Name Lopinavir Synonyms (2S)-N-[(2R,4S,5S)-5-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenyl-hexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:192725-17-0
Min.Order:1 Kilogram
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inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:192725-17-0
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inquiryItems Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------
Cas:192725-17-0
Min.Order:1 Gram
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White powder Storage:Store at RT. Package:100g/bottle; 1k
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inquiryLopinavir CAS No.:192725-17-0 Name: Lopinavir Synonyms: (2S)-N-[(2R,4S,5S)-5-[[
Cas:192725-17-0
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:192725-17-0
Min.Order:1 Gram
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Our advantage:Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scient
Cas:192725-17-0
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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Cas:192725-17-0
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inquiry192725-17-0 Lopinavir product Name Lopinavir Synonyms Kaletra; (1S-(1R*(R*),3R*,4R*))-N-(4-(((2,6-Dimethylphenoxy)acetyl)amino)-3-hydroxy-5-ph
Cas:192725-17-0
Min.Order:1 Metric Ton
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Type:Other
inquiryAppearance:White to off-white powder Storage:Room temperature Package:1kg/bag Application:API Transportation:Express/Sea/Air Port:Any port in china
Cas:192725-17-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
Cas:192725-17-0
Min.Order:10 Gram
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:192725-17-0
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryWe have two GMP facilities in Hubei Province and cooperative factories in Zhejiang Province We are concentrating on the R&D and technical service of APIs and pharmaceutical intermediates FDA Approved Appearance:Clear colorless Storage:2-8
Cas:192725-17-0
Min.Order:1 Gram
FOB Price: $1600.0
Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Lopinavir CAS:192725-17-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
Cas:192725-17-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi
Cas:192725-17-0
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater
Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:192725-17-0
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:192725-17-0
Min.Order:50 Gram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
NewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed
lopinavir
Conditions | Yield |
---|---|
In ethyl acetate at 25℃; for 8h; Solvent; | 97% |
Conditions | Yield |
---|---|
In dichloromethane at 25℃; for 8h; Solvent; | 96% |
N-(2,6-dimethyl-phenyloxy acetyloxy)succinimide
lopinavir
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 25℃; for 8h; Solvent; | 96% |
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 25℃; for 8h; Solvent; | 96% |
2S-(1-tetrahydro-pyrimid-2-onyl)-3-methyl butanoyl chloride
(2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-amino-1,6-diphenylhexane
lopinavir
Conditions | Yield |
---|---|
With 1H-imidazole In ethyl acetate; N,N-dimethyl-formamide at 0 - 20℃; Reagent/catalyst; Inert atmosphere; | 92% |
With 1H-imidazole; dmap In ethyl acetate; N,N-dimethyl-formamide at 0 - 10℃; for 14h; |
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 25℃; for 8h; Solvent; | 92% |
lopinavir
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 25℃; for 8h; Solvent; | 92% |
(2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-amino-1,6-diphenylhexane
(S)-tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetic acid
lopinavir
Conditions | Yield |
---|---|
Stage #1: (2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-amino-1,6-diphenylhexane; (S)-tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetic acid With thionyl chloride In dichloromethane at 0℃; for 2h; Reflux; Stage #2: With triethylamine In dichloromethane at 0 - 20℃; for 5h; | 90.1% |
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide | 70% |
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at 25℃; for 8h; Solvent; | 89% |
lopinavir
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 25℃; for 8h; Solvent; | 89% |
(S)-2-(3-Amino-propylamino)-3-methyl-butyric acid methyl ester
lopinavir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: LiOH 2: EDAC; HOBt View Scheme |
