1,2-Dichloro-4-fluorobenzene supplier

Name
1,2-Dichloro-4-fluorobenzene
EINECS 215-858-3
CAS No. 1435-49-0
Article Data11
CAS DataBase
Density 1.403 g/cm³
Solubility
Melting Point -1 °C(lit.)
Formula C₆H₃Cl₂F
Boiling Point 172.2 °C at 760 mmHg
Molecular Weight 164.994
Flash Point 64.4 °C
Transport Information UN 1993
Appearance clear colorless to slightly yellow liquid
Safety 26-37/39
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xi; Xn
Synonyms 1-Fluoro-3,4-dichlorobenzene;3,4-Dichloro-1-fluorobenzene;3,4-Dichlorofluorobenzene;NSC 82300;
PSA 0.00000
LogP 3.13250

Synthetic route

: potassium m, p-dichloro phenyltrifluoroborate

: 1435-49-0
3,4-dichlorofluorobenzene

Conditions

Conditions	Yield
With lithium hydroxide monohydrate; silver trifluoromethanesulfonate; Selectfluor In ethyl acetate at 55℃; Sealed tube;	75%

: 18282-59-2
4-bromo-1,2-dichlorobenzene

: 1435-49-0
3,4-dichlorofluorobenzene

Conditions

Conditions	Yield
Stage #1: 4-bromo-1,2-dichlorobenzene With TurboGrignard In tetrahydrofuran; 1,4-dioxane at 0 - 25℃; Inert atmosphere; Stage #2: With N-fluorobis(benzenesulfon)imide In dichloromethane; octadecafluorodecahydronaphthalene (cis+trans) at -78 - 20℃; Inert atmosphere;	34%
Stage #1: 4-bromo-1,2-dichlorobenzene With TurboGrignard In tetrahydrofuran at 0℃; Inert atmosphere; Stage #2: With N-fluorobis(benzenesulfon)imide In dichloromethane; octadecafluorodecahydronaphthalene (cis+trans) at -78 - 25℃; Inert atmosphere;	34%

: 452-83-5
2-chloro-5-fluoroaniline

: 1435-49-0
3,4-dichlorofluorobenzene

Conditions

Conditions	Yield
Reaktion nach Sandmeyer;

: 95-76-1
m,p-dichloroaniline

: 1435-49-0
3,4-dichlorofluorobenzene

Conditions

Conditions	Yield
With hydrogenchloride; tetrafluoroboric acid; sodium nitrite Erhitzen des Reaktionsprodukts auf 150grad;

: 36556-50-0
2,3-dichlorofluorobenzene

A: 1435-49-0
3,4-dichlorofluorobenzene

B: 625-98-9
3-chlorofluorobenzene

C: 348-59-4
1,4-dichloro-2-fluorobenzene

D: 1435-48-9
1,3-dichloro-4-fluorobenzene

Conditions

Conditions	Yield
In acetonitrile for 10h; Product distribution; Irradiation;	A 5 % Chromat. B 5 % Chromat. C 13 % Chromat. D 1 % Chromat.

...Expand

: 7664-93-9
sulfuric acid

: 95-76-1
m,p-dichloroaniline

A: 1435-49-0
3,4-dichlorofluorobenzene

B: 95-77-2
3,4-dichlorophenol

C: 95-50-1
1,2-dichloro-benzene

Conditions

Conditions	Yield
Behandeln der Diazoloesung mit heisser Flusssaeure.Diazotization;

...Expand

: 462-06-6
fluorobenzene

iron-powder: iron-powder

A: 1435-49-0
3,4-dichlorofluorobenzene

B: 352-33-0
1-Chloro-4-fluorobenzene

C: 1435-48-9
1,3-dichloro-4-fluorobenzene

Conditions

Conditions	Yield
Einleiten von 2 Mol Chlor;

...Expand

diazotized 5-fluoro-2-chloro-aniline: diazotized 5-fluoro-2-chloro-aniline

: 1435-49-0
3,4-dichlorofluorobenzene

: C18H7Cl2F4S2(1+)*BF4(1-)

: 1435-49-0
3,4-dichlorofluorobenzene

Conditions

Conditions	Yield
With tetrakis(acetonitrile)copper(I)tetrafluoroborate; [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; cesium fluoride In acetone at 30℃; for 20h; Inert atmosphere; Irradiation;	63 %Spectr.

