4-(methylthio)benzaldehyde supplier

Name
4-(Methylthio)benzaldehyde
EINECS 222-365-7
CAS No. 3446-89-7
Article Data171
CAS DataBase
Density 1.13 g/cm³
Solubility Not miscible in water.
Melting Point 6 °C
Formula C₈H₈OS
Boiling Point 267 °C at 760 mmHg
Molecular Weight 152.217
Flash Point 133.3 °C
Transport Information
Appearance clear yellow liquid
Safety 23-24/25-36-26-7/9
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Benzaldehyde,p-(methylthio)- (6CI,7CI,8CI);4-(Methylmercapto)benzaldehyde;4-Methanesulfanylbenzaldehyde;4-Methanethiobenzaldehyde;4-Methylsulfanylbenzaldehyde;Methyl 4-formylphenylthioether;p-(Methylthio)benzaldehyde;
PSA 42.37000
LogP 2.22100

Synthetic route

: 3446-90-0
4-(methylthio)benzyl alcohol

: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With cobalt(II) nitrate hexahydrate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; manganese (II) nitrate tetrahydrate; oxygen; acetic acid at 40℃; under 760.051 Torr; for 0.75h;	100%
With N,N,N',N'-tetramethylguanidine In dichloromethane at 20℃; for 1h;	99%
With hydrogenchloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium nitrite In dichloromethane; water at 20℃; under 760.051 Torr; for 11h; in air;	99%

: 37794-15-3
p-methylsulfinylbenzaldehyde

: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With indium; tungsten(VI) chloride In tetrahydrofuran at 20℃; for 0.0833333h;	95%
With niobium pentachloride; sodium iodide In acetonitrile at 20℃; for 0.0833333h;	95%
With iododioxobis(triphenylphosphine)rhenium(V); phenylsilane In tetrahydrofuran at 20℃; for 2.25h; chemoselective reaction;	92%

: 1,1-diacetoxy-1-(4-methylthiophenyl)methane

: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With H6P2W18O62 In toluene at 100℃; for 0.0833333h;	95%

: 13205-48-6
4-(methylthio)benzoic acid

: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With 4,4'-dimethoxyphenyl disulfide; iridium(lll) bis[2-(2,4-difluorophenyl)-5-methylpyridine-N,C20]-4,40-di-tert-butyl-2,20-bipyridine hexafluorophosphate; triphenylphosphine In toluene for 24h; Irradiation;	94%
With 2,6-dimethylpyridine; nickel(II) bromide trihydrate; phenylsilane; 4,4'-di-tert-butyl-2,2'-bipyridine; zinc; dimethyl dicarbonate In ethyl acetate at 60℃; for 24h; Schlenk technique; Inert atmosphere;	72 %Chromat.

: 2-(4-(methylthio)phenyl)-1,3-dithiane

: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With 1,3,5-trichloro-2,4,6-triazine; dimethyl sulfoxide In dichloromethane at 20℃; for 1h;	93%

: 67-68-5
dimethyl sulfoxide

: 1122-91-4
4-bromo-benzaldehyde

: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane; copper(l) iodide at 130℃; for 12h; Sealed tube; Inert atmosphere;	92%
With copper(l) iodide; zinc(II) fluoride at 150℃; for 36h; Sealed tube; Under air;	85%
With copper(l) iodide; zinc diacetate at 135℃; for 36h; regioselective reaction;	70%

: 2-<4-(methylthio)phenyl>-1,3-dithiolane

: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With iodosylbenzene In dichloromethane at 20℃; for 0.333333h;	90%

: 100-68-5
methyl-phenyl-thioether

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With trichlorophosphate at -5 - 45℃; for 7h;	89.2%

: 2-(4-(methylsulfinyl)phenyl)-1,3-dioxolane

: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With 1,2,3-trimethoxybenzene; oxalyl dichloride In dichloromethane at 0℃; for 0.00166667h; Inert atmosphere; chemoselective reaction;	89%

