Picramic acid supplier | CasNO.96-91-3

Name
Picramic acid
EINECS 202-544-6
CAS No. 96-91-3
Article Data36
CAS DataBase
Density 1.749 g/cm ³
Solubility water: <0.1 g/100 mL at 20.5 °C
Melting Point 169 °C
Formula C₆H₅N₃O₅
Boiling Point 386.3 °C at 760 mmHg
Molecular Weight 199.123
Flash Point 187.5 °C
Transport Information UN 3317
Appearance dark red crystals
Safety 35-61
Risk Codes 1-20/21/22-52/53
Molecular Structure
Hazard Symbols E,Xn
Synonyms 1-Amino-2-hydroxy-3,5-dinitrobenzene;1-Amino-3,5-dinitro-2-hydroxybenzene;1-Hydroxy-2-amino-4,6-dinitrobenzene;2,4-Dinitro-6-aminophenol;2-Amino-4,6-dinitrophenol;4,6-Dinitro-2-aminophenol;6-Amino-2,4-dinitrophenol;C.I. Oxidation Base 21;Fourrine 4R;Fourrine 93;Furro 4R;NSC 36939;NSC 4861;Zoba 4R;
PSA 137.89000
LogP 2.41840

Synthetic route

: 88-89-1
2,4,6-Trinitrophenol

: 96-91-3
picramic acid

Conditions

Conditions	Yield
With sulfur; sodium hydroxide In methanol; water at 80℃; for 8h; Green chemistry;	87%
With ethanol; hydrogen sulfide; ammonia
With sodium hydrogensulfide in der Waerme;

: ammonium 2-amino-4,6-dinitrophenolate

: 96-91-3
picramic acid

Conditions

Conditions	Yield
With acetic acid In water at 60℃; Inert atmosphere;	79%

: 603-87-2
2-amino-6-nitrophenol

: 96-91-3
picramic acid

Conditions

Conditions	Yield
With sulfuric acid; nitric acid at 0 - 5℃;	40%

: 75802-61-8
dopamine picrate

: 96-91-3
picramic acid

Conditions

Conditions	Yield
at 250℃; for 5h;	8%

: 13316-89-7
benzoic acid-(2-hydroxy-3,5-dinitro-anilide)

: 96-91-3
picramic acid

Conditions

Conditions	Yield
With hydrogenchloride at 140℃;
With hydrogenchloride at 130℃;

: 5422-72-0
acetic acid-(2-hydroxy-3,5-dinitro-anilide)

: furan-2,3,5(4H)-trione pyridine (1:1)

: 96-91-3
picramic acid

: 3324-58-1
sodium picrate

: 96-91-3
picramic acid

Conditions

Conditions	Yield
With methanol; sodium hydrogensulfide
With water; sodium disulfide

: 64-17-5
ethanol

: 7783-06-4
hydrogen sulfide

: 7664-41-7
ammonia

: 88-89-1
2,4,6-Trinitrophenol

: 96-91-3
picramic acid

...Expand

: ammonium chloride

: 7732-18-5
water

: 88-89-1
2,4,6-Trinitrophenol

: 96-91-3
picramic acid

Conditions

Conditions	Yield
und im Wasserstoff-Strom erhitztes Aluminium (in Kaeltemischung);

...Expand

: 57-48-7, 87-79-6, 87-81-0, 551-68-8, 3615-39-2, 3615-56-3, 6035-50-3, 7776-48-9, 16354-64-6, 17598-81-1, 17598-82-2, 23140-52-5, 30237-26-4, 65732-90-3, 73952-10-0, 73952-11-1, 139686-85-4
fructose

: 7732-18-5
water

: 88-89-1
2,4,6-Trinitrophenol

alkali: alkali

: 96-91-3
picramic acid

...Expand

: 50-99-7, 59-23-4, 921-60-8, 1949-88-8, 1990-29-0, 2152-76-3, 2595-97-3, 2595-98-4, 3458-28-4, 4205-23-6, 5934-56-5, 5978-95-0, 5987-68-8, 6027-89-0, 6038-51-3, 7635-11-2, 10030-80-5, 15572-79-9, 19163-87-2, 23567-25-1, 26566-61-0, 30077-17-9, 31103-86-3, 39665-52-6, 40866-07-7, 58367-01-4, 58407-05-9, 58407-06-0, 83198-69-0, 83198-70-3, 83198-71-4, 93780-23-5, 145920-48-5
glucose

