Products

Refine

Country

Business Type

Certificate

Display

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Name Lopinavir Synonyms (2S)-N-[(2R,4S,5S)-5-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenyl-hexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide

Lopinavir/192725-17-0

Cas:192725-17-0

Min.Order:1 Gram

FOB Price: $1.0

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Lopinavir Manufacturer/High quality/Best price/In stock

Cas:192725-17-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

Factory Supply Raw Material Lopinavir Powder

Cas:192725-17-0

Min.Order:1 Metric Ton

FOB Price: $10.0 / 1350.0

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 192725-17-0 Lopinavir

Cas:192725-17-0

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

inquiry

Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White powder Storage:Store at RT. Package:100g/bottle; 1k

Good quality Lopinavir CAS 192725-17-0 supplied by manufacturer

Cas:192725-17-0

Min.Order:100 Gram

FOB Price: $1.5 / 3.0

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

Lopinavir CAS No.:192725-17-0 Name: Lopinavir Synonyms: (2S)-N-[(2R,4S,5S)-5-[[

High purity Lopinavir CAS No.:192725-17-0

Cas:192725-17-0

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Lopinavir

Cas:192725-17-0

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Lopinavir 192725-17-0 ISO Producer

Cas:192725-17-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

lopinavir

Cas:192725-17-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our advantage:Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scient

TIANFU-CHEM Lopinavir

Cas:192725-17-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Lopinavir CAS 192725-17-0

Cas:192725-17-0

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 192725-17-0 with competitive price

Cas:192725-17-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Lopinavir

Cas:192725-17-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam

Lopinavir CAS192725-17-0

Cas:192725-17-0

Min.Order:1 Kilogram

FOB Price: $7.0 / 10.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

192725-17-0 Lopinavir product Name Lopinavir Synonyms Kaletra; (1S-(1R*(R*),3R*,4R*))-N-(4-(((2,6-Dimethylphenoxy)acetyl)amino)-3-hydroxy-5-ph

Lopinavir,192725-17-0 Kaletra

Cas:192725-17-0

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White to off-white powder Storage:Room temperature Package:1kg/bag Application:API Transportation:Express/Sea/Air Port:Any port in china

Factory Supply Raw Material Lopinavir Powder Manufacture

Cas:192725-17-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

99%min Lopinavir 192725-17-0 For Anti-AIDS

Cas:192725-17-0

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Lopinavir 192725-17-0

Cas:192725-17-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

We have two GMP facilities in Hubei Province and cooperative factories in Zhejiang Province We are concentrating on the R&D and technical service of APIs and pharmaceutical intermediates FDA Approved Appearance:Clear colorless Storage:2-8

Pharmaceutical High Purity Lopinavir Powder Raw Material Lopinavir

Cas:192725-17-0

Min.Order:1 Gram

FOB Price: $1600.0

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Lopinavir

Cas:192725-17-0

Min.Order:1 Kilogram

FOB Price: $55.0 / 70.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Lopinavir CAS:192725-17-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Lopinavir CAS:192725-17-0

Cas:192725-17-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Lopinavir

Cas:192725-17-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

API-Lopinavir, High purity Lopinavir

Cas:192725-17-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Lopinavir

Cas:192725-17-0

Min.Order:1 Kilogram

FOB Price: $10.0 / 100.0

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Lopinavir

Cas:192725-17-0

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater

Lopinavir

Cas:192725-17-0

Min.Order:0 Metric Ton

FOB Price: $18.0 / 20.0

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

High Purity Lopinavir CAS 192725-17-0 with Fast Shipment

Cas:192725-17-0

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Lopinavir 192725-17-0

Cas:192725-17-0

Min.Order:50 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Lopinavir

Cas:192725-17-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

NewCan Biotech Limited

NewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed

Lopinavir

Cas:192725-17-0

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Synthetic route

(2S,3S,5S)-2-amino-3-hydroxy-5-(2S-(1-tetrahydro-pyrimid-2-onyl)-3-methylbutanoyl)amino-1,6-diphenylhexane (S)-pyroglutamic acid salt

(2S,3S,5S)-2-amino-3-hydroxy-5-(2S-(1-tetrahydro-pyrimid-2-onyl)-3-methylbutanoyl)amino-1,6-diphenylhexane (S)-pyroglutamic acid salt

