Product Name

  • Name

    2-(Vinyloxy)ethanol

  • EINECS 212-124-4
  • CAS No. 764-48-7
  • Article Data21
  • CAS DataBase
  • Density 0.942 g/cm3
  • Solubility
  • Melting Point
  • Formula C4H8O2
  • Boiling Point 133.7 ºC at 760 mmHg
  • Molecular Weight 88.1063
  • Flash Point 50 ºC
  • Transport Information UN 3271 3/PG 3
  • Appearance
  • Safety 16-36
  • Risk Codes 10
  • Molecular Structure Molecular Structure of 764-48-7 (2-(Vinyloxy)ethanol)
  • Hazard Symbols
  • Synonyms 2-Hydroxyethyl vinyl ether;Ethylene glycol vinyl ether;Hydroxyethylvinyl ether;Monovinyl glycol ether;Vinyloxyethanol;
  • PSA 29.46000
  • LogP 0.13880

Synthetic route

2-bromomethyl-1,3-dioxolane
4360-63-8

2-bromomethyl-1,3-dioxolane

2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

Conditions
ConditionsYield
With sodium In diethyl ether for 6h; Heating;70%
ethylene glycol
107-21-1

ethylene glycol

acetylene
74-86-2

acetylene

A

ethylene glycol divinyl ether
764-78-3

ethylene glycol divinyl ether

B

2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

Conditions
ConditionsYield
With sodium hydroxide; cesium fluoride In dimethyl sulfoxide at 100℃; for 6h;A 37%
B 12%
With potassium hydroxide; nitrogen at 120℃; under 11032.6 - 22065.2 Torr;
With potassium hydroxide; nitrogen at 120℃; under 11032.6 - 22065.2 Torr;
ethylene glycol
107-21-1

ethylene glycol

acetylene
74-86-2

acetylene

A

2-methyl-1,3-dioxolane
497-26-7

2-methyl-1,3-dioxolane

B

ethylene glycol divinyl ether
764-78-3

ethylene glycol divinyl ether

C

2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

Conditions
ConditionsYield
With sodium hydroxide; cesium fluoride at 138 - 142℃; under 10297.1 Torr; for 3.5h;A 4%
B 11%
C 26%
2-(2-vinyloxy-ethoxy)-[1,3,2]dioxaphospholane
14690-04-1

2-(2-vinyloxy-ethoxy)-[1,3,2]dioxaphospholane

2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

Conditions
ConditionsYield
With potassium hydroxide
2-[2-(ethenyloxy)ethoxy]ethan-1-ol
929-37-3

2-[2-(ethenyloxy)ethoxy]ethan-1-ol

A

2-methyl-1,3-dioxolane
497-26-7

2-methyl-1,3-dioxolane

B

ethanol
64-17-5

ethanol

C

2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

Conditions
ConditionsYield
With potassium hydroxide at 170 - 250℃; Product distribution;
diethylene glycol
111-46-6

diethylene glycol

A

formaldehyd
50-00-0

formaldehyd

B

ethanol
64-17-5

ethanol

C

ethene
74-85-1

ethene

D

2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

E

acetaldehyde
75-07-0

acetaldehyde

Conditions
ConditionsYield
With oxygen at 400℃; for 0.333333h; Product distribution;
2-bromomethyl-1,3-dioxolane
4360-63-8

2-bromomethyl-1,3-dioxolane

diethyl ether
60-29-7

diethyl ether

sodium

sodium

2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

1,4-dioxane
123-91-1

1,4-dioxane

A

trimethylene oxide
503-30-0

trimethylene oxide

B

formaldehyd
50-00-0

formaldehyd

C

ethene
74-85-1

ethene

D

2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

E

H2

H2

Conditions
ConditionsYield
Mechanism; Product distribution; Quantum yield; Irradiation; 185 nm vacuum-ultraviolet photolysis;
ethylene glycol
107-21-1

