Methyl L-leucinate hydrochloride supplier

Name
Methyl L-leucinate hydrochloride
EINECS 231-375-0
CAS No. 7517-19-3
Article Data137
CAS DataBase
Density 0.955 g/cm³
Solubility H₂O: 50 mg/mL, clear, colorless
Melting Point 151-153 °C(lit.)
Formula C₇H₁₆ClNO₂
Boiling Point 169.2 °C at 760 mmHg
Molecular Weight 181.663
Flash Point 42.7 °C
Transport Information
Appearance Crystalline
Safety 22-24/25-36/37/39-27-26
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms L-Leucine,methyl ester, hydrochloride (9CI);Leucine, methyl ester, hydrochloride, L-(6CI,7CI,8CI);(S)-Leucine methyl ester hydrochloride;Leucine methyl esterhydrochloride;Methyl (S)-leucinate hydrochloride;Methyl L-leucinatehydrochloride;Methyl leucinate hydrochloride;NSC 522233;H-Leu-OMe·HCl;L-Leucine methyl ester hydrochloride;L-leucine methyl ester;
PSA 52.32000
LogP 2.03510

Synthetic route

: 67-56-1
methanol

: 61-90-5
L-leucine

: 7517-19-3
methyl (L)-leucinate hydrochloride

Conditions

Conditions	Yield
Stage #1: methanol With thionyl chloride for 1h; Cooling with ice; Stage #2: L-leucine at 20 - 66℃; for 6.5h;	100%
With thionyl chloride at 20℃; for 4h;	99%
With thionyl chloride	99%

: 128369-74-4
Alloc-Leu-OMe

: 7517-19-3
methyl (L)-leucinate hydrochloride

Conditions

Conditions	Yield
With triethylsilane; chloroform; palladium on activated charcoal In methanol for 0.0833333h;	100%

: 112018-28-7, 112018-29-8, 126574-84-3
(S)-2-(2-Aza-bicyclo[2.2.1]hept-5-en-2-yl)-4-methyl-pentanoic acid methyl ester

: 7517-19-3
methyl (L)-leucinate hydrochloride

Conditions

Conditions	Yield
Bio-Rad AG 50W-X2 In ethanol at 73℃; for 1h;	98%

: 61-90-5
L-leucine

: 7517-19-3
methyl (L)-leucinate hydrochloride

Conditions

Conditions	Yield
With thionyl chloride In methanol	98%
	94%
Multi-step reaction with 2 steps 1: thionyl chloride View Scheme

: 75-77-4
chloro-trimethyl-silane

: 61-90-5
L-leucine

: 7517-19-3
methyl (L)-leucinate hydrochloride

Conditions

Conditions	Yield
In methanol at 20℃; for 24h;	98%

: 67-56-1
methanol

: 760-84-9
L-leucine hydrochloride

: 7517-19-3
methyl (L)-leucinate hydrochloride

Conditions

Conditions	Yield
With thionyl chloride at 0℃;	94%
With acetyl chloride at 20℃; for 0.5h;

: 67-56-1
methanol

: 120335-08-2
L-leucyl chloride

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 113089-14-8
methyl (S)-2-methoxycarbonylamino-4-methyl-valerate

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 61-90-5
L-leucine

: 77-76-9
2,2-dimethoxy-propane

: 7517-19-3
methyl (L)-leucinate hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride at 20℃;

: 2666-93-5
(S)-Leu-OMe

: 7517-19-3
methyl (L)-leucinate hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water

: 51021-87-5
N-benzyloxycarbonyl-L-leucine methyl ester

: 7517-19-3
methyl (L)-leucinate hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen; acetic acid In water

: 67-56-1
methanol

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 7517-19-3
methyl (L)-leucinate hydrochloride

Conditions

Conditions	Yield
With thionyl chloride Inert atmosphere; Reflux;
With thionyl chloride at 20℃; Cooling;
With thionyl chloride at 50℃; for 5h; Inert atmosphere;

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 123-11-5
4-methoxy-benzaldehyde

: 73995-61-6
(S)-2-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-4-methyl-pentanoic acid methyl ester

Conditions

Conditions	Yield
With sodium carbonate In methanol for 12h; Ambient temperature;	100%
With 4 A molecular sieve; titanium tetrachloride; sodium sulfate; triethylamine In dichloromethane at 20℃; for 8h;	92%

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 122-51-0
orthoformic acid triethyl ester

: 54259-27-7
(S)-methyl 2-formamido-4-methylpentanoate

Conditions

Conditions	Yield
at 95℃; for 1h;	100%

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 501-53-1
benzyl chloroformate

