The exponentially increasing use of electromagnetic field (EMF)-emitting devices imposes substantial health burden on modern societies with particular concerns of male infertility. Limited studies have addressed the modulation of this risk by protective agents. We investigated the hazardous effe...

Import of the polyamine spermine from the extracellular environment depends on the presence of cell surface heparan sulfate proteoglycans, such as glypican-1. This proteoglycan is internalized by endocytosis, releases its heparan sulfate chains in endosomes by a nitric oxide-, copper- and amyloi...

Spermine contamination ranks as one of the food safety issues, it will cause some adverse reactions if the intake of spermine is excessive in human body. So it is of great significance to establish fast and efficient analysis method to detect spermine in foods. In this study, the spermine aptame...

A supramolecular system (1@CB[7]) formed between an AIE-active molecule and cucurbit[7]uril (CB[7]) was used to construct selective fluorescent probe for spermine. 1@CB[7] displayed high selectivity toward spermine with a linear range of 0–12 μM and a detection limit of 1.0 μM spermine, which...

Sortase enzymes belong to a family of transpeptidases found in Gram-positive bacteria. Sortase is responsible for the reaction that anchors surface protein virulence factors to the peptidoglycan cell wall of the bacteria. The compound (Z)-3-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl) acrylonitrile...

A series of 2-(5-bromo-2,3-dimethoxyphenyl)-5-(aminomethyl)-1H-pyrrole analogues was prepared and their affinity for dopamine D2, D3, and D4 receptors was measured using in vitro binding assays. The results of receptor binding studies indicated that the incorporation of a pyrrole moiety between ...

3-(2,3-Dimethoxyphenyl)-1-(pyridin-2-yl)prop-2-en-1-one (DMPP) a potential second harmonic generating (SHG) has been synthesized and grown as a single crystal by the slow evaporation technique at ambient temperature. The structure determination of the grown crystal was done by single crystal X-r...

A chalcone derivative, (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)-prop-2-en-1-one (DMMF) was synthesized and evaluated against various cancerous cell lines including colon adenocarcinoma (HT-29), myloplasticleukemia (HL60), breast cancer (MCF-7 and MDA-MB231), normal hepatic cell (WRL-68...

6-(3,4 Dimethoxyphenyl)-1-methyl-3-oxo-2-phenyl-2,3 dihydro1Hpyrazolo[4,3-b]-5-carbonitrile, DMOPC, is a newly synthesized organic compound. DMOPC showed polycrystalline structure and crystallizes in monoclinic crystal system. The deposited thin films showed nanocrystals embedded in amorphous me...

A novel chalcone derivative (2E)-3-(2,3-dimethoxyphenyl)-1-(3-nitrophenyl)prop-2-en-1-one (3DPNP) has been synthesized and crystals have been grown by slow solvent evaporation solution growth technique. The crystals were characterized by FTIR, 1H NMR, DSC, TGA and single crystal X-ray diffractio...

1, 1, 3, 3-Tetraisopropyl-3-(2-(triphenylmethoxy)ethoxy)disiloxane-1-yl (TES) group was designed for solid-phase RNA synthesis as a 5′-O-protecting group, which can be combined with the tetrahydropyranyl group, a 2′-hydroxyl protecting group. The TES group can be selectively introduced to the ...

The alkylation of phenol with alcohols/olefins is an important reaction to transform lignin based phenolics to useful chemicals. In the present study, the sulfonated mesoporous polymers exemplified the exceptional selectivity towards 2,4-DTBP. This remarkable activity of the material is well cor...

A short-step route for the preparation of droloxifene has been established via the novel three-component coupling reaction among 3-pivaloyloxybenzaldehyde, cinnamyltrimethylsilane, and β-chlorophenetole, the successive installation of the side-chain part, and the base-induced migration of the d...

Two new synthetic pathways to the anti-cancer agent tamoxifen and its derivatives were developed. The first route involved the aldol reaction of benzyl phenyl ketone with acetaldehyde followed by Friedel–Crafts substitution with anisole in the presence of Cl2Si(OTf)2 to produce 1,1,2-triaryl-3-...

(R)-6-Hydroxy-5-methylhex-2-enyl(tributyl)stannane 4 transmetallates on treatment with tin(IV) bromide to give an intermediate allyltin tribromide which reacts with aldehydes to give 1-substituted (Z)-6-methylhept-2-ene-1,7-diols 7 with excellent anti-1,6-asymmetric induction.

Macromerine, a β-phenethylamine alkaloid previously isolated from Coryphantha macromeris, has been isolated from Coryphantha runyonti.

The biosynthetic conversion of epinephrine to normacromerine in Coryphantha macromeris (Engelm.) Br. and R. var. runyonii (Br. and R.) L. Benson (Cactaceae) has been studied. Metanephrine, which has been isolated from this cactus and is a normal metabolite of epinephrine in mammalian systems, ap...

Treatment of adult males of the moth, Mamestra configurata, with chlordimeform caused large increases (up to 27-fold) in the concentration of cAMP in the head, thorax, and abdomen but had little effect on cGMP. This pesticidal effect, termed A+G0, likely results from the interaction of chlordime...

Heart rate (HR) and body core temperature (Tco) were monitored in unanesthetized, unrestrained adult Sprague-Dawley rats following intraperitoneal administration of 0, 10, 30, or 60 mgkg of the pesticide chlordimeform (CDM). Significant non-dose-related decreases were observed in both HR and Tco...

1. Since chlordimeform or N′-(4-chloro-o-tolyl)-N,N-dimethylformamidine and certain of its mammalian metabolites prolong ethanol induced sleep in mice, their effect on ethanol and acetate metabolism was examined.2. Intraperitoneal treatment of mice with chlordimeform (50 mg/kg) and demethylchlo...