Acethydrazide supplier | CasNO.1068-57-1

Name
Acethydrazide
EINECS 213-948-7
CAS No. 1068-57-1
Article Data108
CAS DataBase
Density 1.041 g/cm³
Solubility soluble in water
Melting Point 58-68 °C(lit.)
Formula C₂H₆N₂O
Boiling Point 246 °C at 760 mmHg
Molecular Weight 74.0824
Flash Point 102.6 °C
Transport Information
Appearance white solid
Safety 26-36
Risk Codes 22-36/38
Molecular Structure
Hazard Symbols Xn
Synonyms Acetic hydrazide;Acetohydrazide;Acetohydrazine;Acetyl hydrazide;Acetylhydrazine;ENT-61241;Ethanehydrazonic acid;Hydrazine, acetyl-;Monoacetylhydrazine;NSC 2271;NSC 53155;Acetic acid, hydrazide;
PSA 55.12000
LogP 0.08740

Synthetic route

: 108-24-7
acetic anhydride

: 1068-57-1
acetic acid hydrazide

Conditions

Conditions	Yield
With pyridine; aluminum oxide; hydrazine at 102 - 104℃; for 1h; microwave irradiation;	100%

: 141-78-6
ethyl acetate

: 1068-57-1
acetic acid hydrazide

Conditions

Conditions	Yield
With hydrazine hydrate at 85℃; for 0.00277778h;	99%
With hydrazine hydrate	98%
With hydrazine hydrate In ethanol; ethyl acetate for 4h; Reflux;	98%

: 79-20-9
acetic acid methyl ester

: 1068-57-1
acetic acid hydrazide

Conditions

Conditions	Yield
With hydrazine hydrate at 40 - 75℃; for 4h; Temperature; Green chemistry; Large scale;	98%
With hydrazine hydrate In ethanol Heating;
With hydrazine hydrate Reflux;

: acetamido azide

: 5244-34-8
2,2'-ethane-1,2-diylbissulfanyl-bis-ethanol

: 1068-57-1
acetic acid hydrazide

Conditions

Conditions	Yield
With hydrogen In ethanol	98%
With hydrogen In ethanol	98%

: 64-19-7
acetic acid

: 1068-57-1
acetic acid hydrazide

Conditions

Conditions	Yield
With hydrazine hydrate for 0.0222222h; Microwave irradiation;	86%
With hydrazine hydrate Microwave irradiation;
Stage #1: acetic acid With sulfuric acid In methanol at 20℃; for 4h; Reflux; Stage #2: With hydrazine hydrate In methanol at 75℃; for 0.5h;

: 16067-88-2
N-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-acetamide

: 1068-57-1
acetic acid hydrazide

Conditions

Conditions	Yield
With water; hydrazine In ethanol for 0.25h; Ambient temperature;	75%

: 603-69-0
ethyl 2-acetylacetoacetate

A: 35691-93-1
3,5-Dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester

B: 141-97-9
ethyl acetoacetate

C: 1068-57-1
acetic acid hydrazide

Conditions

Conditions	Yield
With hydrazine In chloroform-d1 at 20℃;	A 32% B 68 % Spectr. C 68%
With hydrazine In chloroform-d1 at 20℃;	A 32% B 68% C 68 % Spectr.
With hydrazine In acetone at -20℃;	A 85 % Spectr. B 15% C 15%

...Expand

: 919-19-7
diethyl acetylphosphonate

: 1068-57-1
acetic acid hydrazide

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol for 12h;	55%
With hydrazine In ethanol for 12h; Product distribution; Mechanism; reaction with other subst. hydrazines;	55%

: 896109-94-7
ethyl 4-(1-adamantyl)-3-oxo-2-(1-oxoethyl)butanoate

A: 3-(1-adamantylmethyl)-1H-pyrazol-5-one

B: 1068-57-1
acetic acid hydrazide

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol for 4h; Reflux;	A 39% B n/a