: 51021-87-5
N-benzyloxycarbonyl-L-leucine methyl ester

Conditions

Conditions	Yield
With sodium carbonate In 1,4-dioxane for 4h; Ambient temperature;	100%
With triethylamine In dichloromethane at 20℃;	80%
With sodium hydrogencarbonate In diethyl ether; water at 0 - 20℃; for 3h;	63%
Stage #1: methyl (L)-leucinate hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 0.25h; Inert atmosphere; Stage #2: benzyl chloroformate In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere;
With sodium carbonate In water at 20℃; for 16h;

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 1885-14-9
phenyl chloroformate

: 51021-87-5
N-benzyloxycarbonyl-L-leucine methyl ester

Conditions

Conditions	Yield
With sodium carbonate In 1,4-dioxane; water	100%

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 497-19-8
sodium carbonate

: 1885-14-9
phenyl chloroformate

: 51021-87-5
N-benzyloxycarbonyl-L-leucine methyl ester

Conditions

Conditions	Yield
In 1,4-dioxane; water	100%

...Expand

: 1035609-27-8
C10H12O4

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 1035609-29-0
N-[(2S,3R)-2,3-dihydroxy-4-phenylbutanoyl]-L-leucine methyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 1.5h;	100%

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 88971-40-8
Nα,Nβ-bis(t-butoxycarbonyl)-L-α,β-diaminopropionic acid

: 1156494-69-7
N,N'-di-Boc-2,3-L-Dap-L-Leu-OMe

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃;	100%

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 1821-12-1
4-Phenylbutyric acid

: 1170728-22-9
(S)-methyl 4-methyl-2-(4-phenylbutanamido)pentanoate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In tetrahydrofuran at 20℃; for 5h; Cooling with ice;	100%

: 108-86-1
bromobenzene

: 7517-19-3
methyl (L)-leucinate hydrochloride

A: 92-52-4
biphenyl

B: 78603-97-1
(S)-2-amino-1,1-diphenyl-4-methylpentan-1-ol

Conditions

Conditions	Yield
Stage #1: bromobenzene With magnesium In diethyl ether at 40℃; Inert atmosphere; Stage #2: methyl (L)-leucinate hydrochloride In diethyl ether at 0 - 20℃; for 15.5h;	A n/a B 100%

...Expand

: 1394024-95-3
(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(((tert-butoxycarbonyl)amino)methyl)phenyl)propanoic acid

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 1421639-93-1
Cbz-Phe(4-CH2NHBoc)-Leu-OMe

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane for 2h;	100%

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 7487-10-7
pyromellitic acid monoanhydride

: C17H17NO8

Conditions

Conditions	Yield
Stage #1: methyl (L)-leucinate hydrochloride; pyromellitic acid monoanhydride With N,N-dimethyl acetamide; triethylamine at 20℃; for 22h; Inert atmosphere; Stage #2: With acetic anhydride at 80℃; for 7h; Inert atmosphere;	100%

: 4-nitrophenyl ((αR)-6-((3-carbamoylpyridin-2-yl)oxy )spiro[3.3]heptan-2-yl)carbamate

: 7517-19-3
methyl (L)-leucinate hydrochloride

: methyl (((aR)-6-((3-carbamoylpyridin-2-yl)oxy)spiro[3.3]heptan-2-yl)carbamoyl)-L-leucinate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20 - 50℃; for 14h;	100%

: C23H41N3O6

: 7517-19-3
methyl (L)-leucinate hydrochloride

: C30H54N4O7

Conditions

Conditions	Yield
Stage #1: C23H41N3O6 With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.5h; Stage #2: methyl (L)-leucinate hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;	100%

: 3262-72-4
(S)-N-(tert-butoxycarbonyl)serine

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 85328-90-1
(S)-2-((S)-2-tert-butoxycarbonylamino-3-hydroxypropanoylamino)-4-methylpentanoic acid methyl ester

Conditions

Conditions	Yield
With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at 0 - 20℃; pH=8 - 9;	99%
Stage #1: methyl (L)-leucinate hydrochloride With sodium carbonate In dichloromethane; water at 20℃; for 0.0833333h; Stage #2: (S)-N-(tert-butoxycarbonyl)serine With C12H6B2Br4O3 In 1,2-dichloro-ethane at 90℃; for 18h; chemoselective reaction;	99%
With 4-methyl-morpholine; dicyclohexyl-carbodiimide In acetonitrile 0 deg C, 2 h; room temp., overnight;	70%

