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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-Chloroindole cas no. 25235-85-2 98%

Cas:25235-85-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

4-Chloroindole Manufacturer/High quality/Best price/In stock

Cas:25235-85-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 4-Chloroindole supplier in China

Cas:25235-85-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Chloroindole

Cas:25235-85-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFUCHEM- 4-Chloroindole

Cas:25235-85-2

Min.Order:1 Kilogram

FOB Price: $2000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

4-Chloroindole CAS:25235-85-2

Cas:25235-85-2

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 25235-85-2 with best quality

Cas:25235-85-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material CAS25235-85-2 4-Chloroindole

Cas:25235-85-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

4-Chloroindole CAS:25235-85-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedia

4-Chloroindole CAS:25235-85-2

Cas:25235-85-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-Chloroindole

Cas:25235-85-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:25235-85-2

Cas:25235-85-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-Chloroindole

Cas:25235-85-2

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-Chloroindole

Cas:25235-85-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-Chloroindole

Cas:25235-85-2

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Hangzhou Lingrui Chemical Co.,Ltd.

advantage: 1. The best price, satisfactory quality; 2. customers have the right to choose the delivery of parcels (EMS, DHL, FedEx, UPS); 3. customers have the right to choose from the recent effective packaging methods of their products packaging

Low price 25235-85-2 Reliable quality 4-Chloroindole 99%

Cas:25235-85-2

Min.Order:1 Kilogram

Negotiable

Type:Other

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Shanghai Send Pharmaceutical Technology Co., Ltd.

low price high quality high purity good sevice stock Appearance:white Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,10g...1kg,5kg...more Application:Pharmaceutical intermediat

4-Chloroindole 25235-85-2

Cas:25235-85-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 4-Chloroindole

Cas:25235-85-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

CAS25235-85-2 4-Chloroindole

Cas:25235-85-2

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

4-Chloroindole

Cas:25235-85-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

4-Chloroindole

Cas:25235-85-2

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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Shanghai Minstar Chemical Co., Ltd

4-Chloroindole Basic information Product Name: 4-Chloroindole Synonyms: 4-CHLOROINDOLE;4-CHLORO-1H-INDOLE;4-Chloroindole in stock Factory;TIMTEC-BB SBB004057;Indole, 4-chloro-;NSC 88141;1H-Indole,4-chloro-(9CI);4-CHLOROINDOLE 99% CAS: 25235

4-Chloroindole

Cas:25235-85-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

CAS25235-85-2 4-Chloroindole

Cas:25235-85-2

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

4-Chloroindole

Cas:25235-85-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

CAS25235-85-2 4-Chloroindole

Cas:25235-85-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

CAS25235-85-2 4-Chloroindole

Cas:25235-85-2

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

4-Chloroindole

Cas:25235-85-2

Min.Order:0

Negotiable

Type:Other

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Wuhu Nuowei Chemistry Technologies Co., Ltd.

Wuhu Nuovo Chemical Technology Co., Ltd. was established in August 2014, mainly engaged in the development, production and sales of ionic liquids, ribose, nucleosides, nucleotides and related chemicals; Products are mainly used in new energy, new ma

4-Chloroindole

Cas:25235-85-2

Min.Order:100 Gram

Negotiable

Type:Manufacturers

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

4-Chloroindole

Cas:25235-85-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

4-chloroindole

Cas:25235-85-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

CAS25235-85-2 4-Chloroindole

Cas:25235-85-2

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Synthetic route

methyl 4-chloro-indole-1-carboxylate
81038-36-0

methyl 4-chloro-indole-1-carboxylate

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
With potassium hydroxide In methanol for 1h; Reflux;99%
With sodium hydroxide In methanol for 0.25h; Heating;79%
2-(2-amino-6-chlorophenyl)ethyl alcohol
100376-53-2

