Conditions | Yield |
---|---|
at 50 - 55℃; for 0.5h; Reduction; oxidation; | A 94% B 96.4% |
Conditions | Yield |
---|---|
With magnesium(II) perchlorate; water; methylene green In acetonitrile Irradiation; | A n/a B 91% |
(2-Methyl-1,3-dithiolan-2-yl)essigsaeure-ethylester
A
ethyl acetoacetate
B
ethane-1,2-dithiol
Conditions | Yield |
---|---|
With magnesium(II) perchlorate; water; methylene green In acetonitrile Irradiation; | A 90% B n/a |
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran | 86% |
polymer, product of thiylation with 0.19 g/mol of sulfur, where content of sulfur moieties 2.0 in repeating units; monomer(s): 1,2-dichloroethane, charged content 0.095 g/mol
ethane-1,2-dithiol
Conditions | Yield |
---|---|
With potassium hydroxide; hydrazine hydrate at 80℃; for 2.5h; | 56.8% |
Conditions | Yield |
---|---|
With sodium hydroxide; hydrazine hydrate Heating; | A 37% B 37% |
ethane-1,2-dithiol
Conditions | Yield |
---|---|
With sodium hydroxide; hydrazine hydrate Heating; | 33% |
Conditions | Yield |
---|---|
With methanol; hydrogen sulfide at 60℃; unter Druck; | |
With 2,2'-thiobis-ethanol; hydrogen sulfide at 45℃; |
ethane-1,2-dithiol
Conditions | Yield |
---|---|
With hydrogenchloride |
Conditions | Yield |
---|---|
With sulfur; benzene at 175℃; under 77228.3 - 88260.9 Torr; und Hydrieren des Reaktionsprodukts unter Druck an Co2S3 bei 150grad oder an Nickel-Kieselgur bei 160grad; |
Conditions | Yield |
---|---|
With ethanol; zinc |
S,S'-ethane-1,2-diyl diethanethioate
ethane-1,2-dithiol
Conditions | Yield |
---|---|
With methanol; barium methoxide at -10℃; | |
With sodium hydroxide In acetone Ambient temperature; |
1,2-diphenylisothiocarbamidoethane
ethane-1,2-dithiol
Conditions | Yield |
---|---|
beim Schmelzen; |
Conditions | Yield |
---|---|
With diphosphorus pentasulfide at 110 - 140℃; und Folgenden Destillieren mit Wasser; |
Conditions | Yield |
---|---|
With sodium hydrogensulfide; water at 80 - 100℃; | |
With sodium hydrogensulfide; ethanol at 80 - 100℃; | |
With magnesium hydroxide; sodium disulfide; water und Behandeln des entstandenen Polysulfid mit Natriumamalgam; | |
With ethanol; potassium hydrosulfide |
Conditions | Yield |
---|---|
With sodium hydrogensulfide; water unter Druck; |
Conditions | Yield |
---|---|
With ethanol und Hydrolyse des entstandenen S.S'-Aethylen-diisothioharnstoff-dihydrobromids mit Kalilauge; |
Conditions | Yield |
---|---|
With potassium hydrosulfide Darstellung; | |
With sodium hydrogensulfide; ethanol | |
With ethanol; potassium hydrosulfide |
Conditions | Yield |
---|---|
With 2-hydroxyethanethiol In d(4)-methanol; water-d2 at 25℃; Equilibrium constant; phosphate buffer(0.5 mM, pH7.0); |
Conditions | Yield |
---|---|
With oxonium In 1,4-dioxane; water at 25℃; Rate constant; Mechanism; ionic strength: 0.053-0.95M; thallium ion concentration: 0-0.004M; hydrogen ion concentration: 0.05-0.95M; 25percent (v/v) dioxane-water.; |
1-(2-Mercapto-ethyl)-2-methylsulfanyl-4,6-diphenyl-pyridinium; iodide
ethane-1,2-dithiol
Conditions | Yield |
---|---|
With sodium hydroxide; thiourea 1.) 130 deg C, 0.5 h; 2.) reflux, 3 h; Yield given. Multistep reaction; |
ethane-1,2-dithiol
Conditions | Yield |
---|---|
With hydrogenchloride; 75Se-sodium selenite; sodium acetate at 5℃; for 0.833333h; Equilibrium constant; pH= 1.8; apparent equilibrium constant; | |
With hydrogenchloride; 75Se-sodium selenite; sodium acetate at 5℃; for 0.833333h; Equilibrium constant; pH= 2.5; apparent equilibrium constant; | |
With hydrogenchloride; 75Se-sodium selenite; sodium acetate at 5℃; for 0.833333h; Equilibrium constant; pH= 3.7; apparent equilibrium constant; |
1,3-dithiolane-2-thione
ammonia
A
ammonium thiocyanate
B
ethane-1,2-dithiol
Conditions | Yield |
---|---|
at 150℃; im Rohr; |