ethylene glycol

acetylene
74-86-2

acetylene

KOH

KOH

A

ethylene glycol divinyl ether
764-78-3

ethylene glycol divinyl ether

B

2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

C

2-methyl-1.3-dioxolane

2-methyl-1.3-dioxolane

Conditions
ConditionsYield
at 180℃; unter Druck;
at 120℃; unter Druck;
at 120℃; unter Druck;
at 180℃; unter Druck;
bromoacetaldehyde ethylenacetal

bromoacetaldehyde ethylenacetal

2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

Conditions
ConditionsYield
With diethyl ether; sodium
Vinyl bromide
593-60-2

Vinyl bromide

ethylene glycol
107-21-1

ethylene glycol

potassium salt of ethylene glycol

potassium salt of ethylene glycol

A

ethylene glycol divinyl ether
764-78-3

ethylene glycol divinyl ether

B

2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

Conditions
ConditionsYield
at 120℃; unter Druck;
ethylene glycol
107-21-1

ethylene glycol

potassium salt with vinyl bromide

potassium salt with vinyl bromide

A

ethylene glycol divinyl ether
764-78-3

ethylene glycol divinyl ether

B

2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

Conditions
ConditionsYield
at 120℃; unter Druck;
ethylene glycol
107-21-1

ethylene glycol

acetylene
74-86-2

acetylene

2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

Conditions
ConditionsYield
With potassium hydroxide at 150℃; for 4h; Autoclave;
2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

2-Chloro-2-oxo-1,3,2-dioxaphospholane
6609-64-9

2-Chloro-2-oxo-1,3,2-dioxaphospholane

2-ethylene glycol vinyl ether-1,3,2-dioxaphospholane 2-oxide

2-ethylene glycol vinyl ether-1,3,2-dioxaphospholane 2-oxide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at -20 - 20℃; for 2h;100%
With triethylamine In dichloromethane at 4℃; for 12h;76%
2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

bis(1,3-dioxolan-2-ylmethyl)selenide
1398507-23-7

bis(1,3-dioxolan-2-ylmethyl)selenide

Conditions
ConditionsYield
Stage #1: ethyleneglycol vinyl ether In chloroform at -20 - 20℃; for 0.5h;
Stage #2: With sodium hydrogencarbonate In chloroform at 20℃; for 6h; Reagent/catalyst;
100%
2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

2-propanesulfonyl chloride
10147-37-2

2-propanesulfonyl chloride

1-vinyloxethyl propane 2-sulfonate
810668-09-8

1-vinyloxethyl propane 2-sulfonate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 2h;97.7%
bromobenzene
108-86-1

bromobenzene

2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

2-methyl-2-phenyl-1,3-dioxolane
3674-77-9

2-methyl-2-phenyl-1,3-dioxolane

Conditions
ConditionsYield
With 1,3-bis-(diphenylphosphino)propane; triethylammonium tetrafluoroborate; 1-butyl-3-methylimidazolium Tetrafluoroborate; palladium diacetate; diisopropylamine at 115℃; for 2h; Heck arylation;97%
With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine In ethylene glycol at 145℃; for 2h; Heck reaction; Inert atmosphere; regioselective reaction;88%
With 1,3-bis-(diphenylphosphino)propane; triethylamine; 1-butyl-3-methylimidazolium Tetrafluoroborate; palladium diacetate at 115℃; for 18h; Heck reaction;83%
With palladium diacetate; 1,3-bis-(diphenylphosphino)propane; thallium(I) acetate; triethylamine In N,N-dimethyl-formamide at 80℃; for 144h;81%
2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

para-bromoacetophenone
99-90-1

para-bromoacetophenone

1,4-Diacetylbenzene
1009-61-6

1,4-Diacetylbenzene

Conditions
ConditionsYield
Stage #1: ethyleneglycol vinyl ether; para-bromoacetophenone With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine In isopropyl alcohol at 115℃; Heck reaction; Inert atmosphere;
Stage #2: With hydrogenchloride; water In isopropyl alcohol for 0.5h;
97%
2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

bromostyrene
103-64-0

bromostyrene

(E)-2-methyl-2-styryl-1,3-dioxolane
63511-95-5

(E)-2-methyl-2-styryl-1,3-dioxolane

Conditions
ConditionsYield
With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine In dimethyl sulfoxide at 115℃; for 4h; Heck vinylation; Inert atmosphere; regioselective reaction;97%
5-bromo-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
26166-92-7

