As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine c
Cas:143612-79-7
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inquiry3-(4-Chlorobutyl)indole-5-carbonitrile CAS No.:143612-79-7 Name: 3-(4-Chlorobutyl)indole-5-carbonitrile Synonyms: 3-(4-chlorobutyl)-1H-indole-5-carbonitrile M
Cas:143612-79-7
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inquiryhigh quality Appearance:White or off white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
Cas:143612-79-7
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
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inquiry1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% 5. Chi
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Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:143612-79-7
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Type:Manufacturers
inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) W
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Type:Trading Company
inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/1094.html Product Name 3-(4-Chlorobutyl)indole-5-carbonitrile CAS No.
Cas:143612-79-7
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:143612-79-7
Min.Order:1 Gram
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
Cas:143612-79-7
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Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:143612-79-7
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:143612-79-7
Min.Order:10 Kilogram
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Type:Trading Company
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:143612-79-7
Min.Order:10 Gram
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Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:143612-79-7
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Type:Lab/Research institutions
inquiryProduct Name: 3-(4-Chlorbutyl)-1H-indol-5-carbonitril CAS: 143612-79-7 MF: C13H13ClN2 MW: 232.71 EINECS: 801-938-0 Mol File: 143612-79-7.mol 3-(4-Chlorbutyl)-1H-indol-5-carbonitril Structure 3-(4-Chlorbutyl)-1H-indol-5-carbonitril
Cas:143612-79-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:143612-79-7
Min.Order:1 Kilogram
FOB Price: $68.0 / 75.0
Type:Trading Company
inquiry3-(4-Chlorbutyl)-1H-indol-5-carbonitril CAS:143612-79-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high
Cas:143612-79-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:143612-79-7
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:143612-79-7
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Negotiable
Type:Lab/Research institutions
inquiryProduct Name: 3-(4-Chlorbutyl)-1H-indol-5-carbonitril Synonyms: 3-(4-Chlorbutyl)-1H-indol-5-carbonitril;3-(4-Chlorobutyl)indole-5-carbonitrile;Chlorobutyl)indole-5-carbonitrile, 3-(4-;Vilazodone interMediate;1H-Indole-5-carbonitrile, 3-(4-chloro
Cas:143612-79-7
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryAppearance:White or off white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:S
Cas:143612-79-7
Min.Order:100 Metric Ton
Negotiable
Type:Lab/Research institutions
inquirySpecification:USP/EP Month production ablity:50kg/Month Low price& High quality Manufacturer Appearance:white powder Storage:Room Temperature Application:143612-79-7
Cas:143612-79-7
Min.Order:0 Metric Ton
Negotiable
Type:Other
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:143612-79-7
Min.Order:0 Metric Ton
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Type:Lab/Research institutions
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:143612-79-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product
Cas:143612-79-7
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Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:143612-79-7
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Type:Lab/Research institutions
inquiryChemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Cas:143612-79-7
Min.Order:100 Gram
Negotiable
Type:Other
inquiry1. We can provide customers with "one-stop"packaging service,from research,development,production,export and so on 2. Powerful R&D strength let our technology in a leading level,forever,in turn,to provide customers with better service .
