2-Chloropyrimidine supplier

Name
2-Chloropyrimidine
EINECS 217-020-2
CAS No. 1722-12-9
Article Data42
CAS DataBase
Density 1.303 g/cm³
Solubility Slightly soluble in water. 33.3 mg soluble in 1 mL of alcohol.
Melting Point 63-66 °C(lit.)
Formula C₄H₃ClN₂
Boiling Point 199.2 °C at 760 mmHg
Molecular Weight 114.534
Flash Point 109.2 °C
Transport Information
Appearance yellowish to pale orange crystals or cryst. powder
Safety 26-37/39-36
Risk Codes 22-36-36/38-36/37/38
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms 2 Chloro Pyridine;2-Chlorpyrimidin;2-Chloro-4-deoxyuracil;2-Chloropyrimidine D001;Pyrimidine, 2-chloro-;
PSA 25.78000
LogP 1.13000

Synthetic route

: 557-01-7
2-hydroxypyrimidine

: 1722-12-9
2-chloropyrimidine

Conditions

Conditions	Yield
With trichlorophosphate Chlorination;	70%

: 131242-36-9
2-sulfanylpyrimidine

: 1722-12-9
2-chloropyrimidine

Conditions

Conditions	Yield
Stage #1: 2-sulfanylpyrimidine With trichloroisocyanuric acid; water; benzyltrimethylammonium chloride In acetonitrile at -30 - -25℃; for 0.5h; Stage #2: With isobutylamine In acetonitrile Further stages.;	70%
With hydrogenchloride; sodium hypochlorite In dichloromethane; water
With thionyl chloride; dihydrogen peroxide In water; acetonitrile at 25℃;

: 1003845-06-4
(2-chloropyrimidin-5-yl)boronic acid

: 1722-12-9
2-chloropyrimidine

Conditions

Conditions	Yield
With 2-bromo-pyridine; tetrakis(triphenylphosphine) palladium(0); sodium carbonate In ethanol; toluene Reflux;	65%

: 100-99-2
triisobutylaluminum

: 32779-36-5
5-Bromo-2-chloropyrimidine

A: 1722-12-9
2-chloropyrimidine

B: 2-chloro-5-isobutylpyrimidine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran for 24h; Heating;	A 30% B 50%

...Expand

: 97-93-8
triethylaluminum

: 32779-36-5
5-Bromo-2-chloropyrimidine

A: 1722-12-9
2-chloropyrimidine

B: 111196-81-7
2-chloro-5-ethylpyrimidine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran for 24h; Heating;	A 30% B 42%

...Expand

: 3934-20-1
2,6-Dichloropyrimidine

: 97-93-8
triethylaluminum

A: 1722-12-9
2-chloropyrimidine

B: 188707-99-5
2-chloro-4-ethylpyrimidine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran for 24h; Heating;	A 25% B 37%

...Expand

: 109-12-6
2-aminopyrimidine

: 1722-12-9
2-chloropyrimidine

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite In water at -15 - 0℃; for 2.25h;	34%
With hydrogenchloride; sodium nitrite
With hydrogenchloride; zinc(II) chloride; sodium nitrite In dichloromethane; water
With hydrogenchloride; zinc(II) chloride; sodium nitrite In dichloromethane; water
With hydrogenchloride; copper dichloride; sodium nitrite In dichloromethane

: 3934-20-1
2,6-Dichloropyrimidine

: 1722-12-9
2-chloropyrimidine

Conditions

Conditions	Yield
With zinc
With potassium acetate; palladium diacetate; bis(pinacol)diborane; tricyclohexylphosphine In 1,4-dioxane at 110℃; for 0.166667h; Inert atmosphere;
With hydrogen In methanol; ethanol at 20℃;

: 38353-09-2
2-pyrimidinone hydrochloride

: 1722-12-9
2-chloropyrimidine

Conditions

Conditions	Yield
With phosphorus pentachloride; trichlorophosphate
With trichlorophosphate

: 930-36-9
1-methyl-1H-pyrazole

: 67-66-3
chloroform

A: 4513-94-4
1H-pyrrole-2-carbonitrile

B: 1722-12-9
2-chloropyrimidine

C: 51269-82-0
5-chloronicotinonitrile

Conditions

Conditions	Yield
at 550 - 555℃; Yield given. Title compound not separated from byproducts;
at 550 - 555℃; Title compound not separated from byproducts;