2-imino-1,3-dithiolane
hydrogenchloride
A
[1,2,5,6]tetrathiocane
B
ethane-1,2-dithiol
C
methylammonium carbonate
Conditions | Yield |
---|---|
at 120℃; |
2-(1,3-dithiolan-2-yl)-1-phenylethan-1-one
A
ethane-1,2-dithiol
B
1-phenyl-propan-1-one
Conditions | Yield |
---|---|
unter Durchleiten von Wasserdampf; |
2-[1,3]dithiolan-2-ylidene-1-phenyl-ethanone
A
ethane-1,2-dithiol
B
1-phenyl-propan-1-one
Conditions | Yield |
---|---|
im Wasserdampf-Strom; |
Conditions | Yield |
---|---|
at 100℃; |
Conditions | Yield |
---|---|
With thionyl chloride; silica gel In toluene for 24h; Heating; | 100% |
With bentonite In toluene for 3h; Heating; | 99% |
With silica gel; iron(III) chloride In dichloromethane Ambient temperature; | 99% |
4-methyl-benzaldehyde
ethane-1,2-dithiol
2-(4-methylphenyl)-1,3-dithiolane
Conditions | Yield |
---|---|
With silica gel; toluene-4-sulfonic acid In dichloromethane for 1.5h; Heating; | 100% |
With Cu(OTf)2-SiO2 for 0.5h; Ambient temperature; | 99% |
With PPA; silica gel In 1,2-dichloro-ethane at 20℃; for 0.5h; | 99% |
Conditions | Yield |
---|---|
With thionyl chloride; silica gel In benzene at 20℃; for 5h; | 100% |
With silica gel; toluene-4-sulfonic acid In dichloromethane for 3h; Heating; | 100% |
With acetophenone In dichloromethane at 20℃; for 0.5h; chemoselective reaction; | 100% |
Conditions | Yield |
---|---|
Nafion-H In benzene Heating; | 100% |
With cobalt(II) bromide In dichloromethane for 4h; Ambient temperature; | 99% |
With amberlyst-15 In acetonitrile for 1h; | 99.91% |
dihydrocholesterone
ethane-1,2-dithiol
5α-cholestan-3-one ethanediyl S,S-acetal
Conditions | Yield |
---|---|
With zeolite HSZ-360 In dichloromethane for 15h; Ambient temperature; | 100% |
tellurium tetrachloride In 1,2-dichloro-ethane for 3h; Ambient temperature; | 94% |
With cadmium(II) iodide for 0.0222222h; Irradiation; | 78% |
Conditions | Yield |
---|---|
With perchloric acid; silica gel at 25 - 30℃; for 5h; | 100% |
With toluene-4-sulfonic acid In benzene Heating; | 99% |
With cobalt(II) bromide In dichloromethane for 1.25h; Ambient temperature; | 99% |
ethane-1,2-dithiol
1,2-bis(chlorosulfanyl)ethane
Conditions | Yield |
---|---|
With chlorine In tetrachloromethane at -20℃; | 100% |
With sulfuryl dichloride | |
With chlorine at -15 - -5℃; for 2h; |
Conditions | Yield |
---|---|
With phosphorus trichloride at 20℃; for 3h; | 100% |
With phosphorus trichloride at 20℃; for 3h; | 95% |
With phosphorus trichloride at 20℃; for 3h; Inert atmosphere; | 95% |
2-chloro-benzaldehyde
ethane-1,2-dithiol
2-(2-chlorophenyl)-1,3-dithiolane
Conditions | Yield |
---|---|
With Iron(III) nitrate nonahydrate; sodium iodide In dichloromethane at 20℃; for 16h; | 100% |
With phosphoric acid functionalized ethanolamine grafted polyacrylonitrile fiber In methanol at 65℃; for 4h; Solvent; Temperature; Green chemistry; | 98% |
tungsten(VI) chloride In dichloromethane at 0 - 5℃; for 0.0833333h; | 96% |
4-nitrobenzaldehdye
ethane-1,2-dithiol
2-(4-nitrophenyl)-1,3-dithiolane
Conditions | Yield |
---|---|
With PPA; silica gel In 1,2-dichloro-ethane at 20℃; for 0.5h; | 100% |
With boron trifluoride diethyl etherate In dichloromethane for 6h; Ambient temperature; | 99% |
With iron(III) In dichloromethane for 10h; Ambient temperature; | 98% |
3,4-dimethoxy-benzaldehyde
ethane-1,2-dithiol
2-(3,4-dimethoxyphenyl)-1,3-dithiolane
Conditions | Yield |
---|---|
amberlyst-15 In chloroform for 48h; Ambient temperature; | 100% |
With N-Bromosuccinimide for 0.05h; | 98% |
With silica-supported sulfuric acid at 20℃; for 0.133333h; Neat (no solvent); chemoselective reaction; | 98% |
Conditions | Yield |
---|---|
With thionyl chloride; silica gel In benzene at 20℃; for 5h; | 100% |
With PPA; silica gel In 1,2-dichloro-ethane at 20℃; for 0.5h; | 100% |
