4-Methoxytriphenylmethyl chloride supplier

Name
4-Methoxytriphenylchloromethane
EINECS 238-463-8
CAS No. 14470-28-1
Article Data19
CAS DataBase
Density 1.151 g/cm³
Solubility
Melting Point 122-124 °C(lit.)
Formula C₂₀H₁₇ClO
Boiling Point 426.8 °C at 760 mmHg
Molecular Weight 308.807
Flash Point 208.4 °C
Transport Information
Appearance light orange powder
Safety 26-36-45-36/37/39
Risk Codes 36/37/38-34
Molecular Structure
Hazard Symbols Xi,C
Synonyms Anisole,p-(chlorodiphenylmethyl)- (6CI,7CI,8CI);1-(Chlorodiphenylmethyl)-4-methoxybenzene;4-Anisyl(chloro)diphenylmethane;4-Methoxytrityl chloride;Mono-p-methoxytrityl chloride;NSC 54121;p-(Chlorodiphenylmethyl)anisole;p-Methoxytritylchloride;
PSA 9.23000
LogP 5.22590

Synthetic route

: 847-83-6
p-methoxytrityl alcohol

: 14470-28-1
mono-4-methoxytrityl chloride

Conditions

Conditions	Yield
With acetyl chloride In benzene for 1h; Heating;	89%
With hydrogenchloride In toluene at 15 - 30℃; Solvent; Temperature;	89.1%
With acetyl chloride In benzene at 80℃; for 0.5h; Reflux;	67%

: 119-61-9
benzophenone

: 14470-28-1
mono-4-methoxytrityl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1) Mg / 1) ether, 2) benzene 2: 89 percent / acetyl chloride / benzene / 1 h / Heating View Scheme
Multi-step reaction with 2 steps 1: benzene; diethyl ether 2: benzene View Scheme
Multi-step reaction with 2 steps 1.1: magnesium / diethyl ether / 2 h / 35 °C 1.2: 24 h / Reflux 2.1: acetyl chloride / benzene / Reflux View Scheme
Multi-step reaction with 2 steps 1.1: magnesium / diethyl ether / 2 h / 35 °C 1.2: 24 h / Reflux 2.1: acetyl chloride / benzene / 0.75 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: magnesium / tetrahydrofuran / 24 h / 60 °C / Schlenk technique; Inert atmosphere 2: acetyl chloride / benzene / 0.5 h / 80 °C / Reflux View Scheme

: 104-92-7
1-bromo-4-methoxy-benzene

: 14470-28-1
mono-4-methoxytrityl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1) Mg / 1) ether, 2) benzene 2: 89 percent / acetyl chloride / benzene / 1 h / Heating View Scheme
Multi-step reaction with 2 steps 1.1: magnesium / diethyl ether / 2 h / 35 °C 1.2: 24 h / Reflux 2.1: acetyl chloride / benzene / Reflux View Scheme
Multi-step reaction with 2 steps 1.1: magnesium / diethyl ether / 2 h / 35 °C 1.2: 24 h / Reflux 2.1: acetyl chloride / benzene / 0.75 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: magnesium / tetrahydrofuran / 24 h / 60 °C / Schlenk technique; Inert atmosphere 2: acetyl chloride / benzene / 0.5 h / 80 °C / Reflux View Scheme

: 847-83-6
p-methoxytrityl alcohol

: 75-36-5
acetyl chloride

: 14470-28-1
mono-4-methoxytrityl chloride

Conditions

Conditions	Yield
With benzene
With diethyl ether

: 15658-11-4
p-hydroxytrityl alcohol

: 14470-28-1
mono-4-methoxytrityl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NaOH-solution 2: diethyl ether View Scheme

: 13139-86-1
4-methoxyphenyl magnesium bromide

: 14470-28-1
mono-4-methoxytrityl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: benzene; diethyl ether 2: benzene View Scheme

: 611-94-9
4-Methoxybenzophenone

: 14470-28-1
mono-4-methoxytrityl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: magnesium 1.2: diethyl ether / 1 h / Heating 2.1: thionyl chloride / CCl4 / 5 h / 20 °C View Scheme