: 201230-82-2
carbon monoxide

: 104-95-0
(4-bromophenyl)thioanisole

: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; hydrogen; palladium diacetate; propyl di-tert-butylphosphinite In toluene at 100℃; under 3750.38 Torr; for 20h; Inert atmosphere;	88%

: 38185-19-2
4-(methylthio)benzyl bromide

: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With benzo[c]cinnoline In N,N-dimethyl-formamide at 80℃; Kornblum Aldehyd Synthesis;	87%

: 1778-09-2
4-(Methylthio)acetophenone

: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With copper(l) iodide; oxygen In dimethyl sulfoxide at 120℃; for 25h; chemoselective reaction;	85%

: 3446-90-0
4-(methylthio)benzyl alcohol

A: 3446-89-7
4-(Methylthio)benzaldehyde

B: 4-(methylthio)benzyl 4-(methylthio)benzoate

Conditions

Conditions	Yield
With [Rh(1,3,4,5-tetramethylimidazole-2-ylidene)(trop2NH)][trifluoromethanesulfonate]; potassium tert-butylate; dinitrogen monoxide In tetrahydrofuran; water; toluene at 50℃; under 750.075 Torr; Schlenk technique; Molecular sieve; Overall yield = 88 %; Overall yield = 165 mg;	A 3% B 85%

: 84212-03-3
4-(Methylthio)-N-methylbenzenemethanamine

: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene In dichloromethane at 0 - 20℃; for 0.333333h; Inert atmosphere; Green chemistry;	85%

: 3446-90-0
4-(methylthio)benzyl alcohol

A: 93183-64-3, 106732-70-1
(4-(methylsulfinyl)phenyl)methanol

B: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In neat (no solvent) at 70℃; for 6h; Irradiation; Green chemistry;	A 15% B 85%

: 98546-51-1
(4-thiomethoxyphenyl)boronic acid

: 298-12-4
Glyoxilic acid

: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With 1,2,3,4-tetrahydroisoquinoline In acetonitrile at 20℃; Green chemistry;	77%

: 142070-82-4
1-(azidomethyl)-4-methylsulfanylbenzene

: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
Stage #1: 1-(azidomethyl)-4-methylsulfanylbenzene With sodium hydride In dimethyl sulfoxide; mineral oil at 20℃; for 4h; Inert atmosphere; Stage #2: With water In dimethyl sulfoxide; mineral oil for 0.25h; Inert atmosphere;	75%

: 50978-45-5
3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide

: 57728-76-4
4-(methylthio)phenyl trifluoromethanesulfonate

: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With triethylsilane; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; sodium carbonate In acetonitrile at 80℃; for 16h; Inert atmosphere; Sealed tube;	73%

: 50-00-0
formaldehyd

: 104-95-0
(4-bromophenyl)thioanisole

: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With triethylsilane; dichloro bis(acetonitrile) palladium(II); sodium carbonate; 1,4-di(diphenylphosphino)-butane In N,N-dimethyl-formamide at 20 - 100℃; under 15001.5 Torr; for 20h; Inert atmosphere; Autoclave;	69%

: 50-00-0
formaldehyd

: 83171-39-5
4-(methylthio)benzylamine

: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With iron(III) chloride hexahydrate In 1,4-dioxane; water at 80 - 100℃; for 18h;	66%

: 93033-60-4
(E)-4-(methylthio)benzaldehyde oxime

A: 4-(methylsulfinyl)benzaldehyde oxime

B: 37794-15-3
p-methylsulfinylbenzaldehyde

C: 53147-98-1
4-(methylsulfonyl)benzaldehyde oxime

D: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With dihydrogen peroxide; bis(acetylacetonato)dioxidomolybdenum(VI) In acetone at 20℃; Product distribution; Further Variations:; Catalysts; Solvents;	A 5% B 3% C 3% D 60%

...Expand

: 459-57-4
4-fluorobenzaldehyde

: 67-68-5
dimethyl sulfoxide

: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In water at 189℃; for 48h;	60%

: 3446-90-0
4-(methylthio)benzyl alcohol

A: 37794-15-3
p-methylsulfinylbenzaldehyde

B: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In n-heptane at 80℃; under 760.051 Torr; for 24h;	A 21% B 59%
With polystyrene-supported hypervalent iodine(V) reagent In 1,2-dichloro-ethane at 85℃; for 1h;
With N-(2-iodylphenyl)glutarylamide supported on amonomethylpolystyrene resin In 1,2-dichloro-ethane at 85℃; for 1h;	A 7 %Spectr. B 85 %Spectr.