5-bromo-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

2-(2,6-dioxo-3-piperidyl)-5-[2-(2-hydroxyethoxy)ethyl]isoindoline-1,3-dione

2-(2,6-dioxo-3-piperidyl)-5-[2-(2-hydroxyethoxy)ethyl]isoindoline-1,3-dione

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); N-Methyldicyclohexylamine In 1,4-dioxane at 25℃; for 16h;97%
2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

2-propynyl chloride
624-65-7

2-propynyl chloride

ethylene glycol vinyl propargyl diether
14846-79-8

ethylene glycol vinyl propargyl diether

Conditions
ConditionsYield
With sodium hydroxide; tributyl-amine In water at 50 - 60℃; for 3h; Product distribution; other catalyst;96.8%
With sodium hydroxide; tributyl-amine In water at 50 - 60℃; for 3h;96.8%
o-fluorobromobenzene
1072-85-1

o-fluorobromobenzene

2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

2-(2-fluorophenyl)-2-methyl-1,3-dioxolane
261966-94-3

2-(2-fluorophenyl)-2-methyl-1,3-dioxolane

Conditions
ConditionsYield
With 1,3-bis-(diphenylphosphino)propane; triethylamine; 1-butyl-3-methylimidazolium Tetrafluoroborate; palladium diacetate at 115℃; for 24h; Heck reaction;96%
With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine In ethylene glycol at 145℃; Heck reaction; Inert atmosphere; regioselective reaction;77%
2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

1-Bromo-4-fluorobenzene
460-00-4

1-Bromo-4-fluorobenzene

2-(4-fluorophenyl)-2-methyl-1,3-dioxolane
36881-03-5

2-(4-fluorophenyl)-2-methyl-1,3-dioxolane

Conditions
ConditionsYield
With 1,3-bis-(diphenylphosphino)propane; triethylammonium tetrafluoroborate; 1-butyl-3-methylimidazolium Tetrafluoroborate; palladium diacetate; diisopropylamine at 115℃; for 2h; Heck arylation;96%
With 1,3-bis-(diphenylphosphino)propane; triethylamine; 1-butyl-3-methylimidazolium Tetrafluoroborate; palladium diacetate at 115℃; for 24h; Heck reaction;86%
With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine In ethylene glycol at 145℃; Heck reaction; Inert atmosphere; regioselective reaction;85%
2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

4-Ethynyl-benzoic acid
10602-00-3

4-Ethynyl-benzoic acid

2-vinyloxyethyl 4-ethynylbenzoate

2-vinyloxyethyl 4-ethynylbenzoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 25℃; for 18h; Inert atmosphere;96%
2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

4-fluorobenzalaniline
5676-81-3, 102904-34-7

4-fluorobenzalaniline

(R)-N-(2-(1,3-dioxolan-2-yl)-1-(4-fluorophenyl)ethyl)aniline

(R)-N-(2-(1,3-dioxolan-2-yl)-1-(4-fluorophenyl)ethyl)aniline

Conditions
ConditionsYield
Stage #1: 4-fluorobenzalaniline With (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; magnesium sulfate In toluene at -10℃; Schlenk technique; Inert atmosphere; Sealed tube; Green chemistry;
Stage #2: ethyleneglycol vinyl ether In toluene at -10℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube; Green chemistry; enantioselective reaction;
96%
2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

toluene-4-sulfonic acid 2-vinyloxy-ethyl ester
99051-18-0

toluene-4-sulfonic acid 2-vinyloxy-ethyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 4h;95.46%
With dmap; triethylamine In dichloromethane94%
With pyridine at 0℃; for 1h;90%
With dmap; triethylamine In dichloromethane for 48h;65%
With pyridine In acetone
2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

allyl bromide
106-95-6

allyl bromide

1-allyloxy-2-vinyloxyethane
17271-00-0

1-allyloxy-2-vinyloxyethane

Conditions
ConditionsYield
With sodium hydroxide; PEG-1 In water at 20℃; for 6.5h; Product distribution; other time, other temperature, other ratio, without catalyst;95.3%
With sodium hydroxide; PEG-1 In water at 20℃; for 6.5h;95.3%
2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

