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NEM CHEMICAL CO.,LTD

top quality 542-28-9 Delta-Valerolactone Delta-Valerolactone is all-purpose chemical intermediate, which can be used in various fields. It can be used in the synthesis of pyran pyridine, cilostazol, witting reagent and epothifone anticancer drug

top quality 542-28-9 Delta-Valerolactone

Cas:542-28-9

Min.Order:0 Metric Ton

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Type:Trading Company

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Delta Valerolactone supplier in China

Cas:542-28-9

Min.Order:0 Metric Ton

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Jinan Finer Chemical Co., Ltd

Product description: Product name delta-Valerolactone CAS number 542-28-9 Assay ≥98% Appearance Colorless to light yellow liquid Capacity 200mt/year Application Widely used i

delta-Valerolactone

Cas:542-28-9

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% Pesticides Negative Complies Heavy metal 10ppm max

High purity 542-28-9 Delta-Valerolactone,δ-Valerolactone

Cas:542-28-9

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Delta Valerolactone

Cas:542-28-9

Min.Order:1

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Type:Other

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

delta-Valerolactone

Cas:542-28-9

Min.Order:1 Metric Ton

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Type:Manufacturers

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Chemwill Asia Co., Ltd.

Chemwill Asia co.,Ltd is one of the leading manufacturer in CHINA. Product quality, process, price and service delta-Valerolactone CAS 542-28-9 IN Stock Tetrahydro-2H-2-pyranone 542-28-9 542-28-9 CAS 542-28-9 highly quality and immedaite d

delta-Valerolactone CAS 542-28-9 IN Stock Tetrahydro-2H-2-pyranone 542-28-9

Cas:542-28-9

Min.Order:5 Kiloliter

FOB Price: $3.5 / 5.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

delta-Valerolactone Manufacturer/High quality/Best price/In stock

Cas:542-28-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

delta-Valerolactone Basic information Product Name: delta-Valerolactone Synonyms: 4-VALEROLACTONE;4-PENTANOLIDE;4-HYDROXYVALERIC ACID G-LACTONE;DELTA-VALEROLACTONE;D-VALEROLACTONE;G-VALE

TIANFU-CHEM CAS:542-28-9 delta-Valerolactone

Cas:542-28-9

Min.Order:1 Gram

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Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent

delta-Valerolactone

Cas:542-28-9

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 542-28-9 with best quality

Cas:542-28-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

TIANFUCHEM--High purity delta-Valerolactone factory price

Cas:542-28-9

Min.Order:10 Kilogram

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Type:Trading Company

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Henan Sinotech Import&Export Corporation

Delta-Valerolactone(DVL) CAS 542-28-9 MF: C5H8O2 Application of Delta-Valerolactone(DVL) Use: Delta-Valerolactone is all-purpose chemical intermediate, which can be used in various fields. It can be used in the synthesis o

Delta-Valerolactone

Cas:542-28-9

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:Clear colorless to pale yellow liquid Storage:Room temperature Package:25kg/Barrel Application:Fine chemical intermediates Transportation:Express/Sea/Air Port:Any port in china

Delta-Valerolactone In Stock (DVL) Supplier in China

Cas:542-28-9

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2H-Pyran-2-one,tetrahydro- 542-28-9

Cas:542-28-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Dyestuff Intermediates, Flavor & Fragra, delta-Valerolactone CAS:542-28-9

Cas:542-28-9

Min.Order:1 Kilogram

FOB Price: $54.2 / 58.3

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

delta-Valerolactone CAS:542-28-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic interm

delta-Valerolactone CAS:542-28-9

Cas:542-28-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2H-Pyran-2-one,tetrahydro-

Cas:542-28-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

cas 542-28-9 delta-Valerolactone

Cas:542-28-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Lonwin Chemical Group Limited

delta-Valerolactone CAS:542-28-9 Specification Boiling Point 230℃(lit.) Melting Point -13℃(lit.) Density 1.105 g/mL Purity 99% min Welcome to contact us to get complete COA