: 7732-18-5
water

: 88-89-1
2,4,6-Trinitrophenol

alkali: alkali

: 96-91-3
picramic acid

...Expand

: 88-89-1
2,4,6-Trinitrophenol

: iron(II) sulfate

alkali: alkali

: 96-91-3
picramic acid

...Expand

: 7732-18-5
water

: 88-89-1
2,4,6-Trinitrophenol

: 63-42-3
D-(+)-lactose

alkali: alkali

: 96-91-3
picramic acid

...Expand

: 7664-41-7
ammonia

: 88-89-1
2,4,6-Trinitrophenol

CuCl: CuCl

: 96-91-3
picramic acid

...Expand

: 88-89-1
2,4,6-Trinitrophenol

hydrosulfite sodium: hydrosulfite sodium

: 96-91-3
picramic acid

: 7732-18-5
water

: 88-89-1
2,4,6-Trinitrophenol

iron-turnings: iron-turnings

: 96-91-3
picramic acid

Conditions

Conditions	Yield
at 100℃;

...Expand

: 7732-18-5
water

: 7705-08-0
iron(III) chloride

: 88-89-1
2,4,6-Trinitrophenol

iron-turnings: iron-turnings

: 96-91-3
picramic acid

Conditions

Conditions	Yield
at 100℃;

...Expand

: 7732-18-5
water

: 88-89-1
2,4,6-Trinitrophenol

iron-turnings: iron-turnings

NaCl: NaCl

: 96-91-3
picramic acid

Conditions

Conditions	Yield
at 100℃;

...Expand

: 67-56-1
methanol

: 7732-18-5
water

: 88-89-1
2,4,6-Trinitrophenol

Na2S: Na2S

NaHCO3: NaHCO3

: 96-91-3
picramic acid

Conditions

Conditions	Yield
at 60℃;

...Expand

: 64-17-5
ethanol

: 7732-18-5
water

: 88-89-1
2,4,6-Trinitrophenol

Na2S: Na2S

NaHCO3: NaHCO3

: 96-91-3
picramic acid

Conditions

Conditions	Yield
at 80℃;

...Expand

: 50-99-7, 59-23-4, 921-60-8, 1949-88-8, 1990-29-0, 2152-76-3, 2595-97-3, 2595-98-4, 3458-28-4, 4205-23-6, 5934-56-5, 5978-95-0, 5987-68-8, 6027-89-0, 6038-51-3, 7635-11-2, 10030-80-5, 15572-79-9, 19163-87-2, 23567-25-1, 26566-61-0, 30077-17-9, 31103-86-3, 39665-52-6, 40866-07-7, 58367-01-4, 58407-05-9, 58407-06-0, 83198-69-0, 83198-70-3, 83198-71-4, 93780-23-5, 145920-48-5
glucose

: 88-89-1
2,4,6-Trinitrophenol

natrium carbonate: natrium carbonate

: 96-91-3
picramic acid

...Expand

: 7664-41-7
ammonia

: 88-89-1
2,4,6-Trinitrophenol

SnCl2: SnCl2

: 96-91-3
picramic acid

...Expand

: 88-89-1
2,4,6-Trinitrophenol

sodium ferropyrophosphate: sodium ferropyrophosphate

: 96-91-3
picramic acid

: 7732-18-5
water

: 88-89-1
2,4,6-Trinitrophenol

sodium hydrogensulfide: sodium hydrogensulfide

: 96-91-3
picramic acid

...Expand

: 64-17-5
ethanol

: 7664-93-9
sulfuric acid

: 88-89-1
2,4,6-Trinitrophenol

vanadyl sulfate: vanadyl sulfate

: 96-91-3
picramic acid

Conditions

Conditions	Yield
Electrolysis;

