7-Methoxy-1-tetralone supplier

Name
7-Methoxy-1-tetralone
EINECS 229-916-0
CAS No. 6836-19-7
Article Data69
CAS DataBase
Density 1.124 g/cm³
Solubility 309mg/L at 25℃
Melting Point 59-63 °C(lit.)
Formula C₁₁H₁₂O₂
Boiling Point 312.3 °C at 760 mmHg
Molecular Weight 176.215
Flash Point 145.8 °C
Transport Information
Appearance Off-white powder
Safety 22-24/25-36-26
Risk Codes 20/21/22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms 7-Methoxy-1,2,3,4-tetrahydro-1-oxonaphthalene;3,4-Dihydro-7-methoxy-1(2H)-naphthalenone;7-Methoxy-1,2,3,4-tetrahydro-1-naphthalenone;
PSA 26.30000
LogP 2.21420

Synthetic route

: 6836-18-6
4-(4-methoxyphenyl) butanoyl chloride

: 6836-19-7
7-Methoxy-1-tetralone

Conditions

Conditions	Yield
With Fe-Al-MCM-41 molecular sieve In toluene at 60℃; for 18h; Green chemistry;	98.4%
unter vermindertem Druck;
With aluminium trichloride; 1,1,2,2-tetrachloroethane at -5℃;

: 32820-10-3
7-methoxy-1,2,3,4-tetrahydro-1-naphthol

: 6836-19-7
7-Methoxy-1-tetralone

Conditions

Conditions	Yield
With acetone In toluene at 80℃; for 0.25h; Flow reactor;	96%

: 4521-28-2
4-(4-Methoxyphenyl)butyric acid

: 6836-19-7
7-Methoxy-1-tetralone

Conditions

Conditions	Yield
With phosphoric acid; phosphorus pentoxide at 70 - 80℃; for 2h;	94%
With trifluoroacetic anhydride In 1,2-dichloro-ethane at 0 - 20℃; Friedel-Crafts acylation;	94%
With trichloroacetic acid anhydride at 70℃; Friedel Crafts acylation; Neat (no solvent);	92%

: 106336-27-0
(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-methanol

: 6836-19-7
7-Methoxy-1-tetralone

Conditions

Conditions	Yield
With dipyridinium dichromate; Celite In dichloromethane at 25℃; for 24h;	79%

: 666177-27-1
dimethyl 1,2-dihydro-4-hydroxy-6-methoxynaphthalene-1,3-dicarboxylate

: 6836-19-7
7-Methoxy-1-tetralone

Conditions

Conditions	Yield
With sodium chloride In dimethyl sulfoxide at 200℃;	65%

: 4-(4-Methoxy-phenyl)-butyryl azide

: 6836-19-7
7-Methoxy-1-tetralone

Conditions

Conditions	Yield
	64%

: 65128-90-7
7-methoxy-8a-methyl-1,2,3,4,6,8a-hexahydro-naphthalen-1-one

A: 6836-19-7
7-Methoxy-1-tetralone

: (6S,8aS)-6-Hydroxy-7-methoxy-8a-methyl-3,4,6,8a-tetrahydro-2H-naphthalen-1-one

: (6R,8aS)-6-Hydroxy-7-methoxy-8a-methyl-3,4,6,8a-tetrahydro-2H-naphthalen-1-one

Conditions

Conditions	Yield
With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid In dichloromethane at 4℃; pH=8.3;	A 63% B 20% C 12%

...Expand

: 87543-05-3
1,1-(1,2-Benzenediyldithio)-7-methoxy-1,2,3,4-tetrahydronaphthalene

: 6836-19-7
7-Methoxy-1-tetralone

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate; mercury(II) oxide In tetrahydrofuran; water	62%
With tetrahydrofuran; mercury(II) oxide; boron trifluoride diethyl etherate	56%

: 1202643-83-1
1-(3-methoxyphenyl)cyclobutan-1-ol

: 6836-19-7
7-Methoxy-1-tetralone

Conditions

Conditions	Yield
With potassium carbonate; copper(II) sulfate; Selectfluor In water; acetonitrile at 60℃; for 5h;	59%