: 896109-94-7
ethyl 4-(1-adamantyl)-3-oxo-2-(1-oxoethyl)butanoate

: 100-63-0
phenylhydrazine

A: 33566-14-2
4-adamantan-1-yl-3-oxobutyric acid ethyl ester

B: 1068-57-1
acetic acid hydrazide

C: 33566-15-3
3-(1-adamantylmethyl)-1-phenyl-1H-pyrazol-5-one

Conditions

Conditions	Yield
at 70℃; for 2h;	A n/a B n/a C 27%

...Expand

: 56-81-5
glycerol

A: 20845-34-5
(1-methyl-piperidin-2-yl)-methanol

B: 39986-37-3
2,4-dimethyl-2-oxazoline-4-methanol

C: 2786-22-3
2-(aminooxy)propanoic acid

D: 3,5-dihydroxycyclohexanamine

E: 75-07-0
acetaldehyde

F: 64-19-7
acetic acid

G: 3332-08-9
2-isopropyliminopropane

H: 802294-64-0
propionic acid

I: 1068-57-1
acetic acid hydrazide

J: 107-18-6
allyl alcohol

K: 116-09-6
hydroxy-2-propanone

L: 107-02-8
acrolein

M: 17167-73-6
acetaldehyde methylhydrazone

N: 68078-09-1
N-methylproline

Conditions

Conditions	Yield
With alumina-supported iron; ammonia In water at 340℃; Inert atmosphere;	A n/a B n/a C n/a D n/a E 7.8% F 5% G n/a H 6.7% I n/a J 11.3% K n/a L n/a M n/a N n/a

...Expand

: 625-77-4
N-acetylacetamide

: 1068-57-1
acetic acid hydrazide

Conditions

Conditions	Yield
With hydrazine at 25℃;
With hydrazine hydrochloride; sodium acetate

: 7335-65-1
hydrazinium monoacetate

: 1068-57-1
acetic acid hydrazide

Conditions

Conditions	Yield
Kochen;

: 5-amino-2-hydroxymethyl-benzoic acid hydrazide

: 108-24-7
acetic anhydride

A: 21626-90-4
6-acetylaminophthalide

B: 1068-57-1
acetic acid hydrazide

Conditions

Conditions	Yield
beim Kochen;

...Expand

: N-acetyl-N'-(2-hydroxymethyl-benzoyl)-hydrazine

: 108-24-7
acetic anhydride

A: 87-41-2
2-benzofuran-1(3H)-one

B: 1068-57-1
acetic acid hydrazide

...Expand

: 26090-73-3
p-Chlorbenzaldehyd-acethydrazon

A: 104-88-1
4-chlorobenzaldehyde

B: 1068-57-1
acetic acid hydrazide

Conditions

Conditions	Yield
In water at 25℃; Equilibrium constant;

: Acetic acid N'-[(4-chloro-phenyl)-hydroxy-methyl]-hydrazide

A: 104-88-1
4-chlorobenzaldehyde

B: 1068-57-1
acetic acid hydrazide

Conditions

Conditions	Yield
In water at 25℃; Equilibrium constant;

: 6205-72-7
1-N-acetyl-2-acetamido-2-deoxy-β-D-glucopyranosylamine

A: 3530-15-2
3,5-dimethyl-4H-1,2,4-triazol-4-amine

B: 18615-50-4
1-N-acetyl-2-amino-2-deoxy-β-D-glucopyranosylamine

C: 1068-57-1
acetic acid hydrazide

D: 77045-60-4, 131158-04-8
2-amino-2-deoxy-D-glucose hydrazone

Conditions

Conditions	Yield
With hydrazine at 100℃; for 30h; Product distribution; other temp., time and cat.;