C13H14N2O2

C13H14N2O2

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
In ethyl acetate at 25℃; for 8h; Solvent;97%
C28H40N4O2*C5H7NO3

C28H40N4O2*C5H7NO3

C13H14N2O2

C13H14N2O2

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
In dichloromethane at 25℃; for 8h; Solvent;96%
N-(2,6-dimethyl-phenyloxy acetyloxy)succinimide
224648-11-7

N-(2,6-dimethyl-phenyloxy acetyloxy)succinimide

C28H40N4O2*C5H7NO3

C28H40N4O2*C5H7NO3

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 25℃; for 8h; Solvent;96%
(2S,3S,5S)-2-amino-3-hydroxy-5-(2S-(1-tetrahydro-pyrimid-2-onyl)-3-methylbutanoyl)amino-1,6-diphenylhexane (S)-pyroglutamic acid salt

(2S,3S,5S)-2-amino-3-hydroxy-5-(2S-(1-tetrahydro-pyrimid-2-onyl)-3-methylbutanoyl)amino-1,6-diphenylhexane (S)-pyroglutamic acid salt

N-(2,6-dimethyl-phenyloxy acetyloxy)succinimide
224648-11-7

N-(2,6-dimethyl-phenyloxy acetyloxy)succinimide

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 25℃; for 8h; Solvent;96%
2S-(1-tetrahydro-pyrimid-2-onyl)-3-methyl butanoyl chloride
192800-77-4

2S-(1-tetrahydro-pyrimid-2-onyl)-3-methyl butanoyl chloride

(2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-amino-1,6-diphenylhexane
192725-49-8

(2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-amino-1,6-diphenylhexane

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
With 1H-imidazole In ethyl acetate; N,N-dimethyl-formamide at 0 - 20℃; Reagent/catalyst; Inert atmosphere;92%
With 1H-imidazole; dmap In ethyl acetate; N,N-dimethyl-formamide at 0 - 10℃; for 14h;
C28H40N4O2*C5H7NO3

C28H40N4O2*C5H7NO3

C19H19NO5

C19H19NO5

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 25℃; for 8h; Solvent;92%
(2S,3S,5S)-2-amino-3-hydroxy-5-(2S-(1-tetrahydro-pyrimid-2-onyl)-3-methylbutanoyl)amino-1,6-diphenylhexane (S)-pyroglutamic acid salt

(2S,3S,5S)-2-amino-3-hydroxy-5-(2S-(1-tetrahydro-pyrimid-2-onyl)-3-methylbutanoyl)amino-1,6-diphenylhexane (S)-pyroglutamic acid salt

C19H19NO5

C19H19NO5

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 25℃; for 8h; Solvent;92%
(2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-amino-1,6-diphenylhexane
192725-49-8

(2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-amino-1,6-diphenylhexane

(S)-tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetic acid
192725-50-1

(S)-tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetic acid

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
Stage #1: (2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-amino-1,6-diphenylhexane; (S)-tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetic acid With thionyl chloride In dichloromethane at 0℃; for 2h; Reflux;
Stage #2: With triethylamine In dichloromethane at 0 - 20℃; for 5h;
90.1%
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide70%
C28H40N4O2*C5H7NO3

C28H40N4O2*C5H7NO3

C18H15NO5

C18H15NO5

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
With triethylamine In acetonitrile at 25℃; for 8h; Solvent;89%
(2S,3S,5S)-2-amino-3-hydroxy-5-(2S-(1-tetrahydro-pyrimid-2-onyl)-3-methylbutanoyl)amino-1,6-diphenylhexane (S)-pyroglutamic acid salt

(2S,3S,5S)-2-amino-3-hydroxy-5-(2S-(1-tetrahydro-pyrimid-2-onyl)-3-methylbutanoyl)amino-1,6-diphenylhexane (S)-pyroglutamic acid salt

C18H15NO5

C18H15NO5

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 25℃; for 8h; Solvent;89%
(S)-2-(3-Amino-propylamino)-3-methyl-butyric acid methyl ester
192725-84-1