: 310897-19-9
8a-allyl-7-methoxy-1,2,3,4,6,8a-hexahydro-naphthalen-1-one

A: 6836-19-7
7-Methoxy-1-tetralone

: (6S,8aS)-8a-Allyl-6-hydroxy-7-methoxy-3,4,6,8a-tetrahydro-2H-naphthalen-1-one

: (6R,8aS)-8a-Allyl-6-hydroxy-7-methoxy-3,4,6,8a-tetrahydro-2H-naphthalen-1-one

Conditions

Conditions	Yield
With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid In dichloromethane at 4℃; pH=8.3;	A 54% B 22.5% C 12.5%

...Expand

: 75-91-2
tert.-butylhydroperoxide

: 1730-48-9
6-methoxy-1,2,3,4-tetrahydronaphthalene

A: 6836-19-7
7-Methoxy-1-tetralone

B: 6-methoxy-2,3-dihydronaphthalene-1,4-dione

C: 1-tert-butylperoxy-6-methoxytetralin

D: 1-tert-butylperoxy-7-methoxytetralin

E: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With copper(II) choride dihydrate; tetrabutyl-ammonium chloride; sodium carbonate; 2,2′‐biquinoline‐4,4′‐dicarboxylic acid dipotassium salt In water at 20℃; for 17h; Green chemistry;	A 8% B 12% C n/a D n/a E 50%

...Expand

: 32820-10-3
7-methoxy-1,2,3,4-tetrahydro-1-naphthol

A: 6836-19-7
7-Methoxy-1-tetralone

B: 182965-69-1
(+)-(S)-7-Methoxy-1-tetralol

C: (-)-(R)-7-Methoxy-1-tetralol

Conditions

Conditions	Yield
With 4-vinylbenzyl chloride; [N,N'-bis(2-cyclohexyloxycarbonyl-3-oxobutylidene)-(1S,2S)-dimesitylethylenediaminato]cobalt(II); oxygen In tert-butyl alcohol at 20 - 50℃; for 12h; Resolution of racemate; optical yield given as %ee;	A 41.9% B n/a C n/a

...Expand

: 75-91-2
tert.-butylhydroperoxide

: 1730-48-9
6-methoxy-1,2,3,4-tetrahydronaphthalene

A: 32820-10-3
7-methoxy-1,2,3,4-tetrahydro-1-naphthol

B: 6836-19-7
7-Methoxy-1-tetralone

C: 16821-32-2
6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol

D: 1-tert-butylperoxy-6-methoxytetralin

E: 1-tert-butylperoxy-7-methoxytetralin

F: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With copper(II) choride dihydrate; tetrabutyl-ammonium chloride; sodium carbonate; 2,2′‐biquinoline‐4,4′‐dicarboxylic acid dipotassium salt In water at 20℃; for 17h; Green chemistry;	A n/a B 17% C n/a D n/a E n/a F 39%

...Expand

: 1730-48-9
6-methoxy-1,2,3,4-tetrahydronaphthalene

A: 6836-19-7
7-Methoxy-1-tetralone

B: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; chromium(VI) oxide In dichloromethane for 9h; Ambient temperature;	A 17% B 36%
With tert.-butylhydroperoxide; bis-(tributyltin oxide) dioxochromium(VI) In dichloromethane at 40℃; for 7.5h;	A 15% B 32%
With tert.-butylhydroperoxide; 2,4-dimethyl-2,4-pentanediol cyclic Cr(VI) ester In tetrachloromethane; dichloromethane at 0℃; for 8h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With potassium permanganate; copper(II) sulfate In dichloromethane for 72h; Heating;	A 5 % Chromat. B 85 % Chromat.