...Expand

: 10199-67-4
1-benzylpyrazole

: 67-66-3
chloroform

A: 1722-12-9
2-chloropyrimidine

B: 7431-45-0
2-phenylpyrimidine

C: 244-76-8
α-carboline

Conditions

Conditions	Yield
at 550 - 555℃; Title compound not separated from byproducts;

...Expand

: 67-66-3
chloroform

: 1-benzhydryl-1H-pyrazole

A: 1722-12-9
2-chloropyrimidine

B: 7431-45-0
2-phenylpyrimidine

Conditions

Conditions	Yield
at 550 - 555℃; Title compound not separated from byproducts;

...Expand

: 67-66-3
chloroform

: CDD3502

A: 1722-12-9
2-chloropyrimidine

B: 7431-45-0
2-phenylpyrimidine

Conditions

Conditions	Yield
at 550 - 555℃; Title compound not separated from byproducts;

...Expand

: 67-66-3
chloroform

: 202344-41-0
1-(pyridin-4-ylmethyl)-1H-pyrazol-5-amine

A: 288-13-1
NH-pyrazole

B: 1722-12-9
2-chloropyrimidine

C: 9H-pyrrolo[2,3-b:5,4-c']dipyridine

Conditions

Conditions	Yield
at 550 - 555℃; Title compound not separated from byproducts;
at 550 - 555℃;

...Expand

: 67-66-3
chloroform

: 202344-37-4
1-(4-chlorobenzyl)pyrazole

A: 288-13-1
NH-pyrazole

B: 1722-12-9
2-chloropyrimidine

C: 7-chloro-9H-pyrido[2,3-b]indole

D: 191212-20-1
2-(4-chlorophenyl)pyrimidine

Conditions

Conditions	Yield
at 550 - 555℃; Title compound not separated from byproducts;

...Expand

: 202344-41-0
1-(pyridin-4-ylmethyl)-1H-pyrazol-5-amine

A: 288-13-1
NH-pyrazole

B: 1722-12-9
2-chloropyrimidine

C: 9H-pyrrolo[2,3-b:5,4-c']dipyridine

Conditions

Conditions	Yield
With chloroform at 550 - 555℃; Title compound not separated from byproducts;

...Expand

: 202344-37-4
1-(4-chlorobenzyl)pyrazole

A: 288-13-1
NH-pyrazole

B: 1722-12-9
2-chloropyrimidine

C: 7-chloro-9H-pyrido[2,3-b]indole

D: 191212-20-1
2-(4-chlorophenyl)pyrimidine

Conditions

Conditions	Yield
With chloroform at 550 - 555℃; Title compound not separated from byproducts;

...Expand

: 3934-20-1
2,6-Dichloropyrimidine

: 7664-41-7
ammonia

: 71-43-2
benzene

zinc-powder: zinc-powder

aqueous NaCl: aqueous NaCl

: 1722-12-9
2-chloropyrimidine

...Expand

: 3934-20-1
2,6-Dichloropyrimidine

zinc-powder: zinc-powder

aqueous NH4Cl: aqueous NH4Cl

: 1722-12-9
2-chloropyrimidine

...Expand

: 56-05-3
2-Amino-4,6-dichloropyrimidine

: 55-81-2
4-Methoxyphenethylamine

: 1722-12-9
2-chloropyrimidine

Conditions

Conditions	Yield
With potassium carbonate In ethanol

: 56-05-3
2-Amino-4,6-dichloropyrimidine

: 702-23-8
2-(4-Methoxyphenyl)ethanol

: 1722-12-9
2-chloropyrimidine

Conditions

Conditions	Yield
With NaH In tetrahydrofuran

: 56-05-3
2-Amino-4,6-dichloropyrimidine

: 18217-00-0
1-(2-Chloroethyl)-4-methoxybenzene

: 1722-12-9
2-chloropyrimidine

Conditions

Conditions	Yield
With Na2S In water; N,N-dimethyl-formamide

: 2-chloro-4-(2-(4-tert-butoxycarbonylpiperazin-1-yl)pyridin-5-yl)pyrimidine

: 2937-50-0
Allyl chloroformate

: 1722-12-9
2-chloropyrimidine

Conditions

Conditions	Yield
With sodium bicarbonate; trifluoroacetic acid In dichloromethane