(S)-2-(3-Amino-propylamino)-3-methyl-butyric acid methyl ester

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: LiOH
2: EDAC; HOBt
View Scheme
(S)-3-Methyl-2-(2-oxo-tetrahydro-pyrimidin-1-yl)-butyric acid methyl ester
192725-85-2

(S)-3-Methyl-2-(2-oxo-tetrahydro-pyrimidin-1-yl)-butyric acid methyl ester

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LiOH
2: EDAC; HOBt
View Scheme
2-(3-tert-butoxycarbonylamino-propylamino)-3-methyl-butyric acid methyl ester

2-(3-tert-butoxycarbonylamino-propylamino)-3-methyl-butyric acid methyl ester

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: trifluoroacetic acid
2: LiOH
3: EDAC; HOBt
View Scheme
(2S,3S,5S)-2-amino-3-hydroxy-5-(t-butyloxycarbonylamino)-1,6-diphenylhexane
144163-85-9

(2S,3S,5S)-2-amino-3-hydroxy-5-(t-butyloxycarbonylamino)-1,6-diphenylhexane

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: EDC
2: trifluoroacetic acid
View Scheme
Multi-step reaction with 3 steps
1.1: thionyl chloride; N,N-dimethyl-formamide / ethyl acetate / 4 h / 50 °C
1.2: 5.25 h / 20 °C
2.1: trifluoroacetic acid / dichloromethane / 0 h / 0 - 25 °C / Inert atmosphere
3.1: triethylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere
3.2: 12 h / 20 - 25 °C / Inert atmosphere
View Scheme
(2S,3S,5S)-2-(N,N-dibenzylamino)-3-hydroxy-5-amino-1,6-diphenylhexane
156732-15-9

(2S,3S,5S)-2-(N,N-dibenzylamino)-3-hydroxy-5-amino-1,6-diphenylhexane

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: Pd(OH)2; HCO2NH4
2: EDC
3: trifluoroacetic acid
View Scheme
Multi-step reaction with 3 steps
1.1: 1,1'-carbonyldiimidazole / ethyl acetate / 2 h / 15 - 20 °C
1.2: 4 h / 70 - 75 °C
2.1: 5%-palladium/activated carbon; ammonium formate / methanol / 2 h / 50 - 55 °C
3.1: sodium hydrogencarbonate / water; ethyl acetate / 0.5 h / 10 - 15 °C
View Scheme
(2S,3S,5S)-2-(N,N-dibenzylamino)-3-hydroxy-5-(t-butyloxycarbonylamino)-1,6-diphenylhexane
162849-93-6

(2S,3S,5S)-2-(N,N-dibenzylamino)-3-hydroxy-5-(t-butyloxycarbonylamino)-1,6-diphenylhexane

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Pd(OH)2; HCO2NH4
2: EDC
3: trifluoroacetic acid
View Scheme
(2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-(t-butyloxycarbonylamino)-1,6-diphenylhexane
192725-45-4

(2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-(t-butyloxycarbonylamino)-1,6-diphenylhexane

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trifluoroacetic acid
View Scheme
(2S,3S,5S)-2-amino-3-hydroxy-5-(2S-(1-tetrahydro-pyrimid-2-onyl)-3-methylbutanoyl)amino-1,6-diphenylhexane (S)-pyroglutamic acid salt

(2S,3S,5S)-2-amino-3-hydroxy-5-(2S-(1-tetrahydro-pyrimid-2-onyl)-3-methylbutanoyl)amino-1,6-diphenylhexane (S)-pyroglutamic acid salt

2,6-dimethylphenoxyacetyl chloride
20143-48-0

2,6-dimethylphenoxyacetyl chloride

lopinavir
192725-17-0

lopinavir

(2S,3S,5S)-2-amino-3-hydroxy-5-(2S-(2-oxotetrahydropyrimidin-2-yl)-3-methylbutanoyl)amino-1,6-diphenylhexane
192726-05-9

(2S,3S,5S)-2-amino-3-hydroxy-5-(2S-(2-oxotetrahydropyrimidin-2-yl)-3-methylbutanoyl)amino-1,6-diphenylhexane