2-(2-amino-6-chlorophenyl)ethyl alcohol

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
tris(triphenylphosphine)ruthenium(II) chloride In toluene for 6h; Heating;92%
tris(triphenylphosphine)ruthenium(II) chloride In toluene for 6h; Rate constant; Heating;92%
tris(triphenylphosphine)ruthenium(II) chloride In toluene Heating;80%
2-(2-chloro-6-nitrophenyl)-ethanol
102493-68-5

2-(2-chloro-6-nitrophenyl)-ethanol

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
With hydrogen In o-xylene under 760.051 Torr; for 12h; Reflux;75%
Multi-step reaction with 2 steps
1: H2 / 5percent Pd-C / ethyl acetate
2: 80 percent / RuCl2(PPh3)3 / toluene / Heating
View Scheme
Multi-step reaction with 2 steps
1: 45 percent / Zn/CaCl2/H2O / ethanol / 8 h / Heating
2: 92 percent / RuCl2(PPh3)3 / toluene / 6 h / Heating
View Scheme
Multi-step reaction with 6 steps
1: triethylamine / dichloromethane / 0 - 25 °C
2: 1,4-diaza-bicyclo[2.2.2]octane / N,N-dimethyl acetamide / 12 h / 75 °C
3: zinc; acetic acid / 24 h / 70 °C
4: pyridine / dichloromethane / 0 - 25 °C
5: bis(benzonitrile)palladium(II) dichloride; tert.-butylnitrite; oxygen / tert-butyl alcohol / 16 h / 70 °C / 760.05 Torr / Schlenk technique
6: potassium hydroxide / methanol / 1 h / Reflux
View Scheme
3-chloro-trans-2-[β-(dimethylamino)vinyl]-nitrobenzene
32991-06-3

3-chloro-trans-2-[β-(dimethylamino)vinyl]-nitrobenzene

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
With acetic acid; zinc In methanol; dichloromethane Heating;74%
With hydrazine hydrate In tetrahydrofuran; methanol at 10 - 20℃; Reduction; cyclization;243.3 g
In benzene
2,β-Dinitro-6-chlor-styrol
89892-65-9

2,β-Dinitro-6-chlor-styrol

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
With indium; acetic acid In benzene at 80℃; for 1h; Inert atmosphere;74%
N-(3-chloro-2-(2-(trimethylsilyl)ethynyl)phenyl)-2-hydroxy-2-methylpropanamide
1244651-54-4

N-(3-chloro-2-(2-(trimethylsilyl)ethynyl)phenyl)-2-hydroxy-2-methylpropanamide

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl-formamide at 140℃; for 4h; Inert atmosphere;73%
With sodium hydroxide In N,N-dimethyl-formamide at 140℃; for 4h; Inert atmosphere;73%
4-chloroindoline
41910-64-9

4-chloroindoline

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
With oxygen; sodium t-butanolate In dimethyl sulfoxide at 60℃; under 760.051 Torr; for 4h;63%
With monoamine oxidase D11 In aq. phosphate buffer; dimethyl sulfoxide at 37℃; for 168h; pH=7.8; Enzymatic reaction;44%
methyl 4-chloro-3-indolecarboxylate
101909-42-6

methyl 4-chloro-3-indolecarboxylate

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
With sodium hydroxide In methanol for 1.5h; Heating;61.7%
6-chloro-2-nitrotoluene
83-42-1

6-chloro-2-nitrotoluene

N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
Stage #1: 6-chloro-2-nitrotoluene; N,N-dimethyl-formamide dimethyl acetal With pyrrolidine In 1,4-dioxane at 102℃; for 9h; Leimgruber-Batcho Indole Synthesis; Reflux; Inert atmosphere;
Stage #2: With hydrazine hydrate In 1,4-dioxane at 45℃; for 1h; Leimgruber-Batcho Indole Synthesis;
55%
Stage #1: 6-chloro-2-nitrotoluene; N,N-dimethyl-formamide dimethyl acetal With pyrrolidine In N,N-dimethyl-formamide at 110℃; for 8h; Leimgruber-Batcho indole synthesis; Inert atmosphere;
Stage #2: With iron(III) chloride hexahydrate; pyrographite; hydrazine hydrate In ethanol at 75℃; for 5h; Leimgruber-Batcho indole synthesis;
4-Chloro-1-methoxy-1,3-dihydro-indol-2-one
91523-33-0