methyl levulinate
ethane-1,2-dithiol
methyl 5,5-ethylenedithiohexanoate
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In chloroform | 100% |
2-Phenylpropanal
ethane-1,2-dithiol
2-(1-Phenyl-ethyl)-[1,3]dithiolane
Conditions | Yield |
---|---|
With thionyl chloride; silica gel In benzene at 20℃; for 5h; | 100% |
With trichloroisocyanuric acid In chloroform at 20℃; for 1.5h; | 92% |
76% |
19-nortestosterone
ethane-1,2-dithiol
3,3-Ethandiyldimercapto-oestro-4-en-17β-ol
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In methanol; dichloromethane | 100% |
kryptogenin diacetate
ethane-1,2-dithiol
(25R)-22-oxocholest-5-ene-3β,26-diol 16,16-(cycloethylene dithioketal) 3,26-diacetate
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In acetic acid for 1.5h; Ambient temperature; | 100% |
1,5-Bis<(9'-oxofluoren-2'-yl)oxy>-3-oxapentane
ethane-1,2-dithiol
1,5-Bis<<9',9'-(ethylenedithio)fluoren-2'-yl>oxy>-3-oxapentane
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In acetic acid for 6h; Heating; | 100% |
With boron trifluoride diethyl etherate In acetic acid for 6h; Heating; Yield given; |
1,11-Bis<(9'-oxofluoren-2'-yl)oxy>-3,6,9-trioxaundecane
ethane-1,2-dithiol
1,11-Bis<<9',9'-(ethylenedithio)fluoren-2'-yl>oxy>-3,6,9-trioxaundecane
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In acetic acid for 6h; Heating; | 100% |
With boron trifluoride diethyl etherate In acetic acid for 6h; Heating; Yield given; |
Conditions | Yield |
---|---|
With thionyl chloride; silica gel In dichloromethane for 12h; Ambient temperature; | 100% |
With thionyl chloride; silica gel |
(-)-(1R,2R,6R,7R)-6,7-dimethyl-3-oxo-2,8-dioxabicyclo[3.3.0]octane
ethane-1,2-dithiol
(-)-(3R,4R,5R)-4,5-dimethyl-3-(1,3-dithiolan-2-yl)pentanolide
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In dichloromethane at 0℃; for 0.5h; Cyclization; | 100% |
With boron trifluoride diethyl etherate In dichloromethane Ambient temperature; | 81% |
ethane-1,2-dithiol
1-benzyl-3-formyl-9-methoxy-1H-benzindole
1-benzyl-3-<2-(1,3-dithiolanyl)>-9-methoxy-1H-benzindole
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In acetic acid for 0.75h; Ambient temperature; | 100% |
ethane-1,2-dithiol
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate at 0℃; for 0.5h; | 100% |
ethane-1,2-dithiol
12-chloro-9,9-ethylenedithio-5-hydroxy-6a,7,8,9,10,10a-hexahydronaphthacene-6,11-dione
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In dichloromethane for 2h; Ambient temperature; | 100% |
ethane-1,2-dithiol
cyclohexanecarbaldehyde
Cyclohexancarboxaldehyde dithioethyleneacetal
Conditions | Yield |
---|---|
With zeolite HSZ-360 In dichloromethane for 15h; Ambient temperature; | 100% |
With cobalt(II) bromide In dichloromethane for 0.05h; Ambient temperature; | 99% |
With PPA; silica gel In 1,2-dichloro-ethane at 20℃; for 0.5h; | 96% |
Conditions | Yield |
---|---|
With thionyl chloride; silica gel In benzene at 20℃; for 5h; | 100% |
With N-Bromosuccinimide In chloroform at 20℃; for 0.0833333h; | 94% |
With H-Rho zeolite In hexane for 2.5h; Heating; | 89% |
With iron(III) In dichloromethane for 4h; Ambient temperature; | 75% |
With natural kaolinitic clay In benzene for 2h; Heating; | 70% |
Conditions | Yield |
---|---|
Nafion-H In benzene Heating; | 100% |
With perchloric acid; silica gel at 25 - 30℃; for 0.05h; | 97% |
With P-benzyltriphenylphosphonium tribromide at 20℃; for 1.5h; | 96% |
ethane-1,2-dithiol
1,3-Diphenylpropanone
2,2-bis(benzyl)-1,3-dithiolane
Conditions | Yield |
---|---|
Nafion-H In benzene Heating; | 100% |
With silica gel; zirconium(IV) chloride In dichloromethane for 0.5h; Ambient temperature; | 99% |
With silica gel; iron(III) chloride In dichloromethane Ambient temperature; | 98% |
ethane-1,2-dithiol
