Product Name

  • Name

    D-Aspartic acid

  • EINECS 217-234-6
  • CAS No. 1783-96-6
  • Article Data65
  • CAS DataBase
  • Density 1.514 g/cm3
  • Solubility soluble in water
  • Melting Point >300 °C(lit.)
  • Formula C4H7NO4
  • Boiling Point 264.1 °C at 760 mmHg
  • Molecular Weight 133.104
  • Flash Point 113.5 °C
  • Transport Information 25kgs
  • Appearance White or almost white crystalline powder
  • Safety 24/25-36-26
  • Risk Codes 20/21/22-36/37/38
  • Molecular Structure Molecular Structure of 1783-96-6 (D-Aspartic acid)
  • Hazard Symbols HarmfulXn
  • Synonyms 4-04-00-02998 (Beilstein Handbook Reference);(R)-Aspartic acid;Aspartic acid, D-;(-)-Aspartic acid;D & L-Aspartic Acid;D-Asparaginsaeure;D-Aspartate;Aspartic acid D-form;(R)-2-aminosuccinic acid;H-D-Asp-OH;D-(-)-Aspartic Acid;
  • PSA 100.62000
  • LogP -0.42670

Synthetic route

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

Conditions
ConditionsYield
With sodium hydroxide for 3h;82.5%
(R)-Asparagine
2058-58-4

(R)-Asparagine

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

Conditions
ConditionsYield
With hydrogenchloride
With hydrogenchloride at 85℃; for 19h;
With hydrogenchloride; water In methanol at 110℃; for 24h; Inert atmosphere; Sealed tube;
With L-asparaginase from Thermococcus gammatolerans EJ3 In aq. buffer at 85℃; pH=8.5; Kinetics; pH-value; Solvent; Temperature; Enzymatic reaction;
aspartic Acid
617-45-8

aspartic Acid

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

Conditions
ConditionsYield
durch Spaltung;
With L-glutamic acid
mit Hilfe eines Enzym-Praeparats aus Crotalus adamanteus;
man bringt die Pilze, mit denen sich eine Loesung von l-Asparaginsaeure beim Stehen an der Luft bedeckt, auf eine Loesung von dl-Asparaginsaeure;
bromosuccinic acid
923-06-8, 584-98-5

bromosuccinic acid

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

Conditions
ConditionsYield
With ammonia; water at -50 - -40℃; dann bei 3-5grad, endlich bei Zimmertemperatur;
2-aminosuccinic acid diethyl ester
20268-79-5

2-aminosuccinic acid diethyl ester

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

Conditions
ConditionsYield
With hydrogenchloride
N-acetyl-DL-aspartic acid
2545-40-6

N-acetyl-DL-aspartic acid

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

Conditions
ConditionsYield
enzymatische Herstellung;
N-chloroacetyl-DL-aspartic acid
67036-33-3, 67324-95-2

N-chloroacetyl-DL-aspartic acid

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

Conditions
ConditionsYield
enzymatische Herstellung;
Hydrolysis.mit Hilfe eines Enzym-Praeparats aus Nieren und Kochen der unveraendert zurueckbleibenden N-Chloracetyl-D-asparaginsaeure mit 2n-HCl;
1-amino-ethane-1,1,2,2-tetracarboxylic acid tetraethyl ester
97032-53-6

1-amino-ethane-1,1,2,2-tetracarboxylic acid tetraethyl ester

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

Conditions
ConditionsYield
With hydrogenchloride
L-Aspartic acid
56-84-8

L-Aspartic acid

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

Conditions
ConditionsYield
In water at 140℃; Rate constant; pH 8.0;
at 37℃; Kinetics; racemization in dentin; age determination;
In water at 160℃; for 30h; pH=6;
(R)-aspartic acid ethyl ester
565461-05-4

(R)-aspartic acid ethyl ester

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

Conditions
ConditionsYield
With hydrogenchloride for 5h; Heating;
aspartic Acid
617-45-8

aspartic Acid

A

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

B

L-Aspartic acid
56-84-8

L-Aspartic acid

Conditions
ConditionsYield
With L-alanin In water for 24h; Product distribution; Ambient temperature; other optically active amino acids;
With teicoplanin In methanol; water Product distribution; Further Variations:; Reagents; pH-values; Solvents;
With (2R,3R,11R,12R)-(+)-18-crown-6-2,3,11,12-tetracarbonic acid
{[1-{2-[((S)-1-Benzyl-pyrrolidine-2-carbonyl)-amino]-phenyl}-1-phenyl-meth-(E)-ylidene]-amino}-bromo-acetic acid