: 79-46-9
2-nitropropane

: 38185-19-2
4-(methylthio)benzyl bromide

A: 2-methyl-1-(4-methylsulfanyl-phenyl)-2-nitro-propan-1-ol

B: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran Hass-Bender/Henry reaction;	A 57% B n/a

...Expand

: 38185-19-2
4-(methylthio)benzyl bromide

A: 3446-90-0
4-(methylthio)benzyl alcohol

B: 51927-46-9
1-bromomethyl-4-methanesulfinylbenzene

C: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With dihydrogen peroxide at 70℃; for 1h;	A n/a B 52% C n/a

...Expand

: 623-13-2
4-methylphenyl methylsulfide

: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With 9-(benzoyl(cyclohexyl)carbamoyl)-10-phenylacridinium perchlorate In water; acetonitrile at 20℃; for 18h; Irradiation; Green chemistry; chemoselective reaction;	49%

: 3446-90-0
4-(methylthio)benzyl alcohol

A: 37794-15-3
p-methylsulfinylbenzaldehyde

B: 93183-64-3, 106732-70-1
(4-(methylsulfinyl)phenyl)methanol

C: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With 1-iodyl-2-butoxybenzene In acetonitrile for 15h; Heating;	A 16% B 46% C 32%
With 4-(2-iodylphenoxy)butanoylaminomethylated polystyrene In 1,2-dichloro-ethane for 3h; Heating;

...Expand

: 37794-15-3
p-methylsulfinylbenzaldehyde

A: (R)-4-(methylsulfinyl)benzaldehyde

B: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With DL-dithiothreitol; methionine sulfoxide reductase A from Pseudomonas alcaliphila In aq. phosphate buffer at 30℃; for 1h; pH=8; Resolution of racemate; Enzymatic reaction; enantioselective reaction;	A 43% B n/a
With recombinant methionine sulfoxide reductase A from Pseudomonas monteilii; diothiothreitol In aq. phosphate buffer at 30℃; for 4h; pH=8; Sealed tube; Resolution of racemate; Green chemistry; Enzymatic reaction; enantioselective reaction;	A n/a B n/a

: 100-68-5
methyl-phenyl-thioether

: 3446-89-7
4-(Methylthio)benzaldehyde

Conditions

Conditions	Yield
With N,N-dimethyl-formamide; trichlorophosphate
Multi-step reaction with 2 steps 1: acetic acid 2: hexamethylenetetramine; acetic acid / Erhitzen des Reaktionsprodukts mit H2O View Scheme

: 3446-89-7
4-(Methylthio)benzaldehyde

: 4052-30-6
4-methylsulfonylbenzoic acid

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; sodium hydroxide at 70℃; for 2h;	100%
With oxone In tetrahydrofuran; water at 20℃; for 24h;	94%
With sodium perborate In acetic acid at 45 - 50℃;	90%
With oxygen at 100℃; for 20h; Reagent/catalyst; Schlenk technique; chemoselective reaction;	87%

: 3446-89-7
4-(Methylthio)benzaldehyde

: 90005-49-5
4-(methylthio)benzamide

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; sodium hydroxide; (CTA)2SO4 at 50℃; for 2h;	100%
With nitromethane; trifluoromethylsulfonic anhydride; acetic acid In formic acid at 80 - 120℃;	57%
Multi-step reaction with 2 steps 1: hydroxylamine hydrochloride; pyridine / methanol / 24 h / 20 °C 2: [RuCl2(η2-C6H6){P(NMe2)3}]; water / 3 h / 100 °C / Inert atmosphere; Sealed tube View Scheme