2,6-dimethylphenoxyacetyl chloride
20143-48-0

2,6-dimethylphenoxyacetyl chloride

lopinavir
192725-17-0

lopinavir

2S-(1-tetrahydro-pyrimid-2-onyl)-3-methyl butanoyl chloride
192800-77-4

2S-(1-tetrahydro-pyrimid-2-onyl)-3-methyl butanoyl chloride

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
Stage #1: (2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-amino-1,6-diphenylhexane With 1H-imidazole In ethyl acetate at 20℃;
Stage #2: 2S-(1-tetrahydro-pyrimid-2-onyl)-3-methyl butanoyl chloride In ethyl acetate; N,N-dimethyl-formamide at 0 - 20℃; for 13h;
Multi-step reaction with 4 steps
1: 1H-imidazole / ethyl acetate; N,N-dimethyl-formamide / 2 - 30 °C / Inert atmosphere
2: 5%-palladium/activated carbon; ammonium formate / methanol / 50 °C / Inert atmosphere
3: 1,4-dioxane / 1 h / 20 - 50 °C / Inert atmosphere
4: sodium hydrogencarbonate / ethyl acetate; water / 0.58 h / 20 °C / Inert atmosphere
View Scheme
(2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-amino-1,6-diphenylhexane
192725-49-8

(2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-amino-1,6-diphenylhexane

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
Stage #1: (2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-amino-1,6-diphenylhexane With 1H-imidazole In ethyl acetate; N,N-dimethyl-formamide at 0 - 25℃; for 13h;
Stage #2: With hydrogenchloride In water; ethyl acetate; N,N-dimethyl-formamide at 10 - 15℃;
(2S,3S,5S)-2-amino-3-hydroxy-5-(2S-(1-tetrahydropyramid-2-only)-2-methylbutanoyl)-amino-1,6-diphenylhexane

(2S,3S,5S)-2-amino-3-hydroxy-5-(2S-(1-tetrahydropyramid-2-only)-2-methylbutanoyl)-amino-1,6-diphenylhexane

2,6-dimethylphenoxyacetyl chloride
20143-48-0

2,6-dimethylphenoxyacetyl chloride

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; ethyl acetate at 20 - 25℃; for 1.16667h;
(S)-tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetic acid
192725-50-1

(S)-tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetic acid

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: thionyl chloride / tetrahydrofuran / 5.5 h / 4 - 20 °C / Inert atmosphere
2: 1H-imidazole / ethyl acetate; N,N-dimethyl-formamide / 2 - 30 °C / Inert atmosphere
3: 5%-palladium/activated carbon; ammonium formate / methanol / 50 °C / Inert atmosphere
4: 1,4-dioxane / 1 h / 20 - 50 °C / Inert atmosphere
5: sodium hydrogencarbonate / ethyl acetate; water / 0.58 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: 1,1'-carbonyldiimidazole / ethyl acetate / 2 h / 15 - 20 °C
1.2: 4 h / 70 - 75 °C
2.1: 5%-palladium/activated carbon; ammonium formate / methanol / 2 h / 50 - 55 °C
3.1: sodium hydrogencarbonate / water; ethyl acetate / 0.5 h / 10 - 15 °C
View Scheme
L-valine
72-18-4

L-valine

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: lithium chloride; lithium hydroxide; aluminum oxide / water / 5 h / -20 - -10 °C / pH 9.5 - 10.2 / Inert atmosphere
2: sodium hydroxide / tetrahydrofuran / 2 h / 2 - 10 °C / Inert atmosphere
3: potassium tert-butylate / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere
4: thionyl chloride / tetrahydrofuran / 5.5 h / 4 - 20 °C / Inert atmosphere
5: 1H-imidazole / ethyl acetate; N,N-dimethyl-formamide / 2 - 30 °C / Inert atmosphere
6: 5%-palladium/activated carbon; ammonium formate / methanol / 50 °C / Inert atmosphere
7: 1,4-dioxane / 1 h / 20 - 50 °C / Inert atmosphere
8: sodium hydrogencarbonate / ethyl acetate; water / 0.58 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 7 steps
1.1: potassium hydroxide / water / 2 h / 0 - 5 °C
2.1: sodium hydroxide / water / pH 9.5 - 10.5
3.1: ammonia; hydrogen / methanol / 10 h / 50 °C
4.1: sodium hydroxide / water / 98 - 100 °C
5.1: 1,1'-carbonyldiimidazole / ethyl acetate / 2 h / 15 - 20 °C
5.2: 4 h / 70 - 75 °C
6.1: 5%-palladium/activated carbon; ammonium formate / methanol / 2 h / 50 - 55 °C
7.1: sodium hydrogencarbonate / water; ethyl acetate / 0.5 h / 10 - 15 °C
View Scheme
(2S)-3-Methyl-2-(phenoxycarbonyl)aminobutyric acid
126147-70-4