...Expand

: 7664-41-7
ammonia

: 88-89-1
2,4,6-Trinitrophenol

zinc-dust: zinc-dust

: 96-91-3
picramic acid

...Expand

: 64-17-5
ethanol

: ammonium chloride

: 88-89-1
2,4,6-Trinitrophenol

cerium-powder: cerium-powder

A: 609-24-5
2,4,6-triaminophenol

B: 96-91-3
picramic acid

...Expand

: 7647-01-0
hydrogenchloride

: 13316-89-7
benzoic acid-(2-hydroxy-3,5-dinitro-anilide)

A: 65-85-0
benzoic acid

B: 96-91-3
picramic acid

Conditions

Conditions	Yield
at 130℃;

...Expand

: 3.5-dinitro-2-oxy-phenyl isocyanate

: 7732-18-5
water

: 96-91-3
picramic acid

Conditions

Conditions	Yield
beim Kochen;

: acetic acid-(2-amino-4,6-dinitro-phenyl ester)

aqueous NaOH-solution: aqueous NaOH-solution

: 96-91-3
picramic acid

: C24H26N4O5

: 96-91-3
picramic acid

: C23H15N5O7

Conditions

Conditions	Yield
Stage #1: picramic acid With hydrogenchloride; acetic acid; sodium nitrite In methanol; water at 0℃; for 2h; Stage #2: C24H26N4O5 With sodium hydroxide In methanol; 2-ethoxy-ethanol; water at 0℃; for 2h; pH=11;	98.3%

: 3665-54-1
3-Hydroxy-naphthalene-2-carboxylic acid butylamide

: 96-91-3
picramic acid

: C21H19N5O7

Conditions

Conditions	Yield
Stage #1: picramic acid With hydrogenchloride; acetic acid; sodium nitrite In methanol; water at 0℃; for 2h; Stage #2: 3-Hydroxy-naphthalene-2-carboxylic acid butylamide With sodium hydroxide In methanol; 2-ethoxy-ethanol; water at 0℃; for 2h; pH=11;	95.1%

: 75755-40-7
2,2-dimethyl-3-(N-methyl-N-phenylamino)-2H-azirine

: 96-91-3
picramic acid

: 130138-19-1
2-(1-Amino-1-methylethyl)-5,7-dinitro-1,3-benzoxazole

Conditions

Conditions	Yield
In acetonitrile for 24h; Ambient temperature;	83%

: 116139-91-4
N-methyl-N-phenyl-1-azaspiro[2.4]hept-1-en-2-amine

: 96-91-3
picramic acid

: 130138-32-8
2-(1-Aminocyclopentyl)-5,7-dinitro-1,3-benzoxazole

Conditions

Conditions	Yield
In acetonitrile for 24h; 0 deg C to room temp.;	81%

: 3,3-bis(3,4,5-trimethoxyphenyl)acrylaldehyde

: 96-91-3
picramic acid

: 2-(2,2-bis(3,4,5-trimethoxyphenyl)vinyl)-5,7-dinitrobenzoxazole

Conditions

Conditions	Yield
Stage #1: 3,3-bis(3,4,5-trimethoxyphenyl)acrylaldehyde; picramic acid In ethanol for 3h; Reflux; Stage #2: With lead(IV) tetraacetate; acetic acid at 20℃; for 1h;	78%

: 4-(9H-pyrido[3,4-b]indol-1-yl)thiazole-2-carbaldehyde

: 96-91-3
picramic acid

: 1-(2-(5,7-dinitrobenzo[d]oxazol-2-yl)thiazol-4-yl)−9H-pyrido[3,4-b]indole

Conditions

Conditions	Yield
With [bis(acetoxy)iodo]benzene In 1,4-dioxane at 20℃; for 0.25h;	77%