Cas:143612-79-7
Min.Order:100 Gram
FOB Price: $10.0 / 100.0
Type:Trading Company
inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:143612-79-7
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:143612-79-7
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiry3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In methanol at 50 - 55℃; under 1500.15 - 2250.23 Torr; for 5h; Autoclave; | 95.5% |
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In methanol at 50 - 55℃; under 1500.15 - 2250.23 Torr; for 5h; Reagent/catalyst; Autoclave; | 92.1% |
4-cyanophenyldiazonium tetrafluoroborate
6-chlorohexylzinc bromide
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
With formic acid In toluene at -44 - 120℃; under 228.015 Torr; for 1.33333h; Temperature; Solvent; Reagent/catalyst; Inert atmosphere; | 89% |
4-chlorobutyl bromide
1H-indole-5-carbonitrile
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
With zinc(II) chloride In dichloromethane at -10 - 5℃; for 2h; Temperature; | 88% |
N,N-dimethyl-formamide dimethyl acetal
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
Stage #1: 1-(2-nitro-5-cyano)phenyl-5-chloro-n-pentane; N,N-dimethyl-formamide dimethyl acetal With copper(l) chloride In N,N-dimethyl-formamide at 95 - 100℃; for 5h; Stage #2: With palladium 10% on activated carbon; hydrogen In methanol; N,N-dimethyl-formamide at 50 - 55℃; under 1500.15 - 2250.23 Torr; for 5h; Autoclave; | 87.7% |
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
With chloro-trimethyl-silane; sodium cyanoborohydride In acetonitrile at 0 - 30℃; | 87.2% |
Stage #1: 3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile With aluminum (III) chloride In tetrahydrofuran for 0.5h; Cooling with ice; Stage #2: With sodium tetrahydroborate In tetrahydrofuran Reagent/catalyst; | 80% |
With iron(III) chloride; borane-THF; hydrogen In tetrahydrofuran at 20℃; Reagent/catalyst; Temperature; Inert atmosphere; Flow reactor; | 71% |
trimethyl orthoformate
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
Stage #1: 1-(2-nitro-5-cyano)phenyl-5-chloro-n-pentane; trimethyl orthoformate With zinc(II) chloride In N,N-dimethyl-formamide at 100 - 105℃; for 5h; Stage #2: With palladium 10% on activated carbon; hydrogen In methanol; N,N-dimethyl-formamide at 50 - 55℃; under 1500.15 - 2250.23 Torr; for 5h; Autoclave; | 86.9% |
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
With phosphoric acid In water; toluene for 3h; Solvent; Time; Fischer Indole Synthesis; Reflux; | 74% |
With polyphosphoric acid In acetonitrile for 1h; Reflux; | 60% |
1-p-toluenesulfonyl-3-(4-chlorobutyl)-5-cyanoindole
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl acetamide at 60℃; for 5h; Inert atmosphere; | 65% |
1H-indole-5-carbonitrile
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 73 percent / isobutyl-AlCl2 / CH2Cl2 / 15 - 30 °C 2: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h View Scheme | |
Multi-step reaction with 2 steps 1: isobutylaluminum dichloride / dichloromethane 2: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran View Scheme | |
Multi-step reaction with 2 steps 1.1: titanium tetrachloride / dichloromethane / 0.75 h / 0 - 5 °C / Inert atmosphere 1.2: 5 h / 20 °C / Inert atmosphere 2.1: boron trifluoride diethyl etherate; sodium tetrahydroborate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: aluminum (III) chloride / 1,2-dichloro-ethane 2: sodium tetrahydroborate; boron trifluoride diethyl etherate View Scheme | |
Multi-step reaction with 2 steps 1.1: titanium tetrachloride / dichloromethane / 0.75 h / 0 - 5 °C / Inert atmosphere 1.2: 5 h / 20 °C 2.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere View Scheme |