: 1730-48-9
6-methoxy-1,2,3,4-tetrahydronaphthalene

A: 6836-19-7
7-Methoxy-1-tetralone

B: 6-methoxy-2,3-dihydronaphthalene-1,4-dione

C: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; sodium hydrogencarbonate; dirhodium(II) tetrakis(caprolactam) In decane; 1,2-dichloro-ethane at 20℃; for 16h; Title compound not separated from byproducts;	A n/a B 29% C n/a

...Expand

: 22009-38-7
7-hydroxy-1-tetralone

: 77-78-1
dimethyl sulfate

: 6836-19-7
7-Methoxy-1-tetralone

Conditions

Conditions	Yield
With potassium carbonate In acetone for 2.5h; Heating; Yield given;

: 77-78-1
dimethyl sulfate

7-hydroxy-1-oxo-tetralin: 7-hydroxy-1-oxo-tetralin

: 6836-19-7
7-Methoxy-1-tetralone

Conditions

Conditions	Yield
With sodium hydroxide

7-methoxy-3,4-dihydro-2H-<1-14C>naphthalen-1-one: 7-methoxy-3,4-dihydro-2H-<1-14C>naphthalen-1-one

: 6836-19-7
7-Methoxy-1-tetralone

Conditions

Conditions	Yield
Herstellung;

: 100-66-3
methoxybenzene

(+-)-propylsuccinic acid-anhydride: (+-)-propylsuccinic acid-anhydride

: 6836-19-7
7-Methoxy-1-tetralone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 73.4 percent / AlCl3 / nitromethane / 12 h / 0 - 25 °C 2: 95 percent / NH2NH2*H2O; KOH / bis-(2-hydroxy-ethyl) ether / 7 h / 130 - 195 °C 3: 87.7 percent / H3PO4; P2O5 / 3 h / 70 - 80 °C View Scheme
Multi-step reaction with 3 steps 1: Zn; HCl / toluene 2: PPA View Scheme

: 3153-44-4
4-(4-methoxy-phenyl)-4-oxo-butyric acid

: 6836-19-7
7-Methoxy-1-tetralone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 95 percent / NH2NH2*H2O; KOH / bis-(2-hydroxy-ethyl) ether / 7 h / 130 - 195 °C 2: 87.7 percent / H3PO4; P2O5 / 3 h / 70 - 80 °C View Scheme
Multi-step reaction with 2 steps 1: Zn; HCl / toluene 2: PPA View Scheme
Multi-step reaction with 2 steps 1: Zn/HCl 2: CF3COOH, (CF3COO)2O View Scheme

: 91142-97-1
4-(4-methoxyphenyl)-3-butenoic acid

: 6836-19-7
7-Methoxy-1-tetralone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogen / Pd/C / tetrahydrofuran / 3 h / 20 °C / 760.21 Torr 2: 94 percent / trifluoroacetic anhydride / 1,2-dichloro-ethane / 0 - 20 °C View Scheme

: C23H38O3Sn

: 6836-19-7
7-Methoxy-1-tetralone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrochloric acid / H2O / 0.25 h / 20 °C 2: hydrogen / Pd/C / tetrahydrofuran / 3 h / 20 °C / 760.21 Torr 3: 94 percent / trifluoroacetic anhydride / 1,2-dichloro-ethane / 0 - 20 °C View Scheme

: 100-66-3
methoxybenzene

(+-)-hept-2t(?)-en-4-ol: (+-)-hept-2t(?)-en-4-ol

: 6836-19-7
7-Methoxy-1-tetralone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: AlCl3 2: Zn/HCl 3: CF3COOH, (CF3COO)2O View Scheme

: 100-66-3
methoxybenzene

: 6836-19-7
7-Methoxy-1-tetralone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: 85 percent / polyphosphoric acid / 90 °C View Scheme
Multi-step reaction with 3 steps 1: 72 percent / AlCl3 / nitrobenzene / Ambient temperature 2: 87 percent / Zn, conc. HCl, HgCl2 / H2O; toluene / 24 h / Heating 3: 94 percent / P2O5, H3PO4 / 2 h / 70 - 80 °C View Scheme
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride / nitrobenzene / 0.5 h / 20 °C 1.2: 60 °C 2.1: palladium 10% on activated carbon; hydrogen / acetic acid / 70 °C 3.1: polyphosphoric acid / 90 °C View Scheme

: 87543-11-1
1-<4,4-(1,2-Benzenediyldithio)but-3-enyl>-4-methoxybenzene

: 6836-19-7
7-Methoxy-1-tetralone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 74 percent / p-toluenesulfonic acid / acetonitrile / 24 h / 0 °C 2: 56 percent / HgO, aq. THF / BF3.Et2O View Scheme
Multi-step reaction with 2 steps 1: 74 percent / p-toluenesulfonic acid monohydrate / acetonitrile / 40 - 50 °C 2: 62 percent / mercury(II) oxide, BF3*Et2O / tetrahydrofuran; H2O View Scheme