: 108-86-1
bromobenzene

(hexacarbonyl)chromium: (hexacarbonyl)chromium

: 14470-28-1
mono-4-methoxytrityl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: magnesium 1.2: diethyl ether / 1 h / Heating 2.1: thionyl chloride / CCl4 / 5 h / 20 °C View Scheme

etheric 4-methoxy-triphenyl-carbinol solution: etheric 4-methoxy-triphenyl-carbinol solution

: 14470-28-1
mono-4-methoxytrityl chloride

Conditions

Conditions	Yield
With hydrogenchloride

: 2051-90-3
Dichlorodiphenylmethane

: 100-66-3
methoxybenzene

: 14470-28-1
mono-4-methoxytrityl chloride

Conditions

Conditions	Yield
With carbon disulfide; aluminium trichloride

: 7647-01-0
hydrogenchloride

: 860734-05-0
1,2-bis-(4-methoxy-phenyl)-1,1,2,2-tetraphenyl-ethane

: 71-43-2
benzene

A: 13865-56-0
1-(4-methoxyphenyl)diphenylmethane

B: 14470-28-1
mono-4-methoxytrityl chloride

...Expand

: 66108-04-1
methyl 3-azido-3-deoxy-α-D-arabinofuranoside

: 14470-28-1
mono-4-methoxytrityl chloride

: 153206-09-8
methyl-3-deoxy-3-azido-5-O-para-monomethoxytrityl-α-D-arabinofuranose

Conditions

Conditions	Yield
With pyridine for 17h; Ambient temperature;	100%

: 14470-28-1
mono-4-methoxytrityl chloride

: 50-91-9
5-Fluoro-2'-deoxyuridine

: 103767-37-9
5'-O-(4-monomethoxytrityl)-2'-deoxy-5-fluorouridine

Conditions

Conditions	Yield
With pyridine for 48h; Ambient temperature;	100%
With pyridine at 20℃; for 5h;	94%
In pyridine for 24h; Ambient temperature;	86%

: 188938-33-2
(2Z,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-7-(Diethyl-isopropyl-silanyloxy)-15,17-dihydroxy-2,14-dimethoxy-4,6,8,10,16-pentamethyl-heptadeca-2,4,10,12-tetraenoic acid methyl ester

: 14470-28-1
mono-4-methoxytrityl chloride

: 188938-34-3
(2Z,4E,10E,12E)-(6R,7S,8S,14S,15R,16S)-7-(Diethyl-isopropyl-silanyloxy)-15-hydroxy-2,14-dimethoxy-17-[(4-methoxy-phenyl)-diphenyl-methoxy]-4,6,8,10,16-pentamethyl-heptadeca-2,4,10,12-tetraenoic acid methyl ester

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane for 3.5h; Ambient temperature;	100%
With triethylamine In dichloromethane at 25℃; for 5h;	91%

: 202914-69-0
({(2-Amino-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester

: 14470-28-1
mono-4-methoxytrityl chloride

: 202914-62-3
({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine at 0 - 5℃; for 12h;	100%

: 14470-28-1
mono-4-methoxytrityl chloride

: 213408-82-3
(2Z,4E,12E,14E)-(6R,7R,8S,9S,10R,16S,17R,18S)-7,9-Bis-(diethyl-isopropyl-silanyloxy)-8-ethyl-17,19-dihydroxy-2,16-dimethoxy-4,6,10,12,18-pentamethyl-nonadeca-2,4,12,14-tetraenoic acid methyl ester

: 213408-83-4
(2Z,4E,12E,14E)-(6R,7R,8S,9S,10R,16S,17R,18S)-7,9-Bis-(diethyl-isopropyl-silanyloxy)-8-ethyl-17-hydroxy-2,16-dimethoxy-19-[(4-methoxy-phenyl)-diphenyl-methoxy]-4,6,10,12,18-pentamethyl-nonadeca-2,4,12,14-tetraenoic acid methyl ester