4-Chloro-1-methoxy-1,3-dihydro-indol-2-one

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether for 3h; Heating;40%
3-Chloronitrobenzene
121-73-3

3-Chloronitrobenzene

vinyl magnesium bromide
1826-67-1

vinyl magnesium bromide

A

6-chloroindole
17422-33-2

6-chloroindole

B

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

C

3-chloro-aniline
108-42-9

3-chloro-aniline

Conditions
ConditionsYield
In tetrahydrofuran at -40℃; Yield given;A n/a
B n/a
C 32%
In tetrahydrofuran at -40℃; Yields of byproduct given;A n/a
B n/a
C 32%
1-[(E)-2-(2-chloro-6-nitrophenyl)vinyl]pyrrolidine
320337-94-8

1-[(E)-2-(2-chloro-6-nitrophenyl)vinyl]pyrrolidine

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
With iron(III) chloride hexahydrate; pyrographite; hydrazine hydrate In ethanol at 75℃; for 5h;32%
4-chloro-1H-indole-2-carboxylic acid
24621-73-6

4-chloro-1H-indole-2-carboxylic acid

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
With quinoline; copper(l) chloride Erhitzen auf Siedetemp.;
With quinoline; copper oxide-chromium oxide at 215℃;
at 255℃;
1-[(E)-2-(2-Chloro-6-nitro-phenyl)-vinyl]-piperidine

1-[(E)-2-(2-Chloro-6-nitro-phenyl)-vinyl]-piperidine

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
With titanium(III) chloride; ammonium acetate In acetone Yield given;
6-chloro-2-nitrotoluene
83-42-1

6-chloro-2-nitrotoluene

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 89 percent / CuI; DMF / 0.33 h / 180 °C / 6000.6 - 7500.75 Torr / microwave irradiation
2: 74 percent / Zn; AcOH / methanol; CH2Cl2 / Heating
View Scheme
Multi-step reaction with 2 steps
1: dimethylformamide / 80 h / 110 °C
2: 243.3 g / aq. hydrazine hydrate / tetrahydrofuran; methanol / 10 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1: DMSO, TritonB / methanol
2: H2 / 5percent Pd-C / ethyl acetate
3: 80 percent / RuCl2(PPh3)3 / toluene / Heating
View Scheme
6-chloro-2-nitrotoluene
83-42-1

6-chloro-2-nitrotoluene

HNO3+H2SO4

HNO3+H2SO4

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) Triton B, 2.) Zn, CaCl2 / 1.) Me2SO, 95 deg C, 1 h, 2.) H2O, reflux
2: 92 percent / RuCl2(PPh3)3 / toluene / 6 h / Heating
View Scheme
4-nitro-1H-indoIe
4769-97-5

4-nitro-1H-indoIe

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium hydride / N,N-dimethyl-formamide / 4 h
2: titanium(III) chloride / methanol; water / 0.12 h / Ambient temperature
3: hydrogenchloride; copper(l) chloride; sodium nitrite / 1.) water, 5 deg C, 20 min, 2.) water, room temp., 30 min; 97 deg C, 5 min
4: sodium hydroxide / methanol / 0.25 h / Heating
View Scheme
1-hydroxy-4-nitroindole
78283-23-5