Factory Supply delta-Valerolactone

Cas:542-28-9

Min.Order:1 Kilogram

Negotiable

Type:Other

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2H-Pyran-2-one,tetrahydro-

Cas:542-28-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

High quality Delta Valerolactone supplier in China CAS NO.542-28-9

Cas:542-28-9

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Delta Valerolactone

Cas:542-28-9

Min.Order:0

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Type:Manufacturers

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

delta-Valerolactone

Cas:542-28-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

delta-Valerolactone

Cas:542-28-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

DELTA-VALEROLACTONE

Cas:542-28-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Delta-Valerolactone

Cas:542-28-9

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Delta Valerolactone

Cas:542-28-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Johoo Chemical Co., Ltd

High quality products. Always supply highest grade to you. Purity:≥99% Reasonable & Competitive Price. Huge capacity determines the lowest shared cost. The more you buy the more competitive prices you will get. The sincerest and most pro

Delta-Valerolactone

Cas:542-28-9

Min.Order:1 Metric Ton

FOB Price: $10.0 / 13.0

Type:Trading Company

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TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

delta-Valerolactone

Cas:542-28-9

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Synthetic route

5,6-dihydro-pyran-2-one
3393-45-1

5,6-dihydro-pyran-2-one

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

Conditions
ConditionsYield
With hydrogen; palladium(II) complex of ferrocenylamine sulfide (1) In acetone under 4137.2 Torr; for 10h;100%
1 ,5-pentanediol
111-29-5

1 ,5-pentanediol

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

Conditions
ConditionsYield
With sodium hypochlorite; sodium hydrogencarbonate; potassium bromide In dichloromethane at 0℃; for 0.5h; chemoselective reaction;99%
With sodium bromite In water; acetic acid for 10h; Ambient temperature;98%
With 4-hydroxy-TEMPO benzoate; sodium bromide In dichloromethane; water NaHCO3-buffered at pH 8.6; electrolysis;97%
cyclopentanone
120-92-3

cyclopentanone

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

Conditions
ConditionsYield
With Octanoic acid; dihydrogen peroxide In water at 50℃; for 5h; Baeyer-Villiger oxidation; Ionic liquid; Enzymatic reaction;99%
With dihydrogen peroxide; lithium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate In water; 1,2-dichloro-ethane at 70℃; for 2h; Time; Temperature; Reagent/catalyst;99%
With dihydrogen peroxide; polystyrene-bound phenylselenic acid In dichloromethane for 72h; Ambient temperature;98%
valeric acid
13392-69-3

valeric acid

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

Conditions
ConditionsYield
With molecualar sevies 4A; tetrachlorobis(tetrahydrofuran)hafnium(IV) In toluene at 120℃; for 10h;98%
tetrachlorobis(tetrahydrofuran)hafnium(IV) In toluene for 10h; Heating;96%
With cis-nitrous acid at 25℃; Rate constant;
Equilibrium constant; Rate constant;
propyl 5-hydroxyvalerate

propyl 5-hydroxyvalerate

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

Conditions
ConditionsYield
With 732 sulfonic acid type cation exchange resin at 150℃; for 2h; Time;96.31%
ethyl 2-hydroxyethylpropionate
13107-53-4

ethyl 2-hydroxyethylpropionate

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

Conditions
ConditionsYield
With 732 sulfonic acid type cation exchange resin at 130℃; for 1.5h;96.05%
5-chloro-valeric acid
1119-46-6

5-chloro-valeric acid

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

Conditions
ConditionsYield
With sodium hydroxide for 0.166667h; Heating;96%
With triethylamine at 50℃; under 3750300 Torr; for 3h;90%
With cyclohexene In gas at 349.5℃; for 0.1h; Rate constant; stoichometry;44.3%
5-bromopentanoic acid
2067-33-6

