img _fcksaAppearance:yellowish to pale orange crystals or cryst. powder Storage:Store in dry, dark and ventilated place. Package:according to the clients requirement Application:Pharmaceutical Intermediates Transportation:by sea or by air Port:Shan
Cas:1722-12-9
Min.Order:100 Gram
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Type:Lab/Research institutions
inquiryProduct informations Product Name 2-Chloropyrimidine CAS No. 1722-12-9 Appearan
Cas:1722-12-9
Min.Order:1 Gram
FOB Price: $8.0
Type:Lab/Research institutions
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:1722-12-9
Min.Order:1 Metric Ton
FOB Price: $1.0 / 3.0
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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Cas:1722-12-9
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:1722-12-9
Min.Order:1 Kilogram
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Type:Manufacturers
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Cas:1722-12-9
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryTIANFUCHEM--1722-12-9--2-Chloropyrimidine factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business rel
Cas:1722-12-9
Min.Order:1 Metric Ton
FOB Price: $2000.0
Type:Lab/Research institutions
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:1722-12-9
Min.Order:1 Kilogram
FOB Price: $9.0 / 99.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:1722-12-9
Min.Order:10 Gram
FOB Price: $146.0 / 176.0
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:1722-12-9
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryName: 2-Chloropyrimidine Synonyms: 2-Chloro Pyridine CAS:1722-12-9 MF: C4H3ClN2 Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25kg/drum Application:Syntheses Material Intermediates Transportation:By
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white to light yellow crystalline powder Storage:Store in se
Cas:1722-12-9
Min.Order:100 Gram
Negotiable
Type:Other
inquiry2-chloropyrimidine (CAS: 1722-12-9) Name 2-Chloropyrimidine Molecular Structure Molecular Formula C4H3ClN2 Molecular Weight 114.53 CAS Registry Numb
1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:1722-12-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:1722-12-9
Min.Order:1 Kilogram
FOB Price: $132.0 / 150.0
Type:Trading Company
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:1722-12-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryMinimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,
Cas:1722-12-9
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiry2-Chloropyrimidine CAS: 1722-12-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inte
Cas:1722-12-9
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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Product Name: 2-Chloropyrimidine CAS No.:1722-12-9 MF:C7H12CIN3 MW:173.64 Assay : 98% Packaging: 1kg/Bag, 25kg/Drum or depends on your requirements. Shipping: Timely delivery after your payment Superiority : ISO certificate 2. Pow
Cas:1722-12-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryTriumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:1722-12-9
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:1722-12-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:1722-12-9
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiry2-Chloropyrimidine CAS 1722-12-9 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality contro
Cas:1722-12-9
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryNewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Conditions | Yield |
---|---|
