Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryHebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquirysuperior quality Appearance:clear colorless to light yellow liquid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as Pharmaceutical Intermed
Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
2,5-Dimethylbromobenzene Chemical Properties Melting point 9-10 °C(lit.) Boiling point 199-201 °C(lit.) density 1.34 g/mL at 25 °C(lit.) refractive index n20/D 1.550(lit.) Fp 175 °F form Liquid color Clear
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
Cas:553-94-6
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquiryLocated in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service an
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SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe
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inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
Capability on chemical synthesis1. Beijing High-Tech Enterprises2. Strong R&D Team3. 8 years of experiences in R & D of high-tech Catalyst;4. 5000 production techniques, 69 items of national patents, and 360 kinds of products on sales;5. The producti
We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
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inquiryOur company is engaged in customizing the benzene ring and pyridine derivative organic intermediates, and the quantity is flexible according to customer's needs. It mainly provides high-quality intermediates for domestic and foreign pharmaceutical an
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inquiry1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification
Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
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inquiryLower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou
1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re
Conditions | Yield |
---|---|
With potassium bromide; sodium nitrite In water; trifluoroacetic acid at 20℃; for 0.16h; Product distribution; under argon; | 100% |
With oxygen; potassium bromide; sodium nitrite In water; trifluoroacetic acid at 20℃; for 5h; Product distribution; | 96% |
With sulfuric acid; dihydrogen peroxide; sodium bromide In water at 49.84℃; | 94% |
Conditions | Yield |
---|---|
With carbon dioxide; bromine at 40℃; under 187519 Torr; for 2h; Supercritical conditions; Green chemistry; | A 92% B 8% |
With aluminum oxide; bromine for 0.0166667h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts; | |
With N-Bromosuccinimide at 20℃; for 16h; Overall yield = 85 %Spectr.; regioselective reaction; |
para-xylene
A
4-bromo-m-xylene
B
2,5-dibromo-p-xylene
C
4-Methylbenzyl bromide
Conditions | Yield |
---|---|
With bromine; acetic acid | A 77% B 10% C 13% |
With bromine | A 48% B n/a C n/a |
Conditions | Yield |
---|---|
With sodium bromate; sodium hydrogensulfite In water; acetonitrile at 20℃; for 4h; Bromination; | A 62% B n/a |
With bromine; bentonite In carbon disulfide for 4h; Heating; | A 50% B 30% |
With N-Bromosuccinimide In methanol at 150℃; under 2625.26 Torr; for 0.0666667h; microwave irradiation; | A 27 % Chromat. B 32 % Chromat. |
With hydrogen bromide; dihydrogen peroxide In water at 20℃; for 24h; Darkness; | A 66 %Spectr. B 14 %Spectr. |
With N-Bromosuccinimide; silver hexafluoroantimonate; adamantan-1-yl(methyl)sulfane In 1,2-dichloro-ethane at 20℃; for 1h; Inert atmosphere; Schlenk technique; | A 50 %Chromat. B 20 %Chromat. |
1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,5-dimethylbenzene
4-bromo-m-xylene
Conditions | Yield |
---|---|
With copper(ll) bromide In methanol Heating; | 46% |
Conditions | Yield |
---|---|
With hydrogen bromide diazotization; | 40% |
(i) (diazotization), aq. HBr, (ii) Cu; Multistep reaction; |
Methyl fluoride
2-methylphenyl bromide
A
2-Bromo-m-xylene
B
4-bromo-m-xylene
C
1-bromo-2,4-dimethylbenzene
D
2,3-dimethylbromobenzene
Conditions | Yield |
---|---|
With oxygen at 40℃; under 720 Torr; Mechanism; Irradiation; | A n/a B n/a C 13.7% D 32.8% |
Conditions | Yield |
---|---|
With copper(ll) bromide |
