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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Diethyl 3-hydroxyglutarate Manufacturer/High quality/Best price/In stock

Cas:32328-03-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Diethyl 3-Hydroxyglutarate supplier in China

Cas:32328-03-3

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

diethyl 3-hydroxypentanedioate manufacturer/supplier manufacturer/supplier

Cas:32328-03-3

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-Hydroxyglutaric acid diethyl ester

Cas:32328-03-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Diethyl 3-hydroxyglutarate

Cas:32328-03-3

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 32328-03-3 with best quality

Cas:32328-03-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: Diethyl-3-hydroxyglutarate Synonyms: Diethyl-Beta-Hydroxyglutarate; Diethyl 3-hydroxypentanedioate; Pentanedioic acid, 3-hydroxy-, diethyl ester CAS: 32328-03-3 MF: C9H16O5 Appearance: White powder Storage:Store in cool and dry place, away f

Diethyl-3-hydroxyglutarate

Cas:32328-03-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Pentanedioic acid,3-hydroxy-, 1,5-diethyl ester 32328-03-3

Cas:32328-03-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

N,N-Dimethylacrylamide Basic information Product Name: N,N-Dimethylacrylamide Synonyms: Acrylamide, N,N-dimethyl-;Acylamide, N,N-dimethyl;Dimethylamid kyseliny akrylove;dimethylamidkyselinyakrylove;n,n-dimethyl-2-propenamid;Acryloyldimethylamin

N,N-Dimethylacrylamide

Cas:32328-03-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Diethyl 3-hydroxyglutarate CAS:32328-03-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organ

Diethyl 3-hydroxyglutarate CAS:32328-03-3

Cas:32328-03-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Pentanedioic acid,3-hydroxy-, 1,5-diethyl ester

Cas:32328-03-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Pentanedioic acid,3-hydroxy-, 1,5-diethyl ester

Cas:32328-03-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Price, service, company and transport advantage: 1.place of origin china with super quality by reasonable price. 2. it's customers' right to choose the package (ems, dhl, fedex, ups); 3. it's custo

BEST PRICE/Glutaric acid

Cas:32328-03-3

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Diethyl 3-hydroxyglutarate

Cas:32328-03-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Diethyl 3-hydroxyglutarate

Cas:32328-03-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply diethyl 3-hydroxyglutarate

Cas:32328-03-3

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

cas:32328-03-3

Cas:32328-03-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung, LG, Merck, Thermo Fisher Scientific and so o

32328-03-3

Cas:32328-03-3

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Diethyl 3-hydroxyglutarate Manufacturer/High quality/Best price/In stock

Cas:32328-03-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Diethyl 3-hydroxyglutarate

Cas:32328-03-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Glutaric acid CAS NO.32328-03-3 CAS NO.32328-03-3 CAS NO.32328-03-3

Cas:32328-03-3

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Diethyl 3-hydroxyglutarate

Cas:32328-03-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hebei Lead Bio-Chemicals Co., Ltd.

Hebei Lead Bio-Chemicals Co., Ltd. established in 2006, devolved in resurching, manufacturing and supplying of pharmaceuticals,food ingredients, cosmetics,health care products, Chinese herb, plant extracts and some fine chemicals,is one of leading gr

Diethyl 3-hydroxyglutarate(32328-03-3)

Cas:32328-03-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

Diethyl 3-hydroxyglutarate

Cas:32328-03-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Greenutra Resource Inc

diethyl 3-hydroxyglutarateAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air

diethyl 3-hydroxyglutarate

Cas:32328-03-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

diethyl 3-hydroxyglutarate

Cas:32328-03-3

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air

Diethyl 3-hydroxyglutarate

Cas:32328-03-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Diethyl 3-hydroxyglutarate

Cas:32328-03-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

Diethyl-3-Hdroxyglutarate

Cas:32328-03-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high qualityAppearance:white crystalline powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