{[1-{2-[((S)-1-Benzyl-pyrrolidine-2-carbonyl)-amino]-phenyl}-1-phenyl-meth-(E)-ylidene]-amino}-bromo-acetic acid

diethyl malonate
105-53-3

diethyl malonate

A

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

B

L-Aspartic acid
56-84-8

L-Aspartic acid

Conditions
ConditionsYield
With hydrogenchloride; potassium tert-butylate; bromine; triethylamine; nickel dichloride 1.) iPrOH, 5 deg C, 2.) CH3CN, -50 deg C, 3.) 25 deg C, H2O, reflux, 1 h; Yield given. Multistep reaction;
4-Ethyl 8-phenylmenthyl N-aspartate

4-Ethyl 8-phenylmenthyl N-aspartate

A

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

B

L-Aspartic acid
56-84-8

L-Aspartic acid

Conditions
ConditionsYield
With hydrogenchloride; trifluoroacetic acid for 15h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
pholipeptin

pholipeptin

A

D-Serine
312-84-5

D-Serine

B

L-threonine
72-19-5

L-threonine

C

(R)-leucine
328-38-1

(R)-leucine

D

L-isoleucine
73-32-5

L-isoleucine

E

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

F

L-Aspartic acid
56-84-8

L-Aspartic acid

Conditions
ConditionsYield
With hydrogenchloride at 120℃; for 20h; Product distribution;
bromosuccinic acid
923-06-8, 584-98-5

bromosuccinic acid

ammonium hydroxide

ammonium hydroxide

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

Conditions
ConditionsYield
at -50 - -40℃; levorotatory bromo-succinic acid;
benzoyl-dl-aspartic acid

benzoyl-dl-aspartic acid

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

Conditions
ConditionsYield
With brucine aus den zurueckbleibenden Mutterlaugen entfernt man das Bruzin;die Benzoylasparaginsaeuren werden schliesslich d.Erhitz. m.Salzsaeure auf 100grad u.Neutralis. der erhalt.salzs.Salze m.Kalilauge in freien Asparaginsaeuren verwandelt;
aspartic Acid
617-45-8

aspartic Acid

benzeneacetic acid methyl ester
101-41-7

benzeneacetic acid methyl ester

A

(R)-2-Phenylacetylamino-succinic acid

(R)-2-Phenylacetylamino-succinic acid

B

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

C

L-Aspartic acid
56-84-8

L-Aspartic acid

D

N-phenylacetyl aspartic acid
2752-32-1

N-phenylacetyl aspartic acid

Conditions
ConditionsYield
With sodium hydroxide; E. coli penicillin-G acylase F24A mutant at 25℃; pH=9.6; Title compound not separated from byproducts;
C10H9FeCH2CH(NH2)COOH

C10H9FeCH2CH(NH2)COOH

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

Conditions
ConditionsYield
With ozone In water; trifluoroacetic acid
(SR)-{Ni(O2CCH(CH2CO2C2H5)NC(C6H5)C6H4COC4H7N(CH2C6H5))}

(SR)-{Ni(O2CCH(CH2CO2C2H5)NC(C6H5)C6H4COC4H7N(CH2C6H5))}

A

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

B

(S)-N-(2-benzoylphenyl)-1-benzylpyrrolidine-2-carboxamide
96293-17-3, 105024-93-9, 105112-33-2

(S)-N-(2-benzoylphenyl)-1-benzylpyrrolidine-2-carboxamide

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water refluxing.; neutralized (Na2CO3), extn. of BBP (CHCl3), evapn. of aq. layer to dryness, addn. of aq. HCl, refluxed for 5 h, amino acid isolated on a KRS-12 cation exchanger;;
L-Arg-D-Asp
275354-61-5