6-chlorohexanal
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / toluene / 2 h / 0 - 20 °C 2: phosphoric acid / 65 - 75 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sulfuric acid / water; methanol / 0.33 h / 20 °C 1.2: 20 °C 2.1: phosphoric acid / toluene / 10.16 h / 20 - 60 °C View Scheme |
6-chloro-1-hexanol
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite; sodium hydrogencarbonate / toluene / 0 °C 2: triethylamine / toluene / 2 h / 0 - 20 °C 3: phosphoric acid / 65 - 75 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.67 h / -78 °C / Inert atmosphere 1.2: 0.5 h / -78 - 20 °C / Inert atmosphere 2.1: sulfuric acid / water; methanol / 0.33 h / 20 °C 2.2: 20 °C 3.1: phosphoric acid / toluene / 10.16 h / 20 - 60 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide / dichloromethane / 25 - 30 °C 1.2: 0 - 5 °C 2.1: sulfuric acid / water; N,N-dimethyl acetamide / 1 h / 25 - 35 °C 3.1: phosphoric acid / water; toluene / 3 h / Reflux View Scheme |
(Z)-4-(2-(6-chlorohexylidene)hydrazinyl)benzonitrile
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
With phosphoric acid at 65 - 75℃; |
4-[(2E)-2-(6-chlorohexylidene)hydrazinyl]benzonitrile
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
With phosphoric acid In toluene at 20 - 60℃; for 10.16h; Solvent; Temperature; |
4-Aminobenzonitrile
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium nitrite; hydrogenchloride / water / -10 °C 1.2: -10 °C 2.1: sulfuric acid / water; N,N-dimethyl acetamide / 1 h / 25 - 35 °C 3.1: phosphoric acid / water; toluene / 3 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: hydrogenchloride / water 1.2: 1 h / 2 °C 2.1: sodium hydrogensulfite / water / 2 h / 85 °C 2.2: 0.5 h / 50 °C 3.1: sulfuric acid / water; ethanol / 4 h / 80 °C View Scheme |
6-chlorohexanal
4-hydrazinobenzonitrile hydrochloride
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sulfuric acid / water; N,N-dimethyl acetamide / 1 h / 25 - 35 °C 2: phosphoric acid / water; toluene / 3 h / Reflux View Scheme | |
With sulfuric acid In ethanol; water at 80℃; for 4h; Reagent/catalyst; Temperature; Fischer Indole Synthesis; | 162 g |
4-hydrazinobenzonitrile hydrochloride
1,1-dimethoxy-6-chlorohexane
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
In methanol; water at 70 - 72℃; for 1h; Temperature; Inert atmosphere; | 8 g |
In methanol; water at 72℃; for 1h; Concentration; Solvent; Temperature; Inert atmosphere; | 9.5 g |
SD-169
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride / dichloromethane / 1 h / 5 °C / Cooling with ice; Large scale 1.2: 20 °C / Cooling with ice; Large scale 2.1: trichlorophosphate / dichloromethane / 10 °C / Cooling with ice; Large scale 3.1: diborane / dichloromethane / 4 h / 20 °C / Reflux; Large scale View Scheme |
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
With 5%-palladium/activated carbon; hydrogen In tetrahydrofuran at 10 - 15℃; under 1500.15 Torr; for 4h; Pressure; Temperature; | 17.2 g |
1-bromo-6-chlorohexane
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: zinc; iodine / N,N-dimethyl acetamide / 5 h / 60 °C / Inert atmosphere 2: formic acid / toluene / 1.33 h / -44 - 120 °C / 228.01 Torr / Inert atmosphere View Scheme |
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: zinc(II) chloride / N,N-dimethyl-formamide / 4 h / 100 - 105 °C 2: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 50 - 55 °C / 1500.15 - 2250.23 Torr / Autoclave View Scheme |
hexahydro-2H-oxepin-2-one