5-bromopentanoic acid

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

Conditions
ConditionsYield
With potassium fluoride; tetra(n-butyl)ammonium hydrogensulfate In tetrahydrofuran at 20℃; for 5h;96%
With Amberlyst A26 (hydrogen carbonate form) 1.) aq. MeOH, 20 deg C, 18 h, 2.) THF, reflux, 18 h; Yield given. Multistep reaction;
With potassium carbonate In water; dimethyl sulfoxide at 50℃; Rate constant;
With 2,3,3-trimethylbenzo[e]indole; potassium iodide In acetonitrile at 80 - 85℃; for 96h;
methyl 5-hydroxypentanoate
14273-92-8

methyl 5-hydroxypentanoate

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

Conditions
ConditionsYield
With 732 sulfonic acid type cation exchange resin at 100℃; for 1h; Time;95.08%
porcine pancreatic lipase In diethyl ether at 26℃;
Butane-1,4-diol
110-63-4

Butane-1,4-diol

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

Conditions
ConditionsYield
With trichloromelamine In dichloromethane for 12h; Mechanism; Ambient temperature;95%
5-hydroxypentylamine
2508-29-4

5-hydroxypentylamine

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

Conditions
ConditionsYield
With hydrogenchloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; laccase from Trametes versicolor In water for 15h; pH=5.5; Enzymatic reaction; chemoselective reaction;95%
TETRAHYDROPYRANE
142-68-7

TETRAHYDROPYRANE

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

Conditions
ConditionsYield
With potassium permanganate; iron(III) chloride In acetone at -78 - 20℃; for 16h;92%
With zinc(II) permanganate; silica gel In dichloromethane at 20℃; for 0.17h;69%
Stage #1: TETRAHYDROPYRANE With [bis(acetoxy)iodo]benzene In nitromethane at 0℃;
Stage #2: With tert.-butylhydroperoxide In decane; nitromethane at 0 - 25℃; for 12h;
68%
Cyclopentanol
96-41-3

Cyclopentanol

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In 1,2-dichloro-ethane at 60℃; for 20h;92%
With dihydrogen peroxide In water at 20℃; for 7h; Baeyer-Villiger-type reaction;92%
With water; fluorine In acetonitrile
With 3-chloro-benzenecarboperoxoic acid In 1,2-dichloro-ethane at 60℃; for 24h; Product distribution; Mechanism; other solvent;
5-hydroxypentanal
4221-03-8

5-hydroxypentanal

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

Conditions
ConditionsYield
With N-iodo-succinimide; silver(I) acetate In benzene for 3h; Heating;90%
With dihydrogen peroxide; acetic acid
With manganese(IV) oxide; chloroform
With cobalt(II) acetate at 80 - 90℃; beim Beh. mit Luft;
trimethylsilyl 5-iodopentanoate

trimethylsilyl 5-iodopentanoate

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 0.5h;90%
acetic acid
64-19-7

acetic acid

cyclopentanone
120-92-3

cyclopentanone

A

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

B

5-acetoxypentanoic acid
26976-70-5

5-acetoxypentanoic acid

Conditions
ConditionsYield
With peracetic acid 1.) 50-60 deg C, 6 h; 2.) reflux, 29 h;A n/a
B 85.5%
With peracetic acid 1.) 50-60 deg C, 6 h; 2.) reflux, 29 h; Yields of byproduct given;A n/a
B 85.5%
(CO)5MnCO(CH2)4OSi(CH3)3
77023-79-1

(CO)5MnCO(CH2)4OSi(CH3)3

tris(diethylamino)sulfonium difluorotrimethylsiliconate
59201-86-4

tris(diethylamino)sulfonium difluorotrimethylsiliconate

A

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

B

(CO)5Mn(1-)*{(CH3CH2)2N}3S(1+)=(CO)5Mn{(CH3CH2)2N}3S
89020-18-8

(CO)5Mn(1-)*{(CH3CH2)2N}3S(1+)=(CO)5Mn{(CH3CH2)2N}3S

Conditions
ConditionsYield
In tetrahydrofuran flask charged with ((CH3CH2)2N)3SSi(CH3)3F2, NMR standard and THF, complex in THF added dropwise for 0.5 h with stirring, stirred for 2 h; not isolated, detected by IR;A 85%
B n/a
<α-tetrahydropyrannyloxy>-2 tetrahydropyrone-3 (S*, S*)
73819-79-1, 73819-80-4