L-Arg-D-Asp

A

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

B

L-arginine
74-79-3

L-arginine

Conditions
ConditionsYield
With recombinant Streptomyces coelicolor Sco3058 dipeptidase; water at 30℃; pH=8; Kinetics; Concentration; aq. buffer; Enzymatic reaction;
C28H41N5O10

C28H41N5O10

A

L-alanin
56-41-7

L-alanin

B

L-valine
72-18-4

L-valine

C

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

Conditions
ConditionsYield
With hydrogenchloride; water at 120℃; for 14h;
Oxalacetic acid
328-42-7

Oxalacetic acid

D-Alanine
338-69-2

D-Alanine

A

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

B

2-oxo-propionic acid
127-17-3

2-oxo-propionic acid

Conditions
ConditionsYield
With pyridoxal 5'-phosphate; recombinant Lactobacillus salivarius UCC118 D-amino acid aminotransferase In aq. phosphate buffer at 30℃; for 0.0166667h; pH=7.5; Enzymatic reaction;
haloirciniamide A

haloirciniamide A

A

(S)-2,3-diaminopropionic acid
515-94-6, 1915-96-4, 4033-39-0, 6018-54-8

(S)-2,3-diaminopropionic acid

C

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

Conditions
ConditionsYield
Stage #1: haloirciniamide A With hydrogenchloride In water at 110℃; for 15h;
Stage #2: With sodium hydrogencarbonate; N-(2,4-dinitro-5-fluorophenyl)-L-alaninamide In water; acetone at 40℃; for 1h;
L-Aspartic acid
56-84-8

L-Aspartic acid

A

L-alanin
56-41-7

L-alanin

B

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

Conditions
ConditionsYield
With pyridoxal 5'-phosphate; Pseudomonas dacunhae L-aspartateb β-decarboxylase R37A/T382G In aq. buffer at 30℃; pH=6; Reagent/catalyst; Enzymatic reaction;
methanol
67-56-1

methanol

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

D-2-amino-3-methoxycarbonylpropionic acid hydrochloride
22728-89-8

D-2-amino-3-methoxycarbonylpropionic acid hydrochloride

Conditions
ConditionsYield
With thionyl chloride at -30 - 10℃;100%
With thionyl chloride at -5 - 35℃;87%
With thionyl chloride at -5 - 5℃; for 12.5h;77.6%
Stage #1: methanol With thionyl chloride at -20℃; for 0.75h; Inert atmosphere;
Stage #2: (2R)-aspartic acid at 20℃; for 3.08333h; Inert atmosphere;
60%
With thionyl chloride at -10 - 21℃; for 3h;56%
methanol
67-56-1

methanol

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

dimethyl (R)-2-aminobutanedioate hydrochloride
14358-33-9, 32213-95-9, 69630-50-8

dimethyl (R)-2-aminobutanedioate hydrochloride

Conditions
ConditionsYield
With acetyl chloride100%
With thionyl chloride at 0 - 20℃; for 16.1667h; Inert atmosphere;99%
With acetyl chloride Reflux;73%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

dimethyl (R)-2-aminobutanedioate hydrochloride
14358-33-9, 32213-95-9, 69630-50-8

dimethyl (R)-2-aminobutanedioate hydrochloride

Conditions
ConditionsYield
In methanol at 20℃; Cooling;99.9%
In methanol at 20℃; for 16h; Cooling with ice; enantioselective reaction;99.9%
(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

2-aminosuccinic acid diethyl ester
20268-79-5

2-aminosuccinic acid diethyl ester

Conditions
ConditionsYield
Stage #1: acetyl chloride In ethanol at 0 - 20℃; for 0.5h;
Stage #2: (2R)-aspartic acid In ethanol for 2h; Heating / reflux;
99%
ethanol
64-17-5

ethanol

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

(R)-aspartic acid diethyl ester hydrochloride
112018-26-5

(R)-aspartic acid diethyl ester hydrochloride

Conditions
ConditionsYield
Stage #1: ethanol With acetyl chloride at 0 - 20℃; for 0.5h;
Stage #2: (2R)-aspartic acid for 2h; Heating / reflux;
99%
methanol
67-56-1

methanol

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

Conditions
ConditionsYield
With thionyl chloride at 25℃; for 48h;98%
With thionyl chloride at 20℃; for 48h;98%
With thionyl chloride95%
(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

