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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine Manufacturer/High quality/Best price/In stock

Cas:152460-10-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hubei Vanz Pharm Co.,Ltd

Hubei Vanz Pharm Co. Ltd. is located in Wuhan, Hubei province. We are one of the most professional company in pharm/chmecial industry for more than 10 years. We export to many countries and area with very competitive price, high quality, good ser

Imatinib EP Impurity F N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine

Cas:152460-10-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality N-(5-Amino-2-Methylphenyl)-4-(3-Pyridyl)-2-Pyrimidineamine supplier in China

Cas:152460-10-1

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% -----------------------------------------------------------------------------------------------------------

High purity 152460-10-1 N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine

Cas:152460-10-1

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine Cas 152460-10-1 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off-white powder Storage:coo

Henan Allgreen Chemical Co.,Ltd

T he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality service

152460-10-1

Cas:152460-10-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine

Cas:152460-10-1

Min.Order:0

Negotiable

Type:Trading Company

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine

Cas:152460-10-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl]-1,3-benzenediamine

Cas:152460-10-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

CHENGDU YANXI is a comprehensive manufacturer and an international distribution of products throughout the world. Specialized in Scrap metal, Chemical raw materials, Paper products and color industry. We aim to become leading position in global dis

Imatinib intermediates-- N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine

Cas:152460-10-1

Min.Order:1 Kilogram

FOB Price: $2.0 / 3.0

Type:Trading Company

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/546.html

N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine

Cas:152460-10-1

Min.Order:1 Gram

FOB Price: $635.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

6-methyl-N'-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine Chemical Name : 6-methyl-N'-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine CAS:

6-methyl-N'-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine -

Cas:152460-10-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent out in 24 hours after payment.Tracking number available 2) Secure and disc

CAS:152460-10-1 N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine

Cas:152460-10-1

Min.Order:1 Kilogram

FOB Price: $150.0 / 200.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 152460-10-1 with best quality

Cas:152460-10-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine/ LIDE PHARMA- Factory supply / Best price

Cas:152460-10-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Alias: N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine; 4-Methyl-N'-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine; N-(5-amino-2-methylphenyl)-4-(3-pyrdyl)-2-pydimidineamine; N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine

N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine

Cas:152460-10-1

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:powder Storage:Store in sealed containers at cool & dry pla

Hangzhou Sartort Biopharma Co., Ltd

Appearance:yellow solid Storage:Keep in dark place,Inert atmosphere,2-8°C Package:25kg/Barrel Application:APIs Transportation:Express/Sea/Air Port:Any port in China

Factory supply N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine

Cas:152460-10-1

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine 152460-10-1

Cas:152460-10-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d

For Imatinib mesylate: N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine amine

Cas:152460-10-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Pharmaceutical Intermediate, N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine CAS:152460-10-1

Cas:152460-10-1

Min.Order:1 Kilogram

FOB Price: $34.0 / 37.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine CAS:152460-10-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, sp

N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine CAS:152460-10-1

Cas:152460-10-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine cas:152460-10-1

Cas:152460-10-1

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

4-Methyl-n'-(4-(pyridin-3-yl)pyriMidin-2-yl)benzene-1,3-diaMine

Cas:152460-10-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine

Cas:152460-10-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine

Cas:152460-10-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

Hangzhou Fanda Chemical Co.,Ltd (FandaChem) , a China-based chemical company, specialize in exporting imatinib intermediate;intermediate of imatinib;N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine CAS:152460-10-1 , Please contact us by

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

N-(5-Amino-2-Methylphenyl)-4-(3-Pyridyl)-2-Pyrimidineamine

Cas:152460-10-1

Min.Order:0

Negotiable

Type:Manufacturers

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Synthetic route

N-(5-nitro-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidineamine
152460-09-8

N-(5-nitro-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidineamine

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In ethyl acetate for 3h;100%
With palladium on activated charcoal; hydrogen In ethyl acetate at 20℃; for 3h; Inert atmosphere;100%
With hydrazine hydrate In N,N-dimethyl-formamide at 100℃; for 3h; Green chemistry;100%
imatinib
152459-95-5

imatinib

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
With hydrogenchloride; acetic acid at 20℃; Reflux;97%
tert-butyl (4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamate

tert-butyl (4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamate

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane for 8h;95%
(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
55314-16-4, 75415-01-9, 123367-26-0