: 58008-75-6
7-Oxa-bicyclo[4.1.0]heptan-2-one oxime

: 6836-19-7
7-Methoxy-1-tetralone

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 72 percent / NaHCO3, CF3CO3H, urea / acetonitrile / 1.42 h / 0 °C 2: 85 percent / pyridinium chlorochromate / CH2Cl2 / 3.2 h / 23 °C 3: toluene / 19 h / 80 °C 4: 1.) hydrochloric acid 2.)DBN / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 1 h 5: K2CO3 / acetone / 2.5 h / Heating View Scheme

: 77970-17-3
3-nitro-2-cyclopenten-1-one

: 6836-19-7
7-Methoxy-1-tetralone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: toluene / 19 h / 80 °C 2: 1.) hydrochloric acid 2.)DBN / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 1 h 3: K2CO3 / acetone / 2.5 h / Heating View Scheme

: 67730-57-8
3-nitro-2-cyclohexen-1-ol

: 6836-19-7
7-Methoxy-1-tetralone

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 85 percent / pyridinium chlorochromate / CH2Cl2 / 3.2 h / 23 °C 2: toluene / 19 h / 80 °C 3: 1.) hydrochloric acid 2.)DBN / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 1 h 4: K2CO3 / acetone / 2.5 h / Heating View Scheme

: 5-Methoxy-4a-nitro-7-trimethylsilanyloxy-3,4,4a,5,8,8a-hexahydro-2H-naphthalen-1-one

: 6836-19-7
7-Methoxy-1-tetralone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) hydrochloric acid 2.)DBN / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 1 h 2: K2CO3 / acetone / 2.5 h / Heating View Scheme

: 6836-19-7
7-Methoxy-1-tetralone

: 20175-97-7
7-methoxy-3,4-dihydronaphthalen-1(2H)-one oxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; potassium carbonate In methanol for 16h; Reflux;	100%
With pyridine; hydroxylamine hydrochloride at 25℃; for 3h; Inert atmosphere;	94%
With hydroxylamine hydrochloride; potassium carbonate In methanol; water for 3h; Heating;	92%

: 2537-48-6
diethyl 1-cyanomethylphosphonate

: 6836-19-7
7-Methoxy-1-tetralone

: 127299-26-7
(7-methoxy-3,4-dihydro-2H-naphthalene-1-ylidene)acetonitrile

Conditions

Conditions	Yield
With sodium methylate In methanol at -20 - -10℃; for 24h; Reagent/catalyst; Wittig Rearrangement;	100%
Stage #1: diethyl 1-cyanomethylphosphonate With potassium hydroxide In dimethyl sulfoxide at 15 - 25℃; for 1h; Industry scale; Stage #2: 7-Methoxy-1-tetralone In tetrahydrofuran; dimethyl sulfoxide at 15 - 25℃; for 2.5h; Product distribution / selectivity;	95%
Stage #1: 7-Methoxy-1-tetralone With sodium hydride In 1,2-dimethoxyethane at 15℃; for 0.5h; Stage #2: diethyl 1-cyanomethylphosphonate In monoethylene glycol diethyl ether at 10 - 15℃;	89%

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 6836-19-7
7-Methoxy-1-tetralone

: 724707-85-1
trifluoromethanesulfonic acid 7-methoxy-3,4-dihydronaphthalen-1-yl ester

Conditions

Conditions	Yield
Stage #1: 7-Methoxy-1-tetralone With lithium hexamethyldisilazane In tetrahydrofuran at -79℃; for 0.75h; Stage #2: N,N-phenylbistrifluoromethane-sulfonimide In tetrahydrofuran at -78 - 0℃; for 3h;	100%
With potassium hexamethylsilazane In tetrahydrofuran at -78℃; for 1h;	96%
With potassium hexamethylsilazane In tetrahydrofuran at -78℃; for 1.5h;	96%

