J. Neurochem. (2012) 121, 383–395.Adenosine receptors (AR) belonging to the G protein‐coupled receptor family influence a wide range of physiological processes. Recent elucidation of the structure of human A2AR revealed the conserved amino acids necessary for contact with the Ado moiety. Howev...
ObjectiveAccelerated osteoclastic bone resorption plays a central role in the pathogenesis of osteoporosis and other bone diseases. Because identifying the molecular pathways that regulate osteoclast activity provides a key to understanding the causes of these diseases and developing new treatme...
Objective: Inflammation is likely a major contributor to spinal cord reperfusion injury after aortic reconstruction. Systemic 4-{3-[6-amino-9-(5-ethylcarbamoyl-3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-cyclohexanecarboxylic acid methyl ester (ATL-146e), a selective adenosi...
Relationships between nitrate (NO - 3 ) supply, uptake and assimilation, water uptake and the rate of mobilization of seed reserves were examined for the five main temperate cereals prior to emergence from the substrate. For all species, 21 d after sowing (DAS), residual seed dry wei...
The stability of drugs in extruded granules prepared with low substituted hydroxypropylcellulose (L-HPC) and water was investigated using ascorbic acid (AA) and thiamine nitrate (TN) as model drugs. d-Mannitol was used as the control additive for a comparison with L-HPC. The percentage of AA rem...
The interest in and need for formulating miconazole nitrate (MN), a broad-spectrum antifungal, as an oral disintegrating tablet for treatment of some forms of candidiasis have increased. Formulation of MN in this dosage form will be more advantageous, producing dual effect: local in the buccal c...
Knockout and complement mutants of mannitol‐1‐phosphate dehydrogenase (MPD) and mannitol dehydrogenase (MTD) were constructed to probe the roles of both enzymes in the mannitol metabolism and multi‐stress tolerances of entomopathogenic fungus Beauveria bassiana. Compared with wild‐type and c...
Here we provide evidence that the form of carbon compound and O 2 concentration exert an inter-related regulation on the production and reduction of N 2 O in soil. 6.7 mM d-glucose, 6.7 mM D-mannitol, 8 mM L-glutamic acid or 10 mM butyrate (all equivalent to 0.48 g C l −1 ...
The adverse effects of either NaCl or mannitol on growth, nitrogen content, and antioxidant system in Vicia faba seedlings were investigated. The role of exogenous ascorbic acid in increasing resistance to these stressors was also evaluated. Thus, with an increase in concentration of either NaCl...
Rhizobial symbionts were isolated from the surface (0-0.5 M) and phreatic (3.9-5.0 M) root environments of a mature mesquite woodland in the Sonoran Desert of Southern California, and from variable depths (0-12 m) of non-phreatic mesquite ecosystems in the Chihuahuan Desert of New Mexico. They w...
The tolerance of menadione bisulfite-nicotinamide (MNB) in rainbow trout fed diets supplemented with graded levels (0, 500, 1000 and 2000 mg/kg) of this vitamin K form for 93 days was studied. Weight gain, weight gain/feed ratio and hematological parameters, such as hemoglobin and bilirubin lev...
A reversed-phase high-performance liquid chromatography with series dual glassy carbon electrodes for the amperometric detection of water-soluble menadione is described. The complex post-column derivatization reaction and the high background currents were avoided. The menadione sodium bisulfit...
A novel chemiluminescence (CL) flow system for two sulfite-containing drugs, namely, menadione sodium bisulfite (MSB) and analgin is described. It is based on the weak chemiluminescence induced by the oxidation of sulfite group in drugs with dissolved oxygen in the presence of acidic Rh6G. Tween...
Menadione sodium bisulfite (MSB) is a stable water-soluble derivative of Vitamin K 3 , which is found to be able to enhance the ECL of luminol at potential of 0.88V in phosphate buffer solution. The conditions for the enhanced ECL, such as the selection of the type of buffer solution, ap...
Menadione sodium bisulfite (MSB), vitamin K 3 , a non-fluorescent compound, was converted into an intensive fluorescent compound (λ e x /λ e m =340 nm/465 nm) on irradiation with ultraviolet radiation in an anaerobic alkaline medium, and acetone showed a strong ...
An amperometric method was applied for real-time monitoring of intracellular redox enzyme activity. Baker's yeast (Saccharomyces cerevisiae) cells were immobilized on platinum microband electrodes and mediated anodic currents were measured. The currents were observed in the absence and in the pr...
The mixed‐ligand heterochelates of Cu(II) with 5‐chloro‐7‐iodo‐8‐hydroxyquinoline (clioquinol) and various uninegative bidentate ligands were prepared. The structure of mixed‐ligand heterochelates was investigated using spectral, physicochemical, elemental analysis and thermal studies. Th...
Clioquinol was produced as a topical antiseptic and marketed as an oral intestinal amebicide in 1934, being used to treat a wide range of intestinal diseases. In the early 1970s, it was withdrawn from the market as an oral agent because of its association with subacute myelo‐optic neuropathy (S...
Apoptosis has been shown to be induced by many agents, including the clinically useful Sorafenib and K vitamins (VKs). Since few agents have activity against pancreas cancer cell growth, we evaluated the role of naturally occurring K vitamins and Sorafenib both independently and together on the ...
The multikinase inhibitor sorafenib is the first oral agent to show activity against human hepatocellular carcinoma (HCC). Apoptosis has been shown to be induced in HCC by several agents, including sorafenib as well as by the naturally occurring K vitamins (VKs). As few nontoxic agents have acti...
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