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 98-88-4
benzoyl chloride

: 3005-60-5
N-benzoyl-L-leucine methyl ester

Conditions

Conditions	Yield
With potassium carbonate In chloroform for 3h; Heating;	99%
With N-ethyl-N,N-diisopropylamine In dichloromethane; ethyl acetate at 20℃;	61%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h;	61%

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 100-52-7
benzaldehyde

: 75691-28-0
methyl (S)-2-(benzylideneamino)-4-methylpentanoate

Conditions

Conditions	Yield
With triethylamine In chloroform at 0 - 20℃; for 24h; Inert atmosphere; Sealed tube;	99%
Stage #1: methyl (L)-leucinate hydrochloride With magnesium sulfate; triethylamine In dichloromethane at 20℃; for 0.25h; Inert atmosphere; Stage #2: benzaldehyde In dichloromethane at 20℃; Inert atmosphere;	98%
With triethylamine In dichloromethane for 24h; Ambient temperature;

: 4530-20-5
BOC-glycine

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 7535-69-5
(S)-methyl 2-(2-((tert-butoxycarbonyl)amino)acetamido)-4-methylpentanoate

Conditions

Conditions	Yield
Stage #1: BOC-glycine With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 1h; Inert atmosphere; Stage #2: methyl (L)-leucinate hydrochloride In dichloromethane at 0 - 20℃; Inert atmosphere;	99%
Stage #1: BOC-glycine With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 0.5h; Inert atmosphere; Stage #2: methyl (L)-leucinate hydrochloride In dichloromethane at 20℃; for 1h; Inert atmosphere;	98%
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 24h; Inert atmosphere;	97%

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 203873-66-9
(S)-methyl 4-methyl-2-(4-nitrophenylsulfonamido)pentanoate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 12h; Inert atmosphere;	99%
With triethylamine In dichloromethane at 20℃; for 0.5h;	75%
With pyridine In dichloromethane at 20℃;
Stage #1: methyl (L)-leucinate hydrochloride; 4-Nitrobenzenesulfonyl chloride In dichloromethane at 0℃; for 0.166667h; Inert atmosphere; Stage #2: With triethylamine In dichloromethane at 20℃; for 11h; Inert atmosphere;
Stage #1: methyl (L)-leucinate hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃; for 0.166667h; Stage #2: 4-Nitrobenzenesulfonyl chloride In dichloromethane at 0℃;

: 10379-73-4, 10379-77-8, 18305-96-9, 6277-14-1
acetoxolone

: 7517-19-3
methyl (L)-leucinate hydrochloride

: N-(L-leucine methyl ester)-3β-acetyl-11-oxo-olean-12-en-18β-H-30-amide

Conditions

Conditions	Yield
Stage #1: acetoxolone With oxalyl dichloride In dichloromethane at 20℃; for 2h; Stage #2: methyl (L)-leucinate hydrochloride With triethylamine In dichloromethane at 20℃;	99%

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 56583-58-5, 76985-10-9, 58438-04-3
N-tert-butoxycarbonyl-3-(2-naphthyl)-L-alanine

: 256368-03-3
N-tert-butoxycarbonyl-L-tryptophan-L-leucine methylester

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane; N,N-dimethyl-formamide at 20℃;	99%

: 5618-98-4
N-α-benzyloxycarbonyl-DL-tyrosine

: 7517-19-3
methyl (L)-leucinate hydrochloride

: (S)-2-[(S)-2-benzyloxycarbonylamino-3-(4-hydroxyphenyl)propionylamino]-4-methylpentanoic acid methyl ester

Conditions

Conditions	Yield
With 4-methyl-morpholine; DMT*brucine tetrafluoroborate; brucine In acetonitrile at 0 - 20℃; optical yield given as %ee; enantioselective reaction;	99%

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 4817-93-0
(S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanamido)-4-methylpentanoate

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 12h;	99%
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 0 - 20℃; for 12h;	69%
With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at 0 - 20℃;	69%

: 32315-10-9
bis(trichloromethyl) carbonate

: 7517-19-3
methyl (L)-leucinate hydrochloride

: piperazine-1-carboxylic acid (4-methoxy-phenyl)-amide

: methyl (4-((4-methoxyphenyl)carbamoyl)piperazine-1-carbonyl)-L-leucinate

Conditions

Conditions	Yield
With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine In dichloromethane; water at 0 - 20℃; for 3h;	99%

...Expand

: 32315-10-9
bis(trichloromethyl) carbonate

: C13H19N3O2

: 7517-19-3
methyl (L)-leucinate hydrochloride

: methyl (4-(3-(4-methoxyphenyl)ureido)piperidine-1-carbonyl)-L-leucinate

Conditions

Conditions	Yield
With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine In dichloromethane; water at 0 - 20℃; for 3h;	99%