(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

(2-methyl-5-aminophenyl)guanidine
581076-64-4

(2-methyl-5-aminophenyl)guanidine

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
In butan-1-ol at 70℃;92%
2-bromo-4-nitrotoluene
7745-93-9

2-bromo-4-nitrotoluene

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
Stage #1: 2-bromo-4-nitrotoluene; 4-pyridin-3-ylpyrimidin-2-ylamine With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,4-dioxane at 100℃; for 24h; Buchwald-Hartwig Coupling; Inert atmosphere;
Stage #2: With potassium tert-butylate; bis(pinacol)diborane In 1,4-dioxane; isopropyl alcohol at 110℃; for 4h; Inert atmosphere; chemoselective reaction;
83%
hydrazine hydrate
7803-57-8

hydrazine hydrate

N-(5-nitro-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidineamine
152460-09-8

N-(5-nitro-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidineamine

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
With iron(III) chloride; pyrographite In water at 80℃; for 6 - 8h;80%
(S)-3-allyl-1-benzoyl-4-(4-methoxybenzyl)-3-methylpiperazin-2-one

(S)-3-allyl-1-benzoyl-4-(4-methoxybenzyl)-3-methylpiperazin-2-one

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane; water at 20℃; for 1.5h;75%
4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoic acid
641569-94-0

4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoic acid

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
Stage #1: 4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid With diphenyl phosphoryl azide; triethylamine In toluene at 100℃; for 12h; Curtius Rearrangement;
Stage #2: With hydrogenchloride In water; toluene at 100℃;
60%
Multi-step reaction with 2 steps
1: diphenyl phosphoryl azide; triethylamine / toluene / 12 h / 100 °C
2: trifluoroacetic acid / dichloromethane / 8 h
View Scheme
SnCl2.2H2O

SnCl2.2H2O

N-(5-nitro-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidineamine
152460-09-8

N-(5-nitro-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidineamine

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
In hydrogenchloride46%
methyl-3-pyridylketone
350-03-8

methyl-3-pyridylketone

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ethanol / Heating
2: NaOH / propan-2-ol / 24 h / Heating
3: 8.9 g / SnCl2; aq. HCl / 0.5 h
View Scheme
Multi-step reaction with 2 steps
1: 92 percent / xylene / 140 °C
2: 92 percent / butan-1-ol / 70 °C
View Scheme
Multi-step reaction with 3 steps
2: 41.3 percent / sodium hydroxide / propan-2-ol / 8 h / Heating
3: 60.9 percent / H2 / palladium on charcoal / tetrahydrofuran / 21 h / 750.06 Torr / Ambient temperature
View Scheme
3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
55314-16-4, 75415-01-9, 123367-26-0

3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaOH / propan-2-ol / 24 h / Heating
2: 8.9 g / SnCl2; aq. HCl / 0.5 h
View Scheme
Multi-step reaction with 2 steps
1: 4-methyl-2-pentanone / 12 h / Reflux
2: hydrazine hydrate / palladium 10% on activated carbon / methanol / 8 h / 25 °C / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1.1: sodium ethanolate / ethanol / 6 h / 78 °C
1.2: 0.17 h / 78 °C
2.1: sodium hydroxide / water
2.2: 20 °C
3.1: sodium tungstate monohydrate; water; dihydrogen peroxide / acetone / 10 h / 40 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C
5.1: iron(III) chloride hexahydrate; hydrazine hydrate / methanol / 6 h / 78 °C
View Scheme
1-(2-methyl-5-nitrophenyl)guanidine nitrate

1-(2-methyl-5-nitrophenyl)guanidine nitrate

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaOH / propan-2-ol / 24 h / Heating
2: 8.9 g / SnCl2; aq. HCl / 0.5 h
View Scheme
Multi-step reaction with 2 steps
1: 41.3 percent / sodium hydroxide / propan-2-ol / 8 h / Heating
2: 60.9 percent / H2 / palladium on charcoal / tetrahydrofuran / 21 h / 750.06 Torr / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: NaOH / propan-2-ol / Heating
2: H2 / 5percent Pd-C / tetrahydrofuran / 750.06 Torr / Ambient temperature
View Scheme
2-methyl-5-nitroaniline
99-55-8