With trichlorophosphate Chlorination; | 70% |
2-sulfanylpyrimidine
2-chloropyrimidine
Conditions | Yield |
---|---|
Stage #1: 2-sulfanylpyrimidine With trichloroisocyanuric acid; water; benzyltrimethylammonium chloride In acetonitrile at -30 - -25℃; for 0.5h; Stage #2: With isobutylamine In acetonitrile Further stages.; | 70% |
With hydrogenchloride; sodium hypochlorite In dichloromethane; water | |
With thionyl chloride; dihydrogen peroxide In water; acetonitrile at 25℃; |
(2-chloropyrimidin-5-yl)boronic acid
2-chloropyrimidine
Conditions | Yield |
---|---|
With 2-bromo-pyridine; tetrakis(triphenylphosphine) palladium(0); sodium carbonate In ethanol; toluene Reflux; | 65% |
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran for 24h; Heating; | A 30% B 50% |
triethylaluminum
5-Bromo-2-chloropyrimidine
A
2-chloropyrimidine
B
2-chloro-5-ethylpyrimidine
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran for 24h; Heating; | A 30% B 42% |
2,6-Dichloropyrimidine
triethylaluminum
A
2-chloropyrimidine
B
2-chloro-4-ethylpyrimidine
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran for 24h; Heating; | A 25% B 37% |
Conditions | Yield |
---|---|
With hydrogenchloride; sodium nitrite In water at -15 - 0℃; for 2.25h; | 34% |
With hydrogenchloride; sodium nitrite | |
With hydrogenchloride; zinc(II) chloride; sodium nitrite In dichloromethane; water | |
With hydrogenchloride; zinc(II) chloride; sodium nitrite In dichloromethane; water | |
With hydrogenchloride; copper dichloride; sodium nitrite In dichloromethane |
Conditions | Yield |
---|---|
With zinc | |
With potassium acetate; palladium diacetate; bis(pinacol)diborane; tricyclohexylphosphine In 1,4-dioxane at 110℃; for 0.166667h; Inert atmosphere; | |
With hydrogen In methanol; ethanol at 20℃; |
2-pyrimidinone hydrochloride
2-chloropyrimidine
Conditions | Yield |
---|---|
With phosphorus pentachloride; trichlorophosphate | |
With trichlorophosphate |
1-methyl-1H-pyrazole
chloroform
A
1H-pyrrole-2-carbonitrile
B
2-chloropyrimidine
C
5-chloronicotinonitrile
Conditions | Yield |
---|---|
at 550 - 555℃; Yield given. Title compound not separated from byproducts; | |
at 550 - 555℃; Title compound not separated from byproducts; |
1-benzylpyrazole
chloroform
A
2-chloropyrimidine
B
2-phenylpyrimidine
C
α-carboline
Conditions | Yield |
---|---|
at 550 - 555℃; Title compound not separated from byproducts; |
Conditions | Yield |
---|---|
at 550 - 555℃; Title compound not separated from byproducts; |
Conditions | Yield |
---|---|
at 550 - 555℃; Title compound not separated from byproducts; |
chloroform
1-(pyridin-4-ylmethyl)-1H-pyrazol-5-amine
A
NH-pyrazole
B
2-chloropyrimidine
Conditions | Yield |
---|---|
at 550 - 555℃; Title compound not separated from byproducts; | |
at 550 - 555℃; |
chloroform
1-(4-chlorobenzyl)pyrazole
A
NH-pyrazole
B
2-chloropyrimidine
D
2-(4-chlorophenyl)pyrimidine
Conditions | Yield |
---|---|
at 550 - 555℃; Title compound not separated from byproducts; |
1-(pyridin-4-ylmethyl)-1H-pyrazol-5-amine
A
NH-pyrazole
B
2-chloropyrimidine
Conditions | Yield |
---|---|
With chloroform at 550 - 555℃; Title compound not separated from byproducts; |
1-(4-chlorobenzyl)pyrazole
A
NH-pyrazole
B
2-chloropyrimidine
D
2-(4-chlorophenyl)pyrimidine
Conditions | Yield |
---|---|
With chloroform at 550 - 555℃; Title compound not separated from byproducts; |
Conditions | Yield |
---|---|
With potassium carbonate In ethanol |
2-Amino-4,6-dichloropyrimidine
2-(4-Methoxyphenyl)ethanol
2-chloropyrimidine
Conditions | Yield |
---|---|
With NaH In tetrahydrofuran |
