Ethyl 2-oxoheptanoate supplier

: 52085-97-9
3-(2-chlorophenyl)propionyl chloride

: 13078-80-3
2-(2-chlorophenyl)ethanamine

Conditions

Conditions	Yield
With sodium azide; acetone und Erwaermen des Reaktionsprodukts in Benzol, zuletzt unter Zusatz von wss.Salzsaeure;

: 134306-93-7
3-(2-chlorophenyl)propionamide

: 13078-80-3
2-(2-chlorophenyl)ethanamine

Conditions

Conditions	Yield
With alkaline aqueous sodium hypobromite

: cyano(2-chlorophenyl)methyl ethyl carbonate

: 13078-80-3
2-(2-chlorophenyl)ethanamine

Conditions

Conditions	Yield
With hydrogenchloride; platinum Hydrogenation;

: 2856-63-5
2-Chlorophenylacetonitrile

: 13078-80-3
2-(2-chlorophenyl)ethanamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; aluminium trichloride
With borane-THF In tetrahydrofuran at 0 - 20℃;

: 86423-60-1
Diethyl N-(2-o-chlorophenylethyl)phosphoramidate

: 13078-80-3
2-(2-chlorophenyl)ethanamine

Conditions

Conditions	Yield
With hydrogenchloride at 80 - 85℃; for 1.5h; Yield given;

: 497-25-6
dimethylenecyclourethane

: 108-90-7
chlorobenzene

A: 13078-80-3
2-(2-chlorophenyl)ethanamine

B: 156-41-2
4-chlorophenylethylamine

C CO2: CO2

Conditions

Conditions	Yield
With aluminium trichloride for 12h; Heating; 2 equivalents of AlCl3; Yield given. Title compound not separated from byproducts;

...Expand

: 7647-01-0
hydrogenchloride

: cyano(2-chlorophenyl)methyl ethyl carbonate

platinum: platinum

: 13078-80-3
2-(2-chlorophenyl)ethanamine

Conditions

Conditions	Yield
Hydrogenation;

...Expand

: 1-chloro-2-(2‘-nitrovinyl)benzene

: 13078-80-3
2-(2-chlorophenyl)ethanamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether Heating;

: 64-04-0
phenethylamine

A: 13078-80-3
2-(2-chlorophenyl)ethanamine

B: 156-41-2
4-chlorophenylethylamine

Conditions

Conditions	Yield
With chlorine In tetrachloromethane at 25℃; Product distribution; Further Variations:; Solvents;

: 89-98-5
2-chloro-benzaldehyde

: 13078-80-3
2-(2-chlorophenyl)ethanamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: LiAlH4 / diethyl ether / Heating View Scheme
Multi-step reaction with 2 steps 1: water 2: platinum; aq.-ethanolic hydrochloric acid / Hydrogenation View Scheme
Multi-step reaction with 2 steps 1: ammonium acetate; acetic acid / 16 h / Reflux 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C View Scheme
Multi-step reaction with 2 steps 1.1: ammonium acetate / acetic acid / 0.67 h / Heating / reflux 2.1: lithium aluminium tetrahydride; sulfuric acid / tetrahydrofuran / 0.58 h / 0 - 10 °C / Heating / reflux 2.2: 0.5 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1.1: ammonium acetate; acetic acid / Neat (no solvent); Heating / reflux 2.1: aluminium hydride / tetrahydrofuran / 0.08 h / 0 °C / Heating / reflux 2.2: 0.5 h / 0 - 20 °C / Alkaline aqueous solution View Scheme

: 89-98-5
2-chloro-benzaldehyde

fermenting yeast: fermenting yeast

: 13078-80-3
2-(2-chlorophenyl)ethanamine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 100 percent / toluene / 0.5 h / Ambient temperature 2: NaH / tetrahydrofuran / 2 h / 45 °C 3: NaBH4 / ethanol / 1 h / 50 °C 4: aq. HCl / 1.5 h / 80 - 85 °C View Scheme