: 3446-89-7
4-(Methylthio)benzaldehyde

: 149-73-5
trimethyl orthoformate

: 100515-17-1
1-(1,1-dimethoxy-methyl)-4-methylsulfanyl-benzene

Conditions

Conditions	Yield
With potassium tert-butylate; toluene-4-sulfonic acid In methanol at 20℃; for 1.5h; Inert atmosphere;	100%
With toluene-4-sulfonic acid In methanol for 1.5h; Ambient temperature;	83%
With toluene-4-sulfonic acid In methanol at 20℃; for 1h;

: 3446-89-7
4-(Methylthio)benzaldehyde

: 3446-90-0
4-(methylthio)benzyl alcohol

Conditions

Conditions	Yield
With hydrogen; phosphotungstic acid 44-hydrate; [Fe(C5H4P(i-Pr)2)2Rh(C8H12)]BF4 In water; isopropyl alcohol at 20℃; under 5171.62 Torr; for 16h;	100%
With isopropyl alcohol; hydrotalcite at 81.84℃; for 3h; Kinetics; Further Variations:; Temperatures; Reagents;	100%
Stage #1: 4-(Methylthio)benzaldehyde With chloro(cyclopentadienyl)bis(triphenylphosphine)ruthenium (II); phenylsilane at 80℃; for 0.666667h; Stage #2: With tetrabutyl ammonium fluoride at 20℃; for 0.5h; Reagent/catalyst; Temperature; Time; Solvent; chemoselective reaction;	98%

: 141-97-9
ethyl acetoacetate

: 57-13-6
urea

: 3446-89-7
4-(Methylthio)benzaldehyde

: 423737-44-4
ethyl 6-methyl-4-[4-(methylsulfanyl)phenyl]-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

Conditions

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate) In ethanol at 100℃; for 1h; Biginelli reaction; Microwave irradiation; Inert atmosphere;	100%
Wells-Dawson heteropolyacid catalyst at 80℃; for 1.5h; Biginelli reaction;	92%
With 25,26,27,28-terahydroxycalix[4]arene-5,11,7,23-tetrasulfonic acid In ethanol for 8h; Biginelli reaction; Reflux;	92%

...Expand

: 3446-89-7
4-(Methylthio)benzaldehyde

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 4-BOC-1-(4-methylthio)-benzylpiperazine

Conditions

Conditions	Yield
Stage #1: 4-(Methylthio)benzaldehyde; 1-t-Butoxycarbonylpiperazine In methanol for 0.5h; Stage #2: With borohydride; polymer-supported In methanol for 24h;	100%

: 1009-61-6
1,4-Diacetylbenzene

: 3446-89-7
4-(Methylthio)benzaldehyde

: 404585-30-4
C26H22O2S2

Conditions

Conditions	Yield
With sodium hydroxide In water; isopropyl alcohol at 0 - 20℃; for 5h;	100%
With sodium hydroxide In water; isopropyl alcohol at 0 - 20℃;	100%

: 1483-97-2
1,1′-(9-ethyl-9H-carbazole-3,6-diyl)diethanone

: 3446-89-7
4-(Methylthio)benzaldehyde

: 1104847-99-5
C34H29NO2S2

Conditions

Conditions	Yield
With sodium hydroxide In water; tert-butyl alcohol at 0 - 20℃; for 5h;	100%
With sodium hydroxide In water; tert-butyl alcohol at 0 - 20℃;	100%

: 141-97-9
ethyl acetoacetate

: 504-02-9
1,3-cylohexanedione

: 3446-89-7
4-(Methylthio)benzaldehyde

: 312527-79-0
2-Methyl-4-(4-methylsulfanyl-phenyl)-5-oxo-1,4, 5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With Cu(OTf)2; ammonium acetate In ethanol at 100℃; for 0.25h; Hantzsch reaction; Microwave irradiation;	100%

...Expand

: 719-59-5
2-Amino-5-chlorobenzophenone

: 3446-89-7
4-(Methylthio)benzaldehyde

: 6-chloro-2-[4-(methylsulfanyl)phenyl]-4-phenylquinazoline

Conditions

Conditions	Yield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;	100%
With 1,1,1,3',3',3'-hexafluoro-propanol; ammonium acetate at 55℃; for 1.5h;	84%