2-Amino-4,6-dichloropyrimidine
1-(2-Chloroethyl)-4-methoxybenzene
2-chloropyrimidine
Conditions | Yield |
---|---|
With Na2S In water; N,N-dimethyl-formamide |
Conditions | Yield |
---|---|
With sodium bicarbonate; trifluoroacetic acid In dichloromethane |
2-chloropyrimidine
Conditions | Yield |
---|---|
In chloroform-d1; water at 20℃; |
2-chloropyrimidine
1,4,10,13-tetraoxa-7,16-diazacyclooctadecane
7,16-Di-pyrimidin-2-yl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadecane
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 100℃; under 6000480 Torr; for 96h; | 100% |
2-chloropyrimidine
allylmagnesium bromide
4-allyl-2-chloro-3,4-dihydropyrimidine
Conditions | Yield |
---|---|
In tetrahydrofuran for 0.25h; Ambient temperature; | 100% |
Conditions | Yield |
---|---|
With NmN'''-(butane-1,4-diyl)bisguanidine for 16h; Heating; | 100% |
2-chloropyrimidine
tert.-butyl lithium
4-(tert-butyl)-2-chloropyrimidine
Conditions | Yield |
---|---|
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In diethyl ether at -30 - 0℃; for 1h; | 100% |
With acetic acid; bunazosin In tetrahydrofuran at -78℃; for 3h; |
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride; 2-aminopyrimidine-4,6-diol; copper(I) bromide at 145 - 150℃; for 24h; | 100% |
With potassium carbonate In dimethyl sulfoxide at 70℃; for 24h; Inert atmosphere; | 95% |
With 1-methyl-3-(2-pyridinyl)-3,4,5,6-tetrahydropyrimidin-3-ium hexafluorophosphate; potassium tert-butylate; palladium diacetate In 1,2-dimethoxyethane at 100℃; for 0.666667h; Buchwald-Hartwig Coupling; Microwave irradiation; | 93% |
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride; 2-aminopyrimidine-4,6-diol; copper(I) bromide at 145 - 150℃; for 24h; | 100% |
With copper(I) oxide; 1,10-Phenanthroline; tetrabutyl ammonium fluoride at 140 - 145℃; for 24h; | 98% |
Stage #1: 2-methylimidazole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Stage #2: 2-chloropyrimidine In N,N-dimethyl-formamide; mineral oil at 130℃; | 89% |
With potassium phosphate; benzoin oxime; copper diacetate In dimethyl sulfoxide at 80℃; Inert atmosphere; | 80% |
With copper; caesium carbonate; methyl-alpha-D-glucopyranoside In water; dimethyl sulfoxide at 110℃; for 14h; Sealed tube; Green chemistry; | 80% |
2-chloropyrimidine
2-pivaloylaminophenyl boronic acid
2,2-dimethyl-N-(2-pyrimidin-2-yl-phenyl)-propionamide
Conditions | Yield |
---|---|
Stage #1: 2-chloropyrimidine; tetrakis(triphenylphosphine) palladium(0) In glyco dimethyl ether at 15 - 25℃; for 0.333333 - 0.5h; Stage #2: 2-pivaloylaminophenyl boronic acid With sodium carbonate In 1,2-dimethoxyethane; water at 78 - 83℃; for 3h; Heating / reflux; | 100% |
With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran; water at 20 - 83℃; | |
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water at 0 - 83℃; for 4.33333 - 5.5h; Heating / reflux; | |
With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water at 83℃; for 11h; |
Conditions | Yield |
---|---|
With potassium carbonate; hydrazine hydrate at 100℃; for 0.5h; | 99.8% |
With hydrazine In pyridine at 25℃; for 1.5h; | 95% |
With hydrazine hydrate In ethanol Reflux; | 87% |
Conditions | Yield |
---|---|
With potassium phosphate; bis(η3-allyl-μ-chloropalladium(II)); 1,2-bis(diphenylphosphino)-1'-(diisopropylphosphino)-3',4-di-tert-butyl ferrocene In toluene at 115℃; for 20h; Inert atmosphere; | 99% |
With copper; caesium carbonate In N,N-dimethyl-formamide at 100℃; for 0.166667h; Ullmann ether synthesis; microwave irradiation; | 97% |