(S)-3-Methyl-2-(2-oxo-tetrahydro-pyrimidin-1-yl)-butyric acid methyl ester
lopinavir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: LiOH 2: EDAC; HOBt View Scheme |
lopinavir
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: trifluoroacetic acid 2: LiOH 3: EDAC; HOBt View Scheme |
(2S,3S,5S)-2-amino-3-hydroxy-5-(t-butyloxycarbonylamino)-1,6-diphenylhexane
lopinavir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: EDC 2: trifluoroacetic acid View Scheme | |
Multi-step reaction with 3 steps 1.1: thionyl chloride; N,N-dimethyl-formamide / ethyl acetate / 4 h / 50 °C 1.2: 5.25 h / 20 °C 2.1: trifluoroacetic acid / dichloromethane / 0 h / 0 - 25 °C / Inert atmosphere 3.1: triethylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere 3.2: 12 h / 20 - 25 °C / Inert atmosphere View Scheme |
(2S,3S,5S)-2-(N,N-dibenzylamino)-3-hydroxy-5-amino-1,6-diphenylhexane
lopinavir
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: Pd(OH)2; HCO2NH4 2: EDC 3: trifluoroacetic acid View Scheme | |
Multi-step reaction with 3 steps 1.1: 1,1'-carbonyldiimidazole / ethyl acetate / 2 h / 15 - 20 °C 1.2: 4 h / 70 - 75 °C 2.1: 5%-palladium/activated carbon; ammonium formate / methanol / 2 h / 50 - 55 °C 3.1: sodium hydrogencarbonate / water; ethyl acetate / 0.5 h / 10 - 15 °C View Scheme |
(2S,3S,5S)-2-(N,N-dibenzylamino)-3-hydroxy-5-(t-butyloxycarbonylamino)-1,6-diphenylhexane
lopinavir
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: Pd(OH)2; HCO2NH4 2: EDC 3: trifluoroacetic acid View Scheme |
(2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-(t-butyloxycarbonylamino)-1,6-diphenylhexane
lopinavir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: trifluoroacetic acid View Scheme |
(2S,3S,5S)-2-amino-3-hydroxy-5-(2S-(2-oxotetrahydropyrimidin-2-yl)-3-methylbutanoyl)amino-1,6-diphenylhexane
2,6-dimethylphenoxyacetyl chloride
lopinavir
2S-(1-tetrahydro-pyrimid-2-onyl)-3-methyl butanoyl chloride
lopinavir
Conditions | Yield |
---|---|
Stage #1: (2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-amino-1,6-diphenylhexane With 1H-imidazole In ethyl acetate at 20℃; Stage #2: 2S-(1-tetrahydro-pyrimid-2-onyl)-3-methyl butanoyl chloride In ethyl acetate; N,N-dimethyl-formamide at 0 - 20℃; for 13h; | |
Multi-step reaction with 4 steps 1: 1H-imidazole / ethyl acetate; N,N-dimethyl-formamide / 2 - 30 °C / Inert atmosphere 2: 5%-palladium/activated carbon; ammonium formate / methanol / 50 °C / Inert atmosphere 3: 1,4-dioxane / 1 h / 20 - 50 °C / Inert atmosphere 4: sodium hydrogencarbonate / ethyl acetate; water / 0.58 h / 20 °C / Inert atmosphere View Scheme |
(2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-amino-1,6-diphenylhexane
lopinavir
Conditions | Yield |
---|---|
Stage #1: (2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-amino-1,6-diphenylhexane With 1H-imidazole In ethyl acetate; N,N-dimethyl-formamide at 0 - 25℃; for 13h; Stage #2: With hydrogenchloride In water; ethyl acetate; N,N-dimethyl-formamide at 10 - 15℃; |
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water; ethyl acetate at 20 - 25℃; for 1.16667h; |
(S)-tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetic acid
lopinavir
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: thionyl chloride / tetrahydrofuran / 5.5 h / 4 - 20 °C / Inert atmosphere 2: 1H-imidazole / ethyl acetate; N,N-dimethyl-formamide / 2 - 30 °C / Inert atmosphere 3: 5%-palladium/activated carbon; ammonium formate / methanol / 50 °C / Inert atmosphere 4: 1,4-dioxane / 1 h / 20 - 50 °C / Inert atmosphere 5: sodium hydrogencarbonate / ethyl acetate; water / 0.58 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1.1: 1,1'-carbonyldiimidazole / ethyl acetate / 2 h / 15 - 20 °C 1.2: 4 h / 70 - 75 °C 2.1: 5%-palladium/activated carbon; ammonium formate / methanol / 2 h / 50 - 55 °C 3.1: sodium hydrogencarbonate / water; ethyl acetate / 0.5 h / 10 - 15 °C View Scheme |
L-valine
lopinavir