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 25℃; for 3h;	100%
With dmap; triethylamine In dichloromethane for 3h; Ambient temperature;

: 14470-28-1
mono-4-methoxytrityl chloride

: 287933-70-4
(3S)-4-phenylsulfonyl-2,3-dihydrofuran-3-methanol

: 287933-90-8
(3R)-3-(((4-methoxyphenyl)-diphenylmethoxy)-methyl)-4-phenylsulfonyl-2,3-dihydrofuran

Conditions

Conditions	Yield
With dmap; triethylamine Alkylation;	100%
With dmap; triethylamine In dichloromethane at 20℃; for 2h;	100%

: 2140-11-6
2',3'-O-isopropylideneinosine

: 14470-28-1
mono-4-methoxytrityl chloride

: 239080-20-7
5'-O-(monomethoxytrityl)-2',3'-O-isopropylideneinosine

Conditions

Conditions	Yield
In pyridine at 20℃; for 40h; Alkylation;	100%

: 14470-28-1
mono-4-methoxytrityl chloride

: 349552-49-4
(1R,2S)-1-[(2R,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-2-methyl-propane-1,3-diol

: 349552-50-7
(1R,2S)-1-[(2R,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-2-methyl-propan-1-ol

Conditions

Conditions	Yield
With pyridine; dmap In dichloromethane at 23℃; for 2.7h;	100%

: 14470-28-1
mono-4-methoxytrityl chloride

: 370886-82-1
(2R,3S,5R,6S)-2-Hydroxymethyl-5-triisopropylsilanyloxy-6-vinyl-tetrahydro-pyran-3-ol

: 370886-66-1
(2R,3S,5R,6S)-2-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-5-triisopropylsilanyloxy-6-vinyl-tetrahydro-pyran-3-ol

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 20℃;	100%

: 5003-71-4
3-bromopropylamine hydrochloride

: 14470-28-1
mono-4-methoxytrityl chloride

: 501097-15-0
N-(4-monomethoxytrityl)-3-bromopropylamine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 23℃;	100%
With TEA In dichloromethane at 20℃; for 0h;	95%

: 14470-28-1
mono-4-methoxytrityl chloride

: 516457-60-6
(2Z,5Z)-8-[(2S,4S,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxymethyl)-tetrahydro-furan-2-yl]-6-chloro-2-methyl-octa-2,5-dien-1-ol

: 516457-75-3
tert-Butyl-[(2S,3S,5S)-5-{(3Z,6Z)-3-chloro-8-[(4-methoxy-phenyl)-diphenyl-methoxy]-7-methyl-octa-3,6-dienyl}-2-(4-methoxy-benzyloxymethyl)-tetrahydro-furan-3-yloxy]-dimethyl-silane

Conditions

Conditions	Yield
In pyridine	100%

: 1926-80-3
methyl 6-aminocaproate hydrochloride

: 14470-28-1
mono-4-methoxytrityl chloride

: 766548-72-5
6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid methyl ester

Conditions

Conditions	Yield
With TEA In dichloromethane	100%

: 878550-04-0
1-{2'-[(tert-butyl)dimethylsilyloxy]-4'-hydroxycyclohexyl}uracil

: 14470-28-1
mono-4-methoxytrityl chloride

: 878550-06-2
1-{2'-[(tert-butyl)dimethylsilyloxy]-4'-[(4-methoxyphenyl)diphenylmethoxy]cyclohexyl}uracil

Conditions

Conditions	Yield
With pyridine	100%

: 33069-62-4
taxol

: 14470-28-1
mono-4-methoxytrityl chloride

: 159858-20-5
C67H67NO15

Conditions

Conditions	Yield
With pyridine In dichloromethane	100%

: 930807-83-3
C8H14O5

: 14470-28-1
mono-4-methoxytrityl chloride

: 930807-84-4
C28H30O6

Conditions

Conditions	Yield
With pyridine; dmap In dichloromethane at 20℃; for 1h;	100%

: 1030021-66-9
N-1-(4'-seleno-β-D-ribofuranosyl)-thymine

: 14470-28-1
mono-4-methoxytrityl chloride

: 5-methyl-5'-O-monomethoxytrityl-4'-selenouridine

Conditions

Conditions	Yield
With dmap In pyridine at 20℃;	100%

: 17131-52-1, 124933-35-3, 131064-88-5, 131064-87-4
(R)-3-(p-methoxyphenoxy)-1,2-propanediol