: 563-41-7
semicarbazide hydrochloride

: 3446-89-7
4-(Methylthio)benzaldehyde

: 1-(4-(methylthio)benzylidene)semicarbazide

Conditions

Conditions	Yield
With sodium acetate In ethanol; water at 20℃;	100%

: 3446-89-7
4-(Methylthio)benzaldehyde

: 37794-15-3
p-methylsulfinylbenzaldehyde

Conditions

Conditions	Yield
With phthaloyl peroxide In dichloromethane at 25℃; for 8h; Schlenk technique; chemoselective reaction;	99%
Stage #1: 4-(Methylthio)benzaldehyde With aluminum (III) chloride In methanol; dichloromethane at 20℃; for 0.0166667h; Stage #2: With [bis(acetoxy)iodo]benzene In methanol; dichloromethane at 20℃; for 12h;	99%
With nitric acid; phosphorus pentoxide; silica gel In water for 0.0833333h;	97%

: 3446-89-7
4-(Methylthio)benzaldehyde

: 389082-07-9
γ-aminopropyl-2-methyl-6-phenyl-1,3-dioxa-6-aza-2-silacyclooctane

: γ-N-(p-methylthiobenzylidene)aminopropyl-2-methyl-6-phenyl-1,3-dioxa-6-aza-2-silacyclooctane

Conditions

Conditions	Yield
With potassium carbonate In benzene at 20℃; for 6h;	99%

: 1779-49-3
Methyltriphenylphosphonium bromide

: 3446-89-7
4-(Methylthio)benzaldehyde

: 18760-11-7
4-methythiostyrene

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 20℃; Wittig reaction;	99%
With sodium hydride In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	99%
Stage #1: Methyltriphenylphosphonium bromide With n-butyllithium In tetrahydrofuran; hexane at 0 - 20℃; for 2h; Wittig Olefination; Inert atmosphere; Stage #2: 4-(Methylthio)benzaldehyde In tetrahydrofuran; hexane at 0 - 20℃; for 16h; Wittig Olefination; Inert atmosphere;	96%

: 95-54-5
1,2-diamino-benzene

: 3446-89-7
4-(Methylthio)benzaldehyde

: 2-(4-(methylthio)phenyl)-1H-benzo[d]imidazole

Conditions

Conditions	Yield
With sodium metabisulfite In N,N-dimethyl-formamide at 80℃; for 0.1h; Microwave irradiation;	99%
Stage #1: 4-(Methylthio)benzaldehyde In N,N-dimethyl-formamide at 240℃; under 7500.75 Torr; for 0.0833333h; Microwave irradiation; Stage #2: 1,2-diamino-benzene In N,N-dimethyl-formamide at 240℃; under 7500.75 Torr; for 0.0833333h; Microwave irradiation;

: 1445-73-4
1-Methyl-4-piperidone

: 3446-89-7
4-(Methylthio)benzaldehyde

: 3,5-Bis((E)-4-methylthiobenzylidene)-1-methylpiperidin-4-one

Conditions

Conditions	Yield
With sodium hydroxide In water at 20℃; Aldol Condensation;	99%

: 104-94-9
4-methoxy-aniline

: 762-04-9
phosphonic acid diethyl ester

: 3446-89-7
4-(Methylthio)benzaldehyde

: C19H26NO4PS

Conditions

Conditions	Yield
With chloro(cyclopentadienyl)bis(triphenylphosphine)ruthenium (II) In neat (no solvent) at 80℃; for 0.166667h; chemoselective reaction;	99%

...Expand

: 3446-89-7
4-(Methylthio)benzaldehyde

: 13205-48-6
4-(methylthio)benzoic acid

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; sodium hydroxide; (CTA)2SO4 at 20℃; for 20h;	98%
With sodium hydroxide In water at 20 - 75℃; for 20h;	85%
With perchloric acid; mercury(II) diacetate; N-bromoacetamide In acetic acid at 24.9℃; Kinetics; Mechanism; Thermodynamic data; other temperatures, ΔG(excit.), ΔH(excit.), ΔS(excit.);