1-hydroxy-4-nitroindole

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: triethylamine / methanol / 16 h / Ambient temperature
2: sodium hydride / N,N-dimethyl-formamide / 4 h
3: titanium(III) chloride / methanol; water / 0.12 h / Ambient temperature
4: hydrogenchloride; copper(l) chloride; sodium nitrite / 1.) water, 5 deg C, 20 min, 2.) water, room temp., 30 min; 97 deg C, 5 min
5: sodium hydroxide / methanol / 0.25 h / Heating
View Scheme
Multi-step reaction with 5 steps
1: triethylamine / methanol / 43 h / Ambient temperature
2: sodium hydride / N,N-dimethyl-formamide / 4 h
3: titanium(III) chloride / methanol; water / 0.12 h / Ambient temperature
4: hydrogenchloride; copper(l) chloride; sodium nitrite / 1.) water, 5 deg C, 20 min, 2.) water, room temp., 30 min; 97 deg C, 5 min
5: sodium hydroxide / methanol / 0.25 h / Heating
View Scheme
Multi-step reaction with 5 steps
1: ethyl bromoacetate; triethylamine / methanol / 92.5 h / Ambient temperature
2: sodium hydride / N,N-dimethyl-formamide / 4 h
3: titanium(III) chloride / methanol; water / 0.12 h / Ambient temperature
4: hydrogenchloride; copper(l) chloride; sodium nitrite / 1.) water, 5 deg C, 20 min, 2.) water, room temp., 30 min; 97 deg C, 5 min
5: sodium hydroxide / methanol / 0.25 h / Heating
View Scheme
Multi-step reaction with 6 steps
1: triethylamine / methanol / 16 h / Ambient temperature
2: triethylamine / methanol / 16 h / Ambient temperature
3: sodium hydride / N,N-dimethyl-formamide / 4 h
4: titanium(III) chloride / methanol; water / 0.12 h / Ambient temperature
5: hydrogenchloride; copper(l) chloride; sodium nitrite / 1.) water, 5 deg C, 20 min, 2.) water, room temp., 30 min; 97 deg C, 5 min
6: sodium hydroxide / methanol / 0.25 h / Heating
View Scheme
4-amino-1-methoxycarbonylindole
81038-30-4

4-amino-1-methoxycarbonylindole

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride; copper(l) chloride; sodium nitrite / 1.) water, 5 deg C, 20 min, 2.) water, room temp., 30 min; 97 deg C, 5 min
2: sodium hydroxide / methanol / 0.25 h / Heating
View Scheme
1-methoxycarbonyl-4-nitroindole
81038-41-7

1-methoxycarbonyl-4-nitroindole

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: titanium(III) chloride / methanol; water / 0.12 h / Ambient temperature
2: hydrogenchloride; copper(l) chloride; sodium nitrite / 1.) water, 5 deg C, 20 min, 2.) water, room temp., 30 min; 97 deg C, 5 min
3: sodium hydroxide / methanol / 0.25 h / Heating
View Scheme
methyl 2-hydroxy-2-(4-nitroindol-1-yl)-acetate
81038-27-9

methyl 2-hydroxy-2-(4-nitroindol-1-yl)-acetate

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sodium hydrogencarbonate / methanol; water / 0.08 h / Heating
2: sodium hydride / N,N-dimethyl-formamide / 4 h
3: titanium(III) chloride / methanol; water / 0.12 h / Ambient temperature
4: hydrogenchloride; copper(l) chloride; sodium nitrite / 1.) water, 5 deg C, 20 min, 2.) water, room temp., 30 min; 97 deg C, 5 min
5: sodium hydroxide / methanol / 0.25 h / Heating
View Scheme
methyl 2-(4-nitroindole-1-yl)oxyacetate
81038-26-8

methyl 2-(4-nitroindole-1-yl)oxyacetate

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: triethylamine / methanol / 16 h / Ambient temperature
2: sodium hydride / N,N-dimethyl-formamide / 4 h
3: titanium(III) chloride / methanol; water / 0.12 h / Ambient temperature
4: hydrogenchloride; copper(l) chloride; sodium nitrite / 1.) water, 5 deg C, 20 min, 2.) water, room temp., 30 min; 97 deg C, 5 min
5: sodium hydroxide / methanol / 0.25 h / Heating
View Scheme
3-methoxycarbonylindole
942-24-5