2-Amino-6-methyl-5-nitropyridine

Cas:32328-03-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

diethyl 1,3-acetonedicarboxylate
105-50-0

diethyl 1,3-acetonedicarboxylate

diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

Conditions
ConditionsYield
With sodium tetrahydroborate; ethanol at 0℃; for 0.05h;95%
With sodium amalgam
With 1,4-dioxane; nickel Hydrogenation;
diethyl 3-hydroxypentanedioate
638-18-6

diethyl 3-hydroxypentanedioate

ethanol
64-17-5

ethanol

diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

Conditions
ConditionsYield
With sulfuric acid
With sulfuric acid
ethanol
64-17-5

ethanol

3-hydroxyglutaronitrile
13880-89-2

3-hydroxyglutaronitrile

diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

Conditions
ConditionsYield
With sulfuric acid at 90 - 100℃;
With hydrogenchloride In diethyl ether
3-hydroxyglutaronitrile
13880-89-2

3-hydroxyglutaronitrile

diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

allyl bromide
106-95-6

allyl bromide

diethyl 1,3-acetonedicarboxylate
105-50-0

diethyl 1,3-acetonedicarboxylate

diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

Conditions
ConditionsYield
With sodium ethanolate 1.) EtOH, r.t., overnight, 2.) baker's yeast, H2O, 30 deg C, 72 h; Yield given. Multistep reaction;
diethyl 1,3-acetonedicarboxylate
105-50-0

diethyl 1,3-acetonedicarboxylate

Raney nickel

Raney nickel

diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

Conditions
ConditionsYield
Hydrogenation;
ethanol
64-17-5

ethanol

triethylamine
121-44-8

triethylamine

diethyl 1,3-acetonedicarboxylate
105-50-0

diethyl 1,3-acetonedicarboxylate

Raney nickel

Raney nickel

A

diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

B

pentane-1,3,5-triol
4328-94-3

pentane-1,3,5-triol

Conditions
ConditionsYield
at 125℃; under 250073 Torr; Hydrogenation;
acetonedicarboxylic acid
542-05-2

acetonedicarboxylic acid

diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: sodium amalgam
View Scheme
3-oxopentanedioic acid dimethyl ester
1830-54-2

3-oxopentanedioic acid dimethyl ester

diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaBH4 / methanol
2: KOH / methanol
3: H2SO4
View Scheme
dimethyl 3-hydroxypentanedioate
7250-55-7

dimethyl 3-hydroxypentanedioate

diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: KOH / methanol
2: H2SO4
View Scheme
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

1-(Trimethylsilyl)imidazole
18156-74-6

1-(Trimethylsilyl)imidazole

diethyl 3-<(trimethylsilyl)oxy>pentanedioate
91424-41-8

diethyl 3-<(trimethylsilyl)oxy>pentanedioate

Conditions
ConditionsYield
In dichloromethane for 26.5h; Ambient temperature;100%
for 12.5h; Ambient temperature;
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

3-[[(1,1-Dimethylethyl)dimethylsilyl]-oxy]pentanedioic acid,diethyl ester
91424-39-4

3-[[(1,1-Dimethylethyl)dimethylsilyl]-oxy]pentanedioic acid,diethyl ester

Conditions
ConditionsYield
With 1H-imidazole In dichloromethane Inert atmosphere;99%
With 1H-imidazole In dichloromethane99%
With 1H-imidazole In dichloromethane for 18h; Ambient temperature;95%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

diethyl 3-<(trimethylsilyl)oxy>pentanedioate
91424-41-8

diethyl 3-<(trimethylsilyl)oxy>pentanedioate

Conditions
ConditionsYield
With 1H-imidazole In dichloromethane at 20℃; Inert atmosphere;99%
With 1H-imidazole In dichloromethane at 20℃;99%
With 1H-imidazole In dichloromethane at 20 - 25℃; for 16h; Inert atmosphere;
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