C16H36O4Si4

C16H36O4Si4

C32H68O12Si4

C32H68O12Si4

Conditions
ConditionsYield
With platinum(0)-1,3-divinyl-1,1,3,3-tetramethyldisiloxane complex In toluene at 95℃; for 4h; Inert atmosphere; regioselective reaction;95%
2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

2-iodobenzonitrile
4387-36-4

2-iodobenzonitrile

C11H11NO2

C11H11NO2

Conditions
ConditionsYield
With copper(l) iodide; sodium t-butanolate In N,N-dimethyl-formamide for 24h; Schlenk technique; Inert atmosphere; Molecular sieve; Heating;95%
2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

4-bromobenzenecarbonitrile
623-00-7

4-bromobenzenecarbonitrile

4-(2-methyl-[1,3]dioxolan-2-yl)benzonitrile
14517-91-0

4-(2-methyl-[1,3]dioxolan-2-yl)benzonitrile

Conditions
ConditionsYield
With 1,3-bis-(diphenylphosphino)propane; triethylamine; 1-butyl-3-methylimidazolium Tetrafluoroborate; palladium diacetate at 115℃; for 24h; Heck reaction;94%
With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine In ethylene glycol at 145℃; Heck reaction; Inert atmosphere; regioselective reaction;86%
2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

triphenylstannane
892-20-6

triphenylstannane

(C6H5)3SnCH2CH2OCH2CH2OH
918162-79-5

(C6H5)3SnCH2CH2OCH2CH2OH

Conditions
ConditionsYield
With 2,2'-azobis(isobutyronitrile); diphenyl diselenide In neat (no solvent) heating a mixt. of tin compd., alkene, Se compd. and AIBN at 80°Cfor 2.5 h with stirring;94%
With 2,2'-azobis(isobutyronitrile) In neat (no solvent) heating a mixt. of tin compd., alkene and AIBN at 80°C for 2.5 h with stirring;77%
5-bromo-3-pyridine carboxylic acid methyl ester
29681-44-5

5-bromo-3-pyridine carboxylic acid methyl ester

2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

C11H13NO4
1072933-65-3

C11H13NO4

Conditions
ConditionsYield
With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine at 140℃; for 2h; Heck reaction;94%
2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

4-(1H-1,2,4-triazol-1-yl)benzaldehyde
27996-86-7

4-(1H-1,2,4-triazol-1-yl)benzaldehyde

1-(4-(1H-1,2,4-triazol-1-yl)phenyl)-2-(1,3-dioxolan-2-yl)ethanol

1-(4-(1H-1,2,4-triazol-1-yl)phenyl)-2-(1,3-dioxolan-2-yl)ethanol

Conditions
ConditionsYield
Stage #1: ethyleneglycol vinyl ether With isopropylmagnesium bromide In diethyl ether at 25℃; for 0.0833333h; Schlenk technique; Inert atmosphere;
Stage #2: 4-(1H-1,2,4-triazol-1-yl)benzaldehyde With scandium tris(trifluoromethanesulfonate) at 40℃; for 20h; Schlenk technique; Inert atmosphere;
94%
2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

N-(2-bromobenzylidene)aniline
32347-03-8, 41077-23-0

N-(2-bromobenzylidene)aniline

(R)-N-(1-(2-bromophenyl)-2-(1,3-dioxolan-2-yl)ethyl)aniline

(R)-N-(1-(2-bromophenyl)-2-(1,3-dioxolan-2-yl)ethyl)aniline

Conditions
ConditionsYield
Stage #1: N-(2-bromobenzylidene)aniline With (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; magnesium sulfate In toluene at -10℃; Schlenk technique; Inert atmosphere; Sealed tube; Green chemistry;
Stage #2: ethyleneglycol vinyl ether In toluene at -10℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube; Green chemistry; enantioselective reaction;
94%
4'-Bromopropiophenone
10342-83-3