3-methoxycarbonylindole

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) TTFA, 2.) CuCl2 / 1.) TFA, room temp., 2 h; 2.) DMF, 120 deg C, 1 h
2: 61.7 percent / 40percent NaOH / methanol / 1.5 h / Heating
View Scheme
2-(2-chlorophenyl)-N-methoxyacetamide
119114-47-5

2-(2-chlorophenyl)-N-methoxyacetamide

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 97 percent / tert-butyl hypochlorite / CH2Cl2 / 0.33 h / 0 °C
2: 71 percent / Ag2CO3, trifluoroacetic acid / 0.5 h / 0 °C
3: 40 percent / LiAlH4 / diethyl ether / 3 h / Heating
View Scheme
N-chloro-2-(2-chlorophenyl)-N-methoxyacetamide
91523-29-4

N-chloro-2-(2-chlorophenyl)-N-methoxyacetamide

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 71 percent / Ag2CO3, trifluoroacetic acid / 0.5 h / 0 °C
2: 40 percent / LiAlH4 / diethyl ether / 3 h / Heating
View Scheme
2-(2-chlorophenyl)acetyl chloride
51512-09-5

2-(2-chlorophenyl)acetyl chloride

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 94 percent / sodium carbonate / H2O; benzene / 5 h / Ambient temperature
2: 97 percent / tert-butyl hypochlorite / CH2Cl2 / 0.33 h / 0 °C
3: 71 percent / Ag2CO3, trifluoroacetic acid / 0.5 h / 0 °C
4: 40 percent / LiAlH4 / diethyl ether / 3 h / Heating
View Scheme
(2-chloro-6-nitro-phenyl)-pyruvic acid
36892-19-0

(2-chloro-6-nitro-phenyl)-pyruvic acid

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Fe(OH)2; aqueous NH3
2: copper (I)-chloride; quinoline / Erhitzen auf Siedetemp.
View Scheme
3-chloro-2-iodophenyl N,N-dimethyl O-carbamate
863870-77-3

3-chloro-2-iodophenyl N,N-dimethyl O-carbamate

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydroxide / ethanol / Reflux
2.1: sodium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
2.2: 2 h / 20 °C / Inert atmosphere
3.1: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere
4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / N,N-dimethyl-formamide / 5.5 h / 40 °C / Inert atmosphere
5.1: sodium hydroxide / N,N-dimethyl-formamide / 4 h / 140 °C / Inert atmosphere
View Scheme
N-(3-chloro-2-iodophenyl)-2-hydroxy-2-methylpropanamide
1244651-34-0

N-(3-chloro-2-iodophenyl)-2-hydroxy-2-methylpropanamide

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / N,N-dimethyl-formamide / 5.5 h / 40 °C / Inert atmosphere
2: sodium hydroxide / N,N-dimethyl-formamide / 4 h / 140 °C / Inert atmosphere
View Scheme
4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

2-Bromoethyl methyl ether
6482-24-2

2-Bromoethyl methyl ether

5-chloro-1-(2-methoxyethyl)-1H-indole
1313042-80-6

5-chloro-1-(2-methoxyethyl)-1H-indole

Conditions
ConditionsYield
With sodium hydride; sodium iodide In N,N-dimethyl-formamide; mineral oil at 0℃; for 2.16667h;100%
4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

4-chloroindoline
41910-64-9

4-chloroindoline

Conditions
ConditionsYield
Stage #1: 4-chloro-1H-indole With sodium cyanoborohydride; acetic acid In N,N-dimethyl-formamide at 20℃; for 2h;
Stage #2: With water; sodium hydroxide In N,N-dimethyl-formamide
99%
With sodium cyanoborohydride; acetic acid at 0 - 20℃; Inert atmosphere;89%
With sodium cyanoborohydride; acetic acid for 3h; Ambient temperature;
4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl 4-chloro-1H-indole-1-carboxylate
129822-46-4

tert-butyl 4-chloro-1H-indole-1-carboxylate

Conditions
ConditionsYield
With dmap In tetrahydrofuran at 20℃;99%
With dmap In tetrahydrofuran at 20℃; for 16h; Inert atmosphere; Sealed tube;91%
With dmap In dichloromethane at 20℃; for 0.75h;
4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