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: lithium chloride; lithium hydroxide; aluminum oxide / water / 5 h / -20 - -10 °C / pH 9.5 - 10.2 / Inert atmosphere 2: sodium hydroxide / tetrahydrofuran / 2 h / 2 - 10 °C / Inert atmosphere 3: potassium tert-butylate / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere 4: thionyl chloride / tetrahydrofuran / 5.5 h / 4 - 20 °C / Inert atmosphere 5: 1H-imidazole / ethyl acetate; N,N-dimethyl-formamide / 2 - 30 °C / Inert atmosphere 6: 5%-palladium/activated carbon; ammonium formate / methanol / 50 °C / Inert atmosphere 7: 1,4-dioxane / 1 h / 20 - 50 °C / Inert atmosphere 8: sodium hydrogencarbonate / ethyl acetate; water / 0.58 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 7 steps 1.1: potassium hydroxide / water / 2 h / 0 - 5 °C 2.1: sodium hydroxide / water / pH 9.5 - 10.5 3.1: ammonia; hydrogen / methanol / 10 h / 50 °C 4.1: sodium hydroxide / water / 98 - 100 °C 5.1: 1,1'-carbonyldiimidazole / ethyl acetate / 2 h / 15 - 20 °C 5.2: 4 h / 70 - 75 °C 6.1: 5%-palladium/activated carbon; ammonium formate / methanol / 2 h / 50 - 55 °C 7.1: sodium hydrogencarbonate / water; ethyl acetate / 0.5 h / 10 - 15 °C View Scheme |
(2S)-3-Methyl-2-(phenoxycarbonyl)aminobutyric acid
lopinavir
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: sodium hydroxide / tetrahydrofuran / 2 h / 2 - 10 °C / Inert atmosphere 2: potassium tert-butylate / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere 3: thionyl chloride / tetrahydrofuran / 5.5 h / 4 - 20 °C / Inert atmosphere 4: 1H-imidazole / ethyl acetate; N,N-dimethyl-formamide / 2 - 30 °C / Inert atmosphere 5: 5%-palladium/activated carbon; ammonium formate / methanol / 50 °C / Inert atmosphere 6: 1,4-dioxane / 1 h / 20 - 50 °C / Inert atmosphere 7: sodium hydrogencarbonate / ethyl acetate; water / 0.58 h / 20 °C / Inert atmosphere View Scheme |
lopinavir
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: potassium tert-butylate / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere 2: thionyl chloride / tetrahydrofuran / 5.5 h / 4 - 20 °C / Inert atmosphere 3: 1H-imidazole / ethyl acetate; N,N-dimethyl-formamide / 2 - 30 °C / Inert atmosphere 4: 5%-palladium/activated carbon; ammonium formate / methanol / 50 °C / Inert atmosphere 5: 1,4-dioxane / 1 h / 20 - 50 °C / Inert atmosphere 6: sodium hydrogencarbonate / ethyl acetate; water / 0.58 h / 20 °C / Inert atmosphere View Scheme |
lopinavir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 5%-palladium/activated carbon; ammonium formate / methanol / 50 °C / Inert atmosphere 2: 1,4-dioxane / 1 h / 20 - 50 °C / Inert atmosphere 3: sodium hydrogencarbonate / ethyl acetate; water / 0.58 h / 20 °C / Inert atmosphere View Scheme |
lopinavir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1,4-dioxane / 1 h / 20 - 50 °C / Inert atmosphere 2: sodium hydrogencarbonate / ethyl acetate; water / 0.58 h / 20 °C / Inert atmosphere View Scheme |
lopinavir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hydrogencarbonate / tert-butyl methyl ether; water / 1 h / 25 - 35 °C 1.2: 45 - 60 °C 2.1: ammonium formate; 5%-palladium/activated carbon / methanol / 50 - 55 °C 2.2: 1 h / 50 - 55 °C 3.1: sodium hydrogencarbonate / water; ethyl acetate / 1 h / 25 - 35 °C View Scheme |
dibenzyl N,N-diethylphosphoramidite
lopinavir
Conditions | Yield |
---|---|
Stage #1: dibenzyl N,N-diethylphosphoramidite; lopinavir With 1H-tetrazole In tetrahydrofuran at 20℃; for 68h; Stage #2: With 3-chloro-benzenecarboperoxoic acid In tetrahydrofuran; dichloromethane at -45℃; for 0.5h; | 90% |
4-{[bis(benzyloxy)phosphoryl]oxy}-3,3-dimethylbutanoic acid
lopinavir
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 19h; | 84% |
dimethyl sulfoxide
lopinavir
(2S)-N-{(1S,3S,4S)-1-benzyl-4-{[(2,6-dimethylphenoxy)acetyl]amino}-3-[(methylthio)methoxy]-5-phenylpentyl}-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide
Conditions | Yield |
---|---|
With acetic anhydride at 20℃; for 48h; | 64% |
With acetic anhydride; acetic acid at 20℃; for 48 - 72h; Product distribution / selectivity; | 64% |
diethyl sulphide
lopinavir
(2S)-N-{(1S,3S,4S)-1-benzyl-4-{[(2,6-dimethylphenoxy)acetyl]amino}-3-[1-(ethylthio)ethoxy]-5-phenylpentyl}-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide
Conditions | Yield |
---|---|
With dibenzoyl peroxide In acetonitrile at 0 - 20℃; for 2.33333h; | 61% |
With dibenzoyl peroxide In acetonitrile at 0℃; for 3h; Product distribution / selectivity; | 61% |
Stage #1: diethyl sulphide With N-chloro-succinimide In tetrahydrofuran at -10℃; Stage #2: lopinavir With triethylamine In tetrahydrofuran at -10℃; for 1.5h; Product distribution / selectivity; |
dibenzyl 4-chloro-3,3-dimethyl-4-oxobutyl phosphate
lopinavir
Conditions | Yield |
---|---|
With dmap In dichloromethane at 0 - 20℃; for 16h; | 56% |
Conditions | Yield |
---|---|
With 1H-tetrazole In tetrahydrofuran at 20℃; for 68h; |
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