: 6836-19-7
7-Methoxy-1-tetralone

: 32820-10-3
7-methoxy-1,2,3,4-tetrahydro-1-naphthol

Conditions

Conditions	Yield
With Tetrahydrofurfuryl alcohol; sodium tetrahydroborate; ethanol; (S,S)-(β-oxoaldiminato)cobalt(II) In chloroform at -20℃; for 12h;	99%
With sodium tetrahydroborate In ethanol at 20℃; Inert atmosphere;	99%
With methanol; sodium tetrahydroborate at 20℃;	98%

: 6836-19-7
7-Methoxy-1-tetralone

: 85299-01-0
2-chloro-7-methoxy-3,4-dihydronaphthalen-1(2H)-one

Conditions

Conditions	Yield
With 2,2,3,4,5,6-hexachloro-cyclohexa-2,4-dien-1-one In ethanol for 4h; Reflux;	99%
With 2,2,3,4,5,6-hexachloro-cyclohexa-2,4-dien-1-one In ethanol for 4h; Heating;	76%
Stage #1: 7-Methoxy-1-tetralone With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.5h; Stage #2: With p-toluenesulfonyl chloride In tetrahydrofuran at -78 - 20℃; for 1.33333h;
With N-chloro-succinimide; thiourea In methanol at 35℃; for 2h; Inert atmosphere;

: 6836-19-7
7-Methoxy-1-tetralone

: 61362-78-5
8-bromo-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-one

Conditions

Conditions	Yield
With iron(III) chloride; N-Bromosuccinimide In acetonitrile at 20℃; for 4h;	99%
With iron(III) chloride; N-Bromosuccinimide In acetonitrile at 20℃; for 10h;	98%
With N-Bromosuccinimide In acetonitrile at 20℃;	96%

: 6836-19-7
7-Methoxy-1-tetralone

: (-)-(R)-7-Methoxy-1-tetralol

Conditions

Conditions	Yield
With C32H39BrMnN2O2P; potassium tert-butylate; hydrogen In methanol at 20℃; under 22502.3 Torr; for 16h; Glovebox; Autoclave; enantioselective reaction;	99%
With potassium tert-butylate; hydrogen; trans-RuCl2[(S)-XylBINAP][(R)-IPHAN] In isopropyl alcohol; tert-butyl alcohol at 25℃; under 6840 Torr; for 8h;	95%
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; C49H64FeNOP; hydrogen; sodium t-butanolate In isopropyl alcohol at 25 - 30℃; under 38002.6 Torr; for 12h; Autoclave; enantioselective reaction;	95%

: 6836-19-7
7-Methoxy-1-tetralone

: 107727-34-4
1-methylene-7-methoxy-1,2,3,4-tetrahydronaphthalene

Conditions

Conditions	Yield
With (bromomethyl)triphenyl-λ5-phosphane; potassium tert-butylate In tetrahydrofuran at 20 - 50℃; for 1h; Wittig Olefination; Inert atmosphere;	99%

: 6836-19-7
7-Methoxy-1-tetralone

: 5688-82-4
2-(3,4,5-trimethoxybenzylidene)malononitrile

: 2-amino-5,6-dihydro-9-methoxy-4-(3,4,5-trimethoxyphenyl)benzo[h]quinoline-3-carbonitrile

Conditions

Conditions	Yield
With ammonium acetate; acetic acid In ethanol for 12h; Reflux;	99%

: 6836-19-7
7-Methoxy-1-tetralone

: 75-05-8
acetonitrile

: 59081-65-1
2-(1-hydroxyl-7-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-acetonitrile

Conditions

Conditions	Yield
Stage #1: acetonitrile With n-butyllithium In tetrahydrofuran; hexane at -70℃; for 0.5h; Stage #2: 7-Methoxy-1-tetralone In tetrahydrofuran; hexane at -70℃; for 1h; Stage #3: With ammonium chloride In tetrahydrofuran; hexane; water Product distribution / selectivity;	98.4%
Stage #1: acetonitrile With n-butyllithium In tetrahydrofuran; hexane at -70℃; for 0.5h; Cooling with ethanol-dry ice; Stage #2: 7-Methoxy-1-tetralone In tetrahydrofuran; hexane at -70℃; for 1h; Concentration; Cooling with ether-dry ice;	98.4%
With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h;	95%
Stage #1: 7-Methoxy-1-tetralone; acetonitrile With sodium hexamethyldisilazane In tetrahydrofuran at -80 - -70℃; for 0.75h; Inert atmosphere; Stage #2: With ammonium chloride In tetrahydrofuran

