromethylphenyl]-5-[4-(methylsulfonyl)benzyl]-1H-tetrazole (3a) and 1-[4-chloromethylphenyl]-5-[4-(aminosulfonyl)ph...

The preparation of indane-1,2-dioxime and its use for the precipitation of palladium from homogeneous solution is described. The complex PdC18H14O4N4 has a complex: metal weight ratio greater than those with reagents normally used for the gravimetric determination of palladium. The effect of for...

Carboxylic acids can be transformed into the homologous α-keto acids by Barton-ester based radical chemistry. This method was especially successful when ethyl α-trifluoroacetoxy acrylate was used as a radical trap.

The recent developments in the synthesis of cyclic imides since 2000 are reviewed with an emphasis on high-yielding general methods. The synthetic approaches are divided into fragment-based methods, oxidation of pyrrolidines and lactams, ring expansion and ring contraction, and N- and C-function...

To develop more valuable and effective fungicide candidates, a novel series of 3,4-dichloroisothioxazole-based cycloalkylsulfonamides were synthesized and their structures were identified by 1H NMR, 13C NMR, MS and elemental analysis. Compound 3k was further confirmed by X-ray single crystal dif...

In situ deprotonation of 2-methyl, 2-chloromethyl-, 2-trimethylsilylmethyl-, and 2-methoxymethoxy-substituted allyl chlorides generates allyl carbenoids which insert into zirconacyclopentanes to afford allyl zirconocenes. Allyl bromides, p-toluenesulphonates, or N,N-diisopropylcarbamates may als...

A new method for the synthesis of N-protected allyl- and homoallylglycines was developed from aspartic and glutamic acid derivatives. The carboxylic side-chains of aspartic and glutamic derivatives was first transformed into the Weinreb amide by coupling with N,O-dimethylhydroxylamine and then r...

Nuclear accident and daily nuclear plants are the main strontium (Sr2+) releasing source and the removal of strontium from aqueous solution has aroused great attention. Among the different remediation ways, adsorption with the properties of low cost, high-removal efficiency, and excellent operat...

The highly efficient removal of radioactive metal ions (e.g. 137Cs, 90Sr) remains a challenge from the standpoint of environmental protection and public health. Although adsorption has been proven to be an effective and economical technology to eliminate the radioactive metal ions from aqueous s...

Both strontium and ciprofloxacin are known to be functional materials for the treatment of bone diseases associated to the loss of bone substance. In this work we prepared the strontium (Sr) modified hydroxyapatite (SrHA) and ciprofloxacin (Cip) modified SrHA bone substitutes by one pot facile c...