2-methyl-5-nitroaniline

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: HNO3 / ethanol / Heating
2: NaOH / propan-2-ol / 24 h / Heating
3: 8.9 g / SnCl2; aq. HCl / 0.5 h
View Scheme
Multi-step reaction with 3 steps
1: aq. HCl / butan-1-ol / 150 °C
2: H2 / Pd/C / butan-1-ol
3: 92 percent / butan-1-ol / 70 °C
View Scheme
Multi-step reaction with 4 steps
1.1: nitric acid / ethanol / 25 - 50 °C
1.2: 3 h / Reflux
2.1: sodium hydroxide / water
3.1: 4-methyl-2-pentanone / 12 h / Reflux
4.1: hydrazine hydrate / palladium 10% on activated carbon / methanol / 8 h / 25 °C / Reflux; Inert atmosphere
View Scheme
1-(2-methyl-5-nitrophenyl)guanidine
152460-07-6

1-(2-methyl-5-nitrophenyl)guanidine

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2 / Pd/C / butan-1-ol
2: 92 percent / butan-1-ol / 70 °C
View Scheme
Multi-step reaction with 2 steps
1: 4-methyl-2-pentanone / 12 h / Reflux
2: hydrazine hydrate / palladium 10% on activated carbon / methanol / 8 h / 25 °C / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: acetic acid / 2 h / 90 - 95 °C
1.2: 12 h / Reflux
2.1: hydrazine hydrate / palladium 10% on activated carbon / methanol / 8 h / 25 °C / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: butan-1-ol / 9 h / 120 °C / Large scale
2: hydrogen / methanol / 45 h / 3102.97 Torr
View Scheme
Multi-step reaction with 2 steps
1: butan-1-ol / 9 h / 120 °C
2: hydrogen / methanol / 45 h / 25 °C / 3102.97 Torr
View Scheme
(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
55314-16-4, 75415-01-9, 123367-26-0

(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 41.3 percent / sodium hydroxide / propan-2-ol / 8 h / Heating
2: 60.9 percent / H2 / palladium on charcoal / tetrahydrofuran / 21 h / 750.06 Torr / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: NaOH / propan-2-ol / Heating
2: H2 / 5percent Pd-C / tetrahydrofuran / 750.06 Torr / Ambient temperature
View Scheme
Multi-step reaction with 3 steps
1: sodium hydroxide / butan-1-ol / 4 h / 120 °C / Reflux
2: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 15 h / 120 °C / Inert atmosphere; Reflux
3: iron(III) chloride; hydrazine hydrate / methanol / 6 h / 80 °C / Reflux
View Scheme
Multi-step reaction with 3 steps
1: sodium hydroxide / butan-1-ol / 20 h / Reflux; Inert atmosphere
2: tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / 1,4-dioxane / 24 h / 100 °C / Inert atmosphere
3: palladium on carbon; hydrogen / methanol / 760.05 Torr
View Scheme
Multi-step reaction with 4 steps
1.1: sodium methylate / ethanol; methanol / 6 h / 78 °C / Inert atmosphere; Molecular sieve
1.2: 0.5 h / 20 °C
2.1: sodium tungstate; dihydrogen peroxide / acetone / 10 h / 40 °C
3.1: triethylamine / 2-methyltetrahydrofuran / 5 h / 20 °C / Inert atmosphere
4.1: 5%-palladium/activated carbon; hydrogen / ethanol / 8 h / 20 °C / 1520.1 Torr
View Scheme
palladium
7440-05-3

palladium

N-(5-nitro-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidineamine
152460-09-8

N-(5-nitro-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidineamine

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
In ethyl acetate
In ethyl acetate
6-chloro-N-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidin-amine
1016637-24-3

6-chloro-N-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidin-amine

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
With hydrogen; triethylamine; 5%-palladium/activated carbon In ethanol at 20℃; under 3750.38 Torr; for 40h; Product distribution / selectivity;
With hydrogen; triethylamine; 5% Pd(II)/C(eggshell) In ethanol at 20℃; under 3750.38 Torr; for 40h; Autoclave;
1-(5-amino-2-methylphenyl)-3-[3-oxo-3-(3-pyridinyl)-1-prop-1-enyl]guanidine
1026747-16-9