: 79-04-9
chloroacetyl chloride

: 96-91-3
picramic acid

: 96753-74-1
6,8-dinitro-(2H)-1,4-benzoxazin-3(4H)-one

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water for 4h; Heating;	75%

: 56912-87-9
3-(Dimethylamino)spiro<2H-azirin-2,1'-cyclohexan>

: 96-91-3
picramic acid

A: 130138-33-9
2-(1-Aminocyclohexyl)-5,7-dinitro-1,3-benzoxazole

B: 130138-29-3
1',2',3',4'-Tetrahydro-5',7'-dinitrospiro-2'-one

C: 130138-31-7
2'-(Dimethylamino)-3',4'-dihydro-5',7'-dinitrospiro

D: 130138-35-1
1-Amino-N-<2-(dimethylamino)-3,5-dinitrophenyl>cyclohexanecarboxamide

Conditions

Conditions	Yield
In acetonitrile for 24h; 0 deg C to room temp.;	A 54% B 3% C 8% D 27%

...Expand

: 96-91-3
picramic acid

A: 108805-12-5
3'-(Dimethylamino)spiroazirin>

B: 130138-30-6
2'-(Dimethylamino)-3',4'-dihydro-5',7'-dinitrospiro

C: 130138-34-0
1-Amino-N-<2-(dimethylamino)-3,5-dinitrophenyl>cyclopentanecarboxamide

D: 130138-28-2
1',2',3',4'-Tetrahydro-5',7'-dinitrospiro-2'-one

Conditions

Conditions	Yield
In acetonitrile for 24h; 0 deg C to room temp.;	A 40% B 32% C 16% D 4%

...Expand

: 108805-12-5
3'-(Dimethylamino)spiroazirin>

: 96-91-3
picramic acid

A: 130138-30-6
2'-(Dimethylamino)-3',4'-dihydro-5',7'-dinitrospiro

B: 130138-34-0
1-Amino-N-<2-(dimethylamino)-3,5-dinitrophenyl>cyclopentanecarboxamide

C: 130138-32-8
2-(1-Aminocyclopentyl)-5,7-dinitro-1,3-benzoxazole

D: 130138-28-2
1',2',3',4'-Tetrahydro-5',7'-dinitrospiro-2'-one

Conditions

Conditions	Yield
In acetonitrile for 24h; 0 deg C to room temp.;	A 32% B 16% C 40% D 4%

...Expand

: 119-40-4
2-phenylamino-5-hydroxynaphthalene-7-sulphonic acid

: 96-91-3
picramic acid

: C22H15N5O9S

Conditions

Conditions	Yield
Stage #1: picramic acid With hydrogenchloride; sodium nitrite In water at 0 - 5℃; for 1h; Stage #2: With aminosulfonic acid In water for 0.05h; Stage #3: 2-phenylamino-5-hydroxynaphthalene-7-sulphonic acid In water at 10℃; for 2h;	3.4%

: 110-86-1
pyridine

: 98-59-9
p-toluenesulfonyl chloride

: 96-91-3
picramic acid

: 1-[2,4-dinitro-6-(toluene-4-sulfonylamino)-phenyl]-pyridinium betaine

...Expand

: 85-44-9
phthalic anhydride

: 96-91-3
picramic acid

: N-(2-hydroxy-3,5-dinitro-phenyl)-phthalimide

Conditions

Conditions	Yield
With acetic acid

: O4,O6-((R)-ethylidene)-O2,O3-((1Ξ,3Ξ)-1,3-dimethyl-2-oxa-propanediyl)-D-glucose

: 96-91-3
picramic acid

: O4,O6-((R)-ethylidene)-O2,O3-((1Ξ,3Ξ)-1,3-dimethyl-2-oxa-propanediyl)-D-glucose-(2-hydroxy-3,5-dinitro-phenylimine)

Conditions

Conditions	Yield
With methanol

: 541-41-3
chloroformic acid ethyl ester

: 96-91-3
picramic acid

: (2-hydroxy-3,5-dinitro-phenyl)-carbamic acid ethyl ester

: 108-24-7
acetic anhydride

: 96-91-3
picramic acid

: 98434-14-1
2-methyl-5,7-dinitro-benzooxazole

Conditions

Conditions	Yield
With sulfuric acid

: 108-24-7
acetic anhydride

: 96-91-3
picramic acid

A: acetic acid-(2-amino-4,6-dinitro-phenyl ester)

