6-Bromopyridine-2-carbaldehyde supplier

Name
6-Bromopyridine-2-carbaldehyde
EINECS -0
CAS No. 34160-40-2
Article Data57
CAS DataBase
Density 1.683 g/cm³
Solubility Soluble in dichloromethane, ether, ethyl acetate and methanol. Insoluble in water.
Melting Point 81-85 °C(lit.)
Formula C₆H₄BrNO
Boiling Point 248.2 °C at 760 mmHg
Molecular Weight 186.008
Flash Point 103.9 °C
Transport Information
Appearance Light yellow flakes
Safety 26-36-36/37/39-16
Risk Codes 36/37/38-20/21/22-10
Molecular Structure
Hazard Symbols Xn, Xi, F
Synonyms Picolinaldehyde,6-bromo- (8CI);2-Bromo-6-formylpyridine;2-Bromopyridine-6-carboxaldehyde;2-Bromopyridyl-6-carboxaldehyde;2-Formyl-6-bromopyridine;6-Bromo-2-formylpyridine;6-Bromo-2-pyridinecarbaldehyde;6-Bromo-2-pyridinecarboxaldehyde;6-Bromopicolylaldehyde;6-Bromopyridine-2-aldehyde;Bromo-2-pyridinecarboxaldehyde;
PSA 29.96000
LogP 1.65660

Synthetic route

: 33674-96-3
2-bromo-6-(hydroxymethyl)pyridine

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

Conditions

Conditions	Yield
With fluorosulfonyl fluoride; potassium carbonate; dimethyl sulfoxide at 20℃; for 12h; chemoselective reaction;	98%
With phosphoric acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide for 1.5h; Ambient temperature;	89%
With 1-iodobenzoic acid In dimethyl sulfoxide at 20℃;
With phosphoric acid; dicyclohexyl-carbodiimide In dimethyl sulfoxide at 25℃; for 1.5h;
With 2-Iodobenzoic acid In dimethyl sulfoxide at 20℃; for 2h;

: 626-05-1
2,6-Dibromopyridine

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

Conditions

Conditions	Yield
Stage #1: 2,6-Dibromopyridine With n-butyllithium; butyl magnesium bromide In tetrahydrofuran; hexane; toluene at -10 - -5℃; for 3.5h; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane; toluene at -10 - -5℃; for 0.5h; Further stages.;	97%
Stage #1: 2,6-Dibromopyridine With n-butyllithium; butyl magnesium bromide In tetrahydrofuran; hexane; toluene at -10℃; for 3h; Stage #2: N,N-dimethyl-formamide In toluene at -10 - -5℃; for 1h; Stage #3: With citric acid at 20℃; for 0.166667h;	95%
Stage #1: 2,6-Dibromopyridine With n-butyllithium In tetrahydrofuran; hexane at -70℃; for 2h; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane at -70 - 0℃;	94.2%

: 626-05-1
2,6-Dibromopyridine

: 109-72-8, 29786-93-4
n-butyllithium

: 693-04-9
butyl magnesium bromide

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

Conditions

Conditions	Yield
With acetic acid In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene	95%

...Expand

: 109-04-6
2-bromo-pyridine

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

Conditions

Conditions	Yield
Stage #1: 2-bromo-pyridine With n-butyllithium In tetrahydrofuran; hexane at -78 - -70℃; for 2.5h; Inert atmosphere; Schlenk technique; Stage #2: N,N-dimethyl-formamide With zinc chloride*2(tetrahydrofuran) In tetrahydrofuran; hexane at -78 - 40℃; Inert atmosphere; Schlenk technique;	90.4%