1-(5-amino-2-methylphenyl)-3-[3-oxo-3-(3-pyridinyl)-1-prop-1-enyl]guanidine

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
With potassium hydroxide In butan-1-ol for 18h; Product distribution / selectivity; Heating / reflux;
β-oxo-3-pyridinepropanal sodium salt
39883-42-6, 41403-76-3

β-oxo-3-pyridinepropanal sodium salt

(2-methyl-5-aminophenyl)guanidine
581076-64-4

(2-methyl-5-aminophenyl)guanidine

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
Stage #1: β-oxo-3-pyridinepropanal sodium salt; (2-methyl-5-aminophenyl)guanidine With acetic acid In butan-1-ol at 20℃; for 1h; Inert atmosphere;
Stage #2: With potassium hydroxide In butan-1-ol for 18h; Reflux; Inert atmosphere;
(2-methyl-5-nitrophenyl)guanidine nitrate

(2-methyl-5-nitrophenyl)guanidine nitrate

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / water
2: 4-methyl-2-pentanone / 12 h / Reflux
3: hydrazine hydrate / palladium 10% on activated carbon / methanol / 8 h / 25 °C / Reflux; Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water
2.1: acetic acid / 2 h / 90 - 95 °C
2.2: 12 h / Reflux
3.1: hydrazine hydrate / palladium 10% on activated carbon / methanol / 8 h / 25 °C / Reflux; Inert atmosphere
View Scheme
2-(methylsulfanyl)-4-(3-pyridyl)pyrimidine

2-(methylsulfanyl)-4-(3-pyridyl)pyrimidine

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium tungstate monohydrate; water; dihydrogen peroxide / acetone / 10 h / 40 °C
2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C
3: iron(III) chloride hexahydrate; hydrazine hydrate / methanol / 6 h / 78 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium tungstate monohydrate; water; dihydrogen peroxide / acetone / 10 h / 40 °C
2: potassium carbonate / N,N-dimethyl-formamide / 80 °C
3: iron(III) chloride hexahydrate; hydrazine hydrate / methanol / 6 h / 78 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium tungstate; dihydrogen peroxide / acetone / 10 h / 40 °C
2: triethylamine / 2-methyltetrahydrofuran / 5 h / 20 °C / Inert atmosphere
3: 5%-palladium/activated carbon; hydrogen / ethanol / 8 h / 20 °C / 1520.1 Torr
View Scheme
2-(methylsulfonyl)-4-(pyridin-3-yl)pyrimidine

2-(methylsulfonyl)-4-(pyridin-3-yl)pyrimidine

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C
2: iron(III) chloride hexahydrate; hydrazine hydrate / methanol / 6 h / 78 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 80 °C
2: iron(III) chloride hexahydrate; hydrazine hydrate / methanol / 6 h / 78 °C
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / 2-methyltetrahydrofuran / 5 h / 20 °C / Inert atmosphere
2: 5%-palladium/activated carbon; hydrogen / ethanol / 8 h / 20 °C / 1520.1 Torr
View Scheme
4-(pyridin-3-yl)pyrimidine-2-thiol

4-(pyridin-3-yl)pyrimidine-2-thiol

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydroxide / water
1.2: 20 °C
2.1: sodium tungstate monohydrate; water; dihydrogen peroxide / acetone / 10 h / 40 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C
4.1: iron(III) chloride hexahydrate; hydrazine hydrate / methanol / 6 h / 78 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydroxide / water
1.2: 20 °C
2.1: sodium tungstate monohydrate; water; dihydrogen peroxide / acetone / 10 h / 40 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 80 °C
4.1: iron(III) chloride hexahydrate; hydrazine hydrate / methanol / 6 h / 78 °C
View Scheme
Multi-step reaction with 4 steps
1: 0.5 h / 20 °C
2: sodium tungstate; dihydrogen peroxide / acetone / 10 h / 40 °C
3: triethylamine / 2-methyltetrahydrofuran / 5 h / 20 °C / Inert atmosphere
4: 5%-palladium/activated carbon; hydrogen / ethanol / 8 h / 20 °C / 1520.1 Torr
View Scheme
2-bromo-4-nitrotoluene
7745-93-9

