Objectives(1) To introduce N-of-1 methods and how they can help the researchers identify predictors of behavioural outcomes, (2) to provide examples of studies that test individual theory-based predictions of physical activity and/or exercise; (3) to provide a practical example dataset to illust...

SummarySemiconducting single-walled carbon nanotubes (SWNTs) with controlled chirality (n, m) and band gaps are expected to create a new era of electronics. Here, we report a rational design to enable SWNTs’ near-equilibrium nucleation and then grow a new family of semiconducting SWNTs: (n, n −...

Let Bn=[Bn,k]n,k⩾0 be the Bell matrix. Define the n×n shift Bell matrix Pn,k by (Pn,k)i,j=Bk+i−1,k+j−1 for i,j=1,2,⋯n and k=0,1,2⋯. In this paper, matrix factorizations of the n×n shift Bell matrix and the n×n generalized Riordan matrix are studied. As a result, many lower triangular matrices...

We have designed and synthesized twenty-six N-arylindazole-3-carboxamide (3a-p) and N-benzoylindazole (6a-j) derivatives to discover with excellent inhibition activities of α-MSH-stimulated melanogenesis. In the bio evaluation studies of these compounds, we discovered eighteen compounds, out of...

Four new triterpenoid oligoglycosides (2–5; sarasinosides D–G, respectively) and sarasinoside B1 (1) have been isolated from the butanolic extracts of the sponge Asteropus sarasinosum, which showed in vitro cytotoxic activity against several types of tumour cells and inhibition to protein kina...

The synthesis and structure–activity relationships of novel 4-(4′-fluorophenyl)imidazoles as selective p38α MAPK, CK1δ and JAK2 inhibitors with improved water solubility are described. Microwave-assisted multicomponent reactions afforded 4-fluorophenyl-2,5-disubstituted imidazoles. Carboxyla...

Phase transition behavior of 4-cyano-3-fluorophenyl 4′-n-octylbenzoate (8CFPB) was studied by differential scanning calorimetry (DSC), polarizing microscopy, FT-IR spectroscopy and X-ray diffraction. Liquid-like and solid-like polymorphism with monotropic system of phases was identified. Assign...

Lactim-lactam isomerisation behavior through proton transfer process at the strained four-member intramolecular H-bonded ring in 5-(4-fluorophenyl)-2-hydroxy-nicotinonitrile (FP2HN) has been elaborately investigated by steady state absorption and emission, time-resolved fluorescence spectroscopy...

5-(2-Fluorophenyl)-5-(4-Isopropylphenyl)-2-Amino-4-Pentenoate is a selective and potent inhibitor of the GlyT-2 glycine transporter 2.

Recently the N-(−)-lupinyl-derivative of 7-chloro-4-aminoquinoline ((−)-AM-1; 7-chloro-4-{N-[(1S,9aR)(octahydro-2H-quinolizin-1-yl)methyl]amino}quinoline) showed potent in vitro and in vivo activity against both Chloroquine susceptible and resistant strains of Plasmodium falciparum. However, (−)...

With the aim to investigate the effect of different heterocyclic rings linked to the 4-aminoquinoline nucleus on the antimalarial activity, a set of 7-chloro-N-(heteroaryl)-methyl-4-aminoquinoline and 7-chloro-N-(heteroaryl)-4-aminoquinoline was synthesized and tested in vitro against D-10 (CQ-S...

Using a radioimmunoassay for the peptide sequence Arg-Phe-NH2 (RFamide), a novel peptide has been purified from acetic acid extracts of the sea anemone Anthopleura elegantissima. This peptide has the structure

The anthozoan neuropeptide Antho-RWamide I (

Raney nickel-2H2O exchange reaction on an epimeric mixture of methyl α/β-D-ribofuranoside [α/β = ∼3:10]1 produced methyl 1#,2,3,4#,5,5′-2H6-α/β-ribofuranoside 2 [97 atom % 2H at C2, C3, C5/5′; ∼85 atom % 2H at C4 (C4#); ∼20 atom % 2H at C1(C1#)] which was obtained in 60 – 80 % yield ...

The reactivity of the N-acetoxy metabolite of 2-amino-5-phenylpyridine (Phe-P-1), a pyrolysis product of phenylalanine, towards 2′-deoxyguanosine (dG), 2′-deoxyguanosine-3′-monophosphate (dGMP) and DNA was studied and compared with that of the ortho-methyl derivative. Reaction of 2-acetoxyami...

Copolymer films of diethyleneglycol-bis-allylcarbonate (monomer of CR-39) and selected volume percentages of methacryloyl-L-alanine methyl ester (MA-L-AlaOMe) between 5 and 60% were irradiated with Au ions of 13 MeV nucl-1 and etched in NaOH solution at 60°C. Sensitization of track etching was ...

The OH ⋯ O hydrogen bonds in the 2,2,2-trifluoroethanol (TFE)–methyl ester complexes in the gas phase have been investigated by FTIR spectroscopy and DFT calculations. Methyl formate (MF), methyl acetate (MA), and methyl trifluoroacetate (MTFA) were chosen as the hydrogen bond acceptors. A domi...

l-alanine ethyl ester modified multiwalled carbon nanotubes (MWNTs-Ala) were prepared and characterized with FT-IR spectroscopy. The electrochemical behavior of d- and l-tryptophan on the MWNTs-Ala coated electrode was investigated by using cyclic voltammetry. Meanwhile, in order to understand t...

Various types of Hsp90 inhibitors have been and continue to undergo clinical investigation. One development candidate is the purine-based, synthetic Hsp90 inhibitor 1 (MPC-3100), which successfully completed a phase I clinical study. However, further clinical development of 1 was hindered by poo...

Copolymer films (100 μm thick) were prepared by cast polymerization of methacryloyl-l-alanine methyl ester (MA-l-AlaOMe) and diethyleneglycol-bis-allylcarbonate (CR-39). The films swell in water at temperatures below 60°C. The degree of swelling increases with decreasing temperature down to 0°...