: pyrimidine-2-sulfonyl chloride

: 1722-12-9
2-chloropyrimidine

Conditions

Conditions	Yield
In chloroform-d1; water at 20℃;

: 1722-12-9
2-chloropyrimidine

: 23978-55-4
1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

: 130536-58-2
7,16-Di-pyrimidin-2-yl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadecane

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 100℃; under 6000480 Torr; for 96h;	100%

: 1722-12-9
2-chloropyrimidine

: 1730-25-2
allylmagnesium bromide

: 123703-54-8
4-allyl-2-chloro-3,4-dihydropyrimidine

Conditions

Conditions	Yield
In tetrahydrofuran for 0.25h; Ambient temperature;	100%

: 1722-12-9
2-chloropyrimidine

: 64-17-5
ethanol

: 3739-82-0
2-ethoxy pyrimidine

Conditions

Conditions	Yield
With NmN'''-(butane-1,4-diyl)bisguanidine for 16h; Heating;	100%

: 1722-12-9
2-chloropyrimidine

: 594-19-4
tert.-butyl lithium

: 66522-06-3
4-(tert-butyl)-2-chloropyrimidine

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In diethyl ether at -30 - 0℃; for 1h;	100%
With acetic acid; bunazosin In tetrahydrofuran at -78℃; for 3h;

: 1722-12-9
2-chloropyrimidine

: 51-17-2
benzoimidazole

: 1-(pyrimidin-2-yl)-1H-benzo[d]imidazole

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride; 2-aminopyrimidine-4,6-diol; copper(I) bromide at 145 - 150℃; for 24h;	100%
With potassium carbonate In dimethyl sulfoxide at 70℃; for 24h; Inert atmosphere;	95%
With 1-methyl-3-(2-pyridinyl)-3,4,5,6-tetrahydropyrimidin-3-ium hexafluorophosphate; potassium tert-butylate; palladium diacetate In 1,2-dimethoxyethane at 100℃; for 0.666667h; Buchwald-Hartwig Coupling; Microwave irradiation;	93%

: 1722-12-9
2-chloropyrimidine

: 693-98-1
2-methylimidazole

: 2-(2-methyl-1H-imidazol-1-yl)pyrimidine

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride; 2-aminopyrimidine-4,6-diol; copper(I) bromide at 145 - 150℃; for 24h;	100%
With copper(I) oxide; 1,10-Phenanthroline; tetrabutyl ammonium fluoride at 140 - 145℃; for 24h;	98%
Stage #1: 2-methylimidazole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Stage #2: 2-chloropyrimidine In N,N-dimethyl-formamide; mineral oil at 130℃;	89%
With potassium phosphate; benzoin oxime; copper diacetate In dimethyl sulfoxide at 80℃; Inert atmosphere;	80%
With copper; caesium carbonate; methyl-alpha-D-glucopyranoside In water; dimethyl sulfoxide at 110℃; for 14h; Sealed tube; Green chemistry;	80%

: 1722-12-9
2-chloropyrimidine

: 146140-95-6
2-pivaloylaminophenyl boronic acid

: 797047-16-6
2,2-dimethyl-N-(2-pyrimidin-2-yl-phenyl)-propionamide

Conditions

Conditions	Yield
Stage #1: 2-chloropyrimidine; tetrakis(triphenylphosphine) palladium(0) In glyco dimethyl ether at 15 - 25℃; for 0.333333 - 0.5h; Stage #2: 2-pivaloylaminophenyl boronic acid With sodium carbonate In 1,2-dimethoxyethane; water at 78 - 83℃; for 3h; Heating / reflux;	100%
With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran; water at 20 - 83℃;
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water at 0 - 83℃; for 4.33333 - 5.5h; Heating / reflux;
With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water at 83℃; for 11h;

: 1722-12-9
2-chloropyrimidine

: 7504-94-1
2-pyrimidinylhydrazine

Conditions

Conditions	Yield
With potassium carbonate; hydrazine hydrate at 100℃; for 0.5h;	99.8%
With hydrazine In pyridine at 25℃; for 1.5h;	95%
With hydrazine hydrate In ethanol Reflux;	87%