2-bromo-4-nitrotoluene

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 15 h / 120 °C / Inert atmosphere; Reflux
2: iron(III) chloride; hydrazine hydrate / methanol / 6 h / 80 °C / Reflux
View Scheme
Multi-step reaction with 2 steps
1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 20 h / 20 - 100 °C / Inert atmosphere; Schlenk technique
2: hydrazine hydrate; iron(III) chloride; pyrographite / water / 80 °C / Inert atmosphere; Schlenk technique
View Scheme
Multi-step reaction with 2 steps
1: copper(l) iodide; potassium iodide; potassium carbonate / 1,4-dioxane / Inert atmosphere; Reflux
2: ammonium formate; palladium 10% on activated carbon / methanol / 4 h / 30 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: copper(l) iodide; N,N`-dimethylethylenediamine / 1,4-dioxane / 0.5 h / 120 °C / Microwave irradiation
2: zinc; ammonium chloride / tetrahydrofuran / 0.17 h / 80 °C / Microwave irradiation
View Scheme
Multi-step reaction with 2 steps
1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 24 h / 120 °C / Inert atmosphere
2: palladium on activated charcoal; hydrogen / ethyl acetate / Inert atmosphere
View Scheme
4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 15 h / 120 °C / Inert atmosphere; Reflux
2: iron(III) chloride; hydrazine hydrate / methanol / 6 h / 80 °C / Reflux
View Scheme
Multi-step reaction with 2 steps
1: potassium tert-butylate / dimethyl sulfoxide / 12 h / 120 °C
2: tin(ll) chloride; hydrogenchloride / methanol / 10 h / 50 °C
View Scheme
Multi-step reaction with 2 steps
1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 20 h / 20 - 100 °C / Inert atmosphere; Schlenk technique
2: hydrazine hydrate; iron(III) chloride; pyrographite / water / 80 °C / Inert atmosphere; Schlenk technique
View Scheme
3-pyridylboronic acid
1692-25-7

3-pyridylboronic acid

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1-(2,6-diisopropylphenyl)-3-(2-oxo-2-(2,4,6-tri-tert-butylphenylamino)ethyl)-1H-imidazol-3-ium bromide; palladium diacetate; sodium hydroxide / dimethyl sulfoxide; water / 10 h / 100 °C
2: potassium tert-butylate / dimethyl sulfoxide / 12 h / 120 °C
3: tin(ll) chloride; hydrogenchloride / methanol / 10 h / 50 °C
View Scheme
Multi-step reaction with 4 steps
1.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran; water / 12 h / 85 °C / Inert atmosphere
2.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 100 °C / Inert atmosphere
3.1: sodium hydroxide; water / ethanol / 5 h / 100 °C
4.1: diphenyl phosphoryl azide; triethylamine / toluene / 12 h / 100 °C
4.2: 100 °C
View Scheme
Multi-step reaction with 5 steps
1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran; water / 12 h / 85 °C / Inert atmosphere
2: caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 100 °C / Inert atmosphere
3: sodium hydroxide; water / ethanol / 5 h / 100 °C
4: diphenyl phosphoryl azide; triethylamine / toluene / 12 h / 100 °C
5: trifluoroacetic acid / dichloromethane / 8 h
View Scheme
1-methyl-4-nitrobenzene
99-99-0

1-methyl-4-nitrobenzene

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: bromine; iron / 1.5 h / 80 °C / Inert atmosphere; Schlenk technique
2: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 20 h / 20 - 100 °C / Inert atmosphere; Schlenk technique
3: hydrazine hydrate; iron(III) chloride; pyrographite / water / 80 °C / Inert atmosphere; Schlenk technique
View Scheme
Multi-step reaction with 3 steps
1: sulfuric acid; N-Bromosuccinimide / water
2: copper(l) iodide; potassium iodide; potassium carbonate / 1,4-dioxane / Inert atmosphere; Reflux
3: ammonium formate; palladium 10% on activated carbon / methanol / 4 h / 30 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: 4-pyridin-3-ylpyrimidin-2-ylamine; iron; bromine / 80 °C
2: copper(l) iodide; N,N`-dimethylethylenediamine / 1,4-dioxane / 0.5 h / 120 °C / Microwave irradiation
3: zinc; ammonium chloride / tetrahydrofuran / 0.17 h / 80 °C / Microwave irradiation
View Scheme
N-(4,5-dimethoxy-2-nitrobenzyl)-N-(4-methyl-3-((4-(pyridine-3-yl)pyrimidine-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