(2R)-chlorobutanedioic acid
3972-40-5

(2R)-chlorobutanedioic acid

Conditions
ConditionsYield
Stage #1: (2R)-aspartic acid With hydrogenchloride; potassium bromide; sodium nitrite In water at 0 - 5℃; for 4h;
Stage #2: With urea for 0.166667h;
95%
With hydrogenchloride; urea 1.) 70 deg C, 5 h; 2.) room temp., 18 h;
(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

methyl chloroformate
79-22-1

methyl chloroformate

(R)-N-(methoxycarbonyl) aspartic acid
110935-98-3

(R)-N-(methoxycarbonyl) aspartic acid

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide In water at 20℃; for 1h;95%
(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

benzyl alcohol
100-51-6

benzyl alcohol

(R)-dibenzyl 2-aminosuccinate p-toluenesulfonic acid salt
4079-64-5

(R)-dibenzyl 2-aminosuccinate p-toluenesulfonic acid salt

Conditions
ConditionsYield
In benzene for 7h; Reflux;94%
(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

benzyl chloroformate
501-53-1

benzyl chloroformate

N-(benzyloxycarbonyl)-D-aspartic acid
78663-07-7

N-(benzyloxycarbonyl)-D-aspartic acid

Conditions
ConditionsYield
With potassium carbonate In water at 0 - 20℃; for 3.16667h;93.28%
With sodium hydrogencarbonate In tetrahydrofuran; water at 0 - 20℃;85%
With sodium hydrogencarbonate for 18h; Ambient temperature;79%
N-(benzylcarbonyloxy)-succinamide

N-(benzylcarbonyloxy)-succinamide

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

N-(benzyloxycarbonyl)-D-aspartic acid
78663-07-7

N-(benzyloxycarbonyl)-D-aspartic acid

Conditions
ConditionsYield
In dichloromethane; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide92.5%
methanol
67-56-1

methanol

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

(R)-2-amino-4-methoxy-4-oxobutanoic acid
21394-81-0

(R)-2-amino-4-methoxy-4-oxobutanoic acid

Conditions
ConditionsYield
With acetyl chloride at 0 - 25℃;90%
With hydrogenchloride for 36h; Ambient temperature;
Stage #1: (2R)-aspartic acid With sulfuric acid at 20℃; for 2h;
Stage #2: methanol at 20℃;
(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

Conditions
ConditionsYield
With sulfuric acid; potassium bromide; sodium nitrite In water at -5 - 0℃;90%
With sulfuric acid; potassium bromide; sodium nitrite In water at -5 - 0℃; for 4h;90%
With sulfuric acid; potassium bromide; sodium nitrite at -5℃; for 3h;85%
(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

allyl alcohol
107-18-6

allyl alcohol

β-allyl (2R)-aspartate ester hydrochloride

β-allyl (2R)-aspartate ester hydrochloride

Conditions
ConditionsYield
With acetyl chloride at 20℃; for 18h;89%
(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

(2S)-2-bromobutanedioic acid
584-98-5, 923-06-8, 3972-41-6, 20859-23-8

(2S)-2-bromobutanedioic acid

Conditions
ConditionsYield
With sulfuric acid; potassium bromide; sodium nitrite In water at -2℃; for 2.5h; Inert atmosphere;88%
With sulfuric acid; potassium bromide; sodium nitrite In water at -10 - 20℃; for 5h;84.5%
(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

n-hexadecanoyl chloride
112-67-4

n-hexadecanoyl chloride

N-palmitoyl-D-aspartic acid
863199-04-6

N-palmitoyl-D-aspartic acid

Conditions
ConditionsYield
Stage #1: (2R)-aspartic acid With pyridine; chloro-trimethyl-silane In dichloromethane for 1h;
Stage #2: n-hexadecanoyl chloride In dichloromethane for 1.83333h;
85%
cerium(IV)diammonium nitrate

cerium(IV)diammonium nitrate

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

water
7732-18-5

water

[Ce6(μ3-O)4(μ3-OH)4(H2O)6(D-aspartate)6]