(3S)-5-ethoxy-3-hydroxy-5-oxopentanoic acid
95310-87-5

(3S)-5-ethoxy-3-hydroxy-5-oxopentanoic acid

Conditions
ConditionsYield
With Candida antarctica lipase B; water; sodium hydroxide at 40℃; for 0.5h; pH=7; Kinetics; pH-value; Temperature; Concentration; aq. phosphate buffer; optical yield given as %ee; enantioselective reaction;98.5%
With Esterase 30 000 In cyclohexane; water at 25℃; for 3h; pH 7.5 (0.1 M phosphat buffer);94%
With Arthrobacter sp (ATCC 19140) In various solvent(s) for 48h; Product distribution; Microorganism: Corynebacterium equi. Object: enantioselective hydrolysis;38%
In various solvent(s) for 48h; Corynebacterium equi (IFO-3730) or Arthrobacter sp (ATCC 19140); Yield given;
With lipase B from Candida antarctica at 20℃; for 1h; pH=7; aq. phosphate buffer; Inert atmosphere; Enzymatic reaction; optical yield given as %ee; enantioselective reaction;
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

pentane-1,3,5-triol
4328-94-3

pentane-1,3,5-triol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 66℃; for 72h; Inert atmosphere;97%
Stage #1: diethyl 3-hydroxyglutarate With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃;
Stage #2: With ammonium chloride In tetrahydrofuran at -78℃; Cooling with acetone-dry ice;
78%
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 3h;65%
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

Methoxyacetyl chloride
38870-89-2

Methoxyacetyl chloride

3-(2-Methoxy-acetoxy)-pentanedioic acid diethyl ester
483299-14-5

3-(2-Methoxy-acetoxy)-pentanedioic acid diethyl ester

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃;97%
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

tert-butylchlorodiphenylsilane
58479-61-1

tert-butylchlorodiphenylsilane

3-(tert-butyldiphenylsilanyloxy)pentanedioic acid diethyl ester
923027-81-0

3-(tert-butyldiphenylsilanyloxy)pentanedioic acid diethyl ester

Conditions
ConditionsYield
With 1H-imidazole In dichloromethane at 20℃; for 16h;96%
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

(S)-3-hydroxyglutaric acid monoamidemonoethyl ester

(S)-3-hydroxyglutaric acid monoamidemonoethyl ester

Conditions
ConditionsYield
Novozym 43595%
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

allyl ethyl carbonate
1469-70-1

allyl ethyl carbonate

diethyl 3-(allyloxy)glutarate

diethyl 3-(allyloxy)glutarate

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); 1,4-di(diphenylphosphino)-butane In toluene at 110℃; for 16h; Inert atmosphere;95%
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

benzaldehyde
100-52-7

benzaldehyde

diethyl 3-(benzyloxy)pentanedioate
838906-52-8

diethyl 3-(benzyloxy)pentanedioate

Conditions
ConditionsYield
Stage #1: diethyl 3-hydroxyglutarate; benzaldehyde With Hexamethyldisiloxane; trimethylsilyl trifluoromethanesulfonate In tetrahydrofuran at -30℃; for 2h; Inert atmosphere;
Stage #2: With triethylsilane In tetrahydrofuran at -30℃; for 16h; Inert atmosphere;
Stage #3: With sodium tetrahydroborate In methanol at 0℃; for 1h; Inert atmosphere;
93%
Stage #1: diethyl 3-hydroxyglutarate; benzaldehyde With trimethylsilyl trifluoromethanesulfonate; C6H18OSSi In tetrahydrofuran for 2h; Cooling;
Stage #2: With triethylsilane In tetrahydrofuran for 16h; Cooling;
Stage #3: With methanol; sodium tetrahydroborate at 0℃; for 1h;
93%
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

3-hydroxyglutaramide
16072-48-3

3-hydroxyglutaramide

Conditions
ConditionsYield
With ammonia In methanol at 20℃; for 144h;90%
With ammonia
methanol
67-56-1

methanol

diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

dimethyl 3-hydroxypentanedioate
7250-55-7

dimethyl 3-hydroxypentanedioate

Conditions
ConditionsYield
scandium tris(trifluoromethanesulfonate) at 64℃; for 24h;89%
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

acetic anhydride
108-24-7

acetic anhydride

ethyl 3-acetoxypentanedioate
91967-12-3

ethyl 3-acetoxypentanedioate

Conditions
ConditionsYield
With pyridine Ambient temperature;88%
Benzyloxymethyl chloride
3587-60-8