N-(4,5-dimethoxy-2-nitrobenzyl)-N-(4-methyl-3-((4-(pyridine-3-yl)pyrimidine-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dimethyl sulfoxide / 0.17 h / Irradiation
2: hydrogenchloride; acetic acid / 20 °C / Reflux
View Scheme
N-(2-methyl-5-nitrophenyl)guanidinium hydrochloride
1207534-99-3

N-(2-methyl-5-nitrophenyl)guanidinium hydrochloride

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / isopropyl alcohol / 24 h / Reflux
2: hydrogen; platinum(IV) oxide / tetrahydrofuran / 1.5 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / propan-1-ol / 24 h / Reflux
2: platinum(IV) oxide; hydrogen
View Scheme
6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

3-Iodobenzoic acid
618-51-9

3-Iodobenzoic acid

C23H18IN5O

C23H18IN5O

Conditions
ConditionsYield
Stage #1: 3-Iodobenzoic acid With thionyl chloride; N,N-dimethyl-formamide In N,N-dimethyl-formamide at 20℃; for 17h;
Stage #2: 6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 2.5h;
100%
1,1,1,3,3,3-hexamethyl-disilazane
999-97-3

1,1,1,3,3,3-hexamethyl-disilazane

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

C22H31N5Si2

C22H31N5Si2

Conditions
ConditionsYield
With hydroxylamine hydrochloride for 5h; Reflux;99.6%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

C22H31N5Si2

C22H31N5Si2

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 2h; Solvent;99.6%
4-((4-methylpiperazin-1-yl)methyl)benzoyl chloride dihydrochloride

4-((4-methylpiperazin-1-yl)methyl)benzoyl chloride dihydrochloride

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

imatinib
152459-95-5

imatinib

Conditions
ConditionsYield
Stage #1: 4-((4-methylpiperazin-1-yl)methyl)benzoyl chloride dihydrochloride; 6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine In water at 0℃;
Stage #2: With sodium hydroxide In water at 50 - 55℃; pH=9 - 9.5; Product distribution / selectivity;
99.26%
With pyridine at 0 - 20℃; for 1h; Product distribution / selectivity;95%
Stage #1: 6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine With pyridine for 0.333333h; Autoclave;
Stage #2: 4-((4-methylpiperazin-1-yl)methyl)benzoyl chloride dihydrochloride at 0 - 25℃; for 8h;
92.7%
trimethylsilyl bromide
2857-97-8

trimethylsilyl bromide

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

C22H31N5Si2

C22H31N5Si2

Conditions
ConditionsYield
With triethylamine In 2-methyltetrahydrofuran at 0 - 20℃;99.2%
p-(chloromethyl)benzoyl chloride
876-08-4

p-(chloromethyl)benzoyl chloride

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

4-(chloromethyl)-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]-amino}phenyl)benzamide
404844-11-7

4-(chloromethyl)-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]-amino}phenyl)benzamide

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran at 0 - 20℃; for 4h;99%
With triethylamine In tetrahydrofuran at 0℃; for 1h; Large scale;98.1%
With triethylamine In tetrahydrofuran at 0℃; for 4h;97.4%
p-(chloromethyl)benzoyl chloride
876-08-4

p-(chloromethyl)benzoyl chloride

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

4-(сhloromethyl)-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide hydrochloride
404844-10-6

4-(сhloromethyl)-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide hydrochloride

Conditions
ConditionsYield
In 1,4-dioxane at 22 - 34℃; for 2.75h;99%
C17H23N4O(1+)*CF3O3S(1-)

C17H23N4O(1+)*CF3O3S(1-)