: 82315-66-0
2-bromo-6-(dibromomethyl) pyridine

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

Conditions

Conditions	Yield
With calcium carbonate In water for 8h; Heating;	86%

: 626-05-1
2,6-Dibromopyridine

: 1068-55-9
isopropylmagnesium chloride

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

A: 5431-44-7
2,6-Pyridinedicarboxaldehyde

B: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

C: 153646-83-4
6-isopropyl-2-pyridinecarboxaldehyde

Conditions

Conditions	Yield
Stage #1: 2,6-Dibromopyridine; isopropylmagnesium chloride In tetrahydrofuran at 20℃; for 5h; Stage #2: N,N-dimethyl-formamide With acetic acid at 0℃;	A 1% B 85% C 6%

...Expand

: 5315-25-3
2-bromo-6-methylpyridine

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

Conditions

Conditions	Yield
With selenium(IV) oxide In 1,4-dioxane at 80℃; for 16h;	71%
Multi-step reaction with 2 steps 1: 88 percent / N-bromosuccinimide; benzoylperoxide / CCl4 / 4 h / Heating 2: 86 percent / CaCO3 / H2O / 8 h / Heating View Scheme
Multi-step reaction with 3 steps 1: 53 percent / KMnO4 / H2O / Heating 2: 1) NEt3, ethyl chloroformate, 2) LiAlH4 / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min 3: 89 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H3PO4 / 1.5 h / Ambient temperature View Scheme
Stage #1: 2-bromo-6-methylpyridine With bromine In dichloromethane; water at 10 - 50℃; for 10h; Stage #2: With hexamethylenetetramine In ethanol at 40℃; for 12h; Stage #3: With sulfuric acid; acetic acid In ethanol at 90℃; for 1h;	62.3 g

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

Conditions

Conditions	Yield
Stage #1: With n-butyllithium; n-BuMgCl In tetrahydrofuran; H2O; hexane; N,N-dimethyl-formamide; toluene at -10℃; for 0.5h; Stage #2: 2,6-Dibromopyridine In tetrahydrofuran; hexane; toluene at -10℃; for 2.5h; Stage #3: N,N-dimethyl-formamide With citric acid more than 3 stages;	52%

: 626-05-1
2,6-Dibromopyridine

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

A: 5431-44-7
2,6-Pyridinedicarboxaldehyde

B: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

Conditions

Conditions	Yield
Stage #1: 2,6-Dibromopyridine With n-butyllithium; butyl magnesium bromide In tetrahydrofuran at -10℃; Stage #2: N,N-dimethyl-formamide at 0℃;	A 43% B 49%

...Expand

: 37709-60-7
2-(6-bromopyridinyl)lithium

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

Conditions

Conditions	Yield
In tetrahydrofuran at -75℃; for 0.25h; Yield given;

: 626-05-1
2,6-Dibromopyridine

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

A: 109-04-6
2-bromo-pyridine

B: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

C: 55304-83-1
2,6-dibromo-pyridine-3-carbaldehyde

Conditions

Conditions	Yield
Stage #1: 2,6-Dibromopyridine With n-butyllithium In tetrahydrofuran at -78℃; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran Further stages.;

...Expand

: 1824-81-3
2-Amino-6-methylpyridine

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: HBr; Br2 / H2O / 0.83 h / -20 °C 1.2: NaNO2 / H2O / 2.5 h / -20 °C 2.1: 88 percent / N-bromosuccinimide; benzoylperoxide / CCl4 / 4 h / Heating 3.1: 86 percent / CaCO3 / H2O / 8 h / Heating View Scheme
Multi-step reaction with 4 steps 1: 82 percent / NaNO2, Br2, 48percent HBr / 5 °C 2: 53 percent / KMnO4 / H2O / Heating 3: 1) NEt3, ethyl chloroformate, 2) LiAlH4 / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min 4: 89 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H3PO4 / 1.5 h / Ambient temperature View Scheme

