1,3-DI(O-TOLYL)THIOUREA supplier

Name
1,3-DI(O-TOLYL)THIOUREA
EINECS
CAS No. 137-97-3
Article Data43
CAS DataBase
Density 1.219g/cm³
Solubility
Melting Point 157-159 °C(lit.)
Formula C15H16 N2 S
Boiling Point 367.5°Cat760mmHg
Molecular Weight 256.371
Flash Point 176°C
Transport Information
Appearance
Safety Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of NO_x and SO_x.
Risk Codes 25-36/37/38-50/53
Molecular Structure
Hazard Symbols T
Synonyms Carbanilide,2,2'-dimethylthio- (6CI,7CI,8CI); 1,3-Bis(o-tolyl)thiourea;1,3-Di-o-tolylthiourea; Di-o-tolylthiourea; N,N'-Bis(2-methylphenyl)thiourea;N,N'-Di-o-tolylthiourea; NSC 119321; NSC 37140; sym-Di-o-tolylthiourea
PSA 56.15000
LogP 4.25830

Synthetic route

: 75-15-0
carbon disulfide

: 95-53-4
o-toluidine

: 137-97-3
N,N'-di(o-tolyl)thiourea

Conditions

Conditions	Yield
With sodium carbonate; triethylamine In water at 20 - 90℃; for 19h;	99.3%
With triethanolamine; Lac sulfur; water for 1.5h; Heating;	85%
With potassium hydroxide at 20℃; for 0.75h; Milling; Green chemistry;	84%

: 6160-65-2
1,1'-Thiocarbonyldiimidazole

: 95-53-4
o-toluidine

: 137-97-3
N,N'-di(o-tolyl)thiourea

Conditions

Conditions	Yield
With quinoclamine at 0℃;	95%

: 534-18-9
sodium trithiocarbonate

: 95-53-4
o-toluidine

A: 2044-27-1
1-methyl-2-pyridinethione

B: 137-97-3
N,N'-di(o-tolyl)thiourea

Conditions

Conditions	Yield
With 2-chloro-1-methyl-pyridinium iodide In dimethyl sulfoxide at 40℃; for 4h;	A n/a B 94%

...Expand

: zinc diethyldithiocarbamate

: 95-53-4
o-toluidine

: 137-97-3
N,N'-di(o-tolyl)thiourea

Conditions

Conditions	Yield
With triethanolamine; triethylamine In N,N-dimethyl-formamide for 2h; Heating;	82%

: Ziram

: 95-53-4
o-toluidine

: 137-97-3
N,N'-di(o-tolyl)thiourea

Conditions

Conditions	Yield
With triethanolamine; triethylamine In N,N-dimethyl-formamide for 2h; Heating;	80%

: 17356-08-0
thiourea

: 95-53-4
o-toluidine

: 137-97-3
N,N'-di(o-tolyl)thiourea

Conditions

Conditions	Yield
With PEG-400 In water for 0.0333333h; microwave irradiation;	77%

: 75-15-0
carbon disulfide

: 95-53-4
o-toluidine

: 100-46-9
benzylamine

A: 137-97-3
N,N'-di(o-tolyl)thiourea

B: 40288-37-7
N-benzyl-N'-(2-methylphenyl)thiourea

C: 1424-14-2
dibenzyl thiourea

Conditions

Conditions	Yield
at 100℃; Ionic liquid; Green chemistry;	A 13% B 75% C 12%

...Expand

: 614-69-7
2-tolyl isothiocyanate

: 137-97-3
N,N'-di(o-tolyl)thiourea

Conditions

Conditions	Yield
With copper(l) iodide; caesium carbonate; 2-bromo-4,5-dimethoxy-benzamide; N,N`-dimethylethylenediamine In toluene at 20 - 120℃; Inert atmosphere;	62%

: 56-23-5
tetrachloromethane

: 95-53-4
o-toluidine

: 137-97-3
N,N'-di(o-tolyl)thiourea

Conditions

Conditions	Yield
With sodium sulfide; N-benzyl-N,N,N-triethylammonium chloride In water for 8h; Ambient temperature;	36%

: 40229-47-8
(5-amino-[1,2,4]dithiazol-3-ylidene)-phenyl-amine

: 95-53-4
o-toluidine

: 137-97-3
N,N'-di(o-tolyl)thiourea

Conditions

Conditions	Yield
With ethanol

: 609-72-3
N,N-dimethyl-o-toluidine

: 137-97-3
N,N'-di(o-tolyl)thiourea

Conditions

Conditions	Yield
With sulfur

: 463-71-8
thiophosgene

: 95-53-4
o-toluidine

: 137-97-3
N,N'-di(o-tolyl)thiourea

Conditions

Conditions	Yield
With water

: 95-53-4
o-toluidine

: 57-06-7
N-allyl isothiocyanate

: 137-97-3
N,N'-di(o-tolyl)thiourea

: 95-53-4
o-toluidine

: 614-69-7
2-tolyl isothiocyanate

: 137-97-3
N,N'-di(o-tolyl)thiourea

Conditions

Conditions	Yield
With ethanol

: 95-53-4
o-toluidine

: 137-97-3
N,N'-di(o-tolyl)thiourea

Conditions

Conditions	Yield
With sulfur dichloride
With water; sulfur at 60℃;