: 86423-59-8
Diethyl N-<β-(o-chlorophenyl)-vinyl>phosphoramidate

: 13078-80-3
2-(2-chlorophenyl)ethanamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NaBH4 / ethanol / 1 h / 50 °C 2: aq. HCl / 1.5 h / 80 - 85 °C View Scheme

: 86052-27-9
Diethyl N-o-chlorobenzylideneaminomethylphosphonate

: 13078-80-3
2-(2-chlorophenyl)ethanamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: NaH / tetrahydrofuran / 2 h / 45 °C 2: NaBH4 / ethanol / 1 h / 50 °C 3: aq. HCl / 1.5 h / 80 - 85 °C View Scheme

: 611-19-8
1-chloro-2-(chloromethyl)benzene

: 13078-80-3
2-(2-chlorophenyl)ethanamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dimethylformamide 2: LiAlH4, AlCl3 View Scheme

: 22568-07-6
1-chloro-2-[(E)-2-nitrovinyl]benzene

: 13078-80-3
2-(2-chlorophenyl)ethanamine

Conditions

Conditions	Yield
Stage #1: 1-chloro-2-[(E)-2-nitrovinyl]benzene With lithium aluminium tetrahydride; sulfuric acid In tetrahydrofuran at 0 - 10℃; for 0.583333h; Heating / reflux; Stage #2: With sodium hydroxide In tetrahydrofuran; isopropyl alcohol at 0 - 20℃; for 0.5h;
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃;
Stage #1: 1-chloro-2-[(E)-2-nitrovinyl]benzene With lithium aluminium tetrahydride; sulfuric acid In tetrahydrofuran at 0 - 10℃; for 0.583333h; Heating / reflux; Stage #2: With sodium hydroxide In tetrahydrofuran; water; isopropyl alcohol at 20℃; for 0.5h;
Stage #1: 1-chloro-2-[(E)-2-nitrovinyl]benzene With aluminium hydride In tetrahydrofuran at 0℃; for 0.0833333h; Heating / reflux; Stage #2: With sodium hydroxide; isopropyl alcohol In tetrahydrofuran; water at 0 - 20℃; for 0.5h; Alkaline aqueous solution;

: 22568-07-6, 3156-34-1
1-chloro-2-(2-nitrovinyl)benzene

: 13078-80-3
2-(2-chlorophenyl)ethanamine

Conditions

Conditions	Yield
With sodium tetrahydroborate; boron trifluoride diethyl etherate In tetrahydrofuran for 6h; Reflux;

: 14091-11-3
rac-2-chlorophenylalanine

: 13078-80-3
2-(2-chlorophenyl)ethanamine

Conditions

Conditions	Yield
With decarboxylase from Enterococcus faecium; sodium citrate at 30℃; for 22h; pH=4.4; Enzymatic reaction;	7 %Chromat.

: 3752-25-8
o-chlorocinnamic acid

: 13078-80-3
2-(2-chlorophenyl)ethanamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: phenylalanine ammonia lyase from Anabaena variabilis; ammonium carbamate / 22 h / 30 °C / pH 9.9 / Enzymatic reaction 2: decarboxylase from Enterococcus faecium; sodium citrate / 22 h / 30 °C / pH 4.4 / Enzymatic reaction View Scheme

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 79-04-9
chloroacetyl chloride

: 34162-14-6
2-Chloro-N-[2-(2-chloro-phenyl)-ethyl]-acetamide

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane Ambient temperature;	100%

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 589-87-7
1,4-bromoiodobenzene

: (4-bromophenyl)-[2-(2-chloro-phenyl)-ethyl]-amine

Conditions

Conditions	Yield
With 2-(2-methyl-1-oxopropane)cyclohexanone; caesium carbonate; copper(l) iodide In N,N-dimethyl-formamide at 20℃; for 2h;	99%

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 140-88-5
ethyl acrylate

: 83605-17-8
N,N-bis(2-carbethoxyethyl)-2-chlorophenethylamine

Conditions

Conditions	Yield
With acetic acid at 60℃; for 6h;	98.7%

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 302803-97-0
5-[benzo[d]imidazol-2-yl(cyano)methyl]-6-chloropyrazine-2,3-dicarbonitrile