B: 5422-72-0
acetic acid-(2-hydroxy-3,5-dinitro-anilide)

Conditions

Conditions	Yield
With sulfuric acid

...Expand

: 108-24-7
acetic anhydride

: 96-91-3
picramic acid

: 5422-72-0
acetic acid-(2-hydroxy-3,5-dinitro-anilide)

: 108-24-7
acetic anhydride

: 96-91-3
picramic acid

: 99057-38-2
2-acetoxy-1-acetylamino-3,5-dinitro-benzene

Conditions

Conditions	Yield
With pyridine

: 555-16-8
4-nitrobenzaldehdye

: 96-91-3
picramic acid

: 2,4-dinitro-6-(4-nitro-benzylidenamino)-phenol

: 606-35-9
1-methoxy-2,4,6-trinitrobenzene

: 96-91-3
picramic acid

: 1,3,6,8-tetranitro-phenoxazine

Conditions

Conditions	Yield
With ethanol; sodium acetate at 130℃; im Rohr;

: 100-44-7
benzyl chloride

: 96-91-3
picramic acid

: 2-benzylamino-4,6-dinitro-phenol

Conditions

Conditions	Yield
With water

: 90-02-8
salicylaldehyde

: 96-91-3
picramic acid

: salicylaldehyde-(3.5-dinitro-2-hydroxy-phenylimine)

Conditions

Conditions	Yield
With potassium hydroxide

Picramic acid Chemical Properties

IUPAC Name: Picramic acid
The MF of Picramic acid (96-91-3) is C₆H₅N₃O₅.

The MW of Picramic acid (96-91-3) is 199.12.
Synonyms of Picramic acid (96-91-3): Phenol, 2-amino-4,6-dinitro- ; 1-Amino-2-hydroxy-3,5-dinitrobenzene ; 2,4-Dinitro-6-aminophenol ; 2-Amino-4, 6-dinitrophenol ; 4, 6-Dinitro-2-aminophenol ; 2-Hydroxy-3,5-dinitroaniline
Product Categories: Intermediates of Dyes and Pigments
Form: dark red crystals
Index of Refraction: 1.73
EINECS: 202-544-6
Density: 1.749 g/ml
Flash Point: 187.5 °C
Boiling Point: 386.3 °C
Melting Point: 169 °C
Water Solubility: <0.1 g/100 mL at 20.5 ºC
Merck: 7409
Stability: Stable

Picramic acid Uses

Picramic acid (96-91-3) is used as dye intermediates and indicator.

Picramic acid Toxicity Data With Reference

1.	mmo-sat 5 µmol/plate	NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. 38 (1983),533.
2.	mma-sat 5 µmol/plate	NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. 38 (1983),533.
3.	ivn-dog LDLo:150 mg/kg	AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 50 (1935),20.
4.	ipr-pgn LDLo:140 mg/kg	AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 50 (1935),20.

Picramic acid Safety Profile

Poison by intravenous and intraperitoneal routes. Mutation data reported. Combustible when exposed to heat, flame or oxidizers. A powerful explosive when dry. May explode when shocked or heated. When heated to decomposition it emits toxic fumes of NO_x. See also EXPLOSIVES, HIGH.
Safety information of Picramic acid (96-91-3):
Hazard Codes E,Xn
Risk Statements
1 Explosive when dry
20/21/22 Harmful by inhalation, in contact with skin and if swallowed
52/53 Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Safety Statements
35 This material and its container must be disposed of in a safe way
61 Avoid release to the environment. Refer to special instructions safety data sheet
RIDADR 3317
RTECS SJ5800000
HazardClass 4.1
PackingGroup II

Product Name

Picramic acid

Synthetic route

Picramic acid Chemical Properties

Picramic acid Uses

Picramic acid Toxicity Data With Reference

Picramic acid Safety Profile

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