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

imatinib
152459-95-5

imatinib

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 40 - 50℃; for 6h; Time;97.8%
benzoyl chloride
98-88-4

benzoyl chloride

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

N-(4-methyl-3(4-(pyridine-3-yl)pyrimidin-2-ylamino)phenyl)benzamide
152459-94-4

N-(4-methyl-3(4-(pyridine-3-yl)pyrimidin-2-ylamino)phenyl)benzamide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0 - 25℃; for 3h;97%
With pyridine for 23h; Ambient temperature;18.3%
phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

4-dimethylamino-benzaldehyde
100-10-7

4-dimethylamino-benzaldehyde

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

diethyl ((4-(dimethylamino)phenyl)((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)amino)methyl)phosphonate

diethyl ((4-(dimethylamino)phenyl)((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)amino)methyl)phosphonate

Conditions
ConditionsYield
With nickel(II) oxide In neat (no solvent) for 0.25h; Reagent/catalyst; Microwave irradiation;96.2%
indole-2,3-dione
91-56-5

indole-2,3-dione

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

3-((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)imino)indolin-2-one

3-((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)imino)indolin-2-one

Conditions
ConditionsYield
In toluene for 24h; Dean-Stark; Reflux;96%
4-[(4-methylpiperazin-1-yl)methyl]bromobenzene
368879-17-8

4-[(4-methylpiperazin-1-yl)methyl]bromobenzene

carbon monoxide
201230-82-2

carbon monoxide

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

imatinib
152459-95-5

imatinib

Conditions
ConditionsYield
With palladium diacetate; triethylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 50℃; under 760.051 Torr; for 36h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;95.8%
4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

diethyl ((4-hydroxyphenyl)((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)amino)methyl)phosphonate

diethyl ((4-hydroxyphenyl)((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)amino)methyl)phosphonate

Conditions
ConditionsYield
With nickel(II) oxide In neat (no solvent) for 0.266667h; Microwave irradiation;95.8%
4-Diethylaminobenzaldehyde
120-21-8

4-Diethylaminobenzaldehyde

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

diethyl ((4-(diethylamino)phenyl)((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)amino)methyl)phosphonate

diethyl ((4-(diethylamino)phenyl)((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)amino)methyl)phosphonate

Conditions
ConditionsYield
With nickel(II) oxide In neat (no solvent) for 0.266667h; Microwave irradiation;95.7%
6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

N-(5-azido-2-methylphenyl)-4-(pyridine-3-yl)pyrimidin-2-amine
1346617-84-2

N-(5-azido-2-methylphenyl)-4-(pyridine-3-yl)pyrimidin-2-amine

Conditions
ConditionsYield
Stage #1: 6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine With hydrogenchloride; sodium nitrite In water at 0 - 5℃; for 1.5h;
Stage #2: With sodium azide In water at 0 - 5℃; for 3h;
95%
With fluorosulfonyl azide; potassium hydrogencarbonate In tert-butyl methyl ether; water; N,N-dimethyl-formamide at 20℃; for 0.0833333h;85%
Stage #1: 6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine With sulfuric acid; sodium nitrite In water at 0℃; for 0.5h;
Stage #2: With sodium azide In water at 0 - 20℃; for 3h;
81%
Stage #1: 6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine With hydrogenchloride; sodium nitrite In water at 0℃; for 1h;
Stage #2: With sodium azide In water at 0℃; for 2h;
With hydrogenchloride; sodium azide; sodium nitrite In water at 0℃; for 3h;
succinic acid anhydride
108-30-5

succinic acid anhydride

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

C20H19N5O3
1450754-50-3

C20H19N5O3

Conditions
ConditionsYield
With dmap In N,N-dimethyl-formamide at 20℃; for 12h; Inert atmosphere;95%
ammonium thiocyanate
1147550-11-5

ammonium thiocyanate

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)thiourea

N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)thiourea

Conditions
ConditionsYield
Stage #1: ammonium thiocyanate With benzoyl chloride In acetone for 0.0833333h; Reflux;
Stage #2: 6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine In acetone Reflux;
95%
3,4,5-trimethoxy-benzaldehyde
86-81-7

3,4,5-trimethoxy-benzaldehyde

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

diethyl ((3,4,5-trimethoxyphenyl)((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)amino)methyl)phosphonate

diethyl ((3,4,5-trimethoxyphenyl)((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)amino)methyl)phosphonate