: 1620085-98-4
6-amino-7-(1H-benzo[d]imidazol-2-yl)-5-(4-chlorophenethyl)-5H-pyrrolo[3,2-b]pyrazine-2,3-dicarbonitrile

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 60℃; for 3h; Inert atmosphere;	98%

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 220370-51-4
2,2,2-trifluoro-1-(2-methoxy-3,4-dihydro-2H-5-pyranyl)-2,2,2-trifluoro-1-ethanone

: 5-trifluoroacetyl-2-N-(2-chlorophenethylamino)-1-(2-chlorophenethyl)-1,2,3,4-tetrahydropyridine

Conditions

Conditions	Yield
In methanol at 20℃; for 0.0833333h;	98%

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 939-97-9
4-tert-Butylbenzaldehyde

: (4-tert-butyl-benzyl)-[2-(2-chloro-phenyl)-ethyl]-amine

Conditions

Conditions	Yield
Stage #1: 2-(2-chlorophenyl)ethanamine; 4-tert-Butylbenzaldehyde In methanol at 20℃; for 3h; Heating / reflux; Stage #2: With sodium tetrahydroborate In methanol at 20℃; for 3.08h; Heating / reflux; Stage #3: With hydrogenchloride In methanol; water at 20℃;	97%

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 814-68-6
acryloyl chloride

: 1053240-11-1
N-[2-(2-chlorophenyl)ethyl]acrylamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;	97%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;	93%

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: copper quinoline

: 496-15-1
1-indoline

Conditions

Conditions	Yield
With sodium hydroxide	96%

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 109-94-4
formic acid ethyl ester

: 99838-92-3
N-[2-(2-chlorophenyl)ethyl]formamide

Conditions

Conditions	Yield
at 50℃; for 18h;	95%

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: phenyl-3-(5-chloro-2-thienyl)-N-cyano-4-(2-oxopyrrolidin-1-yl)-4,5-dihydro-1H-pyrazole-1-carboximidoate

: N-[2-(2-chlorophenyl)ethyl]-3-(5-chloro-2-thienyl)-N'-cyano-4-(2-oxopyrrolidin-1-yl)-4,5-dihydro-1H-pyrazol-1-carboximidoate

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; for 1.5h;	94%

: 657408-07-6
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane

: (N,N,N',N'-tetramethylethylenediamine)dimethylpalladium(II)

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 1028206-58-7
chloro(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II)

Conditions

Conditions	Yield
In further solvent(s) treatment of palladium compd. with chlorobenzene deriv. and phosphine deriv. in methyl tert-butyl ether at 55°C; recrystn.;	94%

...Expand

: 13078-80-3
2-(2-chlorophenyl)ethanamine

cupric chloride: cupric chloride

: 141-43-5
ethanolamine

: 496-15-1
1-indoline

Conditions

Conditions	Yield
In 5,5-dimethyl-1,3-cyclohexadiene; nitrogen; water	93%

...Expand

: (N,N,N',N'-tetramethylethylenediamine)dimethylpalladium(II)

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 1070663-78-3
dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine

: chloro[2-(dicyclohexylphosphino)-3 ,6-dimethoxy-2’,4’, 6’-triisopropyl- 1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II)

Conditions

Conditions	Yield
In tert-butyl methyl ether at 55℃; for 5h; Inert atmosphere;	93%

...Expand

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 95-54-5
1,2-diamino-benzene

: 1084-80-6
2-(2-chlorophenyl)quinoxaline

Conditions

Conditions	Yield
With oxygen; copper(I) bromide In chlorobenzene at 20℃; for 7h;	93%
With 4-tert-butyl-5-methoxy-1,2-benzoquinone; oxygen; toluene-4-sulfonic acid In acetonitrile at 60℃; for 24h; Schlenk technique;	59%

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 4070-48-8
L-valine methyl ester

: 327-92-4
1,5-difluoro-2,4-dinitrobenzene

: 535-80-8
3-chlorobenzoate

: 2-(3-chloro-phenyl)-1-[2-(2-chloro-phenyl)-ethyl]-7-isopropyl-1,5,7,8-tetrahydro-imidazo[4,5-g]quinoxalin-6-one