(2S)-3-Methyl-2-(phenoxycarbonyl)aminobutyric acid

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: sodium hydroxide / tetrahydrofuran / 2 h / 2 - 10 °C / Inert atmosphere
2: potassium tert-butylate / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere
3: thionyl chloride / tetrahydrofuran / 5.5 h / 4 - 20 °C / Inert atmosphere
4: 1H-imidazole / ethyl acetate; N,N-dimethyl-formamide / 2 - 30 °C / Inert atmosphere
5: 5%-palladium/activated carbon; ammonium formate / methanol / 50 °C / Inert atmosphere
6: 1,4-dioxane / 1 h / 20 - 50 °C / Inert atmosphere
7: sodium hydrogencarbonate / ethyl acetate; water / 0.58 h / 20 °C / Inert atmosphere
View Scheme
C9H17ClN2O3

C9H17ClN2O3

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: potassium tert-butylate / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere
2: thionyl chloride / tetrahydrofuran / 5.5 h / 4 - 20 °C / Inert atmosphere
3: 1H-imidazole / ethyl acetate; N,N-dimethyl-formamide / 2 - 30 °C / Inert atmosphere
4: 5%-palladium/activated carbon; ammonium formate / methanol / 50 °C / Inert atmosphere
5: 1,4-dioxane / 1 h / 20 - 50 °C / Inert atmosphere
6: sodium hydrogencarbonate / ethyl acetate; water / 0.58 h / 20 °C / Inert atmosphere
View Scheme
[1S]-N-[4-[bis(phenylmethyl)amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-R-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide

[1S]-N-[4-[bis(phenylmethyl)amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-R-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 5%-palladium/activated carbon; ammonium formate / methanol / 50 °C / Inert atmosphere
2: 1,4-dioxane / 1 h / 20 - 50 °C / Inert atmosphere
3: sodium hydrogencarbonate / ethyl acetate; water / 0.58 h / 20 °C / Inert atmosphere
View Scheme
[1S]-N-[4-amino-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-R-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide

[1S]-N-[4-amino-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-R-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1,4-dioxane / 1 h / 20 - 50 °C / Inert atmosphere
2: sodium hydrogencarbonate / ethyl acetate; water / 0.58 h / 20 °C / Inert atmosphere
View Scheme
(2S,3S,5S)-2-(N,N-dibenzylamino)-3-hydroxy-5-amino-1,6-diphenylhexane tartrate

(2S,3S,5S)-2-(N,N-dibenzylamino)-3-hydroxy-5-amino-1,6-diphenylhexane tartrate

lopinavir
192725-17-0

lopinavir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate / tert-butyl methyl ether; water / 1 h / 25 - 35 °C
1.2: 45 - 60 °C
2.1: ammonium formate; 5%-palladium/activated carbon / methanol / 50 - 55 °C
2.2: 1 h / 50 - 55 °C
3.1: sodium hydrogencarbonate / water; ethyl acetate / 1 h / 25 - 35 °C
View Scheme
dibenzyl N,N-diethylphosphoramidite
67746-43-4

dibenzyl N,N-diethylphosphoramidite

lopinavir
192725-17-0

lopinavir

dibenzyl (1S,3S)-1-((1S)-1-{[(2,6-dimethylphenoxy)acetyl]amino}-2-phenylethyl)-3-{[(2S)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanoyl]amino}-4-phenylbutyl phosphate

dibenzyl (1S,3S)-1-((1S)-1-{[(2,6-dimethylphenoxy)acetyl]amino}-2-phenylethyl)-3-{[(2S)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanoyl]amino}-4-phenylbutyl phosphate