: 137-26-8
Thiram

: 95-53-4
o-toluidine

: 137-97-3
N,N'-di(o-tolyl)thiourea

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 1.5h; Heating;

: 97-74-5
bis(dimethylthiocarbamoyl)sulfide

: 95-53-4
o-toluidine

: 137-97-3
N,N'-di(o-tolyl)thiourea

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 2h; Heating;

ammonium salt of/the/ o-tolyl-dithiocarbamic acid: ammonium salt of/the/ o-tolyl-dithiocarbamic acid

: 137-97-3
N,N'-di(o-tolyl)thiourea

Conditions

Conditions	Yield
With water

: 617-07-2
N,N'-bis(2-methylphenyl)urea

CS2: CS2

: 137-97-3
N,N'-di(o-tolyl)thiourea

Conditions

Conditions	Yield
at 200℃;

: 95-53-4
o-toluidine

CS2: CS2

: 137-97-3
N,N'-di(o-tolyl)thiourea

Conditions

Conditions	Yield
With ethanol
With dihydrogen peroxide

o-hydrazotoluene: o-hydrazotoluene

CS2: CS2

: 137-97-3
N,N'-di(o-tolyl)thiourea

Conditions

Conditions	Yield
at 150℃;

: 95-53-4
o-toluidine

zinc-trithiocarbonate: zinc-trithiocarbonate

: 137-97-3
N,N'-di(o-tolyl)thiourea

Conditions

Conditions	Yield
With water

: 45892-06-6
N-(o-tolyl)dithiocarbamic acid

: 7732-18-5
water

: 137-97-3
N,N'-di(o-tolyl)thiourea

Conditions

Conditions	Yield
das Ammonium-Salz reagiert;

: 45892-06-6
N-(o-tolyl)dithiocarbamic acid

: 7732-18-5
water

ammonium carbonate: ammonium carbonate

A: 614-78-8
o-tolylthiourea

B: 137-97-3
N,N'-di(o-tolyl)thiourea

Conditions

Conditions	Yield
das Ammonium-Salz reagiert;

...Expand

: 45892-06-6
N-(o-tolyl)dithiocarbamic acid

: 7732-18-5
water

A: 137-97-3
N,N'-di(o-tolyl)thiourea

B: 614-69-7
2-tolyl isothiocyanate

Conditions

Conditions	Yield
das Kupfer(II)-Salz reagiert;

...Expand

: 32315-10-9
bis(trichloromethyl) carbonate

: 137-97-3
N,N'-di(o-tolyl)thiourea

: C16H14N2OS

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethyl acetate at 20℃; for 0.25h;	100%

: 137-97-3
N,N'-di(o-tolyl)thiourea

: C8H12N2O4

: 5-(ethoxycarbonyl)-4-methyl-3-o-tolyl-2-(o-tolylimino)-2,3-dihydrothiazole

Conditions

Conditions	Yield
Stage #1: N,N'-di(o-tolyl)thiourea; C8H12N2O4 In tetrahydrofuran at 25℃; for 0.5h; Cycloaddition; Stage #2: In tetrahydrofuran for 8.5h; Rearrangement; Elimination; Heating;	96%

: 137-97-3
N,N'-di(o-tolyl)thiourea

: 1215-57-2
N,N'-bis(o-methylphenyl)carbodiimide

Conditions

Conditions	Yield
With dicarbonyl(cyclopentadienyl)methyliron(II); Triethoxysilane In tetrahydrofuran at 60℃; for 24h; Schlenk technique; Inert atmosphere;	95%
With dmap; di-tert-butyl dicarbonate In ethyl acetate at 20℃; for 0.5h;	75%
With diethoxydisulfane; 4 A molecular sieve In dichloromethane for 2h; Heating;	43%

: 137-97-3
N,N'-di(o-tolyl)thiourea

: 617-07-2
N,N'-bis(2-methylphenyl)urea

Conditions

Conditions	Yield
With sodium chlorite for 0.5h; Heating; further reagents;	94%
With potassium superoxide In dimethyl sulfoxide for 24h; Ambient temperature;	72%
With potassium hydroxide; dihydrogen peroxide