Conditions
ConditionsYield
With nickel(II) oxide In neat (no solvent) for 0.25h; Microwave irradiation;94.4%
6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

3-chlorobenzoate
535-80-8

3-chlorobenzoate

3-chloro-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide

3-chloro-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide

Conditions
ConditionsYield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate In N,N-dimethyl-formamide at 20℃; for 1h;94%
2-[(tert-butoxy)carbonyl]-1 ,2,3,4-tetrahydroisoquinoline-7-carboxylic acid
149353-95-7

2-[(tert-butoxy)carbonyl]-1 ,2,3,4-tetrahydroisoquinoline-7-carboxylic acid

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

C31H32N6O3

C31H32N6O3

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 16h;94%
4-(N,N-Dimethylaminocarbonyl)benzoic acid
34231-49-7

4-(N,N-Dimethylaminocarbonyl)benzoic acid

trifluoroacetic acid
76-05-1

trifluoroacetic acid

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

N1,N1-dimethyl-N4-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzene-1,4-dicarboxamide trifluoroacetate salt

N1,N1-dimethyl-N4-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzene-1,4-dicarboxamide trifluoroacetate salt

Conditions
ConditionsYield
Stage #1: 4-(N,N-Dimethylaminocarbonyl)benzoic acid; 6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 50℃; for 1h; Inert atmosphere; Schlenk technique;
Stage #2: trifluoroacetic acid In water; acetonitrile
94%
4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

diethyl ((4-chlorophenyl)((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)amino)methyl)phosphonate

diethyl ((4-chlorophenyl)((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)amino)methyl)phosphonate

Conditions
ConditionsYield
With nickel(II) oxide In neat (no solvent) for 0.283333h; Microwave irradiation;93.8%
6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

3,5-dinitrobenoyl chloride
99-33-2

3,5-dinitrobenoyl chloride

N-[4-methyl-3-(4-pyridin-3-ylpyrimidin-2-ylamino)phenyl]-3,5-dinitrobenzamide
1207534-76-6

N-[4-methyl-3-(4-pyridin-3-ylpyrimidin-2-ylamino)phenyl]-3,5-dinitrobenzamide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0 - 20℃;93%
3-nitro-benzaldehyde
99-61-6

3-nitro-benzaldehyde

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

diethyl ((3-nitrophenyl)((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)amino)methyl)phosphonate

diethyl ((3-nitrophenyl)((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)amino)methyl)phosphonate

Conditions
ConditionsYield
With nickel(II) oxide In neat (no solvent) for 0.3h; Microwave irradiation;92.6%
6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

4-((4-methylpiperazin-1-yl)methyl)benzoic acid dihydrochloride

4-((4-methylpiperazin-1-yl)methyl)benzoic acid dihydrochloride

imatinib
152459-95-5

imatinib

Conditions
ConditionsYield
Stage #1: 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride With pyridine; thionyl chloride at 50 - 60℃; for 3h;
Stage #2: 6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine at -10 - 0℃; for 1h;
92.5%
Stage #1: 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 50℃; for 2h;
Stage #2: 6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine In N,N-dimethyl-formamide at 70℃; for 12h;
91%
Stage #1: 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride With pyridine; thionyl chloride at 20 - 50℃; for 1 - 2h;
Stage #2: 6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine With pyridine at 0 - 25℃; for 1h; Product distribution / selectivity;
90%
4-nitro-3-(trifluoromethyl)benzoyl chloride
98187-16-7

4-nitro-3-(trifluoromethyl)benzoyl chloride

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
152460-10-1

6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

N-[4-methyl-3-(4-pyridin-3-ylpyrimidin-2-ylamino)phenyl]-4-nitro-3-trifluoromethylbenzamide
945028-63-7

N-[4-methyl-3-(4-pyridin-3-ylpyrimidin-2-ylamino)phenyl]-4-nitro-3-trifluoromethylbenzamide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0 - 20℃;92%
With pyridine In dichloromethane at 0℃;
With triethylamine In tetrahydrofuran at 0 - 20℃; for 26h;
With triethylamine In tetrahydrofuran

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