Benzyloxymethyl chloride

diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

diethyl 3-(benzyloxymethyloxy)glutarate
1607830-30-7

diethyl 3-(benzyloxymethyloxy)glutarate

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; Inert atmosphere;85%
With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;85%
With tetrabutyl-ammonium chloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h;60%
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

diethyl 3-hydroxypentanedioate
638-18-6

diethyl 3-hydroxypentanedioate

Conditions
ConditionsYield
With sodium hydroxide In methanol; water for 60h; Ambient temperature;84%
With potassium hydroxide In ethanol
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

β-naphthaldehyde
66-99-9

β-naphthaldehyde

diethyl 3-(naphth-2-yl-methoxy)glutarate

diethyl 3-(naphth-2-yl-methoxy)glutarate

Conditions
ConditionsYield
Stage #1: diethyl 3-hydroxyglutarate; β-naphthaldehyde With Hexamethyldisiloxane; trimethylsilyl trifluoromethanesulfonate In tetrahydrofuran at -30℃; for 2h; Inert atmosphere;
Stage #2: With triethylsilane In tetrahydrofuran at -30℃; for 16h; Inert atmosphere;
Stage #3: With sodium tetrahydroborate In methanol at 0℃; for 1h; Inert atmosphere;
82%
Stage #1: diethyl 3-hydroxyglutarate; β-naphthaldehyde With trimethylsilyl trifluoromethanesulfonate; C6H18OSSi In tetrahydrofuran for 2h; Cooling;
Stage #2: With triethylsilane for 16h; Cooling;
Stage #3: With methanol; sodium tetrahydroborate at 0℃; for 1h;
82%
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

methyl iodide
74-88-4

methyl iodide

diethyl 3-methoxypentanedioate

diethyl 3-methoxypentanedioate

Conditions
ConditionsYield
With silver(l) oxide In N,N-dimethyl-formamide at 20℃; for 72h;82%
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

O-benzyl 2,2,2-trichloroacetimidate
81927-55-1

O-benzyl 2,2,2-trichloroacetimidate

diethyl 3-(benzyloxy)pentanedioate
838906-52-8

diethyl 3-(benzyloxy)pentanedioate

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In dichloromethane; cyclohexane at 0℃; for 24h;79%
With trifluorormethanesulfonic acid In dichloromethane; cyclohexane at 20℃; for 20h; Inert atmosphere;78%
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

(4-chlorophenyl)(pyridin-2-yl)methyl 2,2,2-trichloroacetimidate

(4-chlorophenyl)(pyridin-2-yl)methyl 2,2,2-trichloroacetimidate

diethyl 3-[(4-chlorophenyl)(pyridin-2-yl)methoxy]pentanedioate

diethyl 3-[(4-chlorophenyl)(pyridin-2-yl)methoxy]pentanedioate

Conditions
ConditionsYield
With copper(II) bis(trifluoromethanesulfonate) In dichloromethane at 20℃; for 24h; Molecular sieve; Inert atmosphere; Cooling with ice;73%
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

3-(tert-Butyl-dimethyl-silanyloxy)-pentanedioic acid
113794-48-2

3-(tert-Butyl-dimethyl-silanyloxy)-pentanedioic acid

Conditions
ConditionsYield
Stage #1: tert-butyldimethylsilyl chloride With 1H-imidazole In dichloromethane at 20 - 30℃; for 1 - 2h;
Stage #2: diethyl 3-hydroxyglutarate In dichloromethane at 20 - 30℃; for 4 - 6h;
Stage #3: With hydrogenchloride; sodium hydroxide; water more than 3 stages;
71%
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

(3R)-5-ethoxy-3-hydroxy-5-oxopentanoic acid
95310-88-6

(3R)-5-ethoxy-3-hydroxy-5-oxopentanoic acid

Conditions
ConditionsYield
With Acinetobacter lowfii In various solvent(s) for 48h; Product distribution; Microrganism: Soil isolate S-29. Object: enantioselective hydrolysis.;70%
With disodium hydrogenphosphate; α-chymotrypsin
In various solvent(s) for 48h; Acinetobacter lowfii, or Soil isolate S-29; Yield given;
Multi-step reaction with 3 steps
1: zinc perchlorate / 2 h / 20 °C
2: α-chymotrypsin / aq. buffer / 27 h / 20 °C / pH 8 / Enzymatic reaction
3: immobilized Cephalosporin C acetyl esterase / aq. buffer / 20 °C / pH 8 / Enzymatic reaction
View Scheme
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