<α-tetrahydropyrannyloxy>-2 tetrahydropyrone-3 (S*, S*)

A

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

B

5,6-dihydro-2H-pyran-3(4H)-one
23462-75-1

5,6-dihydro-2H-pyran-3(4H)-one

<α-tetrahydropyrannyloxy>-2 tetrahydropyrone-3 (S*, R*)
73819-79-1, 73819-80-4

<α-tetrahydropyrannyloxy>-2 tetrahydropyrone-3 (S*, R*)

Conditions
ConditionsYield
With further temp. In benzene at 80℃; for 1.5h; Product distribution; Irradiation;A 82%
B 16%
C 5%
ethyl valerolactonium tetrafluoroborate

ethyl valerolactonium tetrafluoroborate

A

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

B

ethyl 5-iodopentanoate
41302-32-3

ethyl 5-iodopentanoate

Conditions
ConditionsYield
With sodium iodide In dichloromethane; acetonitrileA 18%
B 82%
tetrahydrofuran-2-carbaldehyde
7681-84-7

tetrahydrofuran-2-carbaldehyde

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride In dichloromethane at 20℃; for 5h; Inert atmosphere;82%
tetrahydropyran-2-yl hydroperoxide
4676-84-0

tetrahydropyran-2-yl hydroperoxide

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

Conditions
ConditionsYield
With tert-butylhypochlorite In acetonitrile at 20℃; for 0.166667h;78%
glutaric anhydride,
108-55-4

glutaric anhydride,

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

Conditions
ConditionsYield
With lithium borohydride In tetrahydrofuran for 0.25h;77%
With ethanol; sodium
valeric acid
109-52-4

valeric acid

A

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

B

5-methyl-dihydro-furan-2-one
108-29-2

5-methyl-dihydro-furan-2-one

Conditions
ConditionsYield
With sodium persulfate In water at 85 - 90℃; for 5h;A 9%
B 77%
C6H11O2(1+)*BF4(1-)

C6H11O2(1+)*BF4(1-)

A

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

B

methyl 5-iodopentanoate
14273-88-2

methyl 5-iodopentanoate

Conditions
ConditionsYield
With sodium iodide In dichloromethane; acetonitrileA 29%
B 71%
1,4-Diiodobutane
628-21-7

1,4-Diiodobutane

Mo(CO)6

Mo(CO)6

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

Conditions
ConditionsYield
With potassium fluoride; 18-crown-6 ether; water In tetrahydrofuran for 20h; Heating;70%
TETRAHYDROPYRANE
142-68-7

TETRAHYDROPYRANE

A

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

B

1,5-pentanedioic acid
110-94-1

1,5-pentanedioic acid

Conditions
ConditionsYield
With sodium bromate; potassium hydrogensulfate In water at 25 - 30℃; for 20h; Oxidation;A 69%
B 16%
With 2,6-dichloropyridine N-oxide; dichloro(5,10,15,20-tetrakis(pentafluorophenyl)porphyrinato)ruthenium(IV) In 1,2-dichloro-ethane at 40℃; for 20h; Reagent/catalyst; Inert atmosphere;A 56%
B 16%
cyclohexanol
108-93-0

cyclohexanol

A

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

B

Adipic acid
124-04-9

Adipic acid

C

monocyclohexyl adipate
54812-72-5

monocyclohexyl adipate

D

cyclohexanone
108-94-1

cyclohexanone

Conditions
ConditionsYield
With oxygen at 120℃; for 4.33333h; Further byproducts given;A 2.7%
B 12.4%
C 8.9%
D 65%
1,5-pentanedioic acid
110-94-1