[Ce6(μ3-O)4(μ3-OH)4(H2O)6(D-aspartate)6]

Conditions
ConditionsYield
With formic acid at 100℃; for 0.5h; Sealed tube;84%
(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

1-cyclopropyl-6-fluoro-7-(8-methoxyimino-2,6-diaza-spiro[3,4]oct-6-yl)-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid

1-cyclopropyl-6-fluoro-7-(8-methoxyimino-2,6-diaza-spiro[3,4]oct-6-yl)-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid

1-cyclopropyl-6-fluoro-7-(8-methoxyimino-2,6-diaza-spiro[3.4]oct-6-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid D-aspartic acid salt

1-cyclopropyl-6-fluoro-7-(8-methoxyimino-2,6-diaza-spiro[3.4]oct-6-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid D-aspartic acid salt

Conditions
ConditionsYield
In ethanol at 50℃; for 1h;83%
undecyl alcohol
112-42-5

undecyl alcohol

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

C26H51NO4

C26H51NO4

Conditions
ConditionsYield
Stage #1: undecyl alcohol; (2R)-aspartic acid With toluene-4-sulfonic acid In toluene
Stage #2: With hydrogenchloride In water; acetone
80.14%
(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

1-dodecyl alcohol
112-53-8

1-dodecyl alcohol

C28H55NO4

C28H55NO4

Conditions
ConditionsYield
Stage #1: (2R)-aspartic acid; 1-dodecyl alcohol With toluene-4-sulfonic acid In toluene
Stage #2: With hydrogenchloride In water; acetone
80.14%
octanol
111-87-5

octanol

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

C20H39NO4

C20H39NO4

Conditions
ConditionsYield
Stage #1: octanol; (2R)-aspartic acid With toluene-4-sulfonic acid In toluene
Stage #2: With hydrogenchloride In water; acetone
80.14%
(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

nonyl alcohol
143-08-8

nonyl alcohol

C22H43NO4

C22H43NO4

Conditions
ConditionsYield
Stage #1: (2R)-aspartic acid; nonyl alcohol With toluene-4-sulfonic acid In toluene
Stage #2: With hydrogenchloride In water; acetone
80.14%
(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

1-Decanol
112-30-1

1-Decanol

C24H47NO4

C24H47NO4

Conditions
ConditionsYield
Stage #1: (2R)-aspartic acid; 1-Decanol With toluene-4-sulfonic acid In toluene
Stage #2: With hydrogenchloride In water; acetone
80.14%
(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

(6R,7R)-7-{(2Z)-2-(ethoxyimino)-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetylamino}-3-{[4-(1-methyl-4-pyridin-1-iumyl)-1,3-thiazol-2-yl]sulfanyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

(6R,7R)-7-{(2Z)-2-(ethoxyimino)-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetylamino}-3-{[4-(1-methyl-4-pyridin-1-iumyl)-1,3-thiazol-2-yl]sulfanyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

(6R,7R)-7-{(2Z)-2-(ethoxyimino)-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetylamino}-3-{[4-(1-methyl-4-pyridin-1-iumyl)-1,3-thiazol-2-yl]sulfanyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate L-aspartate

(6R,7R)-7-{(2Z)-2-(ethoxyimino)-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetylamino}-3-{[4-(1-methyl-4-pyridin-1-iumyl)-1,3-thiazol-2-yl]sulfanyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate L-aspartate

Conditions
ConditionsYield
In water; acetic acid at 20℃; for 18h; Solvent;75%
methanol
67-56-1

methanol

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

(2R)-N-(p-toluenesulfonyl)-aspartic acid dimethyl ester
616866-44-5

(2R)-N-(p-toluenesulfonyl)-aspartic acid dimethyl ester

Conditions
ConditionsYield
Stage #1: methanol; (2R)-aspartic acid With thionyl chloride at 0 - 25℃; for 15h; Inert atmosphere;
Stage #2: p-toluenesulfonyl chloride With triethylamine at 0 - 25℃; for 2h; Inert atmosphere;
75%
(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

benzaldehyde
100-52-7

benzaldehyde

(R)-N-Benzylasparaginsaeure
6367-42-6

(R)-N-Benzylasparaginsaeure

Conditions
ConditionsYield
With sodium tetrahydroborate74%
With methanol; sodium cyanoborohydride at 20℃; enantioselective reaction;32%
(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