: 6836-19-7
7-Methoxy-1-tetralone

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 77664-95-0
1-chloro-7-methoxy-3,4-dihydronaphthalene-2-carboxaldehyde

Conditions

Conditions	Yield
Stage #1: N,N-dimethyl-formamide With trichlorophosphate for 0.5h; Cooling with ice; Stage #2: 7-Methoxy-1-tetralone at 20 - 70℃; for 2h;	98.1%
Stage #1: N,N-dimethyl-formamide With trichlorophosphate at -10℃; Vilsmeier-Haack reaction; Reflux; Stage #2: 7-Methoxy-1-tetralone In N,N-dimethyl-formamide for 2h; Vilsmeier-Haack reaction; Reflux; Stage #3: With water; sodium acetate In N,N-dimethyl-formamide Vilsmeier-Haack reaction;	93%
With trichlorophosphate at 0 - 90℃; Vilsmeier-Haack Formylation;	91%
Stage #1: N,N-dimethyl-formamide With trichlorophosphate at 0 - 20℃; Stage #2: 7-Methoxy-1-tetralone at 0 - 20℃; for 6h;	90%
With trichlorophosphate 1.) CH2Cl2, 27 deg C, 2 h, 2.) CH2Cl2, 27 deg C, 8 h; Yield given. Multistep reaction;

: 6836-19-7
7-Methoxy-1-tetralone

: 22009-38-7
7-hydroxy-1-tetralone

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid In water at 120℃;	98%
Stage #1: 7-Methoxy-1-tetralone With aluminum (III) chloride In toluene at 20 - 65℃; for 2.6h; Stage #2: In toluene at 0 - 65℃; for 1.5h; Temperature;	96.4%
With aluminium trichloride In toluene Heating;	95%

: 7677-24-9
trimethylsilyl cyanide

: 6836-19-7
7-Methoxy-1-tetralone

: 182621-29-0
7-methoxy-1-(trimethylsilyloxy)-1,2,3,4-tetrahydronaphthalene-1-carbonitrile

Conditions

Conditions	Yield
With zinc(II) iodide In acetonitrile at 20℃; for 48h; Addition;	98%
With zinc(II) iodide In dichloromethane at 25℃; for 24h;
With zinc(II) iodide
With zinc(II) iodide In dichloromethane at 20℃;
With zinc(II) iodide In nitromethane at 0 - 20℃; for 96h; Inert atmosphere;

: 6836-19-7
7-Methoxy-1-tetralone

: 182965-69-1
(+)-(S)-7-Methoxy-1-tetralol

Conditions

Conditions	Yield
With chloro[(1S,2S)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine]-(mesitylene) ruthenium (II); formic acid; triethylamine In dichloromethane at 0 - 20℃; for 72h; Inert atmosphere; Schlenk technique; enantioselective reaction;	98%
With chloro[(1S,2S)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine]-(mesitylene) ruthenium (II); formic acid; triethylamine In dichloromethane at 23℃; for 48h; Inert atmosphere; Cooling with ice; Schlenk technique;	98%
With formic acid; C29H38N3O2RuS; triethylamine at 60℃; for 4h; Inert atmosphere; enantioselective reaction;	96%

: 223552-79-2
3-bromo-1-(4-ethylpiperazin-1-yl)isoquinoline

: 6836-19-7
7-Methoxy-1-tetralone

: 3-(6-methoxy-1,2-dihydronaphthalen-4-yl)-1-(4-ethylpiperazin-1-yl)isoquinoline

Conditions

Conditions	Yield
	98%

: 917-64-6
methyl magnesium iodide

: 6836-19-7
7-Methoxy-1-tetralone

: 30021-91-1
1,2-dihydro-6-methoxy-4-methylnaphthalene

Conditions

Conditions	Yield
Stage #1: methyl magnesium iodide; 7-Methoxy-1-tetralone In diethyl ether at 20℃; for 3h; Stage #2: With hydrogenchloride In water at 40℃; for 3h; pH=5;	97%
With diethyl ether Erhitzen des nach der Hydrolyse erhaltenen Reaktionsprodukts unter Normaldruck auf 100-110grad;
With diethyl ether Erhitzen des nach der Hydrolyse erhaltenen Reaktionsprodukts unter vermindertem Druck auf 120-160grad;