3-bromopropanal dimethyl acetal
36255-44-4

3-bromopropanal dimethyl acetal

4-chloro-1-(3,3-dimethoxypropyl)-1H-indole

4-chloro-1-(3,3-dimethoxypropyl)-1H-indole

Conditions
ConditionsYield
With potassium hydroxide In N,N-dimethyl-formamide at 50℃; for 5h;99%
4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

tert-butyl N-(phenyl(phenylsulfonyl)methyl)carbamate
155396-71-7

tert-butyl N-(phenyl(phenylsulfonyl)methyl)carbamate

4-chloro-3-[phenyl(phenylsulfonyl)methyl]-1H-indole

4-chloro-3-[phenyl(phenylsulfonyl)methyl]-1H-indole

Conditions
ConditionsYield
With dipotassium peroxodisulfate In toluene at 20℃; for 48h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; regioselective reaction;99%
4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

9-phenyl-fluoren-9-ol
25603-67-2

9-phenyl-fluoren-9-ol

4-chloro-3-(9-phenyl-9H-fluoren-9-yl)-1H-indole

4-chloro-3-(9-phenyl-9H-fluoren-9-yl)-1H-indole

Conditions
ConditionsYield
With scandium tris(trifluoromethanesulfonate) In dichloromethane at 60℃; for 4h; Sealed tube;98%
4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

benzyl bromide
100-39-0

benzyl bromide

4-chloro-1-benzyl-1H-indole
77801-60-6

4-chloro-1-benzyl-1H-indole

Conditions
ConditionsYield
Stage #1: 4-chloro-1H-indole With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: benzyl bromide In N,N-dimethyl-formamide at 20℃; for 20h;
97%
Stage #1: 4-chloro-1H-indole With potassium hydroxide In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: benzyl bromide In N,N-dimethyl-formamide at 0 - 20℃;
Stage #1: 4-chloro-1H-indole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 0.666667h; Inert atmosphere;
Stage #2: benzyl bromide In N,N-dimethyl-formamide; mineral oil at 0 - 45℃; for 1h; Inert atmosphere;
4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

methyl oct-1-en-3-yl carbonate
95151-36-3

methyl oct-1-en-3-yl carbonate

(R)-4-chloro-1-(oct-1-en-3-yl)-1H-indole

(R)-4-chloro-1-(oct-1-en-3-yl)-1H-indole

Conditions
ConditionsYield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; C39H51N2O3P In acetonitrile at 100℃; for 36h; enantioselective reaction;97%
4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

acetyl chloride
75-36-5

acetyl chloride

1-(4-chloro-1H-indol-1-yl)ethan-1-one
1261240-69-0

1-(4-chloro-1H-indol-1-yl)ethan-1-one

Conditions
ConditionsYield
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide In dichloromethane at 20℃; for 0.75h;96%
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide In dichloromethane at 20℃; for 1h; Inert atmosphere; Sealed tube;64%
4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

carbon monoxide
201230-82-2

carbon monoxide

butan-1-ol
71-36-3

butan-1-ol

butyl 4-chloro-1H-indole-1-carboxylate
1334225-18-1

butyl 4-chloro-1H-indole-1-carboxylate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; oxygen; copper diacetate; dimethyl sulfoxide; triphenylphosphine In toluene at 100℃; under 760.051 Torr; for 36h; regioselective reaction;95%
4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

(allylsulfonyl)benzene
16212-05-8

(allylsulfonyl)benzene

4-chloro-1-(1-(phenylsulfonyl)propan-2-yl)-1H-indole

4-chloro-1-(1-(phenylsulfonyl)propan-2-yl)-1H-indole

Conditions
ConditionsYield
With potassium tert-butylate In toluene at 22℃; for 0.166667h; Inert atmosphere; Sealed tube; regioselective reaction;95%
4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