: 626-05-1
2,6-Dibromopyridine

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: n-BuLi / tetrahydrofuran / -78 °C 1.2: tetrahydrofuran / -78 °C 1.3: NaBH4 / tetrahydrofuran / 0 °C 2.1: 1-iodobenzoic acid / dimethylsulfoxide / 20 °C View Scheme
Multi-step reaction with 3 steps 1: n-BuLi / tetrahydrofuran / -78 °C / addition of 2,6-dibromopyridine to a solution of BuLi 2: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C / addition of 2,6-dibromopyridine into a solution of dilithiopyridine 3: tetrahydrofuran / 0.25 h / -75 °C View Scheme
With hydrogenchloride; n-butyllithium In N-methyl-acetamide; hexane
With hydrogenchloride
With n-butyllithium; acetic acid In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide	3.33 g (18.0 mmol, 84%)

: 2,6-dilithiopyridine

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C / addition of 2,6-dibromopyridine into a solution of dilithiopyridine 2: tetrahydrofuran / 0.25 h / -75 °C View Scheme

: 21190-87-4
6-bromo-pyridine-2-carboxylic acid

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1) NEt3, ethyl chloroformate, 2) LiAlH4 / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min 2: 89 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H3PO4 / 1.5 h / Ambient temperature View Scheme

: 626-05-1
2,6-Dibromopyridine

NBuli: NBuli

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

Conditions

Conditions	Yield
With hydrogenchloride In N,N-dimethyl-formamide

: 626-05-1
2,6-Dibromopyridine

: 108-20-3
di-isopropyl ether

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

Conditions

Conditions	Yield
With n-butyllithium; ammonium chloride In tetrahydrofuran; N,N-dimethyl-formamide

: 1127647-91-9
6-bromo-2-(2,6-diisopropylphenyl)iminopyridine

: 13922-41-3
1-Naphthylboronic acid

A: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

B: 1169702-61-7
6-(1-naphthyl)-2-[(2,6-diisopropylphenyl)imino]pyridine

Conditions

Conditions	Yield
tetrakis(triphenylphosphine)palladium (0) In ethanol; water; toluene

...Expand

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 104-94-9
4-methoxy-aniline

: C13H11BrN2O

Conditions

Conditions	Yield
for 6h; Molecular sieve; Reflux;	100%
In acetonitrile at 20℃; for 0.166667h;
In [D3]acetonitrile at 25℃; for 0.0833333h; Kinetics; Time;

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 6-bromopyridine-2-carbaldehyde oxime

Conditions

Conditions	Yield
With sodium acetate; hydroxylamine sulfate In ethanol at 20℃; for 16h; Inert atmosphere;	100%
With hydroxylamine hydrochloride; sodium acetate In ethanol at 90℃;	99%
With hydroxylamine hydrochloride; sodium acetate In ethanol at 20℃; for 16h;	90%
With hydroxylamine hydrochloride; sodium acetate In ethanol at 20℃;

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: dibenzo[b,d]thiophen-3-ylboronic acid

: 6-(dibenzo[b,d]thiophen-3-yl)picolinaldehyde

Conditions

Conditions	Yield
With potassium phosphate monohydrate; C66H84O10P2Pd In water; ethyl acetate; toluene at 45℃; for 14h; Suzuki-Miyaura Coupling; Inert atmosphere;	100%

: 4231-74-7
N-methyl-N-(pyridin-2-yl)hydrazine

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

C12H11BrN4: C12H11BrN4

Conditions

Conditions	Yield
for 6h; Molecular sieve; Reflux;	100%
In [D3]acetonitrile at 25℃; for 0.0833333h; Time;

: 245434-15-5
3,5-di-tert-butyl-2-methoxyphenyl boronic acid

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 6-(3,5-di-tert-butyl-2-methoxyphenyl)picolinaldehyde

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; toluene at 90℃; for 20h; Suzuki Coupling;	100%

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 33674-96-3
2-bromo-6-(hydroxymethyl)pyridine

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol at 20℃; for 1h;	99%
With sodium tetrahydroborate In ethanol	99%
With methanol; sodium tetrahydroborate In methanol at 0 - 20℃; for 0.5h;	99%

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 149-73-5
trimethyl orthoformate