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: thionyl chloride / dichloromethane 2: formic acid 3: sulfuric acid / water; ethanol / 4 h / 80 °C View Scheme |
6-chlorohexanoyl chloride
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: formic acid 2: sulfuric acid / water; ethanol / 4 h / 80 °C View Scheme |
p-cyanobenzenediazonium chloride
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium hydrogensulfite / water / 2 h / 85 °C 1.2: 0.5 h / 50 °C 2.1: sulfuric acid / water; ethanol / 4 h / 80 °C View Scheme |
di-tert-butyl dicarbonate
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 40 - 45℃; for 24h; | 96.5% |
3-(4-chlorobutyl)-5-cyanoindole
5-(1-piperazinyl)benzofuran-2-carboxamide
vilazodone
Conditions | Yield |
---|---|
Stage #1: 3-(4-chlorobutyl)-5-cyanoindole With sodium iodide In N,N-dimethyl-formamide at 25 - 30℃; for 0.25h; Stage #2: 5-(1-piperazinyl)benzofuran-2-carboxamide With tetrabutylammomium bromide; sodium hydrogencarbonate In N,N-dimethyl-formamide at 110 - 115℃; for 1.25h; Reagent/catalyst; Temperature; Time; Solvent; | 95.7% |
With sodium carbonate In water at 90 - 100℃; | 94% |
Stage #1: 5-(1-piperazinyl)benzofuran-2-carboxamide With hydrogenchloride In water at 20 - 35℃; pH=6.5 - 7; Stage #2: 3-(4-chlorobutyl)-5-cyanoindole With sodium carbonate In water; isopropyl alcohol at 75 - 85℃; for 12h; Reagent/catalyst; pH-value; | 94% |
3-(4-chlorobutyl)-5-cyanoindole
5-(1-piperazinyl)benzofuran-2-carboxamide
Conditions | Yield |
---|---|
Stage #1: 3-(4-chlorobutyl)-5-cyanoindole With sodium iodide In N,N-dimethyl-formamide at 25 - 30℃; for 0.25h; Stage #2: 5-(1-piperazinyl)benzofuran-2-carboxamide With tetrabutylammomium bromide; sodium hydrogencarbonate In N,N-dimethyl-formamide at 110 - 115℃; for 1.25h; Temperature; Solvent; Reagent/catalyst; | 95.7% |
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
Stage #1: 5-(piperazin-1-yl)benzofuran-2-carboxamide hydrochloride With sodium carbonate; potassium iodide In N,N-dimethyl-formamide at 70℃; Stage #2: 3-(4-chlorobutyl)-5-cyanoindole In N,N-dimethyl-formamide at 80℃; for 12h; | 90.2% |
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
With sodium carbonate; sodium iodide In acetonitrile at 90℃; for 36h; | 86.4% |
With sodium carbonate; sodium iodide In acetonitrile at 90℃; for 36h; | 86.4% |
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
Stage #1: n-butyl 5-(piperazin-1-yl)-1-benzofuran-2-carboxylate hydrochloride; 3-(4-chlorobutyl)-5-cyanoindole With tetrabutylammomium bromide; triethylamine In acetone at 55 - 90℃; Stage #2: With hydrogenchloride In isopropyl alcohol at 50℃; pH=2; Reflux; | 85% |
3-(4-chlorobutyl)-5-cyanoindole
5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-benzofurancarboxylic acid ethyl ester hydrochloride
Conditions | Yield |
---|---|
Stage #1: ethyl 5-(1-piperazinyl)benzofuran-2-carboxylate dihydrochloride; 3-(4-chlorobutyl)-5-cyanoindole With tetrabutylammomium bromide; triethylamine at 85 - 90℃; for 10h; Stage #2: With hydrogenchloride In isopropyl alcohol at 50 - 55℃; pH=2; Reflux; | 83% |
Stage #1: ethyl 5-(1-piperazinyl)benzofuran-2-carboxylate dihydrochloride; 3-(4-chlorobutyl)-5-cyanoindole With potassium iodide In acetonitrile at 20℃; for 0.166667h; Stage #2: With potassium carbonate; triethylamine In acetonitrile at 20 - 80℃; for 20.16h; Reagent/catalyst; Solvent; | 48 g |
ethyl 5-(1-piperazinyl)benzofuran-2-carboxylate hydrobromide
3-(4-chlorobutyl)-5-cyanoindole
5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-benzofurancarboxylic acid ethyl ester hydrochloride
Conditions | Yield |
---|---|