...Expand

: 33643-34-4
2-acetamido-1-N-(L-β-aspartyl)-2-deoxy-β-D-glucopyranosylamine

A: 3530-15-2
3,5-dimethyl-4H-1,2,4-triazol-4-amine

B: 20318-46-1
aspartic acid dihydrazide

C: 86427-77-2
1-deoxy-D-fructose hydrazone

D: 1068-57-1
acetic acid hydrazide

E: 77045-60-4, 131158-04-8
2-amino-2-deoxy-D-glucose hydrazone

Conditions

Conditions	Yield
With hydrazin sulfate; hydrazine at 105℃; for 10h; Product distribution; other temp.and time;

...Expand

: 815-68-9
3-acetylpentane-2,4-dione

A: 1123-48-4
1-(3,5-dimethyl-1H-pyrazol-4-yl)ethanone

B: 1068-57-1
acetic acid hydrazide

C: 123-54-6
acetylacetone

Conditions

Conditions	Yield
With hydrazine In acetone at -20℃;	A 70 % Spectr. B 30 % Spectr. C 30 % Spectr.
With hydrazine In chloroform-d1 at 20℃;	A 26 % Spectr. B 74 % Spectr. C 74 % Spectr.

...Expand

: 19221-93-3
2-acetyldibenzoylmethane

A: 1068-57-1
acetic acid hydrazide

B: 120-46-7
1,3-diphenylpropanedione

Conditions

Conditions	Yield
With hydrazine In chloroform-d1 at 20℃;	A 100 % Spectr. B 100 % Spectr.
With phenylhydrazine In chloroform-d1 at 20℃;	A 100 % Spectr. B 100 % Spectr.

: 4728-02-3
3-benzoylpentane-2,4-dione

A: 1068-57-1
acetic acid hydrazide

B: 93-91-4
1-phenylbutan-1,3-dione

Conditions

Conditions	Yield
With hydrazine In chloroform-d1 at 20℃;	A 100 % Spectr. B 100 % Spectr.

: 569-37-9
ethyl 3-oxo-2-benzoylbutanoate

A: 94-02-0
ethyl 3-oxo-3-phenylpropionate

B: 1068-57-1
acetic acid hydrazide

Conditions

Conditions	Yield
With hydrazine In chloroform-d1 at 20℃;	A 100 % Spectr. B 100 % Spectr.

: 569-37-9
ethyl 3-oxo-2-benzoylbutanoate

A: 94-02-0
ethyl 3-oxo-3-phenylpropionate

B: 1068-57-1
acetic acid hydrazide

C: 76923-16-5
ethyl 3-methyl-5-phenyl-1H-pyrazole-4-carboxylate

Conditions

Conditions	Yield
With hydrazine In acetone at -20℃;	A 42 % Spectr. B 42 % Spectr. C 58 % Spectr.

...Expand

: 19221-93-3
2-acetyldibenzoylmethane

: 100-63-0
phenylhydrazine

A: 1068-57-1
acetic acid hydrazide

B: 120-46-7
1,3-diphenylpropanedione

Conditions

Conditions	Yield
In chloroform-d1 at 20℃;	A 100 % Spectr. B 100 % Spectr.

...Expand

: 5-(2-acetoxy)ethylene-1-benzyl-4-nitroimidazole

A: 1068-57-1
acetic acid hydrazide

B: (3-Benzyl-5-nitro-3H-imidazol-4-yl)-acetaldehyde

Conditions

Conditions	Yield
With hydrazine

: 7512-17-6, 72-87-7, 1136-42-1, 1136-44-3, 6082-29-7, 6730-06-9, 7772-94-3, 10036-64-3, 14131-60-3, 14131-64-7, 14131-68-1, 14215-68-0, 62057-49-2, 62057-50-5, 62057-51-6, 62057-52-7, 62057-53-8, 62057-54-9, 62057-55-0, 62057-56-1, 62075-50-7, 62137-54-6, 134451-97-1, 134522-12-6, 148347-16-4
N-Acetyl-D-glucosamine

A: 1068-57-1
acetic acid hydrazide

B: 190259-04-2
β-D-glucopyranosyl hydrazine

C: 2-amino-2-deoxy-D-glucose hydrazone

D: 202986-41-2
N-((1S,2R,3S,4R)-1-Hydrazonomethyl-2,3,4,5-tetrahydroxy-pentyl)-acetamide