: 128507-76-6
2-bromo-6-(dimethoxymethyl)pyridin

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In methanol for 4h; Reflux; Inert atmosphere; Schlenk technique;	99%
With toluene-4-sulfonic acid In methanol for 4h; Reflux;	98%
toluene-4-sulfonic acid In methanol for 1h; Heating;	96%

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 98-80-6
phenylboronic acid

: 157402-44-3
6-phenylpyridine-2-carbaldehyde

Conditions

Conditions	Yield
With potassium fluoride; tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine In tetrahydrofuran for 18h; Inert atmosphere; Reflux;	99%
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; toluene at 120℃; for 6h; Inert atmosphere;	98%
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine tetrafluoroborate In 1,4-dioxane; water at 100℃; for 16h;	94.6%

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 405520-68-5
4-(N,N-dimethylaminocarbonyl)phenylboronic acid

: 1610373-10-8
4-(6-formylpyridin-2-yl)-N,N-dimethylbenzamide

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In ethanol; water; toluene at 90℃; for 3h; Inert atmosphere;	99%

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 109-89-7
diethylamine

: 174608-36-7
(6-bromopyridin-2-ylmethyl)diethylamine

Conditions

Conditions	Yield
Stage #1: 6-bromo-2-pyridinecarbaldehyde; diethylamine In 1,2-dichloro-ethane at 20℃; for 0.0166667h; Inert atmosphere; Schlenk technique; Stage #2: With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 20℃; for 1.5h; Inert atmosphere; Schlenk technique;	99%
With sodium tris(acetoxy)borohydride In dichloromethane at 0 - 20℃; for 2h;	2.31 g

: 107-10-8
propylamine

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 1366406-65-6
N-[(6-bromopyridin-2-yl)methyl]propan-1-amine

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride In chloroform at 20℃; for 0.75h;	99%

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 56183-69-8
phosphorohydrazidic acid diethyl ester

: diethyl N'-(6-bromopyridin-2-yl)methylenephosphorohydrazidate

Conditions

Conditions	Yield
In dichloromethane for 1.5h; Reflux; Dean-Stark; Inert atmosphere;	99%

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 2537-48-6
diethyl 1-cyanomethylphosphonate

: C8H5BrN2

Conditions

Conditions	Yield
Stage #1: diethyl 1-cyanomethylphosphonate With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.5h; Stage #2: 6-bromo-2-pyridinecarbaldehyde In tetrahydrofuran at 0℃; for 0.5h;	99%

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 87-62-7
2,6-dimethylaniline

: C14H13BrN2

Conditions

Conditions	Yield
In ethanol for 4h; Inert atmosphere; Reflux;	99%

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 24544-04-5
2,6-diisopropylbenzenamine

: 706819-98-9
(6-bromo-pyridin-2-yl-methylene)-(2,6-diisopropyl-phenyl)-amine

Conditions

Conditions	Yield
With formic acid In ethanol for 2 - 3h; Inert atmosphere; Schlenk technique; Reflux;	98%
With magnesium sulfate In diethyl ether at 20℃; Inert atmosphere; Schlenk technique;	98%
With toluene-4-sulfonic acid In toluene at 70℃; for 12h; Molecular sieve;	90.5%

: 67-56-1
methanol

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 26218-75-7
methyl 6-Bromopicolinate

Conditions

Conditions	Yield
With water; iodine; sodium nitrite at 20 - 70℃; chemoselective reaction;	98%

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 64-19-7
acetic acid

: (E)-3-(6-bromopyridin-2-yl)acrylic acid

Conditions

Conditions	Yield
Stage #1: 6-bromo-2-pyridinecarbaldehyde; acetic acid With titanium tetrachloride In dichloromethane at 25℃; for 0.333333h; Inert atmosphere; Stage #2: With triethylamine In dichloromethane at 25℃; Inert atmosphere; stereoselective reaction;	98%

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 137-07-5
2-amino-benzenethiol