Stage #1: ethyl 5-(1-piperazinyl)benzofuran-2-carboxylate hydrobromide; 3-(4-chlorobutyl)-5-cyanoindole With tetrabutylammomium bromide; triethylamine at 85 - 90℃; for 10h; Stage #2: With hydrogenchloride In isopropyl alcohol at 50 - 55℃; pH=2; Reflux; | 83% |
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
Stage #1: ethyl 5-(1-piperazinyl)benzofuran-2-carboxylate dihydrochloride; 3-(4-chlorobutyl)-5-cyanoindole With tetrabutylammomium bromide; triethylamine at 85 - 90℃; for 10h; Stage #2: With hydrogenchloride In isopropyl alcohol; acetone at 50℃; pH=2; Reflux; | 83% |
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
Stage #1: ethyl 5-(1-piperazinyl)benzofuran-2-carboxylate hydrobromide; 3-(4-chlorobutyl)-5-cyanoindole With tetrabutylammomium bromide; triethylamine at 85 - 90℃; for 10h; Stage #2: With hydrogenchloride In isopropyl alcohol; acetone at 50℃; pH=2; Reflux; | 83% |
3-(4-chlorobutyl)-5-cyanoindole
vilazodone
Conditions | Yield |
---|---|
With potassium hydrogencarbonate; sodium iodide In N,N-dimethyl-formamide at 95 - 105℃; for 20h; | 83% |
2-chloropyrimidine
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
Stage #1: 3-(4-chlorobutyl)-5-cyanoindole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Stage #2: 2-chloropyrimidine In N,N-dimethyl-formamide; mineral oil at 130℃; for 24h; | 83% |
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
With sodium carbonate; sodium iodide In acetonitrile at 90℃; for 36h; | 78.8% |
With sodium carbonate; sodium iodide In acetonitrile at 90℃; for 36h; | 78.8% |
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
With sodium carbonate; sodium iodide In acetonitrile at 90℃; for 36h; | 75.6% |
With sodium carbonate; sodium iodide In acetonitrile at 90℃; for 36h; | 75.6% |
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
With sodium carbonate; sodium iodide In acetonitrile at 90℃; for 36h; | 75.1% |
With sodium carbonate; sodium iodide In acetonitrile at 90℃; for 36h; | 75.1% |
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
With sodium carbonate; sodium iodide In acetonitrile at 90℃; for 36h; | 73.6% |
With sodium carbonate; sodium iodide In acetonitrile at 90℃; for 36h; | 73.6% |
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
With sodium carbonate; sodium iodide In acetonitrile at 90℃; for 36h; | 73.6% |
With sodium carbonate; sodium iodide In acetonitrile at 90℃; for 36h; | 73.6% |
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
With sodium carbonate; sodium iodide In acetonitrile at 90℃; for 36h; | 72.6% |
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
With sodium carbonate; sodium iodide In acetonitrile at 90℃; for 6h; | 72.6% |
3-(4-chlorobutyl)-5-cyanoindole
vilazodone
Conditions | Yield |
---|---|
Stage #1: n-propyl 5-(piperazin-1-yl)benzofuran-2-carboxylate; 3-(4-chlorobutyl)-5-cyanoindole With tetrabutylammomium bromide; potassium carbonate; potassium iodide In acetonitrile Reflux; Stage #2: With ammonium hydroxide In acetonitrile at 25 - 30℃; for 72h; | 72% |
4-piperazinylquinoline
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
With triethylamine; potassium iodide In acetonitrile for 24h; Reflux; | 72% |
methyl 5-(piperazin-1-yl)-1-benzofuran-2-carboxylate hydrochloride
3-(4-chlorobutyl)-5-cyanoindole
Conditions | Yield |
---|---|
Stage #1: methyl 5-(piperazin-1-yl)-1-benzofuran-2-carboxylate hydrochloride; 3-(4-chlorobutyl)-5-cyanoindole With tetrabutylammomium bromide; triethylamine In acetone at 55 - 90℃; Stage #2: With hydrogenchloride In isopropyl alcohol at 50℃; pH=2; Reflux; | 70% |
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