: 137-97-3
N,N'-di(o-tolyl)thiourea

: 94126-56-4, 146000-79-5
3-phenylcarbamoylazo-crotonic acid ethyl ester

: 5-(ethoxycarbonyl)-4-methyl-3-o-tolyl-2-(o-tolylimino)-2,3-dihydrothiazole

Conditions

Conditions	Yield
Stage #1: N,N'-di(o-tolyl)thiourea; 3-phenylcarbamoylazo-crotonic acid ethyl ester In tetrahydrofuran at 25℃; for 0.5h; Cycloaddition; Stage #2: In tetrahydrofuran for 8.5h; Rearrangement; Elimination; Heating;	94%

: 141-82-2
malonic acid

: 137-97-3
N,N'-di(o-tolyl)thiourea

: 85788-84-7
1,3-di(2-methylphenyl)-2-thiobarbituric acid

Conditions

Conditions	Yield
With acetyl chloride for 0.0125h; Irradiation;	92%
With chloroform; acetyl chloride

: 137-97-3
N,N'-di(o-tolyl)thiourea

: 74821-71-9
4-methyl-N-(o-tolyl)benzo[d]thiazol-2-amine

Conditions

Conditions	Yield
With polymer-supported tribromide at 100℃; for 0.166667h; Solvent; Temperature; Microwave irradiation;	86%
With disulfur dichloride at 60℃;	77%

: bis(bis(diphenylphosphino)methanido)platinum(II)

: 137-97-3
N,N'-di(o-tolyl)thiourea

: {(bis(diphenylphosphino)methane)PtN(o-tolyl)C(=N(o-tolyl))S} * CH2Cl2

Conditions

Conditions	Yield
With CH2Cl2 In dichloromethane byproducts: (C6H5)2PCH2P(C6H5)2; stirring equimolar amts. in CH2Cl2 for several minutes at room temp.; addn. of pentane;; crystn. on standing at -5°C;;	85%

: 14040-11-0
tungsten hexacarbonyl

: 137-97-3
N,N'-di(o-tolyl)thiourea

: 796047-40-0
pentacarbonyl(sym-di-o-tolylthiourea)tungsten(0)

Conditions

Conditions	Yield
In toluene under Ar or vac., 1 equiv. of S-compd., reflux for 4.5 h; soln. was cooled and evapd. in vac., solid was washed with petroleum ether (40-60 °C), recrystn. from benzene, elem. anal.;	82.4%
In tetrahydrofuran Irradiation (UV/VIS); under Ar or vac., 1 equiv. of S-compd., irradn. for 25 h with UV light; soln. was cooled and evapd. in vac., solid was washed with petroleum ether (40-60 °C), recrystn. from benzene;

: 137-97-3
N,N'-di(o-tolyl)thiourea

: 97-39-2
[3H]-1,3-di-(2-tolyl)guanidine

Conditions

Conditions	Yield
With benzyl(triethyl)ammoniumpermanganate; ammonia In tetrahydrofuran at 5 - 10℃; for 0.5h;	82%
With triethanolamine; lac sulfur on alumina; sodium amide In tetrahydrofuran for 1h; Heating;	68%

: 137-97-3
N,N'-di(o-tolyl)thiourea

: 105-56-6
ethyl 2-cyanoacetate

: 130749-40-5
6-amino-1,3-di(2-methylbenzene)-2-thiouracil

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane at 0 - 5℃;	80%

: 110-91-8
morpholine

: 137-97-3
N,N'-di(o-tolyl)thiourea

: N-o-tolyl-morpholine-4-carboximidic acid 2-methyl-anilide

Conditions

Conditions	Yield
With triethanolamine; lac sulfur on alumina In tetrahydrofuran for 1.5h; Heating;	80%

: 137-97-3
N,N'-di(o-tolyl)thiourea

A: 617-07-2
N,N'-bis(2-methylphenyl)urea

B: 97-39-2
[3H]-1,3-di-(2-tolyl)guanidine

Conditions

Conditions	Yield
With sodium periodate; ammonia In water; N,N-dimethyl-formamide at 80 - 85℃; for 0.5h;	A n/a B 80%

: 14729-20-5
tetracarbonyl(1,10-phenanthroline)tungsten(0)

: 137-97-3
N,N'-di(o-tolyl)thiourea

: 796047-60-4
(o-phenanthroline)tricarbonyl(sym-di-o-tolylthiourea)tungsten(0)

Conditions

Conditions	Yield
In xylene under Ar or vac., 1 equiv. of S-compd., reflux for 4 h; soln. was cooled to room temp., filtered, solid was washed with petroleum ether (40-60 °C) and 2-3 times with benzene, elem. anal.;	78.3%