2,2,2-trifluoroethanol
(E)-1,4-Dimethyl-1,3-hexadien-5-in-1-yl-triflat
A
4-bromo-m-xylene
B
(4-Methylbenzyl)-(2,2,2-trifluorethyl)-ether
C
(Z)-3-Methyl-hept-3-ene-1,5-diyne
D
(2,5-Dimethylphenyl)-(2,2,2-trifluorethyl)-ether
Conditions | Yield |
---|---|
With 1,3,5-triisopropyl benzene; sodium carbonate; lithium bromide In 1,4-dioxane; water at 120℃; for 120h; Mechanism; Product distribution; | A 17 % Chromat. B 14 % Chromat. C n/a D 14 % Chromat. |
Conditions | Yield |
---|---|
With aluminum oxide; copper(ll) bromide In tetrachloromethane at 80℃; for 1.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
para-xylene
A
4-Methylbenzyl alcohol
B
4-bromo-m-xylene
C
1,4-dimethyl-2-(4-methylbenzyl)benzene
D
4-methyl-benzaldehyde
Conditions | Yield |
---|---|
With sulfuric acid; hydrogen bromide In water; acetic acid at 90℃; for 1h; Product distribution; Mechanism; other solvent, effect of the absence of HBr; | A 65 % Chromat. B 30 % Chromat. C 71 % Chromat. D 22 % Chromat. |
3-methylbicyclo<4.1.0>hepta-1,3,5-triene
A
4-bromo-m-xylene
B
1-bromo-2,4-dimethylbenzene
Conditions | Yield |
---|---|
With bromine; tri-n-butyl-tin hydride Product distribution; Mechanism; multistep reaction; reaction regioselectivity; a series of reagents; |
(E)-1,4-Dimethyl-1,3-hexadien-5-in-1-yl-triflat
A
4-bromo-m-xylene
B
(4-Methylbenzyl)-(2,2,2-trifluorethyl)-ether
C
(2,5-Dimethylphenyl)-(2,2,2-trifluorethyl)-ether
D
2,5-dimethylphenyl trifluoromethanesulfonate
Conditions | Yield |
---|---|
With 2,2,2-trifluoroethanol; sodium carbonate; lithium bromide In 1,4-dioxane; water at 100℃; for 120h; Further byproducts given; | A 16.6 % Chromat. B 41.2 % Chromat. C 14.4 % Chromat. D 1 % Chromat. |
Conditions | Yield |
---|---|
beim Bromieren; |
Conditions | Yield |
---|---|
beim Bromieren; |
para-xylene
iodine
A
4-bromo-m-xylene
B
2,5-dibromo-p-xylene
C
2,3,5,6-tetrabromo-p-xylene
Conditions | Yield |
---|---|
beim Bromieren; |
4-bromo-m-xylene
Conditions | Yield |
---|---|
With hydrogen bromide; copper(I) bromide |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 93 percent / pyridine / CH2Cl2 / 0.25 h / 0 °C 2: 99 percent / Et3N / PdCl2(dppf) / dioxane / Heating 3: 46 percent / aq. CuBr2 / methanol / Heating View Scheme |
2,5-dimethylphenyl trifluoromethanesulfonate
4-bromo-m-xylene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 99 percent / Et3N / PdCl2(dppf) / dioxane / Heating 2: 46 percent / aq. CuBr2 / methanol / Heating View Scheme |
Conditions | Yield |
---|---|
With tris(2,2'-bipyridine)ruthenium(II) perchlorate; triethanolamine; Ni((C6H5)CH2O)(C5H2N)(CH2)2(NHCH2CH2CH2)2NH(2+) In acetonitrile at 25℃; for 3h; Photolysis; | |
With nickel(II) 1,4,8,11-tetraazacyclotetradecane; tris(2,2'-bipyridine)ruthenium(II) perchlorate; triethanolamine In acetonitrile at 25℃; for 3h; Photolysis; |
4-bromo-m-xylene
triethyl phosphite
(2,5-dimethylphenyl)diethyl phosphonate
Conditions | Yield |
---|---|
With nickel dibromide at 160℃; for 2h; Inert atmosphere; | 100% |
Irradiation; |
Conditions | Yield |
---|---|
With tris(triphenylphosphine)rhodium(I) chloride; caesium carbonate; diisopropyl(2-tert-butyl)phenoxyphosphine In toluene for 18h; Heating; | 100% |
With caesium carbonate; diisopropyl(2-tert-butyl)phenoxyphosphine; RhCl(PPh3)3 In toluene for 18h; Heating; | 100% |
With caesium carbonate; chloro(1,5-cyclooctadiene)rhodium(I) dimer In toluene for 18h; Heating; | 94 % Spectr. |
Conditions | Yield |
---|---|
With nickel dibromide at 150℃; for 3h; Inert atmosphere; | 100% |
4-bromo-m-xylene
2-chloropropionyl chloride
4-bromo-1-(3'-chloro-1'-oxopropyl)-2,5-dimethylbenzene
Conditions | Yield |
---|---|
Stage #1: 2-chloropropionyl chloride With aluminum (III) chloride In dichloromethane for 0.25h; Schlenk technique; Inert atmosphere; Stage #2: 4-bromo-m-xylene In dichloromethane at 20℃; for 20h; Inert atmosphere; | 99% |
With aluminium trichloride In dichloromethane at 50℃; for 3h; Addition; | 87% |
With aluminum (III) chloride In carbon disulfide at 0℃; for 1h; Reflux; | 61% |
With aluminium trichloride In carbon disulfide at 20℃; for 16h; |
4-bromo-m-xylene
2-Methylphenylboronic acid
2,5,2'-trimethyl-1,1'-biphenyl
Conditions | Yield |
---|---|
With Merrifield resin-bound dicyclohexylphosphinobiphenyl ligand; caesium carbonate; tris(dibenzylideneacetone)dipalladium (0) In tetrahydrofuran at 65℃; Suzuki reaction; | 99% |
Conditions | Yield |
---|---|
With Merrifield resin-bound dicyclohexylphosphinobiphenyl ligand; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium (0) In toluene at 100℃; | 99% |
Conditions | Yield |
---|---|
With palladium diacetate; P(i-BuNCH2CH2)3N; sodium t-butanolate In toluene at 80℃; | 99% |
4-bromo-m-xylene
chloroacetyl chloride
2-(2,5-dimethylphenyl)acetyl chloride
Conditions | Yield |
---|---|
Stage #1: 4-bromo-m-xylene; chloroacetyl chloride With hydrogenchloride; ruthenium(IV) oxide; palladium 10% on activated carbon In dimethyl sulfoxide at 100℃; for 5h; Stage #2: With sodium sulfite In water; dimethyl sulfoxide at 135℃; for 8.25h; Temperature; | 98.1% |
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 80℃; for 4h; | 98% |
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate at 80℃; for 4h; Arylation; | 98% |
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In neat (no solvent) at 80℃; for 4h; Inert atmosphere; | 98% |
With tris(dibenzylideneacetone)dipalladium (0); sodium isopropylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 110℃; for 7h; Substitution; | 68% |
Conditions | Yield |
---|---|
With bis[2-(diphenylphosphino)phenyl] ether; sodium t-butanolate; palladium dichloride In toluene at 80℃; for 17h; | 98% |
With palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether; sodium t-butanolate In toluene at 80℃; for 3h; | 95% |
With tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine; sodium t-butanolate In toluene at 110℃; for 4h; Inert atmosphere; | 67% |
4-bromo-m-xylene
bis(2,5-dimethylphenyl) sulfide
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; thiourea; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In 1,4-dioxane at 100℃; for 18h; Inert atmosphere; | 98% |
4-bromo-m-xylene
1,4-dimethyl-2-(1,2,2-trifluorovinyl)benzene
Conditions | Yield |
---|---|
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); XPhos In tetrahydrofuran at 20 - 80℃; for 15.25h; Suzuki coupling; Inert atmosphere; | 98% |
2-bromoacetyl chloride
4-bromo-m-xylene
2-(2,5-dimethylphenyl)acetyl chloride
Conditions | Yield |
---|---|
Stage #1: 2-bromoacetyl chloride; 4-bromo-m-xylene With hydrogenchloride; ruthenium(IV) oxide; palladium 10% on activated carbon In dimethyl sulfoxide at 100℃; for 5h; Stage #2: With sodium sulfite In water; dimethyl sulfoxide at 135℃; for 8.25h; | 97.1% |
Conditions | Yield |
---|---|
Stage #1: 4-bromo-m-xylene With n-butyllithium In tetrahydrofuran at -78℃; for 3h; Inert atmosphere; Stage #2: dimethylmonochlorosilane In tetrahydrofuran at -78 - 20℃; | 97% |
With tert.-butyl lithium In diethyl ether; pentane 1.) -78 deg C, 2.) -78 deg C to 20 deg C, 2 h; Yield given; |
Conditions | Yield |
---|---|
With tris(dibenzylideneacetone)dipalladium (0); (-)-2-(dicyclohexylphosphino)-2'-(dimethylamino)-1,1'-binaphthyl; sodium t-butanolate In 1,2-dimethoxyethane Ambient temperature; | 97% |
With potassium hexamethylsilazane In 1,4-dioxane at 100℃; for 0.25h; metal-free Buchwald-Hartwig amination; Inert atmosphere; | 88 %Chromat. |
Conditions | Yield |
---|---|
With tris(dibenzylideneacetone)dipalladium (0); sodium isopropylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 110℃; for 19h; Substitution; | 97% |
With bis[2-(diphenylphosphino)phenyl] ether; sodium t-butanolate; palladium dichloride In toluene at 80℃; for 4h; | 93% |
With palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether; sodium t-butanolate In toluene at 80℃; for 21h; | 90% |
4-bromo-m-xylene
trans-2-phenylvinylboronic acid
(E)-2,5-dimethyl-1-styrylbenzene
Conditions | Yield |
---|---|
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate In tetrahydrofuran at 40℃; for 24h; Suzuki-Miyaura coupling; | 97% |
4-bromo-m-xylene
1-Naphthylboronic acid
1-(2,5-dimethylphenyl)naphthalene
Conditions | Yield |
---|---|
With potassium phosphate; C29H37O2P; palladium diacetate In toluene at 110℃; for 3h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique; | 97% |
Conditions | Yield |
---|---|
With palladium diacetate; potassium phosphate; 2-N,N-(dimethylamino)-2'-di-tert-butylphosphino-1,1'-binaphthyl In toluene at 100℃; for 24h; | 96% |
With potassium phosphate; tert-butyl XPhos; palladium diacetate In toluene at 100℃; for 24h; | 92% |
With potassium phosphate; 2-di-tert-butylphosphino-2',4',6'-tricyclohexyl-3,6-dimethoxybiphenyl In 1,2-dimethoxyethane; toluene at 40℃; for 24h; Inert atmosphere; | 80% |
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate at 80℃; for 36h; Arylation; | 95% |
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 80℃; for 36h; | 94% |
With tris(dibenzylideneacetone)dipalladium (0); sodium isopropylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 110℃; for 22h; Substitution; | 85% |
4-bromo-m-xylene
4-Chlorophenylboronic acid
4’-chloro-2,5-dimethyl-1,1’-biphenyl
Conditions | Yield |
---|---|
With potassium phosphate; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In toluene at 100℃; for 14h; Suzuki coupling; | 95% |
With potassium phosphate; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In toluene | 95% |
Conditions | Yield |
---|---|
With palladium diacetate; caesium carbonate; triphenylphosphine In toluene at 20 - 115℃; for 5h; Temperature; Reagent/catalyst; Solvent; Sealed tube; stereoselective reaction; | 95% |
4-bromo-m-xylene
acrylic acid methyl ester
Conditions | Yield |
---|---|
With N-Methyldicyclohexylamine; 2C32H41O4P*Pd(2+)*2Cl(1-) In N,N-dimethyl acetamide at 100℃; for 16h; Heck Reaction; Inert atmosphere; | 95% |
Conditions | Yield |
---|---|
Stage #1: 4-bromo-m-xylene With iodine; magnesium In diethyl ether at 60℃; for 1h; Inert atmosphere; Stage #2: oxirane In diethyl ether at 0℃; for 3h; Temperature; Inert atmosphere; | 94.69% |
(i) Mg, Et2O, (ii) /BRN= 102378/; Multistep reaction; |
Conditions | Yield |
---|---|
With palladium diacetate; potassium fluoride; johnphos In tetrahydrofuran at 45℃; for 12h; Suzuki coupling; | 94% |
With potassium phosphate; Pd (sulfur-containing palladacycle); tetra(n-tert-butyl)ammonium bromide In N,N-dimethyl-formamide at 25℃; for 38h; Suzuki cross-coupling; | 94% |
With Pd(4,4'-bis(diphenylphosphino)-2,2',6,6'-tetra-methoxy-3,3'-bipyridine)Cl2; potassium hydroxide In ethanol; dichloromethane at 25℃; for 6h; Suzuki-Miyaura Coupling; | 94% |
Conditions | Yield |
---|---|
With potassium phosphate; bis(η3-allyl-μ-chloropalladium(II)); N,N,N′,N′-tetra(diphenylphosphinomethyl)-1,2-ethylenediamine In 1,4-dioxane at 105℃; for 20h; Sonogashira coupling; Inert atmosphere; | 94% |
With dichloro[1-(2,4,6-trimethylbenzyl)-3-(4-adamantylbenzyl)-5,6-dimethylbenzimidazole-2-ylidene]triphenylphosphine palladium(II); potassium tert-butylate In N,N-dimethyl-formamide at 100℃; for 3h; Reagent/catalyst; Sonogashira Cross-Coupling; Schlenk technique; | 94% |
With potassium phosphate; bis(η3-allyl-μ-chloropalladium(II)); tetraphosphine N,N,N′,N′-tetra(diphenylphosphinomethyl)-pyridine-2,6-diamine In N,N-dimethyl acetamide; water at 100℃; for 20h; Sonogashira Cross-Coupling; Schlenk technique; Inert atmosphere; | 93% |
2,6-bis-(toluene-4-sulfonyl)-[1,5,2,6]dithiadiazocane
4-bromo-m-xylene
Conditions | Yield |
---|---|
Stage #1: 4-bromo-m-xylene With n-butyllithium In tetrahydrofuran at -78℃; for 1h; Inert atmosphere; Stage #2: 2,6-bis-(toluene-4-sulfonyl)-[1,5,2,6]dithiadiazocane In tetrahydrofuran for 0.5h; Inert atmosphere; | 94% |
Conditions | Yield |
---|---|
With palladium diacetate; caesium carbonate; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine) In 1,4-dioxane at 100℃; for 17h; Arylation; | 93% |
With pyridine; bis(1,5-cyclooctadiene)nickel (0); 1,10-Phenanthroline; sodium t-butanolate at 100℃; Glovebox; Inert atmosphere; | 8 %Chromat. |
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); johnphos; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium (0) In toluene at 80℃; for 6h; Arylation; | 93% |
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