Benzotriazol-1-yl-tetramethyluronium tetrafluoroborate supplier

Name
2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate
EINECS 423-040-4
CAS No. 125700-67-6
Article Data5
CAS DataBase
Density
Solubility acetonitrile: 0.1 g/mL, clear
Melting Point 205°C (dec.)(lit.)
Formula C₁₁H₁₆N₅O^.BF₄
Boiling Point
Molecular Weight 321.086
Flash Point STABILITY
Transport Information
Appearance white or off-white crystalline powder
Safety 26-36-37/39-36/37/39
Risk Codes 36/37/38-5
Molecular Structure
Hazard Symbols Xi,F
Synonyms (1H-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate;Btttfb;Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, tetrafluoroborate(1-);O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate;
PSA 46.19000
LogP 1.34960

Synthetic route

: 150-75-4
N-methyl-p-aminophenol

: 164646-22-4
(R)-N2-[(4-amino-3,5-dichlorophenyl)sulphonyl]-N5-[amino(nitroimino)methyl]-ornithine

: 7087-68-5
N-ethyl-N,N-diisopropylamine

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

Conditions

Conditions	Yield
	58%

...Expand

H-D-Arg(NO2)-OH: H-D-Arg(NO2)-OH

: 164648-71-9
(R)-N5-[amino(nitroimino)methyl]-N2-[(2-naphthyl)carbonyl]-ornithine

: 2243-83-6
2-naphthaloyl chloride

A: 164647-69-2
(R)-N5-[Amino(nitroimino)methyl]-N-[(4-hydroxyphenyl)-methyl]-N2-(2-naphthoyl)-ornithinamide

B: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

Conditions

Conditions	Yield
	A n/a B 36%

...Expand

: 1871-76-7
diphenylacetic acid chloride

A: 164644-76-2
(R,S)-N5-(Aminocarbonyl)-N2-(diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-ornithinamide

B: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

Conditions

Conditions	Yield
	A n/a B 34%

: 56043-45-9, 13829-06-6
N,N,N',N'-tetramethylchlorformamidinium chloride

: 62244-77-3
1-Hydroxy-1,2,3-benzotriazole potassium salt

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

Conditions

Conditions	Yield
With potassium chloride; potassium tetrafluoroborate

: 632-22-4
tetramethylurea

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: oxalyl chloride 2: KBF4,KCl View Scheme

: 108-30-5
succinic acid anhydride

A: Mannose amine

B: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

Conditions

Conditions	Yield
With dmap; benzotriazol-1-ol In ethyl acetate; N,N-dimethyl-formamide

: 123-75-1
pyrrolidine

: 68837-59-2
4-bromo-2-methylbenzoic acid

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: 7087-68-5
N-ethyl-N,N-diisopropylamine

: 276678-35-4
(4-bromo-2-methylphenyl)(pyrrolidin-1-yl)methanone

Conditions

Conditions	Yield
In tetrahydrofuran; water	98%

...Expand

: 6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinoline-2-carboxylic acid

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: tert-butyl 4-[(6-{[6-(trifluoromethyl)pyridin-3-yl]oxy}quinolin-2-yl)carbonyl]piperazine-1-carboxylate

Conditions

Conditions	Yield
With triethylamine In water; ethyl acetate; N,N-dimethyl-formamide	97%

...Expand

: 861359-74-2
diisopropylethyl amine

(L)-α-aspartyl-3-cyclohexyl-(L-alanineamide phenylmethyl ester trifluoroacetate: (L)-α-aspartyl-3-cyclohexyl-(L-alanineamide phenylmethyl ester trifluoroacetate

: 222640-99-5
N-ethyl-N-[1-oxo-4-[1-[(phenylmethoxy)carbonyl]-4-piperidinyl]butyl]glycine

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: N-[N-ethyl-N-[1-oxo-4-[1-[(phenylmethoxy)carbonyl]-4-piperidinyl]butyl]glycyl]-(L)-α-aspartyl-3-cyclohexyl-(L)-alanineamide phenylmethyl ester

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N-methyl-acetamide; N,N-dimethyl-formamide	95%

...Expand

: 508-02-1
Oleanolic acid

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: 1596377-01-3
1-benzotriazolyl 3β-hydroxyolean-12-en-28-oate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 12h;	95%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 5h; Inert atmosphere;	93%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 5h; Inert atmosphere;	93%

