Platinum nanoparticles have been synthesized on polyaniline (PANI) and polypyrrole (PPy) as supports using H2PtCl6 as metal precursor and a reducing treatment with cold Ar plasma. The catalytic activity of the polymer-supported catalysts in the reduction of aqueous nitrate with H2 at room temper...

Nitrogen-Doped graphene is reportedly said to be engineered in fine-tuning its electrochemical performance to suit the high energy requirements of supercapacitors. In an attempt, nickel sulfide nanoflakes are anchored on the surface of N-doped graphene under hydrothermal environment. XRD data id...

We report the first measurements of Fe isotope fractionation between coexisting pyrrhotite and chalcopyrite from the Lengshuiqing Ni-Cu magmatic sulfide deposit, Southwest China. The δ56Fe values of chalcopyrite (Cp) range from 0.24‰ to 1.25‰, much higher than those in the coexisting pyrrhoti...

Fossil fuel power plants often generate sulfur species such as hydrogen sulfide or sulfur dioxide due to the sulfur content of the raw feedstocks. To combat the associated environmental, processing, and corrosion issues, facilities commonly utilize a Claus process to convert hydrogen sulfide (H2...

A series of 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-(substituted benzyl) piperidines with substituents at the ortho and meta positions in the aromatic ring of the N-benzyl side chain were synthesized and their affinities and selectivities for the dopamine transporter (DAT), serotonin transporter...

The syntheses of l-methyl-3-(3-hydroxy-3-phenylpropyl)- 4-phenyl-4-piperidinol and l-methyl-3-(3-hydroxy-3-phenylpropyl)-4-phenyl-4-propanoyloxypiperidine are described. Preliminary pharmacological testing showed these compounds to be weakly active in the writhing test.

1,4-Disubstituted piperazines such as GBR 12909 (1-[2-[bis(4-fluorophenyl)methoxyl]ethyl]-4-(3-phenylpropyl)piperazine)and GBR 12935 (1-[2-[bis(phenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine) are among the most potent and selective ligands for the dopamine transporter in brain. However, they...

SAR and PK studies led to the identification of N-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-methanesulfonylphenyl] propyl}piperidin-4-yl)-N-ethyl-2-[4-methanesulfonylphenyl]acetamide as a highly potent and selective ligand for the human CCR5 chemokine receptor with good oral pharmacokinetic properties.

Monoamine transporters regulate the concentration of monoamine neurotransmitters, which are essential for vital physiological processes, and their dysfunction can cause several central nervous system diseases. Monoamine transporters currently appear to be the potential target in the management o...

Various σ-alkenyl complexes of the general composition (alkenyl)V(CO6−npm (where n = 2, 3 and pm is a potentially m-dentate phosphine coordinated through n of its donor centres, n ⩽ m) have been prepared by photo-induced hydrovanadation of the alkynes 2-butyne, 1-hexyne, 3-hexyne and 3,3-dimeth...

The reactions of selenium dihalides, tellurium tetrachloride and tetrabromide with 3-hexyne and 4-octyne proceed in a stereoselective manner as anti-addition to afford products of E-stereochemistry. First examples of bis-adduct synthesis from tellurium tetrachloride and disubstituted acetylenes ...

The mononuclear unsaturated nickelalactones [Ni{C(Et)C(Et)–COO}(DBU)2] (1) and [Ni{C(Et)C(Et)–COO}(dcpe)] (2) were synthesized by oxidative coupling of CO2 and 3-hexyne at zero-valent nickel in presence of DBU or dpce, respectively. Attempts to use Cy3P or dppe as ligands in this reaction gave...

Mesitylene/1-hexene solvated palladium nanoparticles, obtained by metal vapour synthesis (MVS) technique, were stabilized in solution at room temperature with poly-(N-vinyl-2-pyrrolidone) (PVP) and isolated by precipitation with a diethyl ether or THF as brown powder. HRTEM and FT-IR analyses on...

SUMMARYThe data presented show that M&B 10,755 (4-cyano-2-iodo-6-nitrophenol) is active against Fasciola hepatica in experimentally infected rabbits, sheep and calves. Administered by subcutaneous injection to sheep and calves, the approximate maximum tolerated dose is 40 mg./kg.; the toxic sign...

Dialkyl 4,4′-(2-(1,3-bis(4-(alkoxycarbonyl)phenoxy)propan-2-ylidene)propane-1,3-diyl)bis (oxy)dibenzoate 6a,b were synthesized through the reaction of ethene-1,1,2,2,-tetra-yl-tetra methylene tetra bromide 1 with methyl 4-hydroxy benzoate or ethyl 4-hydroxy benzoate 2a,b. In addition, compounds...

8-Chloro-11-(4-methyl-1-piperazinyl)-dibenz[b,f][1,4]oxazepine labelled with carbon-14 in 11-position was prepared from 2-hydroxy benzonitrile-[cyano-14C].

To prompt the development of 18F-labeled positron emission tomography (PET) tracers for the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, we have prepared 18F-labeled 2-(1-(3-fluorophenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile ([18F]8). The radios...

Farnesyltransferase inhibitors (FTIs) have emerged as a novel class of anti-cancer agents. Analogues of the potent FTI, 4-[3-biphenyl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile, were synthesized and tested in vitro for their inhibitory activities. The synthesis and de...

Conformations of diethyl ether (DEE) were studied at low temperatures in N2 and Ar matrixes. Computations performed at B3LYP/aug-cc-pVDZ level of theory yielded three minima corresponding to tt, tg± and g±g± conformers of DEE. Of the three, the tt and tg± conformers of DEE were experimentall...

A dimeric 4-hydroxyacetophenone oxime-derived palladacycle has been used as a very efficient precatalyst for the chemoselective arylation of acrolein diethyl acetal to give either cinnamaldehyde derivatives or 3-arylpropanoate esters by proper choice of the reaction conditions. The synthesis of ...