S-ethyl 3-phenylpropionic acid thioester
30911-16-1

S-ethyl 3-phenylpropionic acid thioester

3-(3-Phenyl-propionyloxy)-pentanedioic acid diethyl ester
130260-30-9

3-(3-Phenyl-propionyloxy)-pentanedioic acid diethyl ester

Conditions
ConditionsYield
With lithium tetrafluoroborate In acetonitrile Ambient temperature; Pt-electrodes, 50 mA;64%
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

chloromethyl methyl ether
107-30-2

chloromethyl methyl ether

diethyl 3-(methoxymethoxy)glutarate

diethyl 3-(methoxymethoxy)glutarate

Conditions
ConditionsYield
With tetrabutyl-ammonium chloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h;64%
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

but-2-ynyl 2,2,2-trichloroacetimidate
59402-95-8

but-2-ynyl 2,2,2-trichloroacetimidate

diethyl 3-(but-2-yn-1yloxy)glutarate

diethyl 3-(but-2-yn-1yloxy)glutarate

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 20℃; for 1h;60%
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

acetoacetic acid methyl ester
105-45-3

acetoacetic acid methyl ester

methyl 1,8-dihydroxy-3-(methoxycarbonylmethyl)naphthalene-2-carboxylate
107182-04-7

methyl 1,8-dihydroxy-3-(methoxycarbonylmethyl)naphthalene-2-carboxylate

Conditions
ConditionsYield
Stage #1: diethyl 3-hydroxyglutarate; acetoacetic acid methyl ester With lithium diisopropyl amide In tetrahydrofuran at -78℃; Claisen condensation;
Stage #2: With calcium acetate In tetrahydrofuran; methanol
57%
With n-butyllithium; calcium acetate; sodium hydride 1.) THF, hexane, 1 h, room temperature, 2.) MeOH, 2 h, reflux; Yield given. Multistep reaction;
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

1-(1-imino-2,2,2-trichloroethoxy)-3-methyl-2-butene
104808-44-8

1-(1-imino-2,2,2-trichloroethoxy)-3-methyl-2-butene

A

diethyl 3-(3,3-dimethylallyloxy)glutarate

diethyl 3-(3,3-dimethylallyloxy)glutarate

B

diethyl 3-(1,1-dimethylallyloxy)glutarate

diethyl 3-(1,1-dimethylallyloxy)glutarate

Conditions
ConditionsYield
With scandium tris(trifluoromethanesulfonate) In dichloromethane at 20℃; for 0.5h;A 42%
B 24%
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

3-Phenylpropenol
104-54-1

3-Phenylpropenol

C18H24O5

C18H24O5

Conditions
ConditionsYield
Stage #1: diethyl 3-hydroxyglutarate With 1H-imidazole; chloro-trimethyl-silane Inert atmosphere;
Stage #2: 3-Phenylpropenol With triethylsilane; iron(III) chloride Reagent/catalyst; Inert atmosphere;
41%
benzyltrichloroacetimidate

benzyltrichloroacetimidate

diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

diethyl 3-(benzyloxy)pentanedioate
838906-52-8

diethyl 3-(benzyloxy)pentanedioate

Conditions
ConditionsYield
With trifluorormethanesulfonic acid35%
diethyl 3-hydroxyglutarate
32328-03-3

diethyl 3-hydroxyglutarate

benzyl bromide
100-39-0

benzyl bromide

diethyl 3-(benzyloxy)pentanedioate
838906-52-8

diethyl 3-(benzyloxy)pentanedioate

Conditions
ConditionsYield
With silver(l) oxide30%
With silver(l) oxide In acetonitrile for 14h; Heating;24%

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