: 1722-12-9
2-chloropyrimidine

: 108-95-2
phenol

: 18213-90-6
2-phenoxypyrimidine

Conditions

Conditions	Yield
With potassium phosphate; bis(η3-allyl-μ-chloropalladium(II)); 1,2-bis(diphenylphosphino)-1'-(diisopropylphosphino)-3',4-di-tert-butyl ferrocene In toluene at 115℃; for 20h; Inert atmosphere;	99%
With copper; caesium carbonate In N,N-dimethyl-formamide at 100℃; for 0.166667h; Ullmann ether synthesis; microwave irradiation;	97%
With 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate; copper(l) chloride In 1-methyl-pyrrolidin-2-one at 120℃; for 24h; Ullmann coupling; Inert atmosphere;	65%

: 288-32-4
1H-imidazole

: 1722-12-9
2-chloropyrimidine

: 134914-65-1
2-(1H-imidazol-1-yl)pyrimidine

Conditions

Conditions	Yield
With potassium carbonate In neat (no solvent) at 160℃; for 3h; Schlenk technique; Inert atmosphere;	99%
With copper(l) iodide; caesium carbonate In N,N-dimethyl-formamide at 20 - 100℃; for 24.5h;	97%
With copper(l) iodide; caesium carbonate In N,N-dimethyl-formamide at 120℃; for 40h;	97%

: 1722-12-9
2-chloropyrimidine

: 4294-57-9
para-methylphenylmagnesium bromide

: 77232-13-4
2-p-tolyl-pyrimidine

Conditions

Conditions	Yield
With N-heterocyclic carbene-based nickel(II) complex In tetrahydrofuran at 20℃; for 12h; Kumada reaction;	99%
With chloro(1,3-bis(pyridin-2-ylmethyl)imidazolylidene)nickel(II) hexafluorophosphate In tetrahydrofuran at 20℃; for 12h; Kumada-Corriu coupling reaction; Inert atmosphere;	99%
With C16H16Cl2CoN8(1+)*F6P(1-) In tetrahydrofuran at 20℃; for 2h; Kumada-Corriu cross-coupling;	97%
With (IPr)Ni(π-allyl)Cl In tetrahydrofuran at 20℃; for 24h; Kumada Cross-Coupling; Inert atmosphere;	74%
With [Ni(1-(1-ethyl-benzimidazol-2-ylmethyl)-3-mesitylimidazolin-2-ylidene)2][Cl]2; sodium acetate In tetrahydrofuran at 20℃; Kumada-Corriu coupling reaction; Inert atmosphere;

: 1722-12-9
2-chloropyrimidine

: 90252-89-4
p-tolylzinc(II) chloride

: 77232-13-4
2-p-tolyl-pyrimidine

Conditions

Conditions	Yield
With C21H18N8Ni2O(2+)*2F6P(1-) In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 20 - 80℃; Negishi coupling reaction;	99%

: 1722-12-9
2-chloropyrimidine

: 17933-03-8
m-tolylboronic acid

: 2-(3-methylphenyl)-pyrimidine

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,4-dioxane at 90℃; Suzuki coupling reaction;	99%
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,4-dioxane at 90℃; Suzuki coupling;	93%
Suzuki coupling;

: 1722-12-9
2-chloropyrimidine

: 156-87-6
propan-1-ol-3-amine

: 959052-29-0
3-(pyrimidin-2-ylamino)propan-1-ol

Conditions

Conditions	Yield
In ethanol for 18h; Reflux; Inert atmosphere;	99%
With triethylamine In butan-1-ol at 125℃; for 1h; Temperature; Inert atmosphere; Microwave irradiation;	87%

: 1722-12-9
2-chloropyrimidine

: 1414782-20-9
tert-butyl 2-[(R)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonane-7-carboxylate

: 1334785-04-4
tert-butyl 2-[(R)-5-(pyrimidin-2-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonane-7-carboxylate

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane; water Suzuki Coupling; Inert atmosphere; Heating;	99%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In water at 100℃; for 18h; Suzuki Coupling;

: 1722-12-9
2-chloropyrimidine

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 2-(2-(trimethylsilyl)ethoxy)pyrimidine

Conditions

Conditions	Yield
Stage #1: 2-(Trimethylsilyl)ethanol With sodium hydride In tetrahydrofuran at 0℃; for 1h; Stage #2: 2-chloropyrimidine In tetrahydrofuran at 25℃; for 24h;	99%