With 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate; copper(l) chloride In 1-methyl-pyrrolidin-2-one at 120℃; for 24h; Ullmann coupling; Inert atmosphere; | 65% |
Conditions | Yield |
---|---|
With potassium carbonate In neat (no solvent) at 160℃; for 3h; Schlenk technique; Inert atmosphere; | 99% |
With copper(l) iodide; caesium carbonate In N,N-dimethyl-formamide at 20 - 100℃; for 24.5h; | 97% |
With copper(l) iodide; caesium carbonate In N,N-dimethyl-formamide at 120℃; for 40h; | 97% |
2-chloropyrimidine
para-methylphenylmagnesium bromide
2-p-tolyl-pyrimidine
Conditions | Yield |
---|---|
With N-heterocyclic carbene-based nickel(II) complex In tetrahydrofuran at 20℃; for 12h; Kumada reaction; | 99% |
With chloro(1,3-bis(pyridin-2-ylmethyl)imidazolylidene)nickel(II) hexafluorophosphate In tetrahydrofuran at 20℃; for 12h; Kumada-Corriu coupling reaction; Inert atmosphere; | 99% |
With C16H16Cl2CoN8(1+)*F6P(1-) In tetrahydrofuran at 20℃; for 2h; Kumada-Corriu cross-coupling; | 97% |
With (IPr)Ni(π-allyl)Cl In tetrahydrofuran at 20℃; for 24h; Kumada Cross-Coupling; Inert atmosphere; | 74% |
With [Ni(1-(1-ethyl-benzimidazol-2-ylmethyl)-3-mesitylimidazolin-2-ylidene)2][Cl]2; sodium acetate In tetrahydrofuran at 20℃; Kumada-Corriu coupling reaction; Inert atmosphere; |
Conditions | Yield |
---|---|
With C21H18N8Ni2O(2+)*2F6P(1-) In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 20 - 80℃; Negishi coupling reaction; | 99% |
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,4-dioxane at 90℃; Suzuki coupling reaction; | 99% |
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,4-dioxane at 90℃; Suzuki coupling; | 93% |
Suzuki coupling; |
2-chloropyrimidine
propan-1-ol-3-amine
3-(pyrimidin-2-ylamino)propan-1-ol
Conditions | Yield |
---|---|
In ethanol for 18h; Reflux; Inert atmosphere; | 99% |
With triethylamine In butan-1-ol at 125℃; for 1h; Temperature; Inert atmosphere; Microwave irradiation; | 87% |
2-chloropyrimidine
tert-butyl 2-[(R)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonane-7-carboxylate
tert-butyl 2-[(R)-5-(pyrimidin-2-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonane-7-carboxylate
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane; water Suzuki Coupling; Inert atmosphere; Heating; | 99% |
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In water at 100℃; for 18h; Suzuki Coupling; |
Conditions | Yield |
---|---|
Stage #1: 2-(Trimethylsilyl)ethanol With sodium hydride In tetrahydrofuran at 0℃; for 1h; Stage #2: 2-chloropyrimidine In tetrahydrofuran at 25℃; for 24h; | 99% |
4,4-ethylenedioxycyclohexan-1-ol
2-chloropyrimidine
2-(1,4-dioxaspiro[4.5]decan-8-yloxy)pyrimidine
Conditions | Yield |
---|---|
Stage #1: 4,4-ethylenedioxycyclohexan-1-ol With 1H-imidazole; sodium hydride In N,N-dimethyl acetamide; mineral oil at 20℃; for 0.5h; Cooling with ice; Stage #2: 2-chloropyrimidine In N,N-dimethyl acetamide; mineral oil at 20 - 60℃; for 3.5h; | 98.59% |
Stage #1: 4,4-ethylenedioxycyclohexan-1-ol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 0.5h; Stage #2: 2-chloropyrimidine In N,N-dimethyl-formamide; mineral oil at 0 - 70℃; for 17h; | 97% |
Stage #1: 4,4-ethylenedioxycyclohexan-1-ol With sodium hydride In N,N-dimethyl-formamide for 0.333333h; Stage #2: 2-chloropyrimidine at 20 - 100℃; for 9.5h; | |
Stage #1: 4,4-ethylenedioxycyclohexan-1-ol With sodium hydride In N,N-dimethyl-formamide for 0.333333h; Stage #2: 2-chloropyrimidine In N,N-dimethyl-formamide at 100℃; for 9h; |
Conditions | Yield |
---|---|
With cesium acetate; copper In dimethyl sulfoxide at 110℃; for 24h; Inert atmosphere; | 98% |