...Expand

: 32315-10-9
bis(trichloromethyl) carbonate

: N-(4-Fluorophenyl)piperidine-4-carboxamide

: 7517-19-3
methyl (L)-leucinate hydrochloride

: methyl (4-((4-fluorophenyl)carbamoyl)piperidine-1-carbonyl)-L-leucinate

Conditions

Conditions	Yield
With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine In dichloromethane; water at 0 - 20℃; for 3h;	99%

...Expand

: 32315-10-9
bis(trichloromethyl) carbonate

: C9H13N3O2

: 7517-19-3
methyl (L)-leucinate hydrochloride

: methyl (4-(isoxazol-3-ylcarbamoyl)piperidine-1-carbonyl)-L-leucinate

Conditions

Conditions	Yield
With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine In dichloromethane; water at 0 - 20℃; for 3h;	99%

...Expand

: 779999-14-3
4-(3-pyridylcarbamoyl)piperidine

: 32315-10-9
bis(trichloromethyl) carbonate

: 7517-19-3
methyl (L)-leucinate hydrochloride

: methyl (4-(pyridin-3-ylcarbamoyl)piperidine-1-carbonyl)-L-leucinate

Conditions

Conditions	Yield
With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine In dichloromethane; water at 0 - 20℃; for 3h;	99%

...Expand

: 147636-50-8
C13H15ClN2O3

: 7517-19-3
methyl (L)-leucinate hydrochloride

: methyl (1-((4-chlorophenyl)carbamoyl)piperidine-4-carbonyl)-L-leucinate

Conditions

Conditions	Yield
Stage #1: C13H15ClN2O3 With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h; Stage #2: methyl (L)-leucinate hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 3h;	99%

Methyl L-leucinate hydrochloride Chemical Properties

Product Name: L-leucine methyl ester (CAS NO.7517-19-3)

Molecular Formula: C₇H₁₆ClNO₂
Molecular Weight: 181.660440 g/mol
Melting Point: 151-153 °C(lit.)
Solubility: H₂O: 50 mg/mL, clear, colorless
Alpha: 20 °(c=4.5, MeOH)
Refractive index:13 °(C=2, H₂O)
Storage temp.: 0-6°C
Sensitive: Hygroscopic
BRN: 3595133
Flash Point: 42.7 °C
Enthalpy of Vaporization: 40.56 kJ/mol
Boiling Point: 169.2 °C at 760 mmHg
Vapour Pressure: 1.56 mmHg at 25°C
H-Bond Donor: 2
H-Bond Acceptor: 3
Structure Descriptors of L-leucine methyl ester (CAS NO.7517-19-3):
IUPAC Name: methyl 2-amino-4-methylpentanoate hydrochloride
Canonical SMILES: CC(C)CC(C(=O)OC)N.Cl
InChI: InChI=1S/C7H15NO2.ClH/c1-5(2)4-6(8)7(9)10-3;/h5-6H,4,8H2,1-3H3;1H
InChIKey: DODCBMODXGJOKD-UHFFFAOYSA-N
Categories: Protected Amino Acids; Amino Acids; Leucine [Leu, L]; Amino Acids and Derivatives; Amino Acid Methyl Esters; Amino Acids (C-Protected); Biochemistry; Amino hydrochloride; Amino Acid Derivatives; Leucine; Peptide Synthesis

Methyl L-leucinate hydrochloride Uses

L-leucine methyl ester (CAS NO.7517-19-3) is a kind of biochemical reagents, pharmaceutical intermediates.

Methyl L-leucinate hydrochloride Safety Profile

Safety Information of L-leucine methyl ester (CAS NO.7517-19-3):
Hazard Codes:Xi
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:22-24/25-36/37/39-27-26
22:Do not breathe dust
24/25:Avoid contact with skin and eyes
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
27:Take off immediately all contaminated clothing
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
WGK Germany:3

Methyl L-leucinate hydrochloride Specification

L-leucine methyl ester , its CAS NO. is 7517-19-3, the synonyms are Methyl L-leucinate HCl ; Methyl L-leucinate hydrochloride .

Product Name

Methyl L-leucinate hydrochloride

Synthetic route

Methyl L-leucinate hydrochloride Chemical Properties

Methyl L-leucinate hydrochloride Uses

Methyl L-leucinate hydrochloride Safety Profile

Methyl L-leucinate hydrochloride Specification

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