Conditions

Conditions	Yield
With hydrazine hydrate In water for 6h; Ambient temperature;

...Expand

: 7512-17-6, 72-87-7, 1136-42-1, 1136-44-3, 6082-29-7, 6730-06-9, 7772-94-3, 10036-64-3, 14131-60-3, 14131-64-7, 14131-68-1, 14215-68-0, 62057-49-2, 62057-50-5, 62057-51-6, 62057-52-7, 62057-53-8, 62057-54-9, 62057-55-0, 62057-56-1, 62075-50-7, 62137-54-6, 134451-97-1, 134522-12-6, 148347-16-4
N-Acetyl-D-glucosamine

A: 1068-57-1
acetic acid hydrazide

B: 2-amino-2-deoxy-D-glucose hydrazone

C: 202986-41-2
N-((1S,2R,3S,4R)-1-Hydrazonomethyl-2,3,4,5-tetrahydroxy-pentyl)-acetamide

Conditions

Conditions	Yield
With hydrazine hydrate for 3h; Ambient temperature;
With hydrazine hydrate In water for 6h; Ambient temperature;

...Expand

: 1,6-dihydro-4-amino-3-methyl-6-phenyl-1,2,4-triazin-5(4H)-one

A: 1068-57-1
acetic acid hydrazide

B: 19866-39-8
α-hydrazinophenylacetic acid

Conditions

Conditions	Yield
With sulfuric acid at 22℃; Kinetics; Further Variations:; pH-values; Reagents; Hydrolysis;

: 60-29-7
diethyl ether

: 3027-05-2
N,N'-diacetylpiperazin-2,5-dione

: 302-01-2
hydrazine

A: 106-57-0
Glycine anhydride

B: 1068-57-1
acetic acid hydrazide

...Expand

: 1068-57-1
acetic acid hydrazide

: 67-64-1
acetone

: 3742-63-0
acetic acid isopropylidenehydrazide

Conditions

Conditions	Yield
In cyclohexane at 55℃; for 16h;	100%
In hexane Reflux;	93%
In hexane for 4h; Heating;	91%

: 35730-02-0
1-p-tolyl-3-phenylacetone

: 1068-57-1
acetic acid hydrazide

: 190013-93-5
Acetic acid [1-benzyl-2-p-tolyl-eth-(E)-ylidene]-hydrazide

Conditions

Conditions	Yield
With acetic acid In methanol Heating;	100%

: 65636-25-1
1-(4-bromophenyl)-3-phenyl-2-propanone

: 1068-57-1
acetic acid hydrazide

: 190013-95-7
Acetic acid [1-benzyl-2-(4-bromo-phenyl)-eth-(E)-ylidene]-hydrazide

Conditions

Conditions	Yield
With acetic acid In methanol Heating;	100%

: 29917-69-9
1-(4-methoxyphenyl)-3-phenylpropan-2-one

: 1068-57-1
acetic acid hydrazide

: 190013-94-6
Acetic acid [1-benzyl-2-(4-methoxy-phenyl)-eth-(E)-ylidene]-hydrazide

Conditions

Conditions	Yield
With acetic acid In methanol Heating;	100%

: 74426-51-0
4-(trifluoromethyl)phenylacetyl chloride

: 1068-57-1
acetic acid hydrazide

: Acetic acid [1-benzyl-2-(4-trifluoromethyl-phenyl)-eth-(E)-ylidene]-hydrazide

Conditions

Conditions	Yield
With acetic acid In methanol Heating;	100%

: 1068-57-1
acetic acid hydrazide

: 102-04-5
1,3-Diphenylpropanone

: Acetic acid (1-benzyl-2-phenyl-ethylidene)-hydrazide

Conditions

Conditions	Yield
With acetic acid In methanol Heating;	100%

: 859154-69-1
methyl 4-[(tert-butoxycarbonyl)amino]-N-(4-chlorophenyl)piperidine-1-carbimidothioate