Conditions

Conditions	Yield
Multistep reaction;	92%

...Expand

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 1383724-09-1
N-(2-chlorophenethyl)-2-nitrobenzenesulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 2h;	92%

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 306274-87-3
2,2,2-trifluoro-1-(2-ethoxy-3,4-dihydro-2H-5-pyranyl)-2,2,2-trifluoro-1-ethanone

: 5-trifluoroacetyl-2-N-(2-chlorophenethylamino)-1-(2-chlorophenethyl)-1,2,3,4-tetrahydropyridine

Conditions

Conditions	Yield
In ethanol at 20℃; for 0.0833333h;	92%

: 13078-80-3
2-(2-chlorophenyl)ethanamine

ammonium: ammonium

: 496-15-1
1-indoline

Conditions

Conditions	Yield
copper(I) chloride In benzene	90.8%

: 857088-45-0
4-(aminocarbonyl)-3-iodobenzoic acid

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 857088-46-1
N4-[2-(2-chlorophenyl)ethyl]-2-iodoterephthalamide

Conditions

Conditions	Yield
With diphenyl-phosphinic acid; triethylamine In N,N-dimethyl-formamide at 20℃; for 8h;	90%

: (N,N,N',N'-tetramethylethylenediamine)dimethylpalladium(II)

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 564483-18-7
XPhos

: 1028206-56-5
chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct

Conditions

Conditions	Yield
In further solvent(s) treatment of palladium compd. with chlorobenzene deriv. and phosphine deriv. in methyl tert-butyl ether at 55°C; recrystn.;	90%

...Expand

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 79-22-1
methyl chloroformate

: 1403029-48-0
2-2-chlorophenylethylcarbamic acid methyl ester

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 0 - 25℃; for 1h;	90%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;	86%

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: phenazine-1-carboxylic acid chloride

: N-(2-chlorophenylethyl)phenazine-1-carboxamide

Conditions

Conditions	Yield
In dichloromethane at 0 - 5℃; for 1h;	90%

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: (E)-3-(6-chloro-2-(ethoxycarbonyl)-1H-indol-3-yl)acrylic acid

: ethyl (E)-6-chloro-3-(3-((2-chlorophenethyl)amino)-3-oxoprop-1-en-1-yl)-1H-indole-2-carboxylate

Conditions

Conditions	Yield
Stage #1: (E)-3-(6-chloro-2-(ethoxycarbonyl)-1H-indol-3-yl)acrylic acid With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In dichloromethane at 20℃; for 0.5h; Stage #2: 2-(2-chlorophenyl)ethanamine In dichloromethane at 20℃; for 4h;	90%

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 35718-08-2
propargyl chloroformate

: prop-2-ynyl (2-chlorophenethyl)carbamate

Conditions

Conditions	Yield
With trimethylamine In diethyl ether at 20℃; for 60h; Inert atmosphere;	88%

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 4-(1H-1,2,4-triazol-1-yl)-7-(((N-Boc)piperidin-4-yl)methoxy)quinazoline

: tert-butyl 4-{[(4-{[2-(2-chlorophenyl)ethyl]amino}quinazolin-7-yl)oxy]methyl}piperidine-1-carboxylate

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 20℃;	88%

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: (2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropionic acid dicyclohexylamine salt

: C22H33ClN2O4

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; diethyl dicarbonate In dichloromethane at 20℃; for 10h;	88%

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 53554-29-3
ethyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate

: ethyl 2-((2-chlorophenethyl)amino)-4-hydroxypyrimidine-5-carboxylate

Conditions

Conditions	Yield
In ethanol for 24h; Reflux; Sealed tube;	87.7%

: 1-butyl-8-oxo-2-phenyl-1,4,5,6,7,8-hexahydroazocine-4-carboxylic acid

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 1-butyl-N-[2-(2-chlorophenyl)ethyl]-8-oxo-2-phenyl-1,4,5,6,7,8-hexahydroazocine-4-carboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 23℃; for 16h;	87%