: 2-(6-bromopyridin-2-yl)benzo[d]thiazole

Conditions

Conditions	Yield
In ethanol at 20℃;	98%
With amberlite IR-120(H)resin In water at 85℃; Sonication; Microwave irradiation;	96%
In water at 60℃; for 1h; Sonication;	90%

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 7422-06-2
(Z)-3-bromocyclooct-1-ene

: (6-bromopyridin-2-yl)((Z)-cyclooct-2-en-1-yl)methanol

Conditions

Conditions	Yield
With bismuth; lithium iodide In N,N-dimethyl-formamide at 20℃; for 12h; diastereoselective reaction;	98%

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 100379-00-8
2,6-dimethylbenzene boronic acid

: 6-(2,6-dimethylphenyl)picolinaldehyde

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,2-dimethoxyethane; water at 90℃; for 16h; Inert atmosphere;	97%
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In methanol; toluene at 80℃;

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 24544-04-5
2,6-diisopropylbenzenamine

: N-[(1E)-(6-bromopyridin-2-yl)methylene]-2,6-diisopropylaniline

Conditions

Conditions	Yield
In ethanol for 2h; Heating;	97%
In ethanol for 8h; Reflux;
With toluene-4-sulfonic acid In toluene for 0.25h; Reflux;	23.9 g

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 292638-85-8
acrylic acid methyl ester

: methyl 2-[(6-bromopyridin-2-yl)(hydroxy)methyl]prop-2-enoate

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane at 20℃; for 7h; Sonication;	97%
With 1,4-diaza-bicyclo[2.2.2]octane In 1,4-dioxane; water at 20℃; for 3h; Morita-Baylis-Hillman Alkylation;

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 122-51-0
orthoformic acid triethyl ester

: 147133-45-7
2-bromo-6-(diethoxymethyl)pyridine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In ethanethiol at 20℃; for 3h; Inert atmosphere; Schlenk technique;	97%
With toluene-4-sulfonic acid In ethanol at 20℃; for 3h; Inert atmosphere; Schlenk technique;	96%
With toluene-4-sulfonic acid In ethanol Inert atmosphere; Reflux;	76.5%

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 1679-18-1
4-Chlorophenylboronic acid

: 61704-30-1
6-(4-chlorophenyl)-2-pyridinecarboxaldehyde

Conditions

Conditions	Yield
With C64H118O20; C54H72NO6PPdS; triethylamine In water at 45℃; for 16h; Reagent/catalyst; Suzuki-Miyaura Coupling; Inert atmosphere;	97%
With C35H47O3PC15H16N(1-)CH3O3S(1-)*Pd(2+); triethylamine In water at 45℃; for 15h; Suzuki-Miyaura Coupling;	94%
With TPGS-750-M; palladacycle A; triethylamine In tetrahydrofuran; water at 45℃; for 16h; Inert atmosphere;

: 14068-53-2
2-amino-5-ethyl-1,3,4-thiadiazole

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 762-04-9
phosphonic acid diethyl ester

: diethyl ((6-bromopyridin-2-yl)((5-5-ethyl-1,3,4-thiadiazol-2-yl)amino)methyl)phosphonate

Conditions

Conditions	Yield
With phospho sulphonic acid In neat (no solvent) for 0.108333h; Kabachnik-Fields Reaction; Microwave irradiation; Green chemistry;	96.5%

...Expand

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 107-21-1
ethylene glycol

: 34199-87-6
2-bromo-6-(1,3-dioxolan-2-yl)pyridine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene at 100℃; for 24h; Inert atmosphere; Dean-Stark;	96%
With toluene-4-sulfonic acid In benzene at 100℃; for 24h; Dean-Stark; Inert atmosphere;	96%
With toluene-4-sulfonic acid In toluene at 130℃; for 48h; Inert atmosphere; Dean-Stark;	95%

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 109-85-3
2-methoxyethylamine