: 1068-57-1
acetic acid hydrazide

: 859154-99-7
tert-butyl {1-[4-(4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl]piperidin-4-yl}carbamate

Conditions

Conditions	Yield
Stage #1: methyl 4-[(tert-butoxycarbonyl)amino]-N-(4-chlorophenyl)piperidine-1-carbimidothioate; acetic acid hydrazide With trifluoroacetic acid In tetrahydrofuran; water for 7h; Heating / reflux; Stage #2: With ammonia In tetrahydrofuran; water	100%

: 1217301-65-9
ethyl 2-cyano-4,5-difluorophenylcarbamate

: 1068-57-1
acetic acid hydrazide

: 1217301-66-0
8,9-difluoro-2-methyl-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one

Conditions

Conditions	Yield
In 1-methyl-pyrrolidin-2-one for 2h; Reflux;	100%
In 1-methyl-pyrrolidin-2-one for 2h; Reflux;

: 1177420-61-9
3-Fluoro-4-{3-[(1S)-2-methoxy-1-methylethoxy]-5-[5-(1,3-thiazol-2-yl)-1H-pyrrol-2-yl]phenoxy}benzoic acid

: 1068-57-1
acetic acid hydrazide

: 1177420-62-0
N'-Acetyl-3-fluoro-4-{3-[(1S)-2-methoxy-1-methylethoxy]-5-[5-(1,3-thiazol-2-yl)-1H-pyrrol-2-yl]phenoxy}benzohydrazide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 20℃; Inert atmosphere;	100%

: 1443053-94-8
triethylammonium 3,4-bis(benzyloxy)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

: 1068-57-1
acetic acid hydrazide

: 1443054-10-1
ethyl 5-(2-acetylhydrazinecarbonyl)-3,4-bis(benzyloxy)-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h;	100%

: 1443053-94-8
triethylammonium 3,4-bis(benzyloxy)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

: 1068-57-1
acetic acid hydrazide

: ethyl 5-(2-acetylhydrazinecarbonyl)-3,4-bis(benzyloxy)-1-(4-5 methoxyphenyl)-1H-pyrrole-2-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h;	100%

: 4181-05-9
4-(diphenylamino)benzaldehyde

: 1068-57-1
acetic acid hydrazide

: 1471986-40-9
C21H19N3O

Conditions

Conditions	Yield
With acetic acid In dimethyl sulfoxide at 20℃; for 1h; Inert atmosphere;	100%
With trifluoroacetic acid In methanol at 60℃;	320 mg

: 1471985-08-6
C16H14O2S3

: 1068-57-1
acetic acid hydrazide

: 1471986-41-0
C18H18N2O2S3

Conditions

Conditions	Yield
With acetic acid In dimethyl sulfoxide at 20℃; for 1h; Inert atmosphere;	100%

: 1367870-32-3
5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid

: 1068-57-1
acetic acid hydrazide

: 1414570-72-1
N'-acetyl-5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carbohydrazide

Conditions

Conditions	Yield
Stage #1: 5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid With N-ethyl-N,N-diisopropylamine; isobutyl chloroformate In dichloromethane at 20℃; for 1h; Stage #2: acetic acid hydrazide In dichloromethane at 20℃; for 18h;	100%
Stage #1: 5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid With N-ethyl-N,N-diisopropylamine; isobutyl chloroformate In dichloromethane at 20℃; for 1h; Stage #2: acetic acid hydrazide In dichloromethane at 20℃; for 18h;	100%
Stage #1: 5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid With N-ethyl-N,N-diisopropylamine; isobutyl chloroformate In dichloromethane at 20℃; for 1h; Stage #2: acetic acid hydrazide In dichloromethane at 20℃; for 18h;	119 mg