: 3446-89-7
4-(Methylthio)benzaldehyde

: 5398-77-6
para-methanesulfonylbenzaldehyde

Conditions

Conditions	Yield
With sodium hydroxide; 3-chloro-benzenecarboperoxoic acid at 1 - 3℃; for 2h;	98%
With Oxone In neat (no solvent) for 1.5h; Milling; Green chemistry; chemoselective reaction;	97%
With C2MoO9(2-)H2O2C19H42N(1+); dihydrogen peroxide In water at 20℃; for 0.0166667h; chemoselective reaction;	97%

: 75-25-2
Bromoform

: 3446-89-7
4-(Methylthio)benzaldehyde

: 109086-16-0
2-hydroxy-2-(4-methylthiophenyl)ethanoic acid

Conditions

Conditions	Yield
With sodium hydroxide; lithium bromide In 1,4-dioxane	98%
With potassium hydroxide; lithium bromide In 1,4-dioxane; water 1.) 0 deg C, 18 h, 2.) 23 deg C, 24 h;	7.6 g

: 3446-89-7
4-(Methylthio)benzaldehyde

: 93033-60-4
4-(methylthio)benzaldehyde oxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; sodium hydroxide In ethanol at 80℃; for 4h; Inert atmosphere;	98%
With sodium hydroxide; hydroxylamine hydrochloride In ethanol; water at 0℃;	46%
With hydroxylamine hydrochloride; sodium carbonate In ethanol; water for 24h;

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 3446-89-7
4-(Methylthio)benzaldehyde

: 41105-92-4, 107379-09-9
N-[4-(methylthio)benzylidene]methylamine N-oxide

Conditions

Conditions	Yield
With sodium sulfate; sodium carbonate at 20℃; for 0.0833333h; Neat (no solvent);	98%
With sodium hydrogencarbonate In dichloromethane at 20℃;	82%
With sodium acetate In ethanol at 50 - 60℃; for 3h;	78%

: 110-89-4
piperidine

: 82303-13-7
(4-methoxyphenyl)zinc(II) bromide

: 3446-89-7
4-(Methylthio)benzaldehyde

: 1-((4-methoxyphenyl)(4-(methylthio)phenyl)methyl)piperidine

Conditions

Conditions	Yield
With copper(l) iodide In acetonitrile at 20℃; for 3h;	98%

...Expand

: 5003-71-4
3-bromopropylamine hydrochloride

: 3446-89-7
4-(Methylthio)benzaldehyde

: 4-(thiomethyl)benzylidene-(3-bromo-1-propylamine)

Conditions

Conditions	Yield
With triethylamine In chloroform at 20℃; for 16h;	98%

: 74-90-8
hydrogen cyanide

: 3446-89-7
4-(Methylthio)benzaldehyde

: 895570-68-0
2-hydroxy-2-(4-(methylthio)phenyl)acetonitrile

Conditions

Conditions	Yield
With Prunus communis L. (R)-hydroxynitrile lyase In various solvent(s) at 20℃; for 12h;	98%
With hydroxynitrile lyase isozyme 5 from Prunus communis In tert-butyl methyl ether at 25℃; for 4h; pH=5; pH-value; Temperature; Reagent/catalyst; Solvent; Enzymatic reaction;	94%
With hydroxynitrile lyase PcHNL5, L343F mutant at 10℃; for 12h; pH=2.5; Reagent/catalyst; Enzymatic reaction; enantioselective reaction;	n/a

: 106-47-8
4-chloro-aniline

: 3446-89-7
4-(Methylthio)benzaldehyde

: 22116-72-9
4-chloro-N-[4-methylsulfanylbenzylidene]aniline

Conditions

Conditions	Yield
	98%
In methanol for 4h; Reflux;	88%
With acetic acid In ethanol at 78℃; for 10h;