: 866327-71-1
N-[(6-bromopyridin-2-yl)methyl]-2-methoxyethaneamine

Conditions

Conditions	Yield
Stage #1: 6-bromo-2-pyridinecarbaldehyde; 2-methoxyethylamine In dichloromethane at 20℃; for 0.166667h; Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane at 20℃; Stage #3: With hydrogenchloride; water In dichloromethane pH=4;	96%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 229008-97-3
C10H10BrNO2

Conditions

Conditions	Yield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Stage #2: 6-bromo-2-pyridinecarbaldehyde In tetrahydrofuran at 0 - 20℃; Horner-Wadsworth-Emmons reaction; Inert atmosphere;	96%
With sodium hydride In tetrahydrofuran at 0 - 20℃; for 15h; Horner-Wadsworth-Emmons Olefination;	56%
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.25h; Stage #2: 6-bromo-2-pyridinecarbaldehyde In tetrahydrofuran; mineral oil at 0 - 20℃;	56%

6-Bromopyridine-2-carbaldehyde Chemical Properties

Molecule structure of 6-Bromo-2-pyridinecarboxaldehyde (CAS NO.34160-40-2) :

IUPAC Name: 6-bromopyridine-2-carbaldehyde
Molecular Weight: 186.00606 g/mol
Molecular Formula: C₆H₄BrNO
Density: 1.683 g/cm³
Melting Point: 81-85 °C(lit.)
Boiling Point: 248.2 °C at 760 mmHg
Flash Point: 103.9 °C
Molar Volume: 110.5 cm³
Polarizability: 15.37*10^-24 cm³
Surface Tension: 52.1 dyne/cm
Enthalpy of Vaporization: 48.54 kJ/mol
Vapour Pressure: 0.0246 mmHg at 25 °C
Storage temp.: Refrigerator (+4 °C)
Sensitive: air sensitive
Appreance: light yellow flakes
XLogP3-AA: 1.7
H-Bond Acceptor: 2
Rotatable Bond Count: 1
Exact Mass: 184.947626
MonoIsotopic Mass: 184.947626
Topological Polar Surface Area: 30
Heavy Atom Count: 9
Complexity: 107
Canonical SMILES: C1=CC(=NC(=C1)Br)C=O
InChI: InChI=1S/C6H4BrNO/c7-6-3-1-2-5(4-9)8-6/h1-4H
InChIKey: QWFHFNGMCPMOCD-UHFFFAOYSA-N
Product Categories: Pyridine; Aldehydes; Pyridines; Nucleotides and Nucleosides; Bases & Related Reagents; Nucleotides; C6Heterocyclic Building Blocks; Halogenated Heterocycles; Heterocyclic Building Blocks; Building Blocks

6-Bromopyridine-2-carbaldehyde Uses

6-Bromo-2-pyridinecarboxaldehyde (CAS NO.34160-40-2) is a useful synthetic intermediate.

6-Bromopyridine-2-carbaldehyde Safety Profile

Hazard Codes: Irritant Xi, Harmful Xn, F
Risk Statements: 36/37/38-20/21/22-10
R36/37/38: Irritating to eyes, respiratory system and skin
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed
R10: Flammable
Safety Statements: 26-36-36/37/39-16
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36: Wear suitable protective clothing
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S16: Keep away from sources of ignition
WGK Germany: 3
Hazard Note: Irritant

6-Bromopyridine-2-carbaldehyde Specification

6-Bromo-2-pyridinecarboxaldehyde (CAS NO.34160-40-2) is also called 6-Bromopyridine-2-carbaldehyde ; 6-Bromo-2-formylpyridine ; 6-Bromopyridine-2-barboxaldehyde .

Product Name

6-Bromopyridine-2-carbaldehyde

Synthetic route

6-Bromopyridine-2-carbaldehyde Chemical Properties

6-Bromopyridine-2-carbaldehyde Uses

6-Bromopyridine-2-carbaldehyde Safety Profile

6-Bromopyridine-2-carbaldehyde Specification

Related Products

Hot Products