The chemo- and enantioselectivity of the Candida antarctica lipase B (CalB)-catalyzed acetylation reaction of (R,S)-propranolol using vinyl acetate as acyl donor and toluene as organic solvent was studied. Because of the poor solubility of propranolol in toluene small quantities of methanol were...

The cardiovascular effects of the β-adrenergic receptor antagonist propranolol (40 mg) were compared in 20 alcohol-dependent subjects during alcohol withdrawal syndrome (WS; n = 10) on days 1, 2, 3, and 10 to those during remission (n = 10; 50 ± 7.7 days). Significant differences were observed...

The frequent detection of propranolol, a widely used β-blocker, in wastewater effluents and surface waters has raised serious concern, due to its adverse effects on organisms. UV/hydrogen peroxide (UV/H2O2) and UV/persulfate (UV/PDS) processes are efficient in eliminating propranolol in various...

The discovery of the CNS-penetrant and selective α2C adrenergic receptor antagonist N-{2-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1,4]diazepan-1-yl]-ethyl}-2-phenoxy-nicotinamide, 13 is described. Structure–activity studies demonstrate the structural requirements for binding affinity, fun...

The title compound 1-(2-chloro-4-phenylquinolin-3-yl)ethanone (CPQE) was synthesised effectively by chlorination of 3-acetyl-4-phenylquinolin-2(1H)-one (APQ) using POCl3 reagent. Structural and vibrational spectroscopic studies were performed by utilizing single crystal X-ray diffraction, FTIR a...

Antagonists of signaling receptors are often effective non-toxic therapeutic agents. Over the years, there have been evidences describing the role of serotonin or 5-hydroxytryptamine (5-HT) in development of cancer. Although there are reports on the antiproliferative effects of some serotonin re...

The presence of potential carcinogen 4(5)-Methylimidazole (4-MeI) in foods causes much concern, stressing the need of a sensitive determination means. Here, we proposed a high-sensitivity method to determine 4-MeI in biscuits using dansyl chloride derivatization and disperse liquid-liquid micro-...

Following the direction of 1712.09990 and 1712.09994, this article continues to excavate more interesting aspects of the 4-particle amplituhedron for a better understanding of the 4-particle integrand of planar N=4 SYM to all loop orders, from the perspective of positive geometry. At 3-loop orde...

Overconsumption of Ginkgo biloba seeds leads to poisoning. 4’-O-methylpyridoxine (MPN) and 4’-O-methylpyridoxine-5’-glucoside (MPNG) are responsible for poisoning by intaking ginkgo seeds. It had been reported that heat treatment could increase the MPNG content but decrease the MPN content in...

Flavonoids have been reported to exert protective effect against many inflammatory diseases, while the underlying cellular mechanisms are still not completely known. In the present study, we explored the anti-inflammation activity of 5, 7, 2’, 4’, 5’-pentamethoxyflavanone (abbreviated as Pen....

Several hydrazinium (1 +) and dihydrazinium salts of aliphatic and aromatic carboxylic acids have been prepared by neutralisation of these acids with hydrazine hydrate in aqueous medium. They are hydrazinium hydrogendicarboxylates of malonic, succinic, glutaric and adipic acids, hydrazinium hydr...

The first hydrazinium-bearing zeolite-like compound, (N2H5)3Ge7O15(OH)·2.5H2O, has been synthesized by low-temperature hydrazine-induced hydrolysis of fluorogermanic acid, H2GeF6. The crystal structure of hydrazinium germanate has been solved by direct methods and refined by the Rietveld method...

The hydrazinium cations N2H62+/N2H5+ form ion pairs with [Pt(CN)4]2−. Outer-sphere charge transfer excitation (PtII → N2H62+/N2H5+) induces an oxidative addition: N2H62+/N2H5+Pt(CN)42- → [PtIV(CN)4(NH3)2] and [Pt(CN)4(NH3)(NH2)], respectively.

Species including N2H4, NH3 and N2O are known to be present near the surface of burning hydrazinium nitroformate (HNF). In this paper, planar laser induced fluorescence from the near surface region of burning HNF pellets is reported indicating the presence of NO2. These four species are formed i...

Hydrazinium hydrogendicarboxylates of pimelic, suberic, azelaic, sebacic, tartaric, α-ketoglutaric and iminodiacetic acids and dihydrazinium dicarboxylates of malic, aspartic and glutamic acids have been prepared by accomplishing neutralisation of aqueous hydrazine hydrate with the respective a...

A series of new metal hydrazido-oxalates with the formula [M(Hox)2(H2O)2]·nH2O, where M = Co (1), Ni (2) and Zn (3); Hox = hydazido-oxalate; n = 0 (Co), 1 (Ni) and 5 (Zn), as well as (N2H6)0.5[Cd(Hox)2]NO3 (4) and the hydrazinium uranyl oxalate (N2H6)[(UO2)2(C2O4)3]·2H2O (5) were synthesized. ...

In the present work, the UV absorption spectra of seven complexes of hydrazinium 5-aminotetrazolate (HY-5AT), in the range of 4–12 eV, were calculated in both gas and water. The UV absorption spectra of the selected HY-5AT complexes were also calculated in the absence of the intermolecular inte...

Several studies in the literature have investigated the electrochemical effects of oxalic acid and hydrazine on various materials in neutral (pH buffered to 7), basic or weakly acidic media (pH 6). The present work proposes electrochemical techniques that allow for the study of the electrochemic...

A disposable electrochemical sensor was developed for convenient detection of gaseous formaldehyde. The sensor is composed of a three-electrode screen printed system modified with hydrazinium polyacrylate which was synthesised to serve a dual purpose, i.e. as formaldehyde accumulation/derivatisa...

The reaction of dimethyldi(4-N,N-dimethylaminophenyl)silane (1) and chloroplatinic acid hexahydrate was carried out in acetone (ace). A complex salt, [H(dma)]2(PtCl6)·0.5ace (2·0.5ace) (dma = N,N-dimethylphenylamine), was obtained and characterized by Single-crystal X-ray diffraction. At the s...