: 14470-28-1
mono-4-methoxytrityl chloride

: 955948-40-0
C30H30O5

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 1h;	100%
With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 2h;	88%

: C23H28N2O8

: 14470-28-1
mono-4-methoxytrityl chloride

: C43H44N2O9

Conditions

Conditions	Yield
With pyridine at 0 - 20℃; Inert atmosphere;	100%
With pyridine at 0 - 20℃; Inert atmosphere;
With pyridine at 0 - 20℃; Inert atmosphere;

: 14470-28-1
mono-4-methoxytrityl chloride

: 50-89-5
thymidine

: 42926-80-7
5'-O-(4-monomethoxytrityl)-2'-deoxythymidine

Conditions

Conditions	Yield
With dmap; triethylamine In N,N-dimethyl-formamide at 20℃; for 3.5h;	99%
With dmap; triethylamine In N,N-dimethyl-formamide at 20℃; for 4h; Inert atmosphere;	97%
With pyridine	94%

: ethyl N-(2-aminoethyl)glycinate dihydrochloride

: 14470-28-1
mono-4-methoxytrityl chloride

: 178389-68-9
(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethylamino)-acetic acid ethyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 1h;	99%

: 14470-28-1
mono-4-methoxytrityl chloride

: 312934-35-3
3'-deoxy-3'-C-(iodomethyl)-2'-O-(2-methoxyethyl)-5-methyluridine

: 312934-48-8
3'-deoxy-3'-C-(iodomethyl)-2'-O-(2-methoxyethyl)-5'-O-(4-methoxytrityl)-5-methyluridine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethyl acetate at 20℃;	99%
Etherification;
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethyl acetate at 20℃; for 48h;
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethyl acetate
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethyl acetate at 20℃; for 48h;	690 mg

: 951-78-0
2'-deoxyuridine

: 14470-28-1
mono-4-methoxytrityl chloride

: 14270-73-6
O5'-trityl-2'-deoxy-uridine

Conditions

Conditions	Yield
With pyridine for 2h; Heating / reflux;	99%

: 951-78-0
2'-deoxyuridine

: 14470-28-1
mono-4-methoxytrityl chloride

: 70255-96-8
1-{4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydrofuran-2-yl}-1H-pyrimidine-2,4-dione

Conditions

Conditions	Yield
With pyridine for 2h; Heating;	99%
With pyridine; dmap at 50℃; for 40h; Inert atmosphere;	69%

: 17131-52-1, 124933-35-3, 131064-87-4, 131064-88-5
(S)-1-O-(4-methoxyphenyl)glycerol

: 14470-28-1
mono-4-methoxytrityl chloride

: 955948-67-1
C30H30O5

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 1h;	99%
With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 2h;	91%

: 1262858-69-4
5-(3-bromo-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

: 14470-28-1
mono-4-methoxytrityl chloride

: 1266784-96-6
(RS)-[bis-(4-methoxy-phenyl)-phenyl-methyl]-[5-(3-bromo-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-amine

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	99%

: 14470-28-1
mono-4-methoxytrityl chloride

: 6291-84-5
N-Methyl-1,3-propanediamine

: 1599485-90-1
C24H28N2O

Conditions

Conditions	Yield
In diethyl ether; dichloromethane for 2h;	99%

: C19H19ClN8O4

: 14470-28-1
mono-4-methoxytrityl chloride

: C39H35ClN8O5

Conditions

Conditions	Yield
With dmap; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h; Reagent/catalyst; Inert atmosphere;	98.51%