: 6836-19-7
7-Methoxy-1-tetralone

: 199442-41-6
7-methoxy-1-d-1,2,3,4-tetrahydro-1-naphthol

Conditions

Conditions	Yield
With sodium borodeuteride In methanol for 1.5h;	97%
With sodium borodeuteride

: 6836-19-7
7-Methoxy-1-tetralone

: 106-95-6
allyl bromide

A: 310897-19-9
8a-allyl-7-methoxy-1,2,3,4,6,8a-hexahydro-naphthalen-1-one

B: 2,8a-diallyl-7-methoxy-3,4,6,8a-tetrahydro-2H-naphthalen-1-one

Conditions

Conditions	Yield
Stage #1: 7-Methoxy-1-tetralone With ammonia; potassium In diethyl ether; tert-butyl alcohol at -78℃; for 0.25h; Reduction; Stage #2: With lithium bromide In diethyl ether; tert-butyl alcohol at -78℃; for 0.5h; deprotonation; Stage #3: allyl bromide In diethyl ether; tert-butyl alcohol at -78 - 20℃; Alkylation; Birch reductive alkylation;	A 97% B n/a

...Expand

: 6836-19-7
7-Methoxy-1-tetralone

: 456-64-4
phenyl trifluoromethanesulfonamide

: 724707-85-1
trifluoromethanesulfonic acid 7-methoxy-3,4-dihydronaphthalen-1-yl ester

Conditions

Conditions	Yield
Stage #1: 7-Methoxy-1-tetralone With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium diisopropyl amide In tetrahydrofuran at -78℃; for 2h; Stage #2: phenyl trifluoromethanesulfonamide In tetrahydrofuran at 0℃; for 9h;	97%

: 6836-19-7
7-Methoxy-1-tetralone

: 83395-39-5
1-((allyloxy)carbonyl)-1H-imidazole

: allyl 7-methoxy-3,4-dihydronaphthalen-1-yl carbonate

Conditions

Conditions	Yield
Stage #1: 7-Methoxy-1-tetralone With sodium hexamethyldisilazane In 1,2-dimethoxyethane at -78℃; for 1h; Inert atmosphere; Stage #2: 1-((allyloxy)carbonyl)-1H-imidazole With boron trifluoride diethyl etherate In 1,2-dimethoxyethane at -78℃; for 2.16667h; Inert atmosphere;	97%

: 6836-19-7
7-Methoxy-1-tetralone

: 95-92-1
oxalic acid diethyl ester

: 1417448-97-5
ethyl 2-(1-hydroxy-7-methoxy-3,4-dihydronaphthalen-2-yl)-2-oxoacetate

Conditions

Conditions	Yield
With lithium tert-butoxide In tetrahydrofuran at 0 - 20℃; for 4h; Claisen Condensation; Inert atmosphere;	97%

: 6836-19-7
7-Methoxy-1-tetralone

: 372-09-8
cyanoacetic acid

: 861960-34-1
2-(7-methoxy-3,4-dihydronaphthalen-1-yl)acetonitrile

Conditions

Conditions	Yield
With oenanthic acid; benzylamine In toluene at 140℃; for 48h;	96.3%
With oenanthic acid; benzylamine In toluene Product distribution / selectivity; Heating / reflux;	90%
With oenanthic acid; benzylamine In toluene Product distribution / selectivity; Heating / reflux;	90%

: 32820-10-3
7-methoxy-1,2,3,4-tetrahydro-1-naphthol

: 6836-19-7
7-Methoxy-1-tetralone

: 60573-58-2
7-methoxy-3,4-dihydronaphthalene

Conditions

Conditions	Yield
	96%

: 6836-19-7
7-Methoxy-1-tetralone

: 90-02-8
salicylaldehyde

: 1289414-86-3
2-methoxy-7H-benzo[c]xanthene

Conditions

Conditions	Yield
With scandium tris(trifluoromethanesulfonate) In chlorobenzene at 180℃; for 0.5h; Microwave irradiation;	96%