4'-Bromopropiophenone

2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

A

2-(4-propionylbenzyl)-1,3-dioxolane

2-(4-propionylbenzyl)-1,3-dioxolane

B

1-(2-hydroxyethoxy)-1-(4-propionylphenyl)ethene

1-(2-hydroxyethoxy)-1-(4-propionylphenyl)ethene

Conditions
ConditionsYield
With cis,cis,cis-1,2,3,4-tetrakis (diphenylphosphinomethyl)cyclopentane; potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)) In N,N-dimethyl-formamide at 130℃; for 20h;A 93%
B 5 % Spectr.
2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

2-bromonaphthalene
580-13-2

2-bromonaphthalene

methyl 2-naphthyl ketone
93-08-3

methyl 2-naphthyl ketone

Conditions
ConditionsYield
Stage #1: ethyleneglycol vinyl ether; 2-bromonaphthalene With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine In isopropyl alcohol at 115℃; Heck reaction; Inert atmosphere;
Stage #2: With hydrogenchloride; water In isopropyl alcohol for 0.5h;
93%
2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

2-formylbenzo[b]furan
4265-16-1

2-formylbenzo[b]furan

1-(benzofuran-2-yl)-2-(1,3-dioxolan-2-yl)ethanol

1-(benzofuran-2-yl)-2-(1,3-dioxolan-2-yl)ethanol

Conditions
ConditionsYield
Stage #1: ethyleneglycol vinyl ether With isopropylmagnesium bromide In diethyl ether at 25℃; for 0.0833333h; Schlenk technique; Inert atmosphere;
Stage #2: 2-formylbenzo[b]furan With scandium tris(trifluoromethanesulfonate) at 40℃; for 12h; Schlenk technique; Inert atmosphere;
93%
2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

methyl 3-((phenylimino)methyl)benzoate
1159445-34-7

methyl 3-((phenylimino)methyl)benzoate

methyl (R)-3-(2-(1,3-dioxolan-2-yl)-1-(phenylamino)ethyl)benzoate

methyl (R)-3-(2-(1,3-dioxolan-2-yl)-1-(phenylamino)ethyl)benzoate

Conditions
ConditionsYield
Stage #1: methyl 3-((phenylimino)methyl)benzoate With (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; magnesium sulfate In toluene at -10℃; Schlenk technique; Inert atmosphere; Sealed tube; Green chemistry;
Stage #2: ethyleneglycol vinyl ether In toluene at -10℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube; Green chemistry; enantioselective reaction;
93%
1-bromo-butane
109-65-9

1-bromo-butane

2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

ethylene glycol n-butyl vinyl diether
4223-11-4

ethylene glycol n-butyl vinyl diether

Conditions
ConditionsYield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In water92.1%
2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

4-bromobenzenecarbonitrile
623-00-7

4-bromobenzenecarbonitrile

A

4-(2-methyl-[1,3]dioxolan-2-yl)benzonitrile
14517-91-0

4-(2-methyl-[1,3]dioxolan-2-yl)benzonitrile

B

4-(1,3-dioxolan-2-ylmethyl)benzonitrile

4-(1,3-dioxolan-2-ylmethyl)benzonitrile

Conditions
ConditionsYield
With potassium carbonate; (1RS,2RS,3SR,4SR)-1,2,3,4-tetrakis((diphenylphosphanyl)methyl)cyclopentane; bis(η3-allyl-μ-chloropalladium(II)) In N,N-dimethyl-formamide at 130℃; for 20h; Heck reaction;A n/a
B 92%
With cis,cis,cis-1,2,3,4-tetrakis (diphenylphosphinomethyl)cyclopentane; potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)) In N,N-dimethyl-formamide at 130℃; for 20h;A 2 % Spectr.
B 92%
3-bromoquinoline
5332-24-1