at 100℃; for 0.1h; microwave irradiation; | 91% |
With triethylamine In ethanol at 120℃; for 0.0833333h; Microwave irradiation; | 89% |
2-chloropyrimidine
(2-propoxyphenyl)boronic acid
2-(2-Propoxyphenyl)pyrimidine
Conditions | Yield |
---|---|
<1,4-bis-(diphenylphosphine)butane>palladium(II) | 98% |
With sodium carbonate; [1,4-bis(diphenylphosphino)butane] palladium(ll) dichloride In ethanol; toluene for 24h; Heating; | 98% |
2-chloropyrimidine
2-Methylphenylboronic acid
2-(2-methylphenyl)pyrimidine
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,4-dioxane at 90℃; Suzuki coupling reaction; | 98% |
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,4-dioxane at 90℃; Suzuki coupling; | 93% |
With Tedicyp; potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)) In xylene at 130℃; for 20h; Suzuki cross-coupling reaction; | 87% |
Suzuki coupling; |
2-chloropyrimidine
5-(pyrimidin-2-yl)-2,3-dihydro-1H-inden-1-one
Conditions | Yield |
---|---|
With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,2-dimethoxyethane; water at 20 - 95℃; Inert atmosphere; | 98% |
With sodium carbonate In 1,2-dimethoxyethane at 95℃; Suzuki Coupling; Inert atmosphere; | 41% |
Conditions | Yield |
---|---|
With bis(η3-allyl-μ-chloropalladium(II)); 1,1',3,3'-tetrakis(diphenylphosphino)ferrocene; sodium t-butanolate In toluene for 17h; Catalytic behavior; Inert atmosphere; Schlenk technique; Heating; | 98% |
With fac-tris[2-phenylpyridinato-C2,N]iridium(III); caesium carbonate In N,N-dimethyl-formamide at 25℃; for 18h; Schlenk technique; Inert atmosphere; Irradiation; | 83% |
Stage #1: 2-chloropyrimidine With tris-(dibenzylideneacetone)dipalladium(0); triethylamine In toluene at 115℃; for 1h; Inert atmosphere; Schlenk technique; Stage #2: thiophenol In toluene at 115℃; for 24h; Reagent/catalyst; Time; Inert atmosphere; Schlenk technique; | 72% |
Conditions | Yield |
---|---|
With C50H61Cl2N3Pd; potassium tert-butylate In 1,4-dioxane at 100℃; for 2h; | 98% |
With C48H55ClN2Pd; sodium t-butanolate In 1,2-dimethoxyethane at 20℃; for 16h; Inert atmosphere; Sealed tube; | 98% |
With potassium carbonate In tetrahydrofuran for 2h; Reflux; | 44% |
Conditions | Yield |
---|---|
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; zinc diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; for 16h; Buchwald-Hartwig Coupling; Inert atmosphere; | 98% |
2-chloropyrimidine
N,N-dimethyloctanamide
A
2-(dimethylamino)pyrimidine
B
Methyl-octyl-pyrimidin-2-yl-amine
Conditions | Yield |
---|---|
In tetrahydrofuran at 100℃; under 6000480 Torr; for 96h; | A 2% B 97% |
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,4-dioxane at 90℃; Suzuki coupling reaction; | 97% |
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,4-dioxane at 90℃; | 95% |
With oxygen; palladium diacetate; sodium carbonate In 1,4-dioxane at 90℃; Suzuki Coupling; | 93% |
2-chloropyrimidine
2-fluoropyrimidine
Conditions | Yield |
---|---|
With hydrogen fluoride at 50℃; for 1h; other aromatic halides, var. temp., also with HF-base systems; | 97% |
With hydrogen fluoride at 50℃; for 1h; | 97% |
2-chloropyrimidine
1-aza-18-crown-6
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 100℃; under 6000480 Torr; for 96h; | 97% |
Conditions | Yield |
---|---|
for 3h; Reflux; | 97% |
at 20℃; for 2h; | 95% |
for 2h; Heating; Yield given; |
Conditions | Yield |
---|---|
In N,N,N,N,N,N-hexamethylphosphoric triamide at 85℃; for 0.00833333h; microwave irradiation; | 97% |
In ethanol for 4h; Heating; | 14% |
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