1,5-pentanedioic acid

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

Conditions
ConditionsYield
With hydrogen In methanol at 375℃; for 5h; Reagent/catalyst; Time; Solvent;65%
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2: [bis({2‐[bis(propan‐2‐yl)phosphanyl]ethyl})amine](borohydride)(carbonyl)(hydride)iron(II); potassium carbonate / toluene / 5 h / 150 °C / Inert atmosphere; Green chemistry
View Scheme
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

5-hydroxypentanoic acid sodium salt
37435-69-1

5-hydroxypentanoic acid sodium salt

Conditions
ConditionsYield
With water; sodium hydroxide at 20℃; Inert atmosphere;100%
With sodium hydroxide In ethanol at 20 - 80℃; for 2.5h;100%
With sodium hydroxide at 20℃; for 24h;83%
pyrrolidine
123-75-1

pyrrolidine

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

5-hydroxy-1-(pyrrolidin-1-yl)pentan-1-one
73200-35-8

5-hydroxy-1-(pyrrolidin-1-yl)pentan-1-one

Conditions
ConditionsYield
With triethylamine Inert atmosphere; Reflux;100%
In benzene82%
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

methanol
67-56-1

methanol

methyl 5-hydroxypentanoate
14273-92-8

methyl 5-hydroxypentanoate

Conditions
ConditionsYield
With Dowex 50W-X8 resin at 20℃; Inert atmosphere; Reflux;100%
With sulfuric acid for 5h; Heating;99%
With H+ Dowex resin Heating;99%
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

1-amino-2-propene
107-11-9

1-amino-2-propene

N-allyl-5-hydroxypentanamide
133055-24-0

N-allyl-5-hydroxypentanamide

Conditions
ConditionsYield
100%
In ethanol for 15h; Heating;63%
With bis(trifluoromethane)sulfonimide lithium In chloroform at 85℃; for 40h;5%
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

formic acid ethyl ester
109-94-4

formic acid ethyl ester

Sodium; [2-oxo-dihydro-pyran-(3Z)-ylidene]-methanolate

Sodium; [2-oxo-dihydro-pyran-(3Z)-ylidene]-methanolate

Conditions
ConditionsYield
With sodium hydride100%
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

1 ,5-pentanediol
111-29-5

1 ,5-pentanediol

Conditions
ConditionsYield
With trimethoxysilane; lithium methanolate In tetrahydrofuran for 0.5h; Ambient temperature;100%
With hydrogen In 1,2-dimethoxyethane at 80℃; under 60006 Torr; for 2h; Reagent/catalyst;87.7%
With sodium tetrahydroborate; C36H30F6N10Ni4O10(2+)*2C2F3O2(1-); zinc(II) chloride In tetrahydrofuran at 45℃; for 12h;79%
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

(E)-benzyl 4,4,4-trifluoro-3-(trifluoromethyl)but-2-enoate

(E)-benzyl 4,4,4-trifluoro-3-(trifluoromethyl)but-2-enoate

(3S*,2'S*)-Benzyl 3-pentan-5'-olid-2'-yl-3-(trifluoromethyl)propionate

(3S*,2'S*)-Benzyl 3-pentan-5'-olid-2'-yl-3-(trifluoromethyl)propionate

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -78 deg C;100%
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

O-benzylhydoxylamine hydrochloride
2687-43-6

O-benzylhydoxylamine hydrochloride

N-(benzyloxy)-5-hydroxypentanamide

N-(benzyloxy)-5-hydroxypentanamide

Conditions
ConditionsYield
With trimethylaluminum In tetrahydrofuran; toluene100%
Stage #1: O-benzylhydoxylamine hydrochloride With trimethylaluminum In tetrahydrofuran; toluene at 0 - 20℃; for 0.833333h;
Stage #2: 3,4,5,6-tetrahydro-2H-pyran-2-one In tetrahydrofuran; toluene at 0℃; for 1.5h;
50%
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

methyl 5-hydroxypentanoate
14273-92-8

methyl 5-hydroxypentanoate

Conditions
ConditionsYield
With triethylamine In methanol at 20℃; for 1h; Inert atmosphere; Large scale;100%
Stage #1: 3,4,5,6-tetrahydro-2H-pyran-2-one With sulfuric acid In methanol for 12h; Reflux;
Stage #2: With sodium hydrogencarbonate In methanol for 0.166667h; stereoselective reaction;
99%
With sulfuric acid In methanol for 12h; Reflux;94%
With sulfuric acid In methanol for 21h; Inert atmosphere; Reflux;85%
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