: 22428-87-1
4,4-ethylenedioxycyclohexan-1-ol

: 1722-12-9
2-chloropyrimidine

: 1361390-86-4
2-(1,4-dioxaspiro[4.5]decan-8-yloxy)pyrimidine

Conditions

Conditions	Yield
Stage #1: 4,4-ethylenedioxycyclohexan-1-ol With 1H-imidazole; sodium hydride In N,N-dimethyl acetamide; mineral oil at 20℃; for 0.5h; Cooling with ice; Stage #2: 2-chloropyrimidine In N,N-dimethyl acetamide; mineral oil at 20 - 60℃; for 3.5h;	98.59%
Stage #1: 4,4-ethylenedioxycyclohexan-1-ol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 0.5h; Stage #2: 2-chloropyrimidine In N,N-dimethyl-formamide; mineral oil at 0 - 70℃; for 17h;	97%
Stage #1: 4,4-ethylenedioxycyclohexan-1-ol With sodium hydride In N,N-dimethyl-formamide for 0.333333h; Stage #2: 2-chloropyrimidine at 20 - 100℃; for 9.5h;
Stage #1: 4,4-ethylenedioxycyclohexan-1-ol With sodium hydride In N,N-dimethyl-formamide for 0.333333h; Stage #2: 2-chloropyrimidine In N,N-dimethyl-formamide at 100℃; for 9h;

: 1722-12-9
2-chloropyrimidine

: 100-46-9
benzylamine

: 4214-59-9
2-(benzylamino)pyrimidine

Conditions

Conditions	Yield
With cesium acetate; copper In dimethyl sulfoxide at 110℃; for 24h; Inert atmosphere;	98%
at 100℃; for 0.1h; microwave irradiation;	91%
With triethylamine In ethanol at 120℃; for 0.0833333h; Microwave irradiation;	89%

: 1722-12-9
2-chloropyrimidine

: 134896-34-7
(2-propoxyphenyl)boronic acid

: 134896-36-9
2-(2-Propoxyphenyl)pyrimidine

Conditions

Conditions	Yield
<1,4-bis-(diphenylphosphine)butane>palladium(II)	98%
With sodium carbonate; [1,4-bis(diphenylphosphino)butane] palladium(ll) dichloride In ethanol; toluene for 24h; Heating;	98%

: 1722-12-9
2-chloropyrimidine

: 16419-60-6
2-Methylphenylboronic acid

: 188527-65-3
2-(2-methylphenyl)pyrimidine

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,4-dioxane at 90℃; Suzuki coupling reaction;	98%
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,4-dioxane at 90℃; Suzuki coupling;	93%
With Tedicyp; potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)) In xylene at 130℃; for 20h; Suzuki cross-coupling reaction;	87%
Suzuki coupling;

: 1722-12-9
2-chloropyrimidine

: 5-( 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-one

: 1334784-74-5
5-(pyrimidin-2-yl)-2,3-dihydro-1H-inden-1-one

Conditions

Conditions	Yield
With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,2-dimethoxyethane; water at 20 - 95℃; Inert atmosphere;	98%
With sodium carbonate In 1,2-dimethoxyethane at 95℃; Suzuki Coupling; Inert atmosphere;	41%

: 1722-12-9
2-chloropyrimidine

: 108-98-5
thiophenol

: 14080-18-3
2-(pyrimidinylthio)benzene

Conditions

Conditions	Yield
With bis(η3-allyl-μ-chloropalladium(II)); 1,1',3,3'-tetrakis(diphenylphosphino)ferrocene; sodium t-butanolate In toluene for 17h; Catalytic behavior; Inert atmosphere; Schlenk technique; Heating;	98%
With fac-tris[2-phenylpyridinato-C2,N]iridium(III); caesium carbonate In N,N-dimethyl-formamide at 25℃; for 18h; Schlenk technique; Inert atmosphere; Irradiation;	83%
Stage #1: 2-chloropyrimidine With tris-(dibenzylideneacetone)dipalladium(0); triethylamine In toluene at 115℃; for 1h; Inert atmosphere; Schlenk technique; Stage #2: thiophenol In toluene at 115℃; for 24h; Reagent/catalyst; Time; Inert atmosphere; Schlenk technique;	72%