silver(l) oxide
20667-12-3

silver(l) oxide

Ag2(HOOCCH2CHNH2CO2)2

Ag2(HOOCCH2CHNH2CO2)2

Conditions
ConditionsYield
In water to a stirred suspn. of Ag2O in water was added solid aminoacid, stirred for 2 h; filtered, vapor diffusion with ethanol;69.4%
methanol
67-56-1

methanol

N-(Benzyloxycarbonyloxy)succinimide
13139-17-8

N-(Benzyloxycarbonyloxy)succinimide

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

(+)-N-Cbz-β-methyl-D-aspartate
28862-78-4

(+)-N-Cbz-β-methyl-D-aspartate

Conditions
ConditionsYield
Stage #1: methanol; (2R)-aspartic acid With thionyl chloride at 0 - 20℃; for 3h;
Stage #2: N-(Benzyloxycarbonyloxy)succinimide With potassium phosphate In water; toluene at 0 - 20℃; for 14h;
Stage #3: With hydrogenchloride In Isopropyl acetate; water pH=1;
69%
3,4-difluoro-1,2-phenylenediamine

3,4-difluoro-1,2-phenylenediamine

(2R)-aspartic acid
1783-96-6

(2R)-aspartic acid

C10H9F2N3O2
884047-71-6

C10H9F2N3O2

Conditions
ConditionsYield
With hydrogenchloride In water Heating / reflux;66%

D-Aspartic acid Chemical Properties

Molecular Structure:

Molecular Formula: C4H7NO4
Molecular Weight: 133.1027
IUPAC Name: (2R)-2-Aminobutanedioic acid
Synonyms of D-Aspartic acid (CAS NO.1783-96-6): Aspartic acid D-form ; (-)-Aspartic acid ; (R)-Aspartic acid ; 4-04-00-02998 (Beilstein Handbook Reference) ; Aspartic acid, D- ; BRN 1723529 ; D-Aspartate ; EINECS 217-234-6 ; NSC 97922
CAS NO: 1783-96-6
Product Categories: Amino ACIDS SERIES ; chiral ; Amino Acid Derivatives ; Aspartic acid [Asp, D] ; Amino Acids and Derivatives ; for Resolution of Bases ; alpha-Amino Acids;Amino Acids ; Biochemistry ; Optical Resolution ; Synthetic Organic Chemistry ; Amino Acids ; Glutamate receptor ; amino acid ; aspartic acid ; chemicals ; organic acids ; pharmaceutical intermediate
Melting point: >300 °C
Index of Refraction: 1.531
Molar Refractivity: 27.2 cm3
Molar Volume: 87.8 cm3
Surface Tension: 78.2 dyne/cm
Density: 1.514 g/cm3
Flash Point: 113.5 °C
Enthalpy of Vaporization: 55.26 kJ/mol
Boiling Point: 264.1 °C at 760 mmHg
Vapour Pressure: 0.00289 mmHg at 25°C

D-Aspartic acid Uses

 D-Aspartic acid (CAS NO.1783-96-6) is used as the synthesis of drugs.

D-Aspartic acid Toxicity Data With Reference

1. RTECS#: CAS# 1783-96-6: CI9097500 
2. L.D50/LC50: RTECS: Not available. 
3. Carcinogenicity: D-(-)ASPARTIC ACID - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65. 
4. Other: The toxicological properties have not been fully investigated. 

 

D-Aspartic acid Safety Profile

Hazard Codes of D-Aspartic acid (CAS NO.1783-96-6): HarmfulXn
Risk Statements: 20/21/22-36/37/38 
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-36-26 
S24/25: Avoid contact with skin and eyes. 
S36: Wear suitable protective clothing. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: CI9097500

D-Aspartic acid Specification

(1)Fire Fighting Measures of D-aspartic acid (CAS NO.1783-96-6)
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. 
Extinguishing Media: Use WATER spray, dry chemical, CARBON dioxide, or chemical foam.
(2)Handling and Storage of D-aspartic acid
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. 
Storage: Store in a cool, dry place. Store in a tightly closed container.

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