2-aminoindane hydrochloride
2338-18-3

2-aminoindane hydrochloride

N-(indan-2-yl)-5-hydroxypentanamide
1148156-44-8

N-(indan-2-yl)-5-hydroxypentanamide

Conditions
ConditionsYield
With aluminum (III) chloride; triethylamine In 1,2-dichloro-ethane at 20℃; for 1h;100%
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

phenylacetylene
536-74-3

phenylacetylene

5-oxo-5-(2-phenylethynyl)-1-pentanol
67654-84-6

5-oxo-5-(2-phenylethynyl)-1-pentanol

Conditions
ConditionsYield
Stage #1: phenylacetylene With n-butyllithium In tetrahydrofuran at -78℃; for 0.333333h;
Stage #2: With boron trifluoride diethyl etherate In tetrahydrofuran at -78℃; for 0.166667h;
Stage #3: 3,4,5,6-tetrahydro-2H-pyran-2-one In tetrahydrofuran at -78 - 20℃; for 1h;
99%
(i) nBuLi, hexane, THF, (ii) /BRN= 106436/; Multistep reaction;
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

1,3-Benzothiazole
95-16-9

1,3-Benzothiazole

1-(benzo[d]thiazol-2-yl)-5-hydroxypentan-1-one
85450-44-8

1-(benzo[d]thiazol-2-yl)-5-hydroxypentan-1-one

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane -78 deg C, 1 h; to RT, 30 min;99%
Stage #1: 1,3-Benzothiazole With n-butyllithium In tetrahydrofuran at -78℃; Inert atmosphere;
Stage #2: 3,4,5,6-tetrahydro-2H-pyran-2-one In tetrahydrofuran at -78℃; for 1.5h; Inert atmosphere;
Stage #3: With hydrogenchloride In tetrahydrofuran; water
37%
Stage #1: 1,3-Benzothiazole With n-butyllithium In tetrahydrofuran at -78℃; Inert atmosphere;
Stage #2: 3,4,5,6-tetrahydro-2H-pyran-2-one In tetrahydrofuran at -78℃; for 1.5h; Inert atmosphere;
Stage #3: With hydrogenchloride In tetrahydrofuran; water
6.5 g
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

2-allyl-phenylamine
32704-22-6

2-allyl-phenylamine

5-Hydroxy-pentanoic acid (2-allyl-phenyl)-amide
114877-79-1

5-Hydroxy-pentanoic acid (2-allyl-phenyl)-amide

Conditions
ConditionsYield
With dimethylaluminum chloride In dichloromethane for 1h; Ambient temperature;99%
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

tert-butyl(diphenyl)(2-propynyloxy)silane
110824-26-5

tert-butyl(diphenyl)(2-propynyloxy)silane

1-(tert-Butyl-diphenyl-silanyloxy)-8-hydroxy-oct-2-yn-4-one
137445-61-5

1-(tert-Butyl-diphenyl-silanyloxy)-8-hydroxy-oct-2-yn-4-one

Conditions
ConditionsYield
99%
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