Conditions
ConditionsYield
Stage #1: dibenzyl N,N-diethylphosphoramidite; lopinavir With 1H-tetrazole In tetrahydrofuran at 20℃; for 68h;
Stage #2: With 3-chloro-benzenecarboperoxoic acid In tetrahydrofuran; dichloromethane at -45℃; for 0.5h;
90%
4-{[bis(benzyloxy)phosphoryl]oxy}-3,3-dimethylbutanoic acid
170436-73-4

4-{[bis(benzyloxy)phosphoryl]oxy}-3,3-dimethylbutanoic acid

lopinavir
192725-17-0

lopinavir

(1S,3S)-1-((1S)-1-{[(2,6-dimethylphenoxy)acetyl]amino}-2-phenylethyl)3-{[(2S)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanoyl]amino}-4-phenylbutyl 4-{[bis(benzyloxy)phosphoryl]oxy}-3,3-dimethylbutanoate

(1S,3S)-1-((1S)-1-{[(2,6-dimethylphenoxy)acetyl]amino}-2-phenylethyl)3-{[(2S)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanoyl]amino}-4-phenylbutyl 4-{[bis(benzyloxy)phosphoryl]oxy}-3,3-dimethylbutanoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 19h;84%
dimethyl sulfoxide
67-68-5

dimethyl sulfoxide

lopinavir
192725-17-0

lopinavir

(2S)-N-{(1S,3S,4S)-1-benzyl-4-{[(2,6-dimethylphenoxy)acetyl]amino}-3-[(methylthio)methoxy]-5-phenylpentyl}-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide
875435-49-7

(2S)-N-{(1S,3S,4S)-1-benzyl-4-{[(2,6-dimethylphenoxy)acetyl]amino}-3-[(methylthio)methoxy]-5-phenylpentyl}-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide

Conditions
ConditionsYield
With acetic anhydride at 20℃; for 48h;64%
With acetic anhydride; acetic acid at 20℃; for 48 - 72h; Product distribution / selectivity;64%
diethyl sulphide
352-93-2

diethyl sulphide

lopinavir
192725-17-0

lopinavir

(2S)-N-{(1S,3S,4S)-1-benzyl-4-{[(2,6-dimethylphenoxy)acetyl]amino}-3-[1-(ethylthio)ethoxy]-5-phenylpentyl}-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide
875435-61-3

(2S)-N-{(1S,3S,4S)-1-benzyl-4-{[(2,6-dimethylphenoxy)acetyl]amino}-3-[1-(ethylthio)ethoxy]-5-phenylpentyl}-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide

Conditions
ConditionsYield
With dibenzoyl peroxide In acetonitrile at 0 - 20℃; for 2.33333h;61%
With dibenzoyl peroxide In acetonitrile at 0℃; for 3h; Product distribution / selectivity;61%
Stage #1: diethyl sulphide With N-chloro-succinimide In tetrahydrofuran at -10℃;
Stage #2: lopinavir With triethylamine In tetrahydrofuran at -10℃; for 1.5h; Product distribution / selectivity;
dibenzyl 4-chloro-3,3-dimethyl-4-oxobutyl phosphate
875435-99-7

dibenzyl 4-chloro-3,3-dimethyl-4-oxobutyl phosphate

lopinavir
192725-17-0

lopinavir

(1S,3S)-1-((1S)-1-{[(2,6-dimethylphenoxy)acetyl]amino}-2-phenylethyl)-3-{[(2S)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanoyl]amino}-4-phenylbutyl 4-{[bis(benzyloxy)phosphoryl]oxy}-2,2-dimethylbutanoate

(1S,3S)-1-((1S)-1-{[(2,6-dimethylphenoxy)acetyl]amino}-2-phenylethyl)-3-{[(2S)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanoyl]amino}-4-phenylbutyl 4-{[bis(benzyloxy)phosphoryl]oxy}-2,2-dimethylbutanoate

Conditions
ConditionsYield
With dmap In dichloromethane at 0 - 20℃; for 16h;56%
dibenzyl N,N-diethylphosphoramidite
67746-43-4

dibenzyl N,N-diethylphosphoramidite

lopinavir
192725-17-0

lopinavir

C51H61N4O7P

C51H61N4O7P

Conditions
ConditionsYield
With 1H-tetrazole In tetrahydrofuran at 20℃; for 68h;
Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View