: 119-53-9
2-hydroxy-2-phenylacetophenone

: 3446-89-7
4-(Methylthio)benzaldehyde

: 36755-90-5
2-(4-(methylthio)phenyl)-4,5-diphenyl-1H-imidazole

Conditions

Conditions	Yield
With P2O5/SiO2; ammonium acetate at 100℃; for 2h;	98%
With triphenyl(propyl-3-sulphonyl)phosphonium toluenesulfonate; ammonium acetate at 100℃; for 2h; neat (no solvent);	98%
With 1-methyl-2-oxopyrrolidinium hydrogen sulfate; ammonium acetate at 100℃; for 2.5h; Neat (no solvent);	95%
With ammonium acetate at 130℃; for 1.33333h; Neat (no solvent);	90%

: 3446-89-7
4-(Methylthio)benzaldehyde

: 534-85-0
N-phenyl-1,2-benzenediamine

: 1412893-57-2
2-[4-(methylthio)phenyl]-1-phenyl-1H-benzo[d]imidazole

Conditions

Conditions	Yield
With sodium metabisulfite In N,N-dimethyl-formamide at 100℃; for 0.1h; Microwave irradiation;	98%

: 504-02-9
1,3-cylohexanedione

: 56-06-4
2,4-diamino-6-hydroxypyrimidine

: 3446-89-7
4-(Methylthio)benzaldehyde

: 2-amino-8,9-dihydro-5-(4-(methylthio)phenyl)pyrimido[4,5-b]quinoline 4,6(1H,5H,7H,10H)-dione

Conditions

Conditions	Yield
With zirconium(IV) oxide In ethylene glycol at 120℃; for 0.133333h; Green chemistry;	98%

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4-(methylthio)benzaldehyde Chemical Properties

Molecular Structure of 4-(methylthio)benzaldehyde (CAS NO.3446-89-7):

IUPAC Name: 4-methylsulfanylbenzaldehyde
CAS No: 3446-89-7
EINECS: 222-365-7
Molecular Formula: C₈H₈OS
Molecular Weight: 152.21 g/mol
Melting Point: 6 °C
Density: 1.13 g/cm³
H bond acceptors: 1
H bond donors: 0
Freely Rotating Bonds: 2
Polar Surface Area: 42.37 Å²
Index of Refraction: 1.577
Molar Refractivity: 44.36 cm³
Molar Volume: 133.7 cm³
Surface Tension: 43.3 dyne/cm
Flash Point: 133.3 °C
Enthalpy of Vaporization: 50.5 kJ/mol
Boiling Point: 267 °C at 760 mmHg
Vapour Pressure: 0.00836 mmHg at 25°C
Product Categories: Aromatic Aldehydes & Derivatives (substituted)
InChI
InChI=1/C8H8OS/c1-10-8-4-2-7(6-9)3-5-8/h2-6H,1H3
Smiles
O=Cc1ccc(SC)cc1

4-(methylthio)benzaldehyde Production

Product Categories about 4-(methylthio)benzaldehyde (3446-89-7) are Aromatic Aldehydes & Derivatives (substituted)

4-(methylthio)benzaldehyde Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 23-24/25-36-26-7/9
S23:Do not breathe vapour.
S24/25:Avoid contact with skin and eyes.
S36:Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S7:Keep container tightly closed.
S9:Keep container in a well-ventilated place.
WGK Germany: 3
F: 13
Hazard Note: Irritant/Stench
HS Code: 29309070

4-(methylthio)benzaldehyde Specification

4-(methylthio)benzaldehyde , with CAS number of 3446-89-7, can be called p-(Methylthio)benzaldehyde ; benzaldehyde, 4-(methylthio)- ; 4-(Methylsulfanyl)benzaldehyd . 4-(methylthio)benzaldehyde (CAS NO.3446-89-7) is stable under normaltemperatures and pressures.but incompatible with strong oxidizingagents. It is a clear yellow liquid.

Product Name

4-(Methylthio)benzaldehyde

Synthetic route

4-(methylthio)benzaldehyde Chemical Properties

4-(methylthio)benzaldehyde Production

4-(methylthio)benzaldehyde Safety Profile

4-(methylthio)benzaldehyde Specification

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