: 77-52-1
ursolic acid

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: 1-benzotriazolyl 3β-dihydroxyurs-12-en-28-oate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 5h; Inert atmosphere;	93%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 5h; Inert atmosphere;	93%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃;
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 4h;

: 472-15-1
Betulinic acid

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: 1-benzotriazolyl 3β-hydroxy-lup-20(29)-en-28-oate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 5h; Inert atmosphere;	93%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 5h; Inert atmosphere;	93%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃;
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran

N-Methylhept-5-en-1-amine tosylate salt: N-Methylhept-5-en-1-amine tosylate salt

: 1180495-95-7
(2S,4S)-1-(tert-butoxycarbonyl)-4-(8-chloro-2-(4-isopropylthiazol-2-yl)-7-methoxyquinolin-4-yloxy)pyrrolidine-2-carboxylic acid

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: (2S,4S)-tert-butyl 4-(8-chloro-2-(4-isopropylthiazol-2-yl)-7-methoxyquinolin-4-yloxy)-2-(hex-5-enyl(methyl)carbamoyl)pyrrolidine-1-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide	92%

...Expand

: 109-02-4
4-methyl-morpholine

: 68076-36-8
1-amino-4-[(tert-butyloxycarbonyl)amino]butane

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: 1315605-54-9
{4-[3-({2-[(4-Cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-phenyl-amino)-propionylamino]-butyl}-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
In N,N-dimethyl-formamide	92%

...Expand

: 465-99-6
hedaragenin

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: benzotriazol-1-yl (3β)3,23-dihydroxyolean-12-en-28-oate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃;	92%

: 4373-41-5, 5957-40-4, 26563-68-8, 26707-60-8, 120707-84-8, 125137-38-4
maslinic acid

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: C36H51N3O4

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine at 20℃; for 12h;	92%

: 4339-72-4
oleanolic acid 3-acetate

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: C38H53N3O4

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine at 20℃; for 12h;	91%

N-Methylhept-5-en-1-amine tosylate salt: N-Methylhept-5-en-1-amine tosylate salt

: 1180495-88-8
(2S,4S)-1-(tert-butoxycarbonyl)-4-(7-methoxy-8-methyl-2-(4-(trifluoromethyl)thiazol-2-yl)quinolin-4-yloxy)pyrrolidine-2-carboxylic acid

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: (2S,4S)-tert-butyl 2-(hex-5-enyl(methyl)carbamoyl)-4-(7-methoxy-8-methyl-2-(4-(trifluoromethyl)thiazol-2-yl)quinolin-4-yloxy)pyrrolidine-1-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide	90%

...Expand

: 6089-92-5
(2α,3β)-2,3-diacetyloxy-olean-12-en-28-oic acid

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: C40H55N3O6

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine at 20℃; for 12h;	90%

: 471-53-4
enoxolone

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: 1612838-71-7
1H‐benzo[d][1,2,3]triazol‐1‐yl‐3β‐hydroxy‐11‐oxo‐olean‐12‐en‐30‐oate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 24h;	90%

: 510-30-5
echinocystic acid

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: 1438766-88-1
1-benzotriazolyl 3β,16α-dihydroxyolean-12-en-28-oate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 4h;	89%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃;	86%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; Inert atmosphere;	86%

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: 58-85-5
biotin

: C16H19N5O3S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 4h;	89%

: 1159252-14-8
6-[3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-pyridazine-3-carboxylic acid

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: 124-68-5
2-Amino-2-methyl-1-propanol

: 7087-68-5
N-ethyl-N,N-diisopropylamine

: 1159252-13-7
6-[3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-pyridazine-3-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide	88%

...Expand

: 1613191-77-7
2-amino-6-fluoro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: 1613191-75-5
1H-benzo[d][1,2,3]triazol-1-yl 2-amino-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxylate

Conditions

Conditions	Yield
Stage #1: 2-amino-6-fluoro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid With triethylamine In chloroform for 0.0833333h; Stage #2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate In chloroform at 60℃; for 1h;	88%
Stage #1: 2-amino-6-fluoro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid With triethylamine In chloroform for 0.0833333h; Stage #2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate In chloroform at 60℃; for 1h;	88%
Stage #1: 2-amino-6-fluoro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid With triethylamine In chloroform for 0.0833333h; Stage #2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate In chloroform at 60℃; for 1h;	88%
With triethylamine In chloroform at 60℃; for 1h;	88%

: 1613191-81-3
2-amino-6-chloro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: 1613191-79-9
1H-benzo[d][1,2,3]triazol-1-yl 2-amino-6-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate

Conditions

Conditions	Yield
With triethylamine In chloroform at 50℃; for 1h;	88%
With triethylamine In chloroform at 50℃; for 1h;	88%
With triethylamine In chloroform at 50℃; for 1h;	88%

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: 99-57-0
2-hydroxy-5-nitroaniline

: N,N-dimethyl-5-nitro-1,3-benzoxazol-2-amine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 10h;	86.5%

: 2-amino-5-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: 1H-benzo[d][1,2,3]triazol-1-yl 2-amino-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

Conditions

Conditions	Yield
With triethylamine In chloroform at 50℃; for 0.333333h;	86%
In chloroform at 50℃; for 0.333333h;	86%

: 1108656-90-1
N-methylhex-5-en-1-amine tosylate salt

: 1265883-88-2
(1R,2R,4R)-4-(tert-butyldiphenylsilanyloxy)cyclohexane-1,2-dicarboxylic acid 2-tert-butyl ester

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: 7087-68-5
N-ethyl-N,N-diisopropylamine

: (1R,2R,4R)-5-(tert-butyl-diphenyl-silanyloxy)-2-(hex-5-enyl-methyl-carbamoyl)-cyclohexanecarboxylic acid tert-butyl ester

Conditions

Conditions	Yield
In N,N-dimethyl-formamide	85%

...Expand

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: 669065-21-8
N(1)-(4-chlorophenyl)-2-hydrazino-2-thioxoacetamide

: N-(4-chlorophenyl)-5-(dimethylamino)-1,3,4-thiadiazole-2-carboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 10h;	84.6%

: 1613191-85-7
2-amino-6-(cyanomethyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: 1613191-82-4
1H-benzo[d][1,2,3]triazol-1-yl 2-amino-6-(cyanomethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 1h;	84%
With triethylamine In dichloromethane at 20℃; for 1h;	84%
With triethylamine In dichloromethane at 20℃; for 1h;	84%

: 6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxylic acid

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: 53617-35-9
4-(piperidin-4-yl)morpholine

: [4-(morpholin-4-yl)piperidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In ethanol; ethyl acetate; N,N-dimethyl-formamide	84%

...Expand

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: 185563-95-5
5-[4-(1-triphenylmethylimidazol-2-ylamino)butyl]isoxazoline-3-carboxylic acid

: tert-Butyl 3-{5-[4-(1-triphenylmethylimidazol-2-ylamino)butyl]isoxazoline-3-carbonyl}amino-2-(S)-(2,4,6-trimethylbenzenesulfonylamino)propionate

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide	83%

: 6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinoline-2-carboxylic acid

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: 132800-13-6
1-cyclobutyl-piperazine

: (4-cyclobutylpiperazin-1-yl)(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone

Conditions

Conditions	Yield
With triethylamine; trifluoroacetic acid In water; dimethyl sulfoxide; acetonitrile	83%

...Expand

Benzotriazol-1-yl-tetramethyluronium tetrafluoroborate Chemical Properties

IUPAC Name of TBTU (125700-67-6): [benzotriazol-1-yloxy(dimethylamino)methylidene]-dimethylazanium; boron(3+); tetrafluoride
Synonyms:O-Benzotriazol-1-yl-N,N,N',N'-tetramethyluronium tetrafluoroborate; 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate
Molecular Formula: C₁₁H₁₆N₅O.BF₄
Molecular Weight : 321.08 g/mol
EINECS: 423-040-4
storage temp.: 2-8 °C
Melting point: 200 °C
solubility:acetonitrile: 0.1 g/mL, clear
Appearance: white or off-white crystalline powder
Following is the molecular structure of TBTU (125700-67-6):

Benzotriazol-1-yl-tetramethyluronium tetrafluoroborate Safety Profile

Safty informations about TBTU (125700-67-6):
Hazard Symbols: Irritant Xi, Flammable F
Risk Codes :
R36/37/38:Irritating to eyes, respiratory system and skin.
R5 :Heating may cause an explosion.
Safety Description :
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37/39: Wear suitable gloves and eye/face protection.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany: 3
F: 8-10-21
Hazard Note: Irritant/Flammable

Product Name

2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate

Synthetic route

Benzotriazol-1-yl-tetramethyluronium tetrafluoroborate Chemical Properties

Benzotriazol-1-yl-tetramethyluronium tetrafluoroborate Safety Profile

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