5-hydroxy-N,O-dimethyl-pentanohydroxamic acid
187756-41-8

5-hydroxy-N,O-dimethyl-pentanohydroxamic acid

Conditions
ConditionsYield
Stage #1: N,O-dimethylhydroxylamine*hydrochloride With trimethylaluminum In dichloromethane at 0℃; for 0.333333h; Inert atmosphere;
Stage #2: 3,4,5,6-tetrahydro-2H-pyran-2-one In dichloromethane at 0℃; for 0.333333h; Inert atmosphere;
Stage #3: With hydrogenchloride In dichloromethane; chloroform; water at 0℃; for 1h; Inert atmosphere;
99%
Stage #1: N,O-dimethylhydroxylamine*hydrochloride With trimethylaluminum In hexane; dichloromethane at 0℃; Inert atmosphere;
Stage #2: 3,4,5,6-tetrahydro-2H-pyran-2-one In hexane; dichloromethane at 0℃; Inert atmosphere;
Stage #3: With hydrogenchloride In hexane; dichloromethane; chloroform; water at 0℃;
92%
Stage #1: N,O-dimethylhydroxylamine*hydrochloride With trimethylaluminum In hexane; dichloromethane at 0℃; for 0.333333h;
Stage #2: 3,4,5,6-tetrahydro-2H-pyran-2-one In hexane; dichloromethane at 0℃; for 0.333333h;
92%
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
25015-63-8

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

1,5-bis((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy)pentane

1,5-bis((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy)pentane

Conditions
ConditionsYield
With C12H36MgN2Si4 In neat (no solvent) at 20℃; for 0.25h; Catalytic behavior; Reagent/catalyst; Solvent; Inert atmosphere; Schlenk technique;99%
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

Tebbe's reagent

Tebbe's reagent

2-methylidenetetrahydropyran
38614-15-2

2-methylidenetetrahydropyran

Conditions
ConditionsYield
In benzene-d6 for 0.25h;99%
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

(Z)-1-methoxybut-1-en-3-yne
2798-73-4, 3685-19-6, 3685-20-9

(Z)-1-methoxybut-1-en-3-yne

9-hydroxy-1-methoxynon-1-en-3-yn-5-one
112320-60-2

9-hydroxy-1-methoxynon-1-en-3-yn-5-one

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran at -78℃; for 1h;98%
With n-butyllithium 1) THF, -78 deg C, 50 min, 2) -78 deg C, 30 min; Yield given. Multistep reaction;
With n-butyllithium 1.) THF, hexane, -78 deg C, 1 h, 2.) -78 deg C, 1 h; Multistep reaction;
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

9-hydroxymethylanthracene
1468-95-7

9-hydroxymethylanthracene

poly(δ-valerolactone), asymmetric, telechelic, initiated by 9-anthracenemethanol/HCl*Et2O, Mn(NMR)=6900, Mw/Mn=1.1; monomer(s): δ-valerolactone; 9-anthracenemethanol

poly(δ-valerolactone), asymmetric, telechelic, initiated by 9-anthracenemethanol/HCl*Et2O, Mn(NMR)=6900, Mw/Mn=1.1; monomer(s): δ-valerolactone; 9-anthracenemethanol

Conditions
ConditionsYield
With hydrochloric acid diethyl ether In dichloromethane at 0℃; for 2h; Product distribution; Further Variations:; δ-valerolactone/9-anthracenemethanol ratio;98%
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

2-bromoethanol
540-51-2

2-bromoethanol

poly(δ-valerolactone), asymmetric, telechelic, initiated by 2-bromoethanol/HCl*Et2O, Mn(NMR)=11000, Mw/Mn=1.10; monomer(s): δ-valerolactone; 2-bromoethanol

poly(δ-valerolactone), asymmetric, telechelic, initiated by 2-bromoethanol/HCl*Et2O, Mn(NMR)=11000, Mw/Mn=1.10; monomer(s): δ-valerolactone; 2-bromoethanol

Conditions
ConditionsYield
With hydrogenchloride; diethyl ether In dichloromethane at 0℃; for 2.5h;98%
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

butan-1-ol
71-36-3

butan-1-ol

poly(δ-valerolactone), initiated by 1-butanol/HCl*Et2O, Mn(exp)=19000, Mw/Mn=1.06; monomer(s): 1-butanol; δ-valerolactone

poly(δ-valerolactone), initiated by 1-butanol/HCl*Et2O, Mn(exp)=19000, Mw/Mn=1.06; monomer(s): 1-butanol; δ-valerolactone