N,N-Dimethylcarbamoyl chloride
79-44-7

N,N-Dimethylcarbamoyl chloride

4-chloro-N,N-dimethyl-1H-indole-1-carboxamide

4-chloro-N,N-dimethyl-1H-indole-1-carboxamide

Conditions
ConditionsYield
Stage #1: 4-chloro-1H-indole With sodium hydride In N,N-dimethyl-formamide at 75℃; for 3h; Inert atmosphere;
Stage #2: N,N-Dimethylcarbamoyl chloride In N,N-dimethyl-formamide at 75℃; Inert atmosphere;
94%
Stage #1: 4-chloro-1H-indole With sodium hydride In N,N-dimethyl-formamide at 0 - 75℃; Inert atmosphere; Schlenk technique;
Stage #2: N,N-Dimethylcarbamoyl chloride In N,N-dimethyl-formamide at 0 - 75℃; Inert atmosphere; Schlenk technique;
94%
With potassium hydroxide 1.) THF, RT, 15 min, 2.) THF, RT, 4 h; Multistep reaction;
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide In dichloromethane Inert atmosphere; Reflux;
4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

C16H12Cl2N2

C16H12Cl2N2

Conditions
ConditionsYield
With bismuth(III) chloride In dichloromethane at 20℃; for 6h;94%
4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

methyl iodide
74-88-4

methyl iodide

4-chloro-1-methyl-1H-indole
77801-91-3

4-chloro-1-methyl-1H-indole

Conditions
ConditionsYield
Stage #1: 4-chloro-1H-indole With sodium hydride In tetrahydrofuran at 0℃; for 1h;
Stage #2: methyl iodide In tetrahydrofuran at 20℃; for 5h;
93%
Stage #1: 4-chloro-1H-indole With sodium hydride In tetrahydrofuran for 0.25h;
Stage #2: methyl iodide In tetrahydrofuran
Stage #1: 4-chloro-1H-indole With sodium hydride In tetrahydrofuran for 0.25h;
Stage #2: methyl iodide In tetrahydrofuran
1-Phenylprop-1-yne
673-32-5

1-Phenylprop-1-yne

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

(S)-4-chloro-3-(1-phenylallyl)-1H-indole

(S)-4-chloro-3-(1-phenylallyl)-1H-indole

Conditions
ConditionsYield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; diphenyl hydrogen phosphate; (R)-DTBM-BINAP at 60℃; Inert atmosphere; Glovebox; enantioselective reaction;93%
4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

2-Methylphenylboronic acid
16419-60-6

2-Methylphenylboronic acid

4-(o-tolyl)-1H-indole

4-(o-tolyl)-1H-indole

Conditions
ConditionsYield
With potassium phosphate; palladium diacetate; ruphos In tetrahydrofuran; toluene at 100℃; for 15h; Suzuki-Miyaura Coupling; Schlenk technique; Inert atmosphere;93%
4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

4-chloro-1-phenylsulfonyl-1H-indole
896137-68-1

4-chloro-1-phenylsulfonyl-1H-indole

Conditions
ConditionsYield
Stage #1: 4-chloro-1H-indole With sodium hydride In tetrahydrofuran at 20℃; for 1h;
Stage #2: benzenesulfonyl chloride In tetrahydrofuran for 1h;
92%
Stage #1: 4-chloro-1H-indole With sodium hydride In tetrahydrofuran at 0℃;
Stage #2: benzenesulfonyl chloride In tetrahydrofuran at 0 - 20℃;
4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

rac-(E)-1,3-diphenyl-3-acetoxy-prop-1-ene
87751-69-7

rac-(E)-1,3-diphenyl-3-acetoxy-prop-1-ene

C23H18ClN

C23H18ClN

Conditions
ConditionsYield
With iodine In dichloromethane at 20℃; for 1h;92%
pyrrolidine
123-75-1