3-bromoquinoline

2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

C13H13NO2
1072933-62-0

C13H13NO2

Conditions
ConditionsYield
With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine In ethylene glycol at 140℃; for 2h; Heck reaction;92%
3-bromo-5-methoxypyridine
50720-12-2

3-bromo-5-methoxypyridine

2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

C10H13NO3
1072933-64-2

C10H13NO3

Conditions
ConditionsYield
With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine at 140℃; for 1h; Heck reaction;92%
2-hydroxyethyl vinyl ether
764-48-7

2-hydroxyethyl vinyl ether

(E)-4-(2-bromo-vinyl)-anisole
6303-59-9, 60592-52-1, 27570-08-7

(E)-4-(2-bromo-vinyl)-anisole

(E)-2-(4-methoxystyryl)-2-methyl-1,3-dioxolane

(E)-2-(4-methoxystyryl)-2-methyl-1,3-dioxolane

Conditions
ConditionsYield
With palladium diacetate; triethylamine; diphenylphosphino(diphenylphosphonyl)propane In dimethyl sulfoxide at 115℃; for 1h; Heck vinylation; Inert atmosphere; regioselective reaction;92%

2-(Vinyloxy)ethanol Consensus Reports

Glycol ether compounds are on the Community Right-To-Know List.

2-(Vinyloxy)ethanol Specification

The CAS registry number of Ethylene glycol monovinyl ether is 764-48-7. The systematic name is 2-(ethenyloxy)ethanol. In addition, the molecular formula is C4H8O2 and the molecular weight is 88.11. It belongs to the classes of Ethylene Glycols Monofunctional Ethylene Glycols and Monofunctional Ethylene Glycols. What's more, it should be stored in a cool and dry place.

Physical properties about this chemical are: (1)ACD/LogP: -0.27; (2)ACD/LogD (pH 5.5): -0.27; (3)ACD/LogD (pH 7.4): -0.27; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 16.93; (7)ACD/KOC (pH 7.4): 16.93; (8)#H bond acceptors: 2; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 4; (11)Polar Surface Area: 18.46 Å2; (12)Index of Refraction: 1.418; (13)Molar Refractivity: 23.58 cm3; (14)Molar Volume: 93.5 cm3; (15)Polarizability: 9.35 ×10-24cm3; (16)Surface Tension: 28.8 dyne/cm; (17)Density: 0.942 g/cm3; (18)Flash Point: 50 °C; (19)Enthalpy of Vaporization: 43.25 kJ/mol; (20)Boiling Point: 133.7 °C at 760 mmHg; (21)Vapour Pressure: 3.64 mmHg at 25°C.

Preparation of Ethylene glycol monovinyl ether: it can be prepared by ethane-1,2-diol and ethyne. The other product is 1,2-bis-vinyloxy-ethane. This reaction will need reagents CsF and NaOH and solvent dimethylsulfoxide. The reaction time is 6 hours at reaction temperature of 100 °C. The yield is about 37%.

Ethylene glycol monovinyl ether can be prepared by ethane-1,2-diol and ethyne

Uses of Ethylene glycol monovinyl ether: it can be used to get 2-methyl-[1,3]dioxolane. This reaction will need reagent KOH. And it needs cyclization and various alkalis. The yield is about 51% at reaction temperature of 120 °C.
 
Ethylene glycol monovinyl ether can be used to get 2-methyl-[1,3]dioxolane

When you are using this chemical, please be cautious about it as the following:
This chemical is flammable. During using it, wear suitable protective clothing. And you should keep away from sources of ignition.

You can still convert the following datas into molecular structure:
(1)SMILES: O(\C=C)CCO
(2)InChI: InChI=1/C4H8O2/c1-2-6-4-3-5/h2,5H,1,3-4H2
(3)InChIKey: VUIWJRYTWUGOOF-UHFFFAOYAW

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LC50 inhalation 29gm/m3 (29000mg/m3)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(11), Pg. 94, 1974.
mouse LD50 oral 2900mg/kg (2900mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(3), Pg. 12, 1977.
rat LD50 oral 3910mg/kg (3910mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(3), Pg. 12, 1977.

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View