Conditions
ConditionsYield
With hydrochloric acid diethyl ether In dichloromethane at 0℃; for 1.5h; Product distribution; Further Variations:; Temperatures; react. times; δ-VL/1-butanol rat.; init. δ-VL conc.; HCl/1-C4H9OH rat.;98%
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

2-hydroxyethyl acrylate
818-61-1

2-hydroxyethyl acrylate

poly(δ-valerolactone), asymmetric, telechelic, initiated by 2-hydroxyethyl acrylate/HCl*Et2O, Mn(NMR)=11000, Mw/Mn=1.08; monomer(s): δ-valerolactone; 2-hydroxyethyl acrylate

poly(δ-valerolactone), asymmetric, telechelic, initiated by 2-hydroxyethyl acrylate/HCl*Et2O, Mn(NMR)=11000, Mw/Mn=1.08; monomer(s): δ-valerolactone; 2-hydroxyethyl acrylate

Conditions
ConditionsYield
With hydrogenchloride; diethyl ether In dichloromethane at 0℃; for 2.5h;98%
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

β‐cyclodextrin
7585-39-9

β‐cyclodextrin

polymer; monomer(s): β-cyclodextrin; δ-valerolactone

polymer; monomer(s): β-cyclodextrin; δ-valerolactone

Conditions
ConditionsYield
at 100℃; for 48h;98%
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

ethyl acetate
141-78-6

ethyl acetate

ethyl (3R)-3,7-dihydroxyheptanoate
529510-37-0

ethyl (3R)-3,7-dihydroxyheptanoate

Conditions
ConditionsYield
Stage #1: ethyl acetate With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 1h; Inert atmosphere;
Stage #2: 3,4,5,6-tetrahydro-2H-pyran-2-one In tetrahydrofuran at -78℃; for 3h; Inert atmosphere;
Stage #3: With ruthenium trichloride; hydrogen; (+)-(R)-[2,3,2',3'-tetrahydro-5,5'-bi(1,4-benzodioxin)-6,6'-diyl]bis(diphenylphosphane) In ethanol at 80℃; under 7500.75 Torr; for 24h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;
98%
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

2-methoxy-5-bromopyridine
13472-85-0

2-methoxy-5-bromopyridine

5-hydroxy-1-(6-methoxypyridin-3-yl)pentan-1-one
1134621-15-0

5-hydroxy-1-(6-methoxypyridin-3-yl)pentan-1-one

Conditions
ConditionsYield
Stage #1: 2-methoxy-5-bromopyridine With n-butyllithium In diethyl ether; hexane at -78℃; for 0.5h; Inert atmosphere;
Stage #2: 3,4,5,6-tetrahydro-2H-pyran-2-one In diethyl ether; hexane at -78 - 20℃; Inert atmosphere; regioselective reaction;
98%
Stage #1: 2-methoxy-5-bromopyridine With n-butyllithium In diethyl ether; hexane at -78 - 20℃; Inert atmosphere;
Stage #2: 3,4,5,6-tetrahydro-2H-pyran-2-one In diethyl ether; hexane at -78 - 20℃; Inert atmosphere; regioselective reaction;
98%
Stage #1: 2-methoxy-5-bromopyridine With n-butyllithium In diethyl ether; hexane at -78℃; for 0.25h;
Stage #2: 3,4,5,6-tetrahydro-2H-pyran-2-one In diethyl ether; hexane at -78 - 20℃;
85%
3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

N,5-dihydroxypentanamide
59145-82-3

N,5-dihydroxypentanamide

Conditions
ConditionsYield
With hydroxylamine hydrochloride; potassium hydroxide In methanol at 0 - 20℃; Inert atmosphere;98%
With hydroxylamine hydrochloride; potassium hydroxide In methanol
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