: 1367870-32-3
5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid

: 1068-57-1
acetic acid hydrazide

: 543-27-1
isobutyl chloroformate

: 1414570-72-1
N'-acetyl-5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carbohydrazide

Conditions

Conditions	Yield
Stage #1: 5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid; isobutyl chloroformate With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 1h; Stage #2: acetic acid hydrazide In dichloromethane at 20℃; for 18h;	100%

...Expand

: C33H44ClNO5

: 1068-57-1
acetic acid hydrazide

: C35H49N3O6

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 0.5h;	100%

: 1-(6-{[1-(cyclopropylmethyl)-4-ethyl-3-(4-fluorophenyl)-1H-pyrazol-5-yl]amino}pyrimidin-4-yl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid

: 1068-57-1
acetic acid hydrazide

: N'-acetyl-1-(6-{[1-(cyclopropylmethyl)-4-ethyl-3-(4-fluorophenyl)-1H-pyrazol-5-yl]amino}pyrimidin-4-yl)-3,5-dimethyl-1H-pyrazole-4-carbohydrazide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;	100%

: 1-(6-{[4-ethyl-3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]amino}pyrimidin-4-yl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid

: 1068-57-1
acetic acid hydrazide

: N'-acetyl-1-(6-{[4-ethyl-3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]amino}pyrimidin-4-yl)-3,5-dimethyl-1H-pyrazole-4-carbohydrazide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;	100%

: 90-02-8
salicylaldehyde

: 1068-57-1
acetic acid hydrazide

: 5941-05-9
salicylaldehyde acetylhydrazone

Conditions

Conditions	Yield
In propan-1-ol for 24h; Heating;	99%
In water; dimethyl sulfoxide at 20℃; Solvent;	91%
Stage #1: salicylaldehyde; acetic acid hydrazide Schiff Reaction; Heating; Stage #2: With carbon tetrabromide In dimethylsulfoxide-d6 at 25℃; Catalytic behavior; Kinetics; Reagent/catalyst; Schiff Reaction;	66%

: 85-44-9
phthalic anhydride

: 1068-57-1
acetic acid hydrazide

: 16103-11-0
1-Acetyl-2-(o-carboxy-benzoyl)-hydrazin

Conditions

Conditions	Yield
for 2h; Acylation;	99%
In tetrahydrofuran at 20℃; for 0.0833333h; Acylation; ring cleavage;

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1068-57-1
acetic acid hydrazide

: N-[(E)-dimethylaminomethylideneamino]acetamide

Conditions

Conditions	Yield
In dichloromethane for 0.5h; Reflux;	99%
In dichloromethane for 0.5h; Heating;

: 1126367-80-3
4-methyl-3-(4-(pyridin-2-ylmethoxy)benzamido)benzoic acid

: 1068-57-1
acetic acid hydrazide

: 1126367-22-3
N-(5-(2-acetylhydrazinecarbonyl)-2-methylphenyl)-4-(pyridin-2-ylmethoxy)benzamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide	99%

: 1226145-00-1
ethyl 4-(3,5-dichlorophenoxy)-3-oxobutanoate

: 1068-57-1
acetic acid hydrazide

: 1412896-06-0
C12H10Cl2N2O3

Conditions

Conditions	Yield
In ethanol at 20℃; for 7h;	99%

: 40138-16-7
2-formylbenzene boronic acid

: 1068-57-1
acetic acid hydrazide

: C18H16B2N4O3

Conditions

Conditions	Yield
In ethanol; water at 23℃;	99%

: 40138-16-7
2-formylbenzene boronic acid

: 1068-57-1
acetic acid hydrazide

: C18H16B2N4O3

Conditions

Conditions	Yield
In ethanol; water at 23℃;	99%

: 79-20-9
acetic acid methyl ester

: 1068-57-1
acetic acid hydrazide

: 3069-67-8
2-methyl-1,3,4-oxadiazol-5(4H)-one

Conditions

Conditions	Yield
With phosgene; sodium hydrogencarbonate at 0℃; Sealed tube; Green chemistry; Large scale;	99%