: 15668-66-3
(2,2'-bipyridine)tetracarbonyltungsten(0)

: 137-97-3
N,N'-di(o-tolyl)thiourea

: 796047-55-7
(2,2'-bipyridine)tricarbonyl(sym-di-o-tolylthiourea)tungsten(0)

Conditions

Conditions	Yield
In xylene under Ar or vac., 1 equiv. of S-compd., reflux for 4 h; soln. was cooled to room temp., filtered, solid was washed with petroleum ether (40-60 °C) and 2-3 times with benzene, elem. anal.;	76.4%

: 137-97-3
N,N'-di(o-tolyl)thiourea

: 95-53-4
o-toluidine

: 87927-72-8
N,N',N''-tri(2-tolyl)guanidine

Conditions

Conditions	Yield
With potassium hydroxide In water; nitrobenzene at 105℃; for 6h;	75%

: 29743-02-0
pentacarbonyl(triphenylarsine)tungsten(0)

: 137-97-3
N,N'-di(o-tolyl)thiourea

: 796047-50-2
cis-tetracarbonyl(sym-di-o-tolylthiourea)(triphenylarsine)tungsten(0)

Conditions

Conditions	Yield
In xylene under Ar or vac., 1 equiv. of S-compd., reflux for 5 h; soln. was cooled to room temp., solvent was removed in vac., residue waswashed 4-5 times with petroleum ether (40-60 °C), dried in vac., elem. anal.;	70.2%

: 15444-65-2
triphenylphosphine tungsten pentacarbonyl

: 137-97-3
N,N'-di(o-tolyl)thiourea

: 796047-45-5
cis-tetracarbonyl(sym-di-o-tolylthiourea)(triphenylphosphine)tungsten(0)

Conditions

Conditions	Yield
In xylene under Ar or vac., 1 equiv. of S-compd., reflux for 4 h; soln. was cooled to room temp., solvent was removed in vac., residue waswashed 4-5 times with petroleum ether (40-60 °C), dried in vac., elem. anal.;	68.4%

: 137-97-3
N,N'-di(o-tolyl)thiourea

: 638-38-0, 993-02-2, 2180-18-9, 15411-95-7, 22981-23-3, 27004-39-3
manganese triacetate

: 1-acetyl-1,3-di-o-tolyl-urea

Conditions

Conditions	Yield
In acetonitrile for 3h; Heating;	63%

: 137-97-3
N,N'-di(o-tolyl)thiourea

A: 617-07-2
N,N'-bis(2-methylphenyl)urea

B: 87927-72-8
N,N',N''-tri(2-tolyl)guanidine

Conditions

Conditions	Yield
With KO2 In tetrahydrofuran at 20℃; for 35h;	A n/a B 60%

: 137-97-3
N,N'-di(o-tolyl)thiourea

: 79-08-3
bromoacetic acid

: 16240-00-9
2-(o-tolyl)imino-3-(o-tolyl)-thiazolidin-4-one

Conditions

Conditions	Yield
With sodium acetate In ethanol for 6h; Heating;	55.4%

: 137-97-3
N,N'-di(o-tolyl)thiourea

A: 95-53-4
o-toluidine

B: 611-21-2
N,2-dimethylaniline

Conditions

Conditions	Yield
With sodium tetrahydroborate; nickel dichloride In methanol at 20℃; for 1h;	A 44% B 48%

1,3-DI(O-TOLYL)THIOUREA Chemical Properties

1,3-Di(o-tolyl)thiourea(137-97-3)'s molecular formula is C₁₅H₁₆N₂S and its formula weight is 256.37.
1,3-Di(o-tolyl)thiourea(137-97-3)'s melting point is 157-159 °C(lit.).
The molecular structure of 1,3-Di(o-tolyl)thiourea(137-97-3):

1,3-DI(O-TOLYL)THIOUREA Toxicity Data With Reference

1.		ipr-mus LD50:100 mg/kg		NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD277-689 .
2.		orl-rbt LDLo:3000 mg/kg		JPETAB Journal of Pharmacology and Experimental Therapeutics. 17 (1921),349.

1,3-DI(O-TOLYL)THIOUREA Consensus Reports

Reported in EPA TSCA Inventory.

1,3-DI(O-TOLYL)THIOUREA Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of NO_x and SO_x.

Product Name

1,3-DI(O-TOLYL)THIOUREA

Synthetic route

1,3-DI(O-TOLYL)THIOUREA Chemical Properties

1,3-DI(O-TOLYL)THIOUREA Toxicity Data With Reference

1,3-DI(O-TOLYL)THIOUREA Consensus Reports

1,3-DI(O-TOLYL)THIOUREA Safety Profile

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