: 141-43-5
ethanolamine

: 14470-28-1
mono-4-methoxytrityl chloride

: 113019-11-7
2-(((4-methoxyphenyl)diphenylmethyl)amino)ethanol

Conditions

Conditions	Yield
With pyridine; triethylamine at 20℃; for 1h;	98%
With pyridine; triethylamine at 20℃; for 1h;	98%
With pyridine; triethylamine at 20℃; for 1h;	98%

: 58-63-9
Inosine

: 14470-28-1
mono-4-methoxytrityl chloride

: 69659-63-8
5'-O-(4-methoxytrityl)inosine

Conditions

Conditions	Yield
With pyridine In dimethyl sulfoxide for 19h;	98%

: 13089-48-0
N4-benzoylcytidine

: 14470-28-1
mono-4-methoxytrityl chloride

: 72409-15-5
N4-benzoyl-5'-O-(4-monomethoxytrityl)cytidine

Conditions

Conditions	Yield
In pyridine; dimethyl sulfoxide for 24h; Ambient temperature;	98%
With pyridine at 20℃; for 18h;	82%

4-Methoxytriphenylmethyl chloride Specification

The Benzene,1-(chlorodiphenylmethyl)-4-methoxy-, with CAS registry number 14470-28-1, belongs to the following product categories: (1)Aliphatics; (2)Halides; (3)Biochemistry; (4)Nucleosides, Nucleotides & Related Reagents; (5)Protecting Agents for Hydroxyl and Amino Groups; (6)Protecting Agents, Phosphorylating Agents & Condensing Agents; (7)Protection & Derivatization Reagents (for Synthesis); (8)Synthetic Organic Chemistry. It has the systematic name of 1-[chloro(diphenyl)methyl]-4-methoxybenzene. This chemical is a kind of pale yellow to yellow-beige or pink cryst powder. And this chemical should be stored at the temperature of −20°C.

Physical properties of Benzene,1-(chlorodiphenylmethyl)-4-methoxy-: (1)ACD/LogP: 5.48; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 5.48; (4)ACD/LogD (pH 7.4): 5.48; (5)ACD/BCF (pH 5.5): 8656.01; (6)ACD/BCF (pH 7.4): 8656.01; (7)ACD/KOC (pH 5.5): 22904.56; (8)ACD/KOC (pH 7.4): 22904.56; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 9.23 Å²; (13)Index of Refraction: 1.594; (14)Molar Refractivity: 91.06 cm³; (15)Molar Volume: 268.1 cm³; (16)Polarizability: 36.1 10^-24cm³; (17)Surface Tension: 41.2 dyne/cm; (18)Density: 1.151 g/cm³; (19)Flash Point: 208.4 °C; (20)Enthalpy of Vaporization: 65.53 kJ/mol; (21)Boiling Point: 426.8 °C at 760 mmHg; (22)Vapour Pressure: 4.27E-07 mmHg at 25°C.

Preparation: this chemical can be prepared by 1-(chloro-diphenyl-methyl)-4-methoxy-benzene. This reaction will need reagents HCl, diethyl ether, CaCl₂.

When you are using this chemical, please be cautious about it as the following:
The Trimesic acid irritates to eyes, respiratory system and skin. And this chemical may cause burns. When use it, wear suitable protective clothing, gloves and eye/face protection. If contact with eyes, rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

You can still convert the following datas into molecular structure:
(1)SMILES: ClC(c1ccc(OC)cc1)(c2ccccc2)c3ccccc3
(2)InChI: InChI=1/C20H17ClO/c1-22-19-14-12-18(13-15-19)20(21,16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-15H,1H3
(3)InChIKey: OBOHMJWDFPBPKD-UHFFFAOYAG
(4)Std. InChI: InChI=1S/C20H17ClO/c1-22-19-14-12-18(13-15-19)20(21,16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-15H,1H3
(5)Std. InChIKey: OBOHMJWDFPBPKD-UHFFFAOYSA-N

Product Name

4-Methoxytriphenylchloromethane

Synthetic route

4-Methoxytriphenylmethyl chloride Specification

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