: 1-sec-butyl-7-[((R)-cyclopropyl(quinolin-3-yl)methyl)amino]-1H-pyrazolo[4,3-d]pyrimidine-5-carboxylic acid

: 1068-57-1
acetic acid hydrazide

: 1-sec-butyl-7-[((R)-cyclopropyl(quinolin-3-yl)methyl)amino]-1H-pyrazolo[4,3-d]pyrimidine-5-carboxylic acid N'-acetyl-hydrazide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 23℃; for 16h;	99%

: 13139-14-5
Boc-Trp-OH

: 1068-57-1
acetic acid hydrazide

: tert-butyl (S)-(1-(2-acetylhydrazineyl)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)carbamate

Conditions

Conditions	Yield
Stage #1: Boc-Trp-OH With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.25h; Stage #2: acetic acid hydrazide at 20℃; for 18h;	99%

Acethydrazide Consensus Reports

Reported in EPA TSCA Inventory.

Acethydrazide Specification

The Acetyl hydrazide, with the CAS registry number 1068-57-1, is also known as 1-Methylformylhydrazine. Its molecular formula is C₂H₆N₂O and classification codes are Carcinogens; Mutation data; Noxae. Moreover, it has the systematic name acetohydrazide and the product categories Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes; Pesticide Intermediates; Other Pesticides; Pesticide Intermediates; Herbicide Intermediates. However, this chemical should be kept cool and dry, away from oxides. What's more, it's metabolite of isoniazid in animals and humans.

Other characteristics of the Acetyl hydrazide can be summarised as followings: (1)ACD/LogP: -1.64; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.64; (4)ACD/LogD (pH 7.4): -1.64; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 3.05; (8)ACD/KOC (pH 7.4): 3.06; (9)#H bond acceptors: 3; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 23.55 Å²; (13)Index of Refraction: 1.432; (14)Molar Refractivity: 18.47 cm³; (15)Molar Volume: 71.1 cm³; (16)Polarizability: 7.32×10^-24cm³; (17)Surface Tension: 35.5 dyne/cm; (18)Density: 1.041 g/cm³; (19)Flash Point: 102.6 °C; (20)Enthalpy of Vaporization: 48.31 kJ/mol; (21)Boiling Point: 246 °C at 760 mmHg; (22)Vapour Pressure: 0.0279 mmHg at 25°C.

Production method of the Acetyl hydrazide: It could be obtained by the ethyl acetate and hydrazine hydrate in the presence of Al₂O₃. The reaction equation is as following: CH₃COOC₂H₅ + NH₂N₂.H₂O→CH₃CONHNH₂ + C₂H₅OH

Uses of the Acetyl hydrazide: It's important intermediates in organic synthesis, such as pyrazine ketones intermediates in pesticides, benzene and metribuzin intermediates in herbicide. It's mainly used for synthesis of nitric furosemide Long (nifuratrone) in medicine.

When you are using this chemical, please be cautious about it as the following: This chemical is harmful if swallowed. It's also irritating to eyes and skin.You should wear suitable protective clothing if you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1.SMILES: O=C(NN)C
2.InChI: InChI=1/C2H6N2O/c1-2(5)4-3/h3H2,1H3,(H,4,5)
3.InChIKey: OFLXLNCGODUUOT-UHFFFAOYAS

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - wild	LD50	oral	42200ug/kg (42.2mg/kg)		Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
mouse	LD50	intraperitoneal	153mg/kg (153mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Pharmacology and Experimental Therapeutics. Vol. 122, Pg. 110, 1958.
rabbit	LDLo	subcutaneous	116mg/kg (116mg/kg)	ENDOCRINE: HYPOGLYCEMIA	Journal of Pharmacology and Experimental Therapeutics. Vol. 30, Pg. 87, 1927.

Product Name

Acethydrazide

Synthetic route

Acethydrazide Consensus Reports

Acethydrazide Specification

Related Products

Hot Products