: 1722-12-9
2-chloropyrimidine

: 32231-06-4
1-Piperonylpiperazine

: 3605-01-4
piribedil

Conditions

Conditions	Yield
With C50H61Cl2N3Pd; potassium tert-butylate In 1,4-dioxane at 100℃; for 2h;	98%
With C48H55ClN2Pd; sodium t-butanolate In 1,2-dimethoxyethane at 20℃; for 16h; Inert atmosphere; Sealed tube;	98%
With potassium carbonate In tetrahydrofuran for 2h; Reflux;	44%

: 1722-12-9
2-chloropyrimidine

: 271-73-8
1H-Pyrazolo[3,4-b]pyridine

: 1-(pyrimidin-2-yl)-1H-pyrazolo[3,4-b]pyridine

Conditions

Conditions	Yield
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; zinc diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; for 16h; Buchwald-Hartwig Coupling; Inert atmosphere;	98%

: 1722-12-9
2-chloropyrimidine

: 7378-99-6
N,N-dimethyloctanamide

A: 5621-02-3
2-(dimethylamino)pyrimidine

B: 141193-16-0
Methyl-octyl-pyrimidin-2-yl-amine

Conditions

Conditions	Yield
In tetrahydrofuran at 100℃; under 6000480 Torr; for 96h;	A 2% B 97%

...Expand

: 1722-12-9
2-chloropyrimidine

: 98-80-6
phenylboronic acid

: 7431-45-0
2-phenylpyrimidine

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,4-dioxane at 90℃; Suzuki coupling reaction;	97%
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,4-dioxane at 90℃;	95%
With oxygen; palladium diacetate; sodium carbonate In 1,4-dioxane at 90℃; Suzuki Coupling;	93%

: 1722-12-9
2-chloropyrimidine

: 31575-35-6
2-fluoropyrimidine

Conditions

Conditions	Yield
With hydrogen fluoride at 50℃; for 1h; other aromatic halides, var. temp., also with HF-base systems;	97%
With hydrogen fluoride at 50℃; for 1h;	97%

: 1722-12-9
2-chloropyrimidine

: 33941-15-0
1-aza-18-crown-6

: 16-(pyrimidin-2-yl)-1,4,7,10,13-pentaoxa-16-azacyclooctadecane

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 100℃; under 6000480 Torr; for 96h;	97%

: 1722-12-9
2-chloropyrimidine

: 107-11-9
1-amino-2-propene

: 5176-93-2
2-(prop-2-enylamino)pyrimidine

Conditions

Conditions	Yield
for 3h; Reflux;	97%
at 20℃; for 2h;	95%
for 2h; Heating; Yield given;

: 1722-12-9
2-chloropyrimidine

: 930-69-8
sodium thiophenolate

: 14080-18-3
2-(pyrimidinylthio)benzene

Conditions

Conditions	Yield
In N,N,N,N,N,N-hexamethylphosphoric triamide at 85℃; for 0.00833333h; microwave irradiation;	97%
In ethanol for 4h; Heating;	14%

2-Chloropyrimidine Chemical Properties

2-Chloropyrimidine is the chemical compound with the formula C₄H₃ClN₂.Its molecular weight is 114.53.It is white crystalline.
EINECS 217-020-2
Molecular Structure:

Melting point:66 ^oC
Boiling point:75-76 ^oC (10 mmHg)
Flash point:98 ^oC
Storage temp. : Refrigerator
Sensitive : Moisture Sensitive

2-Chloropyrimidine Uses

2-Chloropyrimidine is the intermediate of Medicine and 2-Chloropyrimidine also is the intermediate of pesticide

2-Chloropyrimidine Safety Profile

2-Chloropyrimidine's Hazard Symbols:

Xi
2-Chloropyrimidine's Risk Codes:
36/38:Irritating to eyes and skin
2-Chloropyrimidine's Safety Description:
26:In case of contact with eyes, rinse immediately with plenty of WATER and seek medical advice
37/39:Wear suitable gloves and eye/face protection

2-Chloropyrimidine Standards and Recommendations

Loss on drying：≤0.3
Content：≥98%

Product Name

2-Chloropyrimidine

Synthetic route

2-Chloropyrimidine Chemical Properties

2-Chloropyrimidine Uses

2-Chloropyrimidine Safety Profile

2-Chloropyrimidine Standards and Recommendations

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