: 6836-19-7
7-Methoxy-1-tetralone

: 593-56-6
N-methoxylamine hydrochloride

: C12H15NO2

Conditions

Conditions	Yield
With pyridine In ethanol for 1h; Inert atmosphere; Reflux;	96%

: 6836-19-7
7-Methoxy-1-tetralone

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: (E)-2-(3,4,5-trimethoxybenzylidene)-7-methoxy-3,4-dihydronaphthalen-1(2H)-one

Conditions

Conditions	Yield
With sodium methylate In methanol at 20℃;	96%
With sodium hydroxide In ethanol

: 6836-19-7
7-Methoxy-1-tetralone

: 1730-48-9
6-methoxy-1,2,3,4-tetrahydronaphthalene

Conditions

Conditions	Yield
With palladium dichloride In methanol at 40℃; for 24h; Inert atmosphere; Green chemistry;	95%
With potassium hydroxide; hydrazine hydrate In diethylene glycol for 0.333333h; Wolff-Kishner reduction; Irradiation;	87%
With hydrazine hydrate; sodium hydroxide In methanol at 200℃; under 37503.8 Torr; Wolff-Kishner Reduction; Microwave irradiation;	81%
With copper oxide-chromium oxide at 125 - 200℃; under 154457 Torr; Hydrogenolyse;
With hydrogenchloride; amalgamated zinc

: 6836-19-7
7-Methoxy-1-tetralone

: 105-36-2
ethyl bromoacetate

: 99416-97-4
ethyl 1-hydroxy-7-methoxy-1,2,3,4-tetrahydro-1-naphthaleneacetate

Conditions

Conditions	Yield
Stage #1: 7-Methoxy-1-tetralone; ethyl bromoacetate With zinc In tert-butyl methyl ether at 55 - 60℃; Reformatsky Reaction; Stage #2: With hydrogenchloride; water at 10 - 15℃;	95%
With toluene; zinc
With iodine; zinc In benzene for 2.5h; Reformatsky reaction; Heating;

7-Methoxy-1-tetralone Chemical Properties

IUPAC Name: 7-Methoxy-3,4-dihydro-2H-naphthalen-1-one
Synonyms of 7-Methoxy-1-tetralone (CAS NO.6836-19-7): 7-Methoxy-1,2,3,4-tetrahydronaphthalen-1-one
CAS NO: 6836-19-7
Molecular Formula: C₁₁H₁₂O₂
Molecular Weight: 176.21
Molecular Structure:
EINECS: 229-916-0
H bond acceptors: 2
H bond donors: 0
Freely Rotating Bonds: 1
Polar Surface Area: 26.3 Å²
Index of Refraction: 1.548
Molar Refractivity: 49.84 cm³
Molar Volume: 156.7 cm³
Surface Tension: 40.8 dyne/cm
Density: 1.124 g/cm³
Flash Point: 145.8 °C
Enthalpy of Vaporization: 55.32 kJ/mol
Boiling Point: 312.3 °C at 760 mmHg
Vapour Pressure: 0.000535 mmHg at 25°C
Melting Point: 59-63 °C(lit.)
Appearance: Off-White Powder
Product Categories of 7-Methoxy-1-tetralone (CAS NO.6836-19-7): Benzocycles;Naphthalene derivatives;Aromatics Compounds;Butorphanol;Aromatics;C11 to C12;Carbonyl Compounds;Ketones

7-Methoxy-1-tetralone Uses

7-Methoxy-1-tetralone (CAS NO.6836-19-7) is used for pharmaceutical intermediate.

7-Methoxy-1-tetralone Safety Profile

Safety Information about 7-Methoxy-1-tetralone (CAS NO.6836-19-7):
Hazard Codes: Harmful Xn
Risk Statements: 20/21/22-36/37/38
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-36-26
S22: Do not breathe dust.
S24/25: Avoid contact with skin and eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
WGK Germany: 3

Product Name

7-Methoxy-1-tetralone

Synthetic route

7-Methoxy-1-tetralone Chemical Properties

7-Methoxy-1-tetralone Uses

7-Methoxy-1-tetralone Safety Profile

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