Oral formulation of quinine is of great potential interest in uncomplicated malaria, especially in chloroquine-resistant strains. As a preliminary step to efficacy and safety studies in children, 3 studies were undertaken with a new formulation of quinine in white young healthy adults at the th...
There is a limited amount of information available about taste as a discriminative stimulus in non-human primates. The objective of this study was to establish a bitter taste (quinine sulfate) as a cue for lever selection and food reward in rhesus monkeys. Training took place in a series of step...
The aim of this study was to investigate the relationship of taster status with taste detection and recognition thresholds for sucrose and quinine.Sixty-nine subjects (35 men and 34 women; mean age, 23.9±1.2 years) were included. Stimulus fluids were prepared, one each for phenylthiocarbamide (...
Quinine sulfate dihydrate (QNS), IUPAC name: (8S,9R)-6-methoxy-4-quinolenyl-5-vinyl-2-quinuclidinyl methanol sulfate dihydrate, was tested as corrosion inhibitor for carbon steel in 1.5 mol L−1 HCl solution using the potentiodynamic polarization and the electrochemical impedance spectroscopy (EI...
It is essential for everyone working with experimental science to be certain that their instruments produce reliable results, and for fluorescence lifetime experiments, information about fluorescence lifetime standards is crucial. A large part of the literature on lifetime standards dates back t...
A simple and selective method of flow injection (FI) using a micro-column packed with quinine modified resin as solid phase extractant has been developed for preconcentration and separation of trace amount of vanadium(V) and vanadium(IV) in water samples, followed by determination with fluorinat...
Subjects were asked to assess the bitterness of one 6-n-propyl-2-thiouracil (PROP) and two quinine HCl (QHCl) concentrations presented via filter papers of varying sizes. The number of taste papillae stimulated by these filter papers was counted in each individual. Whole mouth sensitivity to PRO...
Quinine, a natural product, was investigated as a corrosion inhibitor for low carbon steel in 1.0 m HCl solution. Electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization were used to study the inhibition action in the temperature range 20–50 °C. The corrosion of steel was...
A reversed-phase high-performance liquid chromatographic method coupled with photodiode-array detection (HPLC–PAD) has been developed and validated for simultaneous quantitation of dl-tetrahydropalmatine (dl-THP) and protopine (PTP), two active constituents of the herbal medicine Rhizoma Coryda...
The kinetics of the solid–liquid extraction of protopine from Fumaria officinalis were examined in this study in order to deduce the diffusivity and explain the mass transfer. Extraction was carried out by varying the following operating conditions: temperature, solid/solvent ratio and percenta...
This paper describes oxidation of the isoquinoline alkaloid, protopine (PR) at a pyrolytic graphite electrode (PGE) using cyclic and square‐wave voltammetry. In the alkaline range (pH 7.5–10.5) of a Britton–Robinson (B–R) buffer, a PR oxidation can be observed as a well‐developed voltammetr...
The tumor suppressor p53 plays essential roles in cellular protection mechanisms against a variety of stress stimuli and its activation induces apoptosis or autophagy in certain cancer cells. Here, we identified protopine, an isoquinoline alkaloid isolated from Nandina domestica, as an activator...
In this present study, a sensitive and rapid UPLC–MS/MS method was developed for simultaneous quantification of paeoniflorin, albiflorin, ferulic acid, tetrahydropalmatine, protopine, typhaneoside and senkyunolide I in Beagle dog plasma after oral administration of the Shao-Fu-Zhu-Yu Decoction....
RationaleAllocryptopine (AL) and protopine (PR) have been extensively studied because of their anti‐parasitic, anti‐arrhythmic, anti‐thrombotic, anti‐inflammatory and anti‐bacterial activity. However, limited information on the pharmacokinetics and metabolism of AL and PR has been reported....
We previously showed that pamoic acid (PA) could be utilized as a reducing and capping reagent for preparing monodispersed gold nanoparticles (AuNPs) with diameters of 10.8 nm. Here, we show that the size of these PA-capped AuNPs can be varied in a controlled manner by changing the pH used in th...
In this study, we labeled N,N′-bis(diethylenetriamine pentaacetic acid)-pamoic acid bis-hydrazide (bis-DTPA-PA) with the generator produced PET radionuclide gallium-68 and evaluated 68 Ga-bis-DTPA-PA as a potential tracer for in vivo visualization of necrosis by positron emission tomogr...
Two new metal–organic frameworks; namely, [Cd2(pam)2(bpe)1.5(DMF)2(H2O)] n ·2n(DMF) (1) and [Cd(pam)(bix)] n (2) (H2pam = pamoic acid, bpe = 1,2-di(4-pyridyl)ethylene, bix = 4,4′-bis(imidazol-1-ylmethyl)benzene, DMF = N,N′-dimethylformamide), were solvothermally synthesized via varying the ...
We report a facile hydrothermal method using the disodium salt of pamoic acid (Na2PA) as an organic additive, In(NO3)3·xH2O as an indium precursor, and SnCl2·2H2O as a tin precursor for preparation of ITO nanoparticles (NPs) at low temperature (200 °C). After drying at 110 °C, the as hydroth...
In the present work, we prepared memantine–pamoic acid (MEM–PAM) salt by counter ion exchange in the aqueous phase to reduce the water solubility of MEM hydrochloride (native form) to make it suitable for long acting injection. The ratio of MEM to PAM in salt formation was optimized to maximiz...
The effect of the estrogen diethylstilbestrol (DES) on intracellular Ca 2 + concentrations ([Ca 2 + ] i ) in Madin Darby canine kidney (MDCK) cells was investigated, using the fluorescent dye fura-2 as a Ca 2 + indicator. DES (10-50 μM) evoked [Ca ...
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