pyrrolidine

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

3-Chlorobenzaldehyde
587-04-2

3-Chlorobenzaldehyde

4-chloro-3-((3-chlorophenyl)(pyrrolidin-1-yl)methyl)-1H-indole
1634687-04-9

4-chloro-3-((3-chlorophenyl)(pyrrolidin-1-yl)methyl)-1H-indole

Conditions
ConditionsYield
In methanol at 30℃; for 72h;92%
4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

ethyl 2-(4-methoxyphenyl)-6-methyl-3,4-dihydro-2H-pyran-5-carboxylate
1301176-55-5

ethyl 2-(4-methoxyphenyl)-6-methyl-3,4-dihydro-2H-pyran-5-carboxylate

ethyl 2-acetyl-5-(4-chloro-1H-indol-3-yl)-5-(4-methoxyphenyl)pentanoate
1301176-78-2

ethyl 2-acetyl-5-(4-chloro-1H-indol-3-yl)-5-(4-methoxyphenyl)pentanoate

Conditions
ConditionsYield
With manganese(II) chloride tetrahydrate In nitromethane at 80℃; for 23h;91%
4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

benzyl chloride
100-44-7

benzyl chloride

4-chloro-1-benzyl-1H-indole
77801-60-6

4-chloro-1-benzyl-1H-indole

Conditions
ConditionsYield
Stage #1: 4-chloro-1H-indole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Cooling with ice; Inert atmosphere;
Stage #2: benzyl chloride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 15h; Inert atmosphere;
91%
4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

cyclopropanemethylamine
2516-47-4

cyclopropanemethylamine

N-(cyclopropylmethyl)-1H-indol-4-amine
1248591-02-7

N-(cyclopropylmethyl)-1H-indol-4-amine

Conditions
ConditionsYield
With dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); lithium hexamethyldisilazane In tetrahydrofuran at 80℃; for 4h; Inert atmosphere; Sealed vial;90%
9-hydroxyxanthene
90-46-0

9-hydroxyxanthene

4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

4-chloro-3-(9H-xanthen-9-yl)-1H-indole
1339112-99-0

4-chloro-3-(9H-xanthen-9-yl)-1H-indole

Conditions
ConditionsYield
With betaine dihydrogenphosphate In octanol at 50℃;90%
at 20℃; Ionic liquid;85%
With 1,3-dichloro-1,1,3,3-tetrabutylstannoxane In dichloromethane at 20℃; for 10h;85%
4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

benzoyl chloride
98-88-4

benzoyl chloride

(4-chloro-1H-indol-1-yl)(phenyl)methanone
858230-84-9

(4-chloro-1H-indol-1-yl)(phenyl)methanone

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 14h; Inert atmosphere;90%
4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

malononitrile
109-77-3

malononitrile

C18H11Cl2N3

C18H11Cl2N3

Conditions
ConditionsYield
With L-proline In ethanol at 20℃; for 72h;90%
4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

methyldiphenylsilane
776-76-1

methyldiphenylsilane

4-chloro-1-(methyldiphenylsilyl)-1H-indole

4-chloro-1-(methyldiphenylsilyl)-1H-indole

Conditions
ConditionsYield
With dodecacarbonyl-triangulo-triruthenium In toluene at 120℃; for 16h; Schlenk technique; Inert atmosphere;90%
4-chloro-1H-indole
25235-85-2

4-chloro-1H-indole

ammonium thiocyanate
1147550-11-5

ammonium thiocyanate

4-chloro-3-thiocyanato-1H-indole

4-chloro-3-thiocyanato-1H-indole

Conditions
ConditionsYield
With oxygen In tetrahydrofuran at 25℃; under 750.075 Torr; for 10h; Irradiation;90%
With copper(II) choride dihydrate; oxygen In ethanol at 20℃; for 24h; Irradiation;86%

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