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate for 0.0833333h; | 100% |
ethane-1,2-dithiol
13α-acetyl-8β(H)-podocarpane
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In dichloromethane Ambient temperature; | 100% |
5,7-dimethoxy-4-oxo-1,2,3,4-tetrahydro-2-naphthoic acid methyl ester
ethane-1,2-dithiol
methyl 3',4'-dihydro-6',8'-dimethoxyspiro[1,3-dithiolane-2,1'(2H)-naphthalene-3-carboxylate]
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In dichloromethane at 25℃; for 18h; Cyclization; | 100% |
The 1,2-Ethanedithiol, with the CAS registry number 540-63-6, has the IUPAC name of ethane-1,2-dithiol. As to its usage, it is usually used as building block in organic synthesis and an excellent ligand for metal ions. And its product categories are including Phenoles and thiophenoles; Other Reagents; thiol Flavor; Chemistry.
The physical properties of this chemical are as below: (1)ACD/LogP: 1.31; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.31; (4)ACD/LogD (pH 7.4): 1.3; (5)ACD/BCF (pH 5.5): 5.82; (6)ACD/BCF (pH 7.4): 5.76; (7)ACD/KOC (pH 5.5): 122.84; (8)ACD/KOC (pH 7.4): 121.56; (9)#H bond acceptors: 0; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 77.6; (13)Index of Refraction: 1.516; (14)Molar Refractivity: 27.1 cm3; (15)Molar Volume: 89.6 cm3; (16)Polarizability: 10.74×10-24 cm3; (17)Surface Tension: 33.3 dyne/cm; (18)Density: 1.05 g/cm3; (19)Flash Point: 44.4 °C; (20)Enthalpy of Vaporization: 37.93 kJ/mol; (21)Boiling Point: 144.3 °C at 760 mmHg; (22)Vapour Pressure: 6.45 mmHg at 25°C; (23)Exact Mass: 93.991092; (24)MonoIsotopic Mass: 93.991092; (25)Topological Polar Surface Area: 2; (26)Heavy Atom Count: 4; (27)Complexity: 6.
Use of this chemical: 1,2-Ethanedithiol could react with diketene to produce 1,2-bis-(4-oxo-oxetan-2-ylmethylsulfanyl)-ethane, with the following condition: reagent: cyclohexane azoisobutyronitrile; other condition: unter Bestrahlung mit UV-Licht.
Production method of this chemical: [1,3]dithiolane-2-thione could react to produce 1,2-Ethanedithiol, with the following condition: reagent: LAH; solvent: tetrahydrofuran; yield: 86 %.
When you are dealing with this chemical, you should be much more cautious. For one thing, it is harmful which may cause damage to health. For another thing, it is toxic which at low levels cause damage to health. If by inhalation, in contact with skin and if swallowed, it will be very toxic. In addition, it is highly flammable which may catch fire in contact with air, only needing brief contact with an ignition source, and it has a very low flash point or evolve highly flammable gases in contact with water.
Therefore, you should take different measures to deal with different cases. Wear suitable protective clothing, gloves and eye/face protection. And if in case of contact with eyes, rinse immediately with plenty of water and seek medical advice and if in case of accident or if you feel unwell, seek medical advice immediately (show label where possible). Then while store it, keep the container tightly closed and in a well-ventilated place, away from sources of ignition - No smoking.
In addition, you could convert the following datas into the molecular structure:
(1)Canonical SMILES: C(CS)S
(2)InChI: InChI=1S/C2H6S2/c3-1-2-4/h3-4H,1-2H2
(3)InChIKey: VYMPLPIFKRHAAC-UHFFFAOYSA-N
Below are the toxicity information of this chemical:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 50mg/kg (50mg/kg) | European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 17, Pg. 235, 1982. | |
mouse | LD50 | intravenous | 56200ug/kg (56.2mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02101, | |
mouse | LD50 | oral | 342mg/kg (342mg/kg) | Drug and Chemical Toxicology. Vol. 3, Pg. 249, 1980. |
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