: 1435-49-0
3,4-dichlorofluorobenzene

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 95399-95-4
2,3-Dichloro-6-fluorobenzaldehyde

Conditions

Conditions	Yield
Stage #1: 3,4-dichlorofluorobenzene With lithium diisopropyl amide In tetrahydrofuran at -65℃; for 0.5h; Inert atmosphere; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at -65℃; for 0.333333h; Inert atmosphere;	94%

: 56-23-5
tetrachloromethane

: 1435-49-0
3,4-dichlorofluorobenzene

: C7H2Cl5F

Conditions

Conditions	Yield
With 1,2-bis(N-methylimidazolium)ethane chloroaluminate at 60℃; for 4h; Time;	92.9%

: 75-77-4
chloro-trimethyl-silane

: 1435-49-0
3,4-dichlorofluorobenzene

: 1265682-42-5
1-fluoro-3,4-bis(trimethylsilyl)benzene

Conditions

Conditions	Yield
With 1,3-dimethyl-2-imidazolidinone; magnesium; copper(l) chloride; lithium chloride at 55℃; for 17h;	88%

: 7031-93-8
2,2,6,6-tetramethylpiperidin-1-ol

: 1435-49-0
3,4-dichlorofluorobenzene

: 4-(3,4-dichloro-phenoxy)-2,2,6,6-tetramethyl-piperidine hydrochloride

Conditions

Conditions	Yield
Stage #1: 2,2,6,6-tetramethylpiperidin-1-ol; 3,4-dichlorofluorobenzene With potassium tert-butylate In tetrahydrofuran at 20℃; for 4h; Stage #2: With hydrogenchloride In diethyl ether for 0.166667h; Product distribution / selectivity;	84%

: 1435-49-0
3,4-dichlorofluorobenzene

: 585-79-5
3-Bromonitrobenzene

: 1638159-33-7
2,3-dichloro-6-fluoro-3’-nitrobiphenyl

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium pivalate In N,N-dimethyl acetamide at 150℃; for 16h; Inert atmosphere; regioselective reaction;	64%

: 1435-49-0
3,4-dichlorofluorobenzene

: 616-29-5
1,3-Diamino-2-hydroxypropane

: 676167-20-7
2-(3,4-dichlorophenoxy)propane-1,3-diamine

Conditions

Conditions	Yield
Stage #1: 1,3-Diamino-2-hydroxypropane With sodium hydride In N,N-dimethyl acetamide Stage #2: 3,4-dichlorofluorobenzene In N,N-dimethyl acetamide at 170℃; for 0.0694444h; microwave irradiation;	62%

: 500-99-2
3,5-dimethoxyphenol

: 1435-49-0
3,4-dichlorofluorobenzene

: 1379803-46-9
1,2-dichloro-4-(3,5-dimethoxyphenoxy)benzene

Conditions

Conditions	Yield
Stage #1: 3,5-dimethoxyphenol With caesium carbonate In 1-methyl-pyrrolidin-2-one at 50℃; for 0.5h; Inert atmosphere; Stage #2: 3,4-dichlorofluorobenzene In 1-methyl-pyrrolidin-2-one at 120℃; for 2h; Inert atmosphere;	60%

: 626-55-1
3-Bromopyridine

: 1435-49-0
3,4-dichlorofluorobenzene

: 1638159-34-8
3-(2,3-dichloro-6-fluorophenyl)pyridine

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium pivalate In N,N-dimethyl acetamide at 150℃; for 16h; Inert atmosphere; regioselective reaction;	58%

: 612-62-4
2-Chloroquinoline

: 1435-49-0
3,4-dichlorofluorobenzene

: 2-(2,3-dichloro-6-fluorophenyl)quinoline

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); tetrabutylammomium bromide; potassium pivalate In N,N-dimethyl acetamide at 150℃; for 16h; Inert atmosphere; Green chemistry; regioselective reaction;	39%

: 1435-49-0
3,4-dichlorofluorobenzene

: 124-41-4
sodium methylate

: 95-77-2
3,4-dichlorophenol

Conditions

Conditions	Yield
at 180℃; nach 7 Tagen;

: 1435-49-0
3,4-dichlorofluorobenzene

: 124-41-4
sodium methylate

: 36404-30-5
3,4-dichloroanisole

Conditions

Conditions	Yield
With methanol at 180℃;
at 180℃; nach 6 Stunden;

: 1435-49-0
3,4-dichlorofluorobenzene

: 95-77-2
3,4-dichlorophenol

Conditions

Conditions	Yield
With sodium methylate
With methanol; sodium methylate at 180℃;

: 1435-49-0
3,4-dichlorofluorobenzene

: 2339-78-8
1,2-dichloro-4-fluoro-5-nitrobenzene

Conditions

Conditions	Yield
With sulfuric acid; nitric acid

: 1435-49-0
3,4-dichlorofluorobenzene

: 59410-15-0
1,2,4-Tribromo-5,6-dichloro-3-fluoro-benzene

Conditions

Conditions	Yield
(i) Hg(O2CCF3)2, (ii) KBr3, aq. MeOH; Multistep reaction;

: 1435-49-0
3,4-dichlorofluorobenzene

: 13656-52-5
4,5-dichloro-2-fluorobenzenesulfonyl chloride

Conditions

Conditions	Yield
With chlorosulfonic acid

: 1435-49-0
3,4-dichlorofluorobenzene

: 269740-46-7, 269741-35-7
4-(hydroxyphenylmethyl)piperidine-1-carboxylic acid tert-butyl ester

: 4-[(3,4-dichloro-phenoxy)-phenyl-methyl]-piperidine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
Stage #1: 4-(hydroxyphenylmethyl)piperidine-1-carboxylic acid tert-butyl ester With sodium hydride In dimethyl sulfoxide at 20℃; Stage #2: 3,4-dichlorofluorobenzene With Potassium benzoate In dimethyl sulfoxide at 65℃;

: 1435-49-0
3,4-dichlorofluorobenzene

: 5-(3,4-dichlorophenoxy)-3,4,5,6-tetrahydropyrimidin-2(1H)-one

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: NaH / N,N-dimethyl-acetamide 1.2: 62 percent / N,N-dimethyl-acetamide / 0.07 h / 170 °C / microwave irradiation 2.1: 53 percent / ethanol / 0.06 h / 140 °C / microwave irradiation 3.1: 95 percent / acetonitrile / 0.14 h / 130 °C / microwave irradiation 4.1: 100 percent / NH4OH / H2O / 0.14 h / 150 °C / microwave irradiation View Scheme

: 1435-49-0
3,4-dichlorofluorobenzene

: 676167-23-0
5-(3,4-dichlorophenoxy)-3,4,5,6-tetrahydropyrimidine-2(1H)-thione

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: NaH / N,N-dimethyl-acetamide 1.2: 62 percent / N,N-dimethyl-acetamide / 0.07 h / 170 °C / microwave irradiation 2.1: 53 percent / ethanol / 0.06 h / 140 °C / microwave irradiation View Scheme

: 1435-49-0
3,4-dichlorofluorobenzene

: 5-(3,4-dichlorophenoxy)-2-methylsulfanyl-3,4,5,6-tetrahydropyrimidine hydroiodide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: NaH / N,N-dimethyl-acetamide 1.2: 62 percent / N,N-dimethyl-acetamide / 0.07 h / 170 °C / microwave irradiation 2.1: 53 percent / ethanol / 0.06 h / 140 °C / microwave irradiation 3.1: 95 percent / acetonitrile / 0.14 h / 130 °C / microwave irradiation View Scheme

: 1435-49-0
3,4-dichlorofluorobenzene

: 2-amino-5-(3,4-dichlorophenoxy)-3,4,5,6-tetrahydropyrimidine hydrobromide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: NaH / N,N-dimethyl-acetamide 1.2: 62 percent / N,N-dimethyl-acetamide / 0.07 h / 170 °C / microwave irradiation 2.1: 53 percent / propan-2-ol / 0.17 h / 120 °C / microwave irradiation View Scheme

1,2-Dichloro-4-fluorobenzene Specification

The Benzene,1,2-dichloro-4-fluoro-, with CAS registry number 1435-49-0, belongs to the following product categories: (1)Chlorine Compounds; (2)Fluorine Compounds. It has the systematic name of 1,2-dichloro-4-fluorobenzene. This chemical is a kind of clear colorless to slightly yellow liquid. The main use of this chemical is for the intermediate of pesticide, medicine and liquid crystal material.

Physical properties of Benzene,1,2-dichloro-4-fluoro-: (1)ACD/LogP: 2.84; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.84; (4)ACD/LogD (pH 7.4): 2.84; (5)ACD/BCF (pH 5.5): 85.36; (6)ACD/BCF (pH 7.4): 85.36; (7)ACD/KOC (pH 5.5): 839.47; (8)ACD/KOC (pH 7.4): 839.47; (9)#H bond acceptors: 0; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 0 Å²; (13)Index of Refraction: 1.525; (14)Molar Refractivity: 36.03 cm³; (15)Molar Volume: 117.5 cm³; (16)Polarizability: 14.28×10^-24cm³; (17)Surface Tension: 35.1 dyne/cm; (18)Enthalpy of Vaporization: 39.18 kJ/mol; (19)Vapour Pressure: 1.79 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
The Benzene,1,2-dichloro-4-fluoro- irritates to eyes, respiratory system and skin. And this chemical is harmful if swallowed. When use it, wear suitable protective clothing, gloves and eye/face protection. If contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: Fc1cc(Cl)c(Cl)cc1
(2)InChI: InChI=1/C6H3Cl2F/c7-5-2-1-4(9)3-6(5)8/h1-3H
(3)InChIKey: QSDKXMVGRLVIQV-UHFFFAOYAG
(4)Std. InChI: InChI=1S/C6H3Cl2F/c7-5-2-1-4(9)3-6(5)8/h1-3H
(5)Std. InChIKey: QSDKXMVGRLVIQV-UHFFFAOYSA-N

Product Name

1,2-Dichloro-4-fluorobenzene

Synthetic